• United States

Research Output 1974 2019

2019
1 Citation (Scopus)

Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing

Li, H., Torab, P., Mach, K. E., Surrette, C., England, M. R., Craft, D., Thomas, N., Liao, J. C., Puleo, C. & Wong, P. K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 21, p. 10270-10279 10 p.

Research output: Contribution to journalArticle

Microfluidics
Urine
Anti-Bacterial Agents
Bacteria
Bacterial Infections

Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Naïve Patients with Schizophrenia

Lin, Y., Li, M., Zhou, Y., Deng, W., Ma, X., Wang, Q., Guo, W., Li, Y., Jiang, L., Hu, X., Zhang, N. & Li, T., Aug 1 2019, In : Neuroscience Bulletin. 35, 4, p. 688-696 9 p.

Research output: Contribution to journalArticle

Gyrus Cinguli
Schizophrenia
Temporal Lobe
Brain
Therapeutics

All-night functional magnetic resonance imaging sleep studies

Moehlman, T. M., de Zwart, J. A., Chappel-Farley, M. G., Liu, X., McClain, I. B., Chang, C., Mandelkow, H., Özbay, P. S., Johnson, N. L., Bieber, R. E., Fernandez, K. A., King, K. A., Zalewski, C. K., Brewer, C. C., van Gelderen, P., Duyn, J. H. & Picchioni, D., Mar 15 2019, In : Journal of Neuroscience Methods. 316, p. 83-98 16 p.

Research output: Contribution to journalArticle

Sleep
Magnetic Resonance Imaging
Sleep Deprivation
REM Sleep
Sleep Stages

A Multiwell Microfluidic Device for Analyzing and Screening Nonhormonal Contraceptive Agents

Li, H., Garner, T., Diaz, F. & Wong, P. K., Jul 12 2019, In : Small. 15, 28, 1901910.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Contraceptive Agents
Microfluidics
Oocytes
Screening

A role for the claustrum in salience processing?

Smith, J. B., Watson, G. D. R., Liang, Z., Liu, Y., Zhang, N. & Alloway, K., Jun 3 2019, In : Frontiers in Neuroanatomy. 13, 64.

Research output: Contribution to journalArticle

Open Access
Basal Ganglia
Rodentia
Gyrus Cinguli
Prefrontal Cortex
Thalamus
2 Citations (Scopus)

Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing

Zhao, N., Coyne, J., Xu, M., Zhang, X., Suzuki, A., Shi, P., Lai, J., Fong, G. H., Xiong, N. & Wang, Y., Feb 12 2019, In : Chemistry of Materials. 31, 3, p. 1006-1015 10 p.

Research output: Contribution to journalArticle

Hydrogels
Fibrinogen
Vascular Endothelial Growth Factor A
Skin
Molecular recognition

Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs

Randolph, L. N. & Lian, X., Jan 1 2019, In : Cell Stem Cell.

Research output: Contribution to journalShort survey

Preclinical Drug Evaluations
Tissue Engineering
Cardiac Myocytes
Transcription Factors
Stem Cells

Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo

Simonson, A. W., Lawanprasert, A., Goralski, T. D. P., Keiler, K. C. & Medina, S. H., Apr 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 391-400 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Polysaccharides
Peptides
Cells
Proteins
3 Citations (Scopus)
Bacterial Adhesion
Biomimetics
Polyurethanes
Texturing
Nitric oxide
Electrodes
Blood
Left ventricular assist devices
Pumps
Echocardiography
1 Citation (Scopus)

Cellular Based Strategies for Microvascular Engineering

Koduru, S., Leberfinger, A. N., Pasic, D., Forghani, A., Lince, S., Hayes, D. J., Ozbolat, I. T. & Ravnic, D., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 218-240 23 p.

