Research Output 1965 2020

(Not giving up) the marathon race of Met targeting therapy: Are we there yet?

Ma, P. C-C., Apr 15 2019, In : Clinical Cancer Research. 25, 8, p. 2375-2378 4 p.

Research output: Contribution to journalArticle

Biomarkers
Therapeutics
21 Citations (Scopus)

[2+2] versus [4+2] cycloaddition reactions of 1,3-diaza-1,3-butadienes with various mono- and disubstituted ketenes and supporting mechanistic considerations

Mukherjee, S., Mazumdar, S. N., Sharma, A. & Mahajan, M. P., Dec 1 1998, In : Heterocycles. 47, 2, p. 933-950 18 p.

Research output: Contribution to journalArticle

Cycloaddition
Cycloaddition Reaction
Electrons
1,3-butadiene
ketene
101 Citations (Scopus)

[21] Construction of High Copy Yeast Vectors Using 2-μm Circle Sequences

Broach, J., Jan 1 1983, In : Methods in enzymology. 101, C, p. 307-325 19 p.

Research output: Contribution to journalArticle

Fungal DNA
Genetic engineering
Genetic Vectors
DNA Restriction Enzymes
Yeast
2 Citations (Scopus)

[3H]naloxone binding in the brains of young rats perinatally exposed to methadone

Zagon, I. S., Kirby, M. L., McLaughlin, P. J. & Stewart, D. E., Jan 1 1984, In : Research Communications in Substances of Abuse. 5, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Methadone
Naloxone
Opioid Receptors
Brain
Levorphanol
17 Citations (Scopus)

[Ca2+]i as a potential downregulator of α2β1-integrin-mediated A2058 tumor cell migration to type IV collagen

Hodgson, L. & Dong, C., Oct 16 2001, In : American Journal of Physiology - Cell Physiology. 281, 1 50-1, p. C106-C113

Research output: Contribution to journalArticle

Collagen Type IV
Integrins
Cell Movement
Thapsigargin
Ionophores
1 Citation (Scopus)

[Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis].

Kawano, H., Minagawa, K., Wakahashi, K., Kawano, Y., Sada, A., Matsui, T. & Katayama, Y., Jan 1 2012, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 53, 8, p. 785-787 3 p.

Research output: Contribution to journalArticle

CD7 Antigens
Lymphocytosis
Surface Antigens
T-Lymphocytes
Leukocytosis

[Thrombopoietin receptor agonists administration for acute exacerbation of chronic idiopathic thrombocytopenic purpura and subsequent anticoagulant therapy for accompanying deep venous thrombosis of the lower limbs].

Kawano, H., Suzuki, T., Ishii, S., Wakahashi, K., Kawano, Y., Sada, A., Minagawa, K., Takaya, T., Yamashita, T., Hirata, K. I., Koriyama, K., Nagamatsu, Y., Matsui, T. & Katayama, Y., Jan 1 2014, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 6, p. 697-702 6 p.

Research output: Contribution to journalArticle

Thrombopoietin Receptors
Idiopathic Thrombocytopenic Purpura
Venous Thrombosis
Anticoagulants
Lower Extremity
21 Citations (Scopus)

1,2,3,4,6-penta-o-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells

Park, K. Y., Lee, H. J., Jeong, S. J., Lee, H. J., Kim, H. S., Kim, S. H., Lim, S., Kim, H. C., Lu, J. & Kim, S. H., Nov 19 2010, In : Biological and Pharmaceutical Bulletin. 33, 11, p. 1835-1840 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Rubiaceae
Prostatic Neoplasms
Glucose
1-Phosphatidylinositol 4-Kinase

10th World Conference on Lung Cancer, Vancouver, British Columbia, Canada

Klem, J., Maung, K., Lee, D., Tyagi, P., Belani, C. & Ramalingam, S., Jan 1 2003, In : Clinical Lung Cancer. 5, 3, p. 142-147 6 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Quinazolines
Taxoids
Deoxycytidine
British Columbia

