Research Output 1965 2020

2019
7 Citations (Scopus)

The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases

Thakar, M. S., Broglie, L., Logan, B., Artz, A., Bunin, N., Burroughs, L. M., Fretham, C., Jacobsohn, D. A., Loren, A. W., Kurtzberg, J., Martinez, C. A., Mineishi, S., Nelson, A. S., Woolfrey, A., Pasquini, M. C. & Sorror, M. L., Feb 14 2019, In : Blood. 133, 7, p. 754-762 9 p.

Research output: Contribution to journalArticle

Transplants
Cell Transplantation
Comorbidity
Survival
Hazards

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Bao, L., Festa, F., Freet, C. S., Lee, J. P., Hirschler-Laszkiewicz, I. M., Chen, S. J., Keefer, K. A., Wang, H. G., Patterson, A. D., Cheung, J. Y. & Miller, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 14132.

Research output: Contribution to journalArticle

Open Access
Transient Receptor Potential Channels
Ion Channels
Cell Survival
NADP
NAD

The Impact of Minimally Invasive Gastrectomy on Survival in the USA

Hendriksen, B. S., Brooks, A. J., Hollenbeak, C. S., Taylor, M. D., Reed, M. F. & Soybel, D., Jan 1 2019, In : Journal of Gastrointestinal Surgery.

Research output: Contribution to journalArticle

Gastrectomy
Survival
Propensity Score
Minimally Invasive Surgical Procedures
Robotics
1 Citation (Scopus)

The impact of patient-specific vascular structure on localized cooling in the human heart

Spangenberg, N., Merrill, T., Mitchell, J. & Attaluri, A., Jan 1 2019, Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
Hypothermia
Cooling
Catheters
Flow rate
Pulsatile flow

The importance of 2 views in the combined antegrade-retrograde dilation procedure

Walsh, L. T. & Moyer, M. T., Dec 2019, In : VideoGIE. 4, 12, 1 p.

Research output: Contribution to journalLetter

Open Access
1 Citation (Scopus)

The Journey of an EGFR-Mutant Lung Adenocarcinoma through Erlotinib, Osimertinib and ABCP Immunotherapy Regimens: Sensitivity and Resistance

Kibirova, A., Mattes, M. D., Smolkin, M. & Ma, P. C., Jan 1 2019, (Accepted/In press) In : Case Reports in Oncology. p. 765-776 12 p.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Immunotherapy
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Carboplatin
2 Citations (Scopus)

Therapy of acute myeloid leukemia: therapeutic targeting of tyrosine kinases

Cioccio, J. & Claxton, D., Apr 3 2019, In : Expert Opinion on Investigational Drugs. 28, 4, p. 337-349 13 p.

Research output: Contribution to journalReview article

Acute Myeloid Leukemia
Protein-Tyrosine Kinases
Therapeutics
Gene Targeting
Expert Testimony

Thin Film PZT-Based PMUT Arrays for Deterministic Particle Manipulation

Cheng, C. Y., Dangi, A., Ren, L., Tiwari, S., Benoit, R. R., Qiu, Y., Lay, H. S., Agrawal, S., Pratap, R., Kothapalli, S. R., Mallouk, T. E., Cochran, S. & Trolier-Mckinstry, S., Oct 2019, In : IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 66, 10, p. 1605-1615 11 p., 8753665.

Research output: Contribution to journalArticle

Ultrasonic transducers
Piezoelectric transducers
Diaphragms
manipulators
transducers
4 Citations (Scopus)
Bioprinting
Cartilage
Orthopedics
Bone and Bones
Computer-Aided Design

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

Atkinson, J. M., Ye, Y., Gebru, M. T., Liu, Q., Zhou, S., Young, M. M., Takahashi, Y., Lin, Q., Tian, F. & Wang, H. G., Jan 1 2019, In : Journal of Biological Chemistry. 294, 38, p. 14033-14042 10 p.

Research output: Contribution to journalArticle

Open Access
Autophagy
Nuclear magnetic resonance
Peptides
Proteins
GABA Receptors
1 Citation (Scopus)

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

Tang, Z., Takahashi, Y., He, H., Hattori, T., Chen, C., Liang, X., Chen, H., Young, M. M. & Wang, H. G., Aug 13 2019, In : Cell Reports. 28, 7, p. 1744-1757.e5

Research output: Contribution to journalArticle

Open Access
Mitochondria
Membranes
Fluxes
Mitochondrial Proteins
Autophagy

Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition

Gómez Tejeda Zañudo, J., Guinn, M. T., Farquhar, K., Szenk, M., Steinway, S. N., Balázsi, G. & Albert, R., Mar 7 2019, In : Physical Biology. 16, 3, 031002.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Decision Making
Synthetic Biology
Neoplasm Metastasis
Wound Healing
1 Citation (Scopus)
Meta-Analysis
Radiotherapy
Collagen Diseases
Vascular Diseases
Inflammatory Bowel Diseases

Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype

Chiou, B., Neely, E. B., Mcdevitt, D. S., Simpson, I. & Connor, J., Jan 1 2019, (Accepted/In press) In : Journal of neurochemistry.

Research output: Contribution to journalArticle

Apoferritins
Sexual Development
Transferrin
Brain
Iron
1 Citation (Scopus)

Transluminal washout and debridement of extraluminal contamination as an adjunct to endoscopic defect repair

Moyer, M. T., Chintanaboina, J., Walsh, L. T., Loloi, J., Maranki, J., Stern, B. & Mathew, A., Feb 2019, In : VideoGIE. 4, 2, p. 91-94 4 p.

Research output: Contribution to journalArticle

Debridement
Drainage
Multiple Endocrine Neoplasia Type 1
Acute Abdomen
Therapeutic Irrigation
30 Citations (Scopus)

Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis

Wang, Y., Zhou, S., Yang, F., Qi, X., Wang, X., Guan, X., Shen, C., Duma, N., Vera Aguilera, J., Chintakuntlawar, A., Price, K. A., Molina, J. R., Pagliaro, L. C., Halfdanarson, T. R., Grothey, A., Markovic, S. N., Nowakowski, G. S., Ansell, S. M. & Wang, M. L., Jul 2019, In : JAMA Oncology. 5, 7, p. 1008-1019 12 p.

Research output: Contribution to journalReview article

CD274 Antigen
Meta-Analysis
Clinical Trials
Incidence
Odds Ratio

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation

Miller, B., Wang, J. F., Song, J., Zhang, X. Q., Hirschler-Laszkiewicz, I., Santhanam, S., Tomar, D., Rajan, S., Feldman, A. M., Madesh, M., Sheu, S. S. & Cheung, J. Y., Sep 1 2019, In : Journal of Cellular Physiology. 234, 9, p. 15048-15060 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Phosphorylation
Energy Metabolism
Muscle Cells
Wounds and Injuries
5 Citations (Scopus)

TRPM2 in Cancer

Miller, B., Jun 1 2019, In : Cell Calcium. 80, p. 8-17 10 p.

Research output: Contribution to journalReview article

Cell Survival
Neoplasms
Neuroblastoma
Autophagy
Breast Neoplasms
1 Citation (Scopus)

Uncovered Dynamic Coupling Resolves the Ambiguous Mechanism of Phenylalanine Hydroxylase Oxygen Binding

Reilley, D. J., Popov, K. I., Dokholyan, N. V. & Alexandrova, A. N., May 30 2019, In : Journal of Physical Chemistry B. 123, 21, p. 4534-4539 6 p.

Research output: Contribution to journalArticle

Phenylalanine Hydroxylase
phenylalanine
Molecular dynamics
Enzymes
Iron
3 Citations (Scopus)

Unraveling the multiplex folding of nucleosome chains in higher order chromatin

Grigoryev, S. & Schubert, M., Jan 1 2019, In : Essays in biochemistry. 63, 1, p. 109-121 13 p.

Research output: Contribution to journalReview article

Nucleosomes
Chromatin
Chromosomes
Epigenomics
DNA
3 Citations (Scopus)

Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon

Li, X., Deng, M., Petrucelli, A. S., Zhu, C., Mo, J., Zhang, L., Tam, J. W., Ariel, P., Zhao, B., Zhang, S., Ke, H., Li, P., Dokholyan, N. V., Duncan, J. A. & Ting, J. P. Y., Mar 19 2019, In : Immunity. 50, 3, p. 591-599.e6

Research output: Contribution to journalArticle

Interferon alpha-beta Receptor
Viral DNA
Nucleic Acids
Interferons
Interferon Type I
1 Citation (Scopus)

Vitamin D receptor–mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis

Wakahashi, K., Minagawa, K., Kawano, Y., Kawano, H., Suzuki, T., Ishii, S., Sada, A., Asada, N., Sato, M., Kato, S., Shide, K., Shimoda, K., Matsui, T. & Katayama, Y., Apr 11 2019, In : Blood. 133, 15, p. 1619-1629 11 p.

Research output: Contribution to journalArticle

Osteosclerosis
Primary Myelofibrosis
Macrophages
Vitamin D
Calcitriol Receptors
1 Citation (Scopus)

VPS37A directs ESCRT recruitment for phagophore closure

Takahashi, Y., Liang, X., Hattori, T., Tang, Z., He, H., Chen, H., Liu, X., Abraham, T., Imamura-Kawasawa, Y., Buchkovich, N. J., Young, M. M. & Wang, H. G., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3336-3354 19 p.

Research output: Contribution to journalArticle

Open Access
Endosomal Sorting Complexes Required for Transport
Clustered Regularly Interspaced Short Palindromic Repeats
Multivesicular Bodies
Ubiquitin
Epidermal Growth Factor Receptor

Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy

Hain, B. A., Jude, B., Xu, H., Smuin, D. M., Fox, E. J., Elfar, J. C. & Waning, D. L., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

zoledronic acid
Carboplatin
Muscle Weakness
Bone and Bones
Drug Therapy

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Proctor, E. A., Mowrey, D. D. & Dokholyan, N. V., Jul 2019, In : PLoS computational biology. 15, 7, e1007225.

Research output: Contribution to journalArticle

Open Access
etiology
Amyotrophic Lateral Sclerosis
Alanine
alanine
serine
2018
6 Citations (Scopus)

3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering

Moncal, K. K., Heo, D. N., Godzik, K. P., Sosnoski, D. M., Mrowczynski, O. D., Rizk, E., Ozbolat, V., Tucker, S. M., Gerhard, E. M., Dey, M., Lewis, G., Yang, J. & Ozbolat, I. T., Jul 27 2018, In : Journal of Materials Research. 33, 14, p. 1972-1986 15 p.

Research output: Contribution to journalArticle

tissue engineering
Durapatite
Hydroxyapatite
Tissue engineering
printing
4 Citations (Scopus)

5′/ 3′ imbalance strategy to detect ALK fusion genes in circulating tumor RNA from patients with non-small cell lung cancer

Tong, Y., Zhao, Z., Liu, B., Bao, A., Zheng, H., Gu, J., McGrath, M., Xia, Y., Tan, B., Song, C. & Li, Y., Mar 27 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 68.

Research output: Contribution to journalArticle

Gene Fusion
Non-Small Cell Lung Carcinoma
RNA
Neoplasms
Sensitivity and Specificity
4 Citations (Scopus)

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia

Ge, Z., Han, Q., Gu, Y., Ge, Q., Ma, J., Sloane, J., Gao, G., Payne, K. J., Szekely, L., Song, C. & Dovat, S., Nov 1 2018, In : Oncogenesis. 7, 11, 84.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fingers
Cell Proliferation
Protein Domains
Casein Kinase II
1 Citation (Scopus)

A carbon nanotube integrated microfluidic device for blood plasma extraction

Yeh, Y. T., Lin, Z., Zheng, S. Y. & Terrones, M., Dec 1 2018, In : Scientific reports. 8, 1, 13623.

Research output: Contribution to journalArticle

Lab-On-A-Chip Devices
Carbon Nanotubes
Equipment and Supplies
Biomarkers
Microtechnology

Acceptability of Switching from Usual Brand to SPECTRUM Research Cigarettes with Normal Nicotine Content

Veldheer, S., Midya, V., Lester, C., Liao, J. J., Yingst, J. M., Hrabovsky, S., Allen, SI., Krebs, N. M., Reinhart, L., Evins, AE., Horn, K., Richie, J., Muscat, J. & Foulds, J., 2018, In : Tobacco Regulatory Science. 4, 1, p. 573-585

Research output: Contribution to journalArticle

A comprehensive review of Mongolian spots with an update on atypical presentations

Alimi, Y., Iwanaga, J., Loukas, M., Oskouian, R. J., Rizk, E., Oakes, W. J. & Tubbs, R. S., Dec 1 2018, In : Child's Nervous System. 34, 12, p. 2371-2376 6 p.

Research output: Contribution to journalReview article

Mongolian Spot
Inborn Genetic Diseases
Newborn Infant
Neurocutaneous Syndromes
Lysosomal Storage Diseases

Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma

Sivik, J. M., Davidson, J., Hale, C. M., Drabick, J. & Talamo, G., Sep 1 2018, In : Supportive Care in Cancer. 26, 9, p. 3055-3061 7 p.

Research output: Contribution to journalArticle

Doxycycline
Ciprofloxacin
Multiple Myeloma
Stem Cells
Transplants
6 Citations (Scopus)

Adoptive cell transfer: Is it a promising immunotherapy for colorectal cancer?

Fan, J., Shang, D., Han, B., Song, J., Chen, H. & Yang, J. M., Jan 1 2018, In : Theranostics. 8, 20, p. 5784-5800 17 p.

Research output: Contribution to journalReview article

Adoptive Transfer
Immunotherapy
Colorectal Neoplasms
Natural Killer Cells
Dendritic Cells
3 Citations (Scopus)

Advanced Cell and Tissue Biomanufacturing

Ye, K., Kaplan, D. L., Bao, G., Bettinger, C., Forgacs, G., Dong, C., Khademhosseini, A., Ke, Y., Leong, K., Sambanis, A., Sun, W. & Yin, P., Jul 9 2018, In : ACS Biomaterials Science and Engineering. 4, 7, p. 2292-2307 16 p.

Research output: Contribution to journalReview article

Tissue
Biomedical engineering
Biotechnology
Industry
2 Citations (Scopus)

A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells

Wang, S., Xiao, Y., Zhang, D. D. & Wong, P. K., Feb 1 2018, In : Biomaterials. 156, p. 56-64 9 p.

Research output: Contribution to journalArticle

Transcription
Monitoring
Nucleic Acid Probes
Proteins
Messenger RNA
2 Citations (Scopus)

Analysis of protein–protein interaction by Co-IP in human cells

Tang, Z. & Takahashi, Y., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 289-296 8 p. (Methods in Molecular Biology; vol. 1794).

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteins
Antigen-Antibody Complex
Immunoblotting
Mass Spectrometry
Carrier Proteins
25 Citations (Scopus)

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H-G., Dec 1 2018, In : Nature communications. 9, 1, 2855.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
regulators
Autophagy
classifying
closures
3 Citations (Scopus)

Antagonizing CD105 enhances radiation sensitivity in prostate cancer

Madhav, A., Andres, A., Duong, F., Mishra, R., Haldar, S., Liu, Z., Angara, B., Gottlieb, R., Zumsteg, Z. S. & Bhowmick, N. A., Aug 9 2018, In : Oncogene. 37, 32, p. 4385-4397 13 p.

Research output: Contribution to journalArticle

Radiation Tolerance
Prostatic Neoplasms
Radiation
DNA Repair
Sirtuin 1

A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Zain, J., Claxton, D., Tuscano, J., Newman, E. M., Gandara, D. R. & Lara, P. N., Feb 1 2018, In : British Journal of Haematology. 180, 3, p. 445-448 4 p.

Research output: Contribution to journalLetter

Recombinant Fusion Proteins
Vascular Endothelial Growth Factor Receptor
Myelodysplastic Syndromes
Vascular Endothelial Growth Factor A
Clinical Trials
3 Citations (Scopus)

A phase I trial of topotecan plus tivantinib in patients with advanced solid tumors

Liu, S. V., Groshen, S. G., Kelly, K., Reckamp, K. L., Belani, C., Synold, T. W., Goldkorn, A., Gitlitz, B. J., Cristea, M. C., Gong, I. Y., Semrad, T. J., Xu, Y., Xu, T., Koczywas, M., Gandara, D. R. & Newman, E. M., Oct 1 2018, In : Cancer Chemotherapy and Pharmacology. 82, 4, p. 723-732 10 p.

Research output: Contribution to journalArticle

Topotecan
Tumors
Circulating Neoplastic Cells
Neoplasms
Phosphorylation

A Portable Device Integrated with Aligned Carbon Nanotubes for Sensitive Virus Capture and Detection

Yeh, Y-T., Lu, H., Zheng, S. & Terrones Maldonado, M., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., Vol. 2018-July. p. 6072-6075 4 p. 8513515

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carbon Nanotubes
Viruses
Carbon nanotubes
Point-of-Care Systems
Equipment and Supplies
2 Citations (Scopus)

A possible role for platelet-activating factor receptor in amyotrophic lateral sclerosis treatment

Briones, M. R. S., Snyder, A. M., Ferreira, R. C., Neely, E. B., Connor, J. R. & Broach, J. R., Feb 6 2018, In : Frontiers in Neurology. 9, FEB, 39.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Platelet Activating Factor
ginkgolide B
Interleukin-18
WEB 2086
24 Citations (Scopus)

Aptamer-conjugated extracellular nanovesicles for targeted drug delivery

Wan, Y., Wang, L., Zhu, C., Zheng, Q., Wang, G., Tong, J., Fang, Y., Xia, Y., Cheng, G., He, X. & Zheng, S. Y., Feb 1 2018, In : Cancer Research. 78, 3, p. 798-808 11 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Ligands
Antigen Receptors
Drug Delivery Systems
Cell- and Tissue-Based Therapy
5 Citations (Scopus)

ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation

Koubek, E. J. & Santy, L. C., May 4 2018, In : Small GTPases. 9, 3, p. 242-259 18 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Recycling
Chemical activation
Guanosine Triphosphate
Monomeric GTP-Binding Proteins
6 Citations (Scopus)

A role for sex and a common HFE gene variant in brain iron uptake

Duck, K. A., Neely, E. B., Simpson, I. A. & Connor, J. R., Mar 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 3, p. 540-548 9 p.

Research output: Contribution to journalArticle

Iron
Brain
Genes
Mutation
Genotype
4 Citations (Scopus)

A single simulation platform for hybrid photoacoustic and RF-acoustic computed tomography

Fadden, C. & Kothapalli, S. R., Sep 6 2018, In : Applied Sciences (Switzerland). 8, 9, 1568.

Research output: Contribution to journalArticle

Thermoacoustics
Photoacoustic effect
Tomography
radio frequencies
platforms
18 Citations (Scopus)

A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells

Hao, S., Ha, L., Cheng, G., Wan, Y., Xia, Y., Sosnoski, D. M., Mastro, A. M. & Zheng, S., Mar 22 2018, In : Small. 14, 12, 1702787.

Research output: Contribution to journalArticle

Bone
Cells
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
4 Citations (Scopus)

ATM/RB1 mutations predict shorter overall survival in urothelial cancer

Yin, M., Grivas, P., Emamekhoo, H., Mendiratta, P., Ali, S., Hsu, J. A., Vasekar, M., Drabick, J. J., Pal, S. & Joshi, M., Mar 30 2018, In : Oncotarget. 9, 24