Research output: Contribution to journalReview article

Blood Vessels
Tissue Engineering
Microvessels
Microtechnology
Microfluidics
2 Citations (Scopus)

Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression

Wang, H., Zhang, H., Sun, Q., Yang, J., Zeng, C., Ding, C., Cai, D., Liu, A. & Bai, X., Mar 1 2019, In : Journal of Cellular Physiology. 234, 3, p. 2730-2740 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Chondrocytes
Osteoarthritis
Chemical activation
Hypertrophy
1 Citation (Scopus)

Chronic In Vivo Test of a Right Heart Replacement Blood Pump for Failed Fontan Circulation

Cysyk, J., Clark, J. B., Newswanger, R., Jhun, C-S., Izer, J., Finicle, H., Reibson, J., Doxtater, B., Weiss, W. & Rosenberg, G., Aug 1 2019, In : ASAIO journal (American Society for Artificial Internal Organs : 1992). 65, 6, p. 593-600 8 p.

Research output: Contribution to journalArticle

Superior Vena Cava
Venous Pressure
Inferior Vena Cava
Blood
Right Heart Bypass

Chronic Ovine Studies Demonstrate Low Thromboembolic Risk in the Penn State Infant Ventricular Assist Device

Lukic, B., Clark, J., Izer, J., Cooper, T. K., Finicle, H. A., Cysyk, J., Doxtater, B., Yeager, E., Reibson, J., Newswanger, R. K., Leibich, P., Bletcher, K. & Weiss, W., May 1 2019, In : ASAIO journal (American Society for Artificial Internal Organs : 1992). 65, 4, p. 371-379 9 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Sheep
Animals
Equipment and Supplies
Left ventricular assist devices
Extracorporeal Membrane Oxygenation
Pediatrics
Health
Registries
Networks (circuits)

Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats

Moncal, K. K., Aydin, R. S. T., Abu-Laban, M., Heo, D. N., Rizk, E., Tucker, S. M., Lewis, G., Hayes, D. J. & Ozbolat, I. T., Dec 1 2019, In : Materials Science and Engineering C. 105, 110128.

Research output: Contribution to journalArticle

bone marrow
stem cells
collagens
Scaffolds (biology)
Stem cells

Collective Cell Migration in 3D Epithelial Wound Healing

Xiao, Y., Riahi, R., Torab, P., Zhang, D. D. & Wong, P. K., Jan 1 2019, In : ACS nano.

Research output: Contribution to journalArticle

wound healing
Actins
Ablation
Gene expression
cells
4 Citations (Scopus)

Combined CD25, CD64, and CD69 biomarker panel for flow cytometry diagnosis of sepsis

Zhou, Y., Zhang, Y., Johnson, A., Venable, A., Griswold, J. & Pappas, D., Jan 1 2019, In : Talanta. 191, p. 216-221 6 p.

Research output: Contribution to journalArticle

Lymphocytes
Flow cytometry
Biomarkers
Sepsis
Flow Cytometry

Computational translation of genomic responses from experimental model systems to humans

Brubaker, D. K., Proctor, E. A., Haigis, K. M. & Lauffenburger, D. A., Jan 1 2019, In : PLoS computational biology. 15, 1, e1006286.

Research output: Contribution to journalArticle

translation (genetics)
Genomics
Mouse
genomics
Theoretical Models

Computer assisted photoacoustic imaging guided device for safer percutaneous needle operations

Zhang, J., Agrawal, S., Dangi, A., Frings, N. & Kothapalli, S-R., Jan 1 2019, Photons Plus Ultrasound: Imaging and Sensing 2019. Oraevsky, A. A. & Wang, L. V. (eds.). SPIE, 1087866. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10878).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photoacoustic effect
needles
Needles
Blood vessels
Imaging techniques

Confinement and substrate topography control cell migration in a 3D computational model

Winkler, B., Aronson, I. & Ziebert, F., Dec 1 2019, In : Communications Physics. 2, 1, 82.

Research output: Contribution to journalArticle

Open Access
topography
cells
locomotion
pathology
metastasis

Correcting errors in the BRCA1 warning system

Liang, Y., Dearnaley, W. J., Alden, N. A., Solares, M. J., Gilmore, B. L., Pridham, K. J., Varano, C., Sheng, Z., Alli, E. & Kelly, D., Jan 1 2019, In : DNA Repair. 73, p. 120-128 9 p.

