Core Facilities and Instrumentation

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2D Crystal Consortium
- Bulk Growth Facility
- Theory/Simulation Facility
- Thin Films Facility
3T MRI Facility
- ETT Olfactometer
- Eyelink 1000
- Eye Tracker - Goggles
- Eye Tracker - Long Range Optics
- fMRI Joystick
- fMRI Response Boxes
- fMRI Response Grips
- MRI Digital Projection System
- Siemens 3T Magnetom Prisma Fit
- VisuaStim Digital Goggles & Headphones
Accelerator Mass Spectrometer Laboratory
- National Electrostatics Corporation 500kV 1.5SDH-1 Compact Accelerator Mass Spectrometer (AMS)
Automated Biological Calorimetry Facility
- Data analysis
- Differential scanning calorimetry
  - MicroCal VP-capillary DSC
- Isothermal titration calorimetry
- Protein and lipid quantification
  - Millipore Direct Detect Biomolecular Quantitation System
CEL Core Endocrinology
Center for Quantitative Imaging (CQI)
- Micro CT Scanner: GE v|tome|x L300 multi-scale nano/microCT system
Community Sciences and Health Outcomes (CSHO) - Penn State Cancer Institute
Cryo-Electron Microscopy Facility
- FEI Titan Krios
- Tecnai BioTwin Spirit
- Tecnai LaB6
- Titan Krios Computer Support
- Titan Krios Prep Space
- Vitrobot
CyberScience Advanced CyberInfrastructure (ICDS-ACI)
CyberScience Advanced CyberInfrastructure (ICS-ACI)
Deployable Energy and Environmental Sustainability Laboratory (DEESL)
- California Analytical Instruments 700 Fourier Transform Infrared Analyzer (FTIR)
- GSSI EMP-400 - Multi-Frequency Electro Magnetic Conductivity Meter (MFEMCM)
- INNOVA Photoacoustic Multi-Gas Infrared (IR) Analyzer
- LI-COR Inc./LI-6400XT - Portable Photosynthesis and Fluorescence System
- Sensornet Oryx DTS - Distributed Temperature Sensor
- Syscal Pro Switch 48 Resistivity - Electrical Resistivity and Induced Polarization Instrument
- TSI Nanoscan SMPS nanoparticle sizer 3910 and Optical Particle Sizer - Particle Size Analyzer
Drug Discovery, Development and Delivery Core
- Beckman System Gold High-Performance Liquid Chromatograph
- Eppendorf epMotion 5070 robot
- GE Biacore 3000
- Integra VIAFLOW 96/384 pipette
- Malvern Zetasizer
- Molecular Devices Flexstation 3 plate reader
- Seahorse XFe96 Analyzer
Fermentation Facility
- AdvanceBio SüPR•2G bench-scale hydrolyzer system
- Agilent HP 1100 high-performance liquid chromatography (HPLC) system
- ÄKTA Pure 150L FPLC & Frac-950 fraction collector
- BioFlo 3000 1-5 L benchtop bioreactor
- BioService 150 L fermentor
- BioService 300 L fermentor
- Microfluidizer processor
- Micros 30 L microbial fermentor
- Mobile Pilot Plant 80 L fermentor
- Munson SCC-10-MS cutter
- Sharples AS-16 centrifuge
- Sharples T-1-P super-centrifuge
- SixFors 6x500 ml research console / Fermentor
Flow Cytometry & Cell Sorting
- 10-color FACSCanto
- 16-color LSR Fortessa
- 16-color LSR II
- 17-color BD FACS Aria SORP high-performance cell sorter
- 4-color FACSCalibur
Genome Sciences Facility
- ABI 3130XL Capillary Sequencer
- ABI QuantStudio 12K Flex system
- ABI QuantStudio 3D Digital PCR System
- Agilent 2100 Bioanalyzer
- Bullet Blender (high-throughput tissue homogenizer)
- Covaris Adaptive Focused Acoustics Ultrasonicator E-Series
- Illumina HiSeq 2500
- Illumina iScan
- Illumina MiSeq
- Molecular Devices UV/Vis/Fluor Spectrophotometer
- Nanodrop ND-1000 Spectrophotometer
- QIA Symphony DNA/RNA Extraction Robot
- Qubit Fluorometer
Genomics Core Facility
- Affymetrix GeneChip Fluidics Station 450
- Affymetrix GeneChip Hybridization Oven 640
- Affymetrix GeneChip Scanner 3000 7G
- Applied Biosystems 3730XL
- Applied Biosystems 7300 Sequence Detection System
