Organic Synthesis

The overall goal of the Organic Synthesis shared resource is to provide to Penn State Cancer Institute members chemical compounds that are either not commercially available or that are too cost-prohibitive to allow research to be conducted.

In addition, the shared resource provides radioisotope compounds (3H, 14C, 32P) for pharmacokinetic studies and stable isotope compounds (2H, 15N, 13C) as internal standards for qualitative and quantitative biochemical and metabolomic studies.

The shared resource also provides cancer chemopreventive agents, therapeutic agents and natural products, as well as chemical carcinogens such as tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons and food mutagens.

Sensitive and selective biomarkers of uptake and metabolic activation of carcinogens for the identification of etiologically significant host factors are also provided.