Research output: Contribution to journalArticle

BRCA1 Protein
Alarm systems
Repair
Biochemical Phenomena
Cells

Correction: Oncogenic KRAS confers chemoresistance by upregulating Nrf2 (Cancer Research (2014) 74 (7430-7441) DOI: 10.1158/0008-5472.CAN-14-1439)

Tao, S., Wang, S., Moghaddam, S. J., Ooi, A., Chapman, E., Wong, P. K. & Zhang, D. D., Mar 1 2019, In : Cancer Research. 79, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Western Blotting
Research
Neoplasms
Emotions

Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules

Alden, N. A., Varano, C., Dearnaley, W. J., Solares, M. J., Luqiu, W. Y., Liang, Y., Sheng, Z., McDonald, S. M., Damiano, J., McConnell, J., Dukes, M. J. & Kelly, D., May 24 2019, In : Small. 15, 21, 1900918.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Macromolecules
Electron microscopy
Tumors
Cells

Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles

Hauser, M., Dearnaley, W. J., Varano, C., Casasanta, M., McDonald, S. M. & Kelly, D., Jan 1 2019, In : Computational and Structural Biotechnology Journal. 17, p. 1178-1183 6 p.

Research output: Contribution to journalArticle

Open Access
Rotavirus
Transcription
RNA
Proteins
Messenger RNA
1 Citation (Scopus)

Decreasing Wound Edge Stress Enhances Leader Cell Formation during Collective Smooth Muscle Cell Migration

Dean, Z. S., Jamilpour, N., Slepian, M. J. & Wong, P. K., Aug 12 2019, In : ACS Biomaterials Science and Engineering. 5, 8, p. 3864-3875 12 p.

Research output: Contribution to journalArticle

Muscle
Cells
Repair
Gene expression
Microscopic examination

Detection of culture-negative sepsis in clinical blood samples using a microfluidic assay for combined CD64 and CD69 cell capture

Zhou, Y., Zhang, Y., Johnson, A., Venable, A., Griswold, J. & Pappas, D., Jul 25 2019, In : Analytica Chimica Acta. 1062, p. 110-117 8 p.

Research output: Contribution to journalArticle

Microfluidics
Assays
Sepsis
Blood
blood

Determination and pharmacokinetics and bioavailability of O-demethyl nuciferine in mice by UPLC–MS/MS

Wu, H., Lu, M., He, J., Huang, M., Zheng, A., Zhang, M., Wen, C. & Ye, J., Jan 1 2019, In : Acta Chromatographica. 31, 3, p. 222-227 6 p.

Research output: Contribution to journalArticle

Open Access
Pharmacokinetics
formic acid
Blood
Mass spectrometers
Diazepam

Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration

He, Y., Li, Q., Ma, C., Xie, D., Li, L., Zhao, Y., Shan, D., Chomos, S. K., Dong, C., Tierney, J. W., Sun, L., Lu, D., Gui, L. & Yang, J., Jul 15 2019, In : Acta Biomaterialia. 93, p. 180-191 12 p.

Research output: Contribution to journalArticle

Glycerophosphates
Bone Regeneration
Citric Acid
Durapatite
Hydroxyapatite

Differentiation of Adipose Tissue–Derived CD34+/CD31− Cells into Endothelial Cells In Vitro

Forghani, A., Koduru, S., Chen, C., Leberfinger, A. N., Ravnic, D. & Hayes, D. J., Jan 1 2019, In : Regenerative Engineering and Translational Medicine.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Tissue
Vascular Endothelial Growth Factor A
Cells
6 Citations (Scopus)

Direct observation of individual tubulin dimers binding to growing microtubules

Mickolajczyk, K. J., Geyer, E. A., Kim, T., Rice, L. M. & Hancock, W. O., Apr 9 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 15, p. 7314-7322 9 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
Observation
Cell Division
Microscopy
1 Citation (Scopus)

DNA Transformer for Visualizing Endogenous RNA Dynamics in Live Cells

Wan, Y., Zhu, N., Lu, Y. & Wong, P. K., Feb 19 2019, In : Analytical Chemistry. 91, 4, p. 2626-2633 8 p.