- Applied Biosystems 7900HT Fast Real-Time PCR System
- Applied Biosystems 7900HT Fast Real-Time PCR System
- Applied Biosystems OpenArray Real-Time PCR Instrument and AccuFill System
- Applied Biosystems Quantstudio 12K Flex Real-Time PCR Instrument
- Digital PCR
- Genotyping of SNPs and VNTRs
- Illumina HiSeq 2500
- Illumina MiSeq
- Microarray analysis
- Molecular Devices GenePix 4000B
- Next-generation sequencing
- Real-time qPCR
- Sanger DNA sequencing
High Field Magnetic Resonance Imaging Facility
- Agilent 14.1 tesla system
- Agilent 7 tesla system
High Field MRI Facility
- Varian 14.1 Tesla
- Varian 7 Tesla
Human Electrophysiology Facility
- 3D motion tracking system by Polhemus
- Brain Vision actiCAP
- Brain Vision system - BrainAmpDC
- Geodesic EEG System - NA 200
- Geodesic EEG System - NA 300
- HydrocCel Geodesic Sensor Net (HCGSN)
Institute for Personalized Medicine
Laboratory for Analysis of Strategic Element Resources (LASER)
Laboratory for Isotopes and Metals in the Environment (LIME)
- Combi PAL autosampler with Gas Bench Interface attached to a Thermo Delta V Mass Spectrometer
- Gas Pre-Concentrator/Delta V IRMS
- GC/FID - Hewlett Packard 5890 Series II Gas Chromatography equipped with a flame ionization detector
- Perkin-Elmer Optima 5300DV ICP-AES
- Solid C and N Isotope Analyzer
- Thermo-Scientific Neptune Plus [multiple collector ICP-MS] w/ UPS and Aridus II and APEX HF desolvating nebulizers
- X Series II-SBM and X Series II-MFM Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)
Macromolecular Synthesis Core
Mass Spectrometry and Proteomics
- ABI/MDS Sciex 5800 MALDI TOF-TOF Mass Spec
- ABI Voyager DE-PRO Reflectron MALDI TOF Mass Spec
- ABSciex TripleTOF 5600+ Mass Spec
- Biacore 3000 Surface Plasmon Resonance System
- Gel Imaging and Analysis Tools
- HPLC/UPLC and Gel Separation Systems
- MDS Sciex 4000 QTrap Hybrid Ion Trap Mass Spec
- MesoScale Discoveries (MSD) Sector Imager 2400 Electrochemiluminescence Detector/Plate Reader
- Shimadzu CHiP Printer
- Spot-Cutting and Robotics
- Waters Q-TOF Premier
- Waters Synapt HDMS Hybrid QTOF with Ion Mobility
- Wyatt DAWN HELEOS Light-Scattering Detection System (for protein sizing)
Materials Characterization lab
- MRI-MCL-FEI Talos F200X
- MRI-MCL-FEI Tecnai G20 20 XTWIN
- MRI-MCL-Helium Pycnometer
- MRI-MCL-Mercury Intrusion Porosimetry
- MRI-MCL-nanoTOF II ToF-SIMS
- MRI-MCL-PANalytical X’Pert3 MRD
- MRI-MCL-Raman System: "Lucy"
- MRI-MCL-Raman System: "Vlabinir"
- MRI-MCL-TEM-FEI Talos F200C
- MRI-MCL-TEM-FEI Titan3 G2
- MRI-MCL-Xeuss 2.0 HR SAXS/WAXS
Materials Computation Center
Metabolomics Facility
- AB SCIEX 5600 Triple TOF
- Agilent 5975 MSD (GC-MS)
- Agilent gas chromatography-mass spectrometry (GC-MS)
- Quadrupole Time-of-Flight (Q-TOF) tandem mass spectrometers
- Thermo Scientific EXACTIVE PLUS high resolution mass spectrometer
- Thermo Scientific Orbitrap Fusion Lumos Tribrid
- Triple quadrupole mass spectrometers (Waters Xevo TQ-S, and Waters Xevo TQ-D, both with Waters Acquity UPLCs)
- Waters Synapt G2-S
- Waters Xevo TQ-S
Micro CT Scanner Core
Microscopy and Cytometry Facility
- BioVision VT-iSIM
- Electron microscopy
- Flow cytometry
- Fluoresence and confocal microscopy services
- Histology services
- Keyence BZ-9000 E
- Laser-capture microdissection services
- Nikon N-SIM/N-STORM
- Olympus BX61 (materials scope)
- Olympus Fluoview 1000
- Olympus Fluoview 10i-LIV
- Training and consultation
- Zeiss AxioZoom V16
- Zeiss PALM MicroBeam IV laser-capture microdissection system
Microscopy Imaging
- Auto3dem and EMAN2 Workstations
- Confocal, Super-Resolution STED and Deconvolution Microscopes
- Cryo- and Transmission Electron Microscopes
- IMARIS, VOLOCITY and HUYGENS Workstations
MRI Core
Multimodal Multiphoton Microscope
Nanofabrication Lab
Organic Synthesis
- CE 2014 UV Spectrophotometer (CECIL)
- Discover microwave reactor (CEM)
- Excella E24 Incubator Shaker (New Brunswick Scientific)
- Expression-S benchtop compact mass spectrometer (Advion)
- Freeze Dry Lyophilizer system (Labconco)
- Glove box for inert atmosphere-sensitive reaction
- Legend T Plus benchtop centrifuge (Thermo Scientific)
- Photochemical immersion well reactor with a mercury-vapor lamp
- Seven high-pressure liquid chromatography instruments with a variety of detectors such as UV, β-flow radioactivity, photodiode array (PDA), fluorescence and evaporative light scattering (ELS)
- Temperature-sensitive probes (J-KEM Scientific)
Proteomics and Mass Spectrometry Core Facility
- Bruker UltrafleXtreme MALDI-TOF-TOF
- Criterion Dodeca cell for SDS-PAGE (Bio-Rad)
- Criterion electrophoresis cell (Bio-Rad)
- Criterion protein blotter (Bio-Rad)
- Ettan DALTsix electrophoresis unit (Amersham Biosciences)
- Gel electrophoresis
- MiniPROTEAN Tetra cell (Bio-Rad)
- Molecular mass determination of small molecules
- Multiphor II electrophoresis unit (Amersham Biosciences)
- Protean IEF cell (Bio-Rad)
- Proteomics
- Speed Vac (Savant)
- Thermo LTQ Orbitrap Velos ETD
Sartorius SARTOFLOW Smart
Satellite Energy and Environmental Sustainability Laboratory (SEESL)
- Kintek SX 300 Stopped Flow Spectrometer (SEESL - SFS)
- Thermo Scientific ISQ LT Single Quadrupole Gas Chromatograph/Mass Spectrometer (GC/MS)
Solution Phase NMR
- 500 MHz Bruker Avance II
- 600 MHz Bruker Avance II
Thermo Triton Thermal Ionization Mass Spectrometer (TIMS)
Transgenic Animal Core
Transgenic Mouse Facility
- Additional services
- Gene-targeted (knockout) mouse production
- Special projects
- Transgenic mouse production
  - Consulting
Water Quality Laboratory
- 2100N Hach Turbidimeter
- Automated Wet Chemistry Analyzer: SEAL AQ2 Automated Advanced Discrete Analyzer
- Beckman 360 pH meter
- Binder ED115 Oven and Mettler AE 200 Balance
- Dionex ICS-3000 Ion Chromatography
- Mettler Toledo DL15 Potentiometric Titrator for Endpoint Titrations
- Milestone DMA-80 Direct Mercury Analyzer
- Perkin Elmer AAnalyst 800 Atomic Absorption Spectrometer-Flame/Furnace
- Picarro L2130-i Analyzer - Stable Isotopes
- Radiometer TIM865 TitraLab: acid neutralizing capacity
- Shimadzu TOC-VCPH Total Organic Carbon Analyzer
- YSI 3200 Conductivity Meter
X-ray Crystallography Core
- Olympus SZ-61
X-Ray Crystallography Facility
- 3D structure determination and analysis
- Ab initio protein modeling
  - Mac Pro graphics workstation
- Access to the Protein Data Bank
- Circular Dichroism(CD) Spectrometer
- Crystallization
- Crystal screening for x-ray diffraction
  - Rigaku Microfocus Micromax 007 X-ray generator and Saturn 944+ CCD detector
- Dynamic light scattering
  - Viscotek 802 Dynamic Light Scattering Instrument
- Macromolecular binding interactions
  - Fortebio Octet QK
- Manuscript and grant preparation
- Small angle x-ray scattering
- X-ray data collection
  - Rigaku Microfocus Micromax 007 X-ray generator and Saturn 944+ CCD detector
Zebrafish Functional Genomics Core
- Eppendorf FemtoJet microinjectors
- Leica MZ FLIII Fluorescence Stereomicroscope
- Manual micromanipulators
- Olympus MVX10 MacroView Macro Zoom Fluorescence Microscope
- ZEISS Axio Zoom.V16 Zoom Fluorescence Microscope with ZEISS ApoTome.2
- ZEISS Stereo Discovery.V8 microscopes