10th World Congress on Lung Cancer, Vancouver, British Columbia, Canada

Tyagi, P., Lee, D., Belani, C. & Ramalingam, S., Jan 1 2003, In : Clinical Lung Cancer. 5, 2, p. 78-82 5 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Emission-Computed Tomography
British Columbia
Survival Analysis
Non-Small Cell Lung Carcinoma
46 Citations (Scopus)

11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X., Yang, J. M., Zhou, N., Liu, A., Liu, L. F. & LaVoie, E. J., Feb 15 2004, In : Bioorganic and Medicinal Chemistry. 12, 4, p. 795-806 12 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Cytotoxicity
Nude Mice
Antineoplastic Agents
Tumors

14th EORTC-NCI-AACR symposium on molecular targets and cancer Therapeutics, Frankfurt, Germany

Hightower, M., Klem, J., Socinski, M., Belani, C. & Jain, V. K., Jan 1 2003, In : Clinical Lung Cancer. 4, 6, p. 333-335 3 p.

Research output: Contribution to journalArticle

Germany
Neoplasms
Therapeutics
76 Citations (Scopus)
Thioredoxins
Cyclic GMP
Estrogen Receptors
Estradiol
Oxidative stress
68 Citations (Scopus)

1 H and 15 N Magnetic Resonance Assignments, Secondary Structure, and Tertiary Fold of Escherichia coli DnaJ(1-78)

Hill, R. B., Prestegard, J. H. & Flanagan, J., Apr 1 1995, In : Biochemistry. 34, 16, p. 5587-5596 10 p.

Research output: Contribution to journalArticle

Magnetic resonance
Amides
Escherichia coli
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
93 Citations (Scopus)

2', 2'-difluorodeoxycytidine metabolism and mechanism of action in human leukemia cells

Plunkett, W., Gandhi, V., Chubb, S., Nowak, B., Heinemann, V., Mineishi, S. & Sen, A., Jan 1 1989, In : Nucleosides and Nucleotides. 8, 5-6, p. 775-785 11 p.

Research output: Contribution to journalArticle

gemcitabine
Metabolism
Leukemia
Ribonucleotide Reductases
DNA
18 Citations (Scopus)

2-(Acyloxy)ethylphosphonate analogues of prenyl pyrophosphates: synthesis and biological characterization

Cermak, D. M., Wiemer, D. F., Lewis, K. & Hohl, R., Nov 27 2000, In : Bioorganic and Medicinal Chemistry. 8, 12, p. 2729-2737 9 p.

Research output: Contribution to journalArticle

Organophosphonates
Diphosphates
Phosphorous Acids
Esters
Bearings (structural)
Medical Oncology
Austria

27th Congress of the European Society for Medical Oncology. Nice, France

DeGrendele, H., Belani, C. & Jain, V. K., Jan 1 2003, In : Clinical Lung Cancer. 4, 4, p. 205-209 5 p.

Research output: Contribution to journalArticle

France
10 Citations (Scopus)

2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d] pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance

Gangjee, A., Namjoshi, O. A., Keller, S. N. & Smith, C. D., Jul 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 14, p. 4355-4365 11 p.

Research output: Contribution to journalArticle

Antimitotic Agents
P-Glycoprotein
Antineoplastic Agents
Tumors
Cells
45 Citations (Scopus)

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

Bursavich, M. G., Parker, D. P., Willardsen, J. A., Gao, Z., Davis, T., Ostanin, K., Robinson, R., Peterson, A., Cimbora, D. M., Zhu, J. F. & Richards, B., Mar 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1677-1679 3 p.

Research output: Contribution to journalArticle

Thiazoles
NF-kappa B
Enzyme Inhibitors
Ubiquitin
Proteolysis
3 Citations (Scopus)

2-D analysis of Gabor-filter output signatures for texture segmentation

Dunn, D., Higgins, W. & Wakeley, J., Jan 1 1992, ICASSP 1992 - 1992 International Conference on Acoustics, Speech, and Signal Processing. Institute of Electrical and Electronics Engineers Inc., p. 65-68 4 p. 226275. (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gabor filters
Textures
Image segmentation
12 Citations (Scopus)

2-Deoxy-D-glucose produces delayed hypophagia and conditioned taste aversion in rats

Thompson, C. I. & Zagon, I. S., Dec 1981, In : Physiology and Behavior. 27, 6, p. 1001-1004 4 p.

Research output: Contribution to journalArticle

Deoxyglucose
Saccharin
Eating
Injections
Pharmaceutical Preparations

39th Annual Meeting of the American Society of Clinical Oncology Chicago, Illinois

Lee, D., DeGrendelle, H., Pass, H. & Belani, C., Jan 1 2003, In : Clinical Lung Cancer. 5, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

3D CT-Video Fusion for Image-Guided Bronchoscopy

Higgins, W. E., Helferty, J. P., Lu, K., Merritt, S. A., Rai, L. & Yu, K. C., Jan 1 2008, In : Computerized Medical Imaging and Graphics. 32, 3, p. 159-173 15 p.

Research output: Contribution to journalArticle

Bronchoscopy
Tomography
Fusion reactions
Physicians
Biopsy
8 Citations (Scopus)

3-D Deep penetration photoacoustic imaging with a 2-D CMUT array

Ma, T. J., Kothapalli, S. R., Vaithilingam, S., Oralkan, Ö., Kamaya, A., Wygant, I. O., Zhuang, X., Gambhir, S. S., Jeffrey, R. B. & Khuri-Yakub, B. T., Dec 1 2010, 2010 IEEE International Ultrasonics Symposium, IUS 2010. p. 375-377 3 p. 5935647. (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

transducers
penetration
ultrasonics
low noise
integrated circuits
3 Citations (Scopus)

3D endobronchial ultrasound reconstruction and analysis for multimodal image-guided bronchoscopy

Zang, X., Bascom, R., Gilbert, C. R., Toth, J. & Higgins, W. E., Jan 1 2014, Medical Imaging 2014: Ultrasonic Imaging and Tomography. SPIE, 90400X. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9040).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Multidetector computed tomography
Bronchoscopy
Ultrasonics
Tomography
tomography
4 Citations (Scopus)

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines

Kuder, C. H., Weivoda, M. M., Zhang, Y., Zhu, J., Neighbors, J. D., Wiemer, D. F. & Hohl, R. J., Dec 1 2015, In : Lipids. 50, 12, p. 1195-1207 13 p.

Research output: Contribution to journalArticle

Cultured Cells
Cholesterol
Cells
Cell Line
Liver
18 Citations (Scopus)

3D human airway segmentation for virtual bronchoscopy

Kiraly, A. P., Higgins, W. E., Higgins, W. E., Hoffman, E. A., McLennan, G. & Reinhardt, J. M., Jan 1 2002, In : Proceedings of SPIE-The International Society for Optical Engineering. 4683, p. 16-29 14 p.

Research output: Contribution to journalArticle

Segmentation
operators
Hybrid Approach
Region Growing
Operator
2 Citations (Scopus)

3-D image enhancement technique for volumetric cardiac images

Higgins, W. E., Dec 1 1990, Proceedings of SPIE - The International Society for Optical Engineering. Bovik, A. C. & Higgins, E. W. (eds.). Publ by Int Soc for Optical Engineering, p. 159-170 12 p. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 1245).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

image enhancement
Image enhancement
filters
homogeneity
smoothing
10 Citations (Scopus)

3D image fusion and guidance for computer-assisted bronchoscopy

Higgins, W. E., Rai, L., Merritt, S. A., Lu, K., Linger, N. T. & Yu, K. C., Dec 1 2005, In : Proceedings of SPIE - The International Society for Optical Engineering. 6016, 60160A.

Research output: Contribution to journalConference article

Electronic guidance systems
physicians
Image fusion
Image Fusion
3D Image
2 Citations (Scopus)

3D intrathoracic region definition and its application to PET-CT analysis

Cheirsilp, R., Bascom, R., Allen, T. & Higgins, W. E., Jan 1 2014, Medical Imaging 2014: Computer-Aided Diagnosis. SPIE, 90352J. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9035).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Positron emission tomography
X Ray Computed Tomography
Positron-Emission Tomography
Tomography
positrons
36 Citations (Scopus)

3D MDCT-based system for planning peripheral bronchoscopic procedures

Gibbs, J. D., Graham, M. W. & Higgins, W. E., Mar 1 2009, In : Computers in Biology and Medicine. 39, 3, p. 266-279 14 p.

Research output: Contribution to journalArticle

Multidetector computed tomography
Multidetector Computed Tomography
Thorax
Bronchoscopy
Planning
294 Citations (Scopus)

3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood

Zheng, S., Lin, H. K., Lu, B., Williams, A., Datar, R., Cote, R. J. & Tai, Y. C., Feb 1 2011, In : Biomedical Microdevices. 13, 1, p. 203-213 11 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Blood
Cells
Equipment and Supplies
16 Citations (Scopus)

3D model-based vascular tree analysis using differential geometry

Yu, K. C., Higgins, W. E. & Ritman, E. L., 2004, 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano. Vol. 1. p. 177-180 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Geometry
Medical imaging

3D numerical study of tumor blood perfusion and oxygen transport during vascular normalization

Wu, J., Cai, Y., Fu, Y., Tan, Z., Sun, R., Xu, S., Ding, Z. & Dong, C., Jan 1 2015, In : Applied Mathematics and Mechanics (English Edition). 36, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

Normalization
Blood
Tumors
Oxygen
Numerical Study
2 Citations (Scopus)

3D numerical study of tumor microenvironmental flow in response to vascular-disrupting treatments

Wu, J., Cai, Y., Xu, S., Long, Q., Ding, Z. & Dong, C., Aug 24 2012, In : MCB Molecular and Cellular Biomechanics. 9, 2, p. 95-125 31 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasms
Microvessels
Tumor Microenvironment
Hemodynamics
6 Citations (Scopus)

3D path planning and extension for endoscopic guidance

Gibbs, J. D. & Higgins, W. E., Oct 15 2007, Medical Imaging 2007: Visualization and Image-Guided Procedures. PART 2 ed. 65091K. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 6509, no. PART 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

trajectory planning
Motion planning
organs
routes
physicians
37 Citations (Scopus)

3D Printing of Personalized Artificial Bone Scaffolds

Jariwala, S. H., Lewis, G., Bushman, Z. J., Adair, J. H. & Donahue, H. J., Jun 1 2015, In : 3D Printing and Additive Manufacturing. 2, 2, p. 56-64 9 p.

Research output: Contribution to journalArticle

Scaffolds
Printing
Bone
3D printers
Grafts
6 Citations (Scopus)

3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering

Moncal, K. K., Heo, D. N., Godzik, K. P., Sosnoski, D. M., Mrowczynski, O. D., Rizk, E., Ozbolat, V., Tucker, S. M., Gerhard, E. M., Dey, M., Lewis, G., Yang, J. & Ozbolat, I. T., Jul 27 2018, In : Journal of Materials Research. 33, 14, p. 1972-1986 15 p.

Research output: Contribution to journalArticle

tissue engineering
Durapatite
Hydroxyapatite
Tissue engineering
printing
33 Citations (Scopus)

3D-Printing Strong High-Resolution Antioxidant Bioresorbable Vascular Stents

van Lith, R., Baker, E., Ware, H., Yang, J., Farsheed, A. C., Sun, C. & Ameer, G., Jan 1 2016, In : Advanced Materials Technologies. 1, 9, 1600138.

Research output: Contribution to journalArticle

3D printers
Stents
Antioxidants
Curing
Printing
3 Citations (Scopus)

3D segmentation and reconstruction of endobronchial ultrasound

Zang, X., Breslav, M. & Higgins, W. E., Jun 5 2013, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy. Vol. 8675. 867505

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Multidetector Computed Tomography
Multidetector computed tomography
tomography
Ultrasonics
lungs

40th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA

Price, N., Reddy, G. K. & Belani, C. P., Jul 2004, In : Clinical Lung Cancer. 6, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

Quinazolines
Medical Societies
Ethnic Groups
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
3 Citations (Scopus)

4D Morphological processing of cardiac image sequences

Higgins, W. E. & Lee, J., Dec 1 1993, Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 1 ed. Publ by IEEE, p. 136-137 2 p. (Proceedings of the Annual Conference on Engineering in Medicine and Biology; vol. 15, no. pt 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mathematical Concepts
Mathematical morphology
Image analysis
Topology
Imaging techniques
88 Citations (Scopus)

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L. F. & LaVoie, E. J., May 1 2003, In : Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

Research output: Contribution to journalArticle

Naphthyridines
Type I DNA Topoisomerase
Antineoplastic Agents
Tumors
Nude Mice
4 Citations (Scopus)

5′/ 3′ imbalance strategy to detect ALK fusion genes in circulating tumor RNA from patients with non-small cell lung cancer

Tong, Y., Zhao, Z., Liu, B., Bao, A., Zheng, H., Gu, J., McGrath, M., Xia, Y., Tan, B., Song, C. & Li, Y., Mar 27 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 68.

Research output: Contribution to journalArticle

Gene Fusion
Non-Small Cell Lung Carcinoma
RNA
Neoplasms
Sensitivity and Specificity
23 Citations (Scopus)

6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits Lewis lung cancer by antiangiogenesis and apoptosis

Hyo, J. L., Lee, H. J., Song, G. Y., Li, G., Lee, J. H., Lu, J. & Kim, S. H., Jun 1 2007, In : International Journal of Cancer. 120, 11, p. 2481-2490 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Apoptosis
Lewis Lung Carcinoma
Vascular Endothelial Growth Factor A
Neoplasms
36 Citations (Scopus)

7 Å projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals

Norville, J. E., Kelly, D., Knight, T. F., Belcher, A. M. & Walz, T., Dec 1 2007, In : Journal of Structural Biology. 160, 3, p. 313-323 11 p.

Research output: Contribution to journalArticle

Trehalose
Lipids
Electron Microscopy
Protein Array Analysis
Nanotechnology
1576 Citations (Scopus)

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions

Cheng, K., Cahill, D. S., Kasai, H., Nishimura, S. & Loeb, L. A., Jan 1 1992, In : Journal of Biological Chemistry. 267, 1, p. 166-172 7 p.

Research output: Contribution to journalArticle

DNA Damage
Substitution reactions
Assays
Mutation
DNA
130 Citations (Scopus)

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation

Lin, E. Y., Orlofsky, A., Wang, H. G., Reed, J. C. & Prystowsky, M. B., Feb 1 1996, In : Blood. 87, 3, p. 983-992 10 p.

Research output: Contribution to journalArticle

Interleukin-3
Cell Survival
Cells
Myeloid Cells
Transfection
16 Citations (Scopus)

A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis

Jia, W., Wang, S., Horner, J. W., Wang, N., Wang, H., Gunther, E. J., De Pinho, R. A. & Zhu, J., Mar 1 2011, In : FASEB Journal. 25, 3, p. 979-989 11 p.

Research output: Contribution to journalArticle

Bacterial Artificial Chromosomes
Chromosomes
Renilla Luciferases
Transcription
Carcinogenesis