Research output: Contribution to journalArticle

RNA
Messenger RNA
DNA
Cells
Endothelial cells

Dual aptamer-functionalized in situ injectable fibrin hydrogel for promotion of angiogenesis via co-delivery of growth factors

Zhao, N., Suzuki, A., Zhang, X. & Wang, Y., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hydrogel
Fibrin
Hydrogels
Intercellular Signaling Peptides and Proteins
Injections
1 Citation (Scopus)

Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes

Dumas, M. E., Chen, G. Y., Kendrick, N. D., Xu, G., Larsen, S. D., Jana, S., Waterson, A. G., Bauer, J. A., Hancock, W. O., Sulikowski, G. A. & Ohi, R., Jan 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 148-154 7 p.

Research output: Contribution to journalArticle

Quinazolinones
Kinesin
Microtubules
Spindle Apparatus
Chromosomes
2 Citations (Scopus)

Effect of dose and release rate of CTGF and TGFβ3 on avascular meniscus healing

Tarafder, S., Gulko, J., Kim, D., Sim, K. H., Gutman, S., Yang, J., Cook, J. L. & Lee, C. H., Jul 1 2019, In : Journal of Orthopaedic Research. 37, 7, p. 1555-1562 8 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Thromboplastin
Intercellular Signaling Peptides and Proteins
Mesenchymal Stromal Cells
Stem Cells
3 Citations (Scopus)

Effects of Pulsatile Control Algorithms for Diagonal Pump on Hemodynamic Performance and Hemolysis

Wang, S., Force, M., Moroi, M. K., Patel, S., Kunselman, A. & Undar, A., Jan 1 2019, In : Artificial organs. 43, 1, p. 60-75 16 p.

Research output: Contribution to journalArticle

Hemodynamics
Hemolysis
Pumps
Pediatrics
Oxygenators

Enabling biodegradable functional biomaterials for the management of neurological disorders

Shan, D., Ma, C. & Yang, J., Jan 1 2019, (Accepted/In press) In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Biocompatible Materials
Nervous System Diseases
Fever
Therapeutics
Nerve Regeneration

Enhanced detection of tumour-secreted vesicles

Wan, Y. & Zheng, S., Jun 1 2019, In : Nature Biomedical Engineering. 3, 6, p. 421-422 2 p.

Research output: Contribution to journalArticle

Microfluidics
Ovarian Neoplasms
Tumors
Plasmas
Neoplasms

Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice

Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Zhang, W. L., Hao, S. J., Yee, N. S-S. & Zheng, S., Jun 1 2019, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., p. 273-276 4 p. 8808761. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanoprobes
Vesicles
Lipids
Silica
Silicon Dioxide

Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

Wan, Y., Maurer, M., He, H. Z., Xia, Y. Q., Hao, S. J., Zhang, W. L., Yee, N. S-S. & Zheng, S., Jan 1 2019, In : Lab on a Chip. 19, 14, p. 2346-2355 10 p.

Research output: Contribution to journalArticle

Nanoprobes
Pancreatic Neoplasms
Silicon Dioxide
Lipids
Silica
1 Citation (Scopus)
Pulsatile Flow
Pulsatile flow
Extracorporeal Membrane Oxygenation
Hemodynamics
Thigh
1 Citation (Scopus)

Exosome Release Is Regulated by mTORC1

Zou, W., Lai, M., Zhang, Y., Zheng, L., Xing, Z., Li, T., Zou, Z., Song, Q., Zhao, X., Xia, L., Yang, J., Liu, A., Zhang, H., Cui, Z. K., Jiang, Y. & Bai, X., Feb 6 2019, In : Advanced Science. 6, 3, 1801313.

Research output: Contribution to journalArticle

Open Access
Exosomes
Proteins
Nutrients
Membranes
nutrients

Fabrication and characterization of thiol-triacrylate polymer via Michael addition reaction for biomedical applications

Forghani, A., Garber, L., Chen, C., Tavangarian, F., Tighe, T. B., Devireddy, R., Pojman, J. A. & Hayes, D. J., Jan 1 2019, In : Biomedical Materials (Bristol). 14, 1, 015001.

Research output: Contribution to journalArticle

Addition reactions
Surface topography
Stem cells
Sulfhydryl Compounds
Polymers

Facile synthesis and structural insight of nanostructure akermanite powder

Tavangarian, F., Zolko, C. A., Fahami, A., Forghani, A. & Hayes, D. J., Apr 15 2019, In : Ceramics International. 45, 6, p. 7871-7877 7 p.

Research output: Contribution to journalArticle

Powders
Nanostructures
Nanocrystalline powders
Calcium carbonate
Thermoanalysis
1 Citation (Scopus)

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Nicholas, D. A., Proctor, E. A., Agrawal, M., Belkina, A. C., Van Nostrand, S. C., Panneerseelan-Bharath, L., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., Cacicedo, J. M., Habib, C., Sainz-Rueda, N., Persky, L., Sullivan, P. G., Corkey, B. E., Apovian, C. M., Kern, P. A., Lauffenburger, D. A. & Nikolajczyk, B. S., Sep 3 2019, In : Cell Metabolism. 30, 3, p. 447-461.e5

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Fatty Acids
Inflammation
Glycolysis
Cytokines

Fight the flow: The role of shear in artificial rheotaxis for individual and collective motion

Baker, R., Kauffman, J. E., Laskar, A., Shklyaev, O. E., Potomkin, M., Dominguez-Rubio, L., Shum, H., Cruz-Rivera, Y., Aronson, I., Balazs, A. C. & Sen, A., Jun 14 2019, In : Nanoscale. 11, 22, p. 10944-10951 8 p.

Research output: Contribution to journalArticle

Nanorods
Microfluidics
Fluids
Biomimetics
Platinum

GABAergic Abnormalities Associated with Sensorimotor Cortico-striatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naïve Patients with Schizophrenia

Zhang, C., Ni, P., Liu, Y., Tian, Y., Wei, J., Xiang, B., Zhao, L., Li, X., Ma, X., Deng, W., Guo, W., Ni, R., Zhang, Y., Wang, Q., Huang, H., Zhang, N. & Li, T., Jan 1 2019, (Accepted/In press) In : Neuroscience Bulletin.

Research output: Contribution to journalArticle

Corpus Striatum
Knockout Mice
Schizophrenia
gamma-Aminobutyric Acid
Parvalbumins
4 Citations (Scopus)

Hemodynamic Evaluation of Avalon Elite Bi-Caval Dual Lumen Cannulas and Femoral Arterial Cannulas

Wang, S., Force, M., Kunselman, A., Palanzo, D., Brehm, C. & Undar, A., Jan 1 2019, In : Artificial organs. 43, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

Venae Cavae
Hemodynamics
Thigh
Networks (circuits)
Extracorporeal Membrane Oxygenation

Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer

Medina, S. H., Bush, B., Cam, M., Sevcik, E., DelRio, F. W., Nandy, K. & Schneider, J. P., May 1 2019, In : Biomaterials. 202, p. 1-11 11 p.

Research output: Contribution to journalArticle

Stiffness
Breast Neoplasms
Cells
Substrates
Cell culture
2 Citations (Scopus)

Identification of Key Signaling Pathways Orchestrating Substrate Topography Directed Osteogenic Differentiation Through High-Throughput siRNA Screening

Ozdemir, T., Bowers, D. T., Zhan, X., Ghosh, D. & Brown, J. L., Dec 1 2019, In : Scientific reports. 9, 1, 1001.

Research output: Contribution to journalArticle

Small Interfering RNA
Cell Shape
Bone Regeneration
GTP Phosphohydrolases
Gene Silencing