Organization profile

Organization profile

The Experimental Therapeutics research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients. 

Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Population Health and Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.

Fingerprint Dive into the research topics where Cancer Institute, Experimental Therapeutics is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Neoplasms Medicine & Life Sciences
Non-Small Cell Lung Carcinoma Medicine & Life Sciences
Proteins Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Cells Chemical Compounds
Iron Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Growth Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Research Output 1965 2019

(Not giving up) the marathon race of Met targeting therapy: Are we there yet?

Ma, P. C-C., Apr 15 2019, In : Clinical Cancer Research. 25, 8, p. 2375-2378 4 p.

Research output: Contribution to journalArticle

Biomarkers
Therapeutics

Absolute Quantification of All Identified Plasma Proteins from SWATH Data for Biomarker Discovery

Rice, S. J., Liu, X., Zhang, J. & Belani, C., Feb 1 2019, In : Proteomics. 19, 3, 1800135.

Research output: Contribution to journalArticle

Biomarkers
Blood Proteins
Proteins
Plasma (human)
Monitoring

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson-Kennedy, P. S., Deneke, E., Vrana, K., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V., Ang, K., Wang, Y., Xiao, X., De Carlo, F., Van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

Chirasani, V. R., Xu, L., Addis, H. G., Pasek, D. A., Dokholyan, N., Meissner, G. & Yamaguchi, N., Aug 1 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C358-C365

Research output: Contribution to journalArticle

Central Core Myopathy
Ryanodine Receptor Calcium Release Channel
Skeletal Muscle
Binding Sites
Mutation
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Activation of Wnt signaling promotes olaparib resistant ovarian cancer

Yamamoto, T. M., McMellen, A., Watson, Z. L., Aguilera, J., Ferguson, R., Nurmemmedov, E., Thakar, T., Moldovan, G-L., Kim, H., Cittelly, D. M., Joglar, A. M., Brennecke, E. P., Wilson, H., Behbakht, K., Sikora, M. J. & Bitler, B. G., Oct 1 2019, In : Molecular Carcinogenesis. 58, 10, p. 1770-1782 13 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Ovarian Diseases
Recombinational DNA Repair
Cell Line

Acupuncture for Hot Flashes in Cancer Patients: Clinical Characteristics and Traditional Chinese Medicine Diagnosis as Predictors of Treatment Response

Liu, W., Qdaisat, A., Lopez, G., Narayanan, S., Underwood, S., Spano, M., Reddy, A., Guo, Y., Zhou, S., Yeung, S. C., Bruera, E., Garcia, M. K. & Cohen, L., May 1 2019, In : Integrative Cancer Therapies. 18

Research output: Contribution to journalArticle

Open Access
Hot Flashes
Chinese Traditional Medicine
Acupuncture
Neoplasms
Acupuncture Therapy
1 Citation (Scopus)

Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing

Li, H., Torab, P., Mach, K. E., Surrette, C., England, M. R., Craft, D., Thomas, N., Liao, J. C., Puleo, C. & Wong, P. K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 21, p. 10270-10279 10 p.

Research output: Contribution to journalArticle

Microfluidics
Urine
Anti-Bacterial Agents
Bacteria
Bacterial Infections

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C., May 1 2019, In : Lung Cancer. 131, p. 58-61 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Interleukin-6
T-Lymphocytes
Population
STAT1 Transcription Factor

Activities 2017 2017

  • 3 Oral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation