Differential scanning calorimetry

    Equipment/facility: Service

    • Location

      Automated Biological Calorimetry Facility Huck Institutes for Life Sciences Penn State University 8 Althouse Lab University Park, PA 16802

      United States

    Description

    Differential scanning calorimetry (DSC) is a technique that measures the thermal stability of a macromolecule's tertiary and secondary structure.
    The raw data obtained in this experiment is a plot of heat capacity difference as a function of temperature, and analysis will yield the macromolecule's Tm as well as the enthalpy of folding.

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    Macromolecules
    Differential scanning calorimetry
    Specific heat
    Enthalpy
    Thermodynamic stability
    Experiments
    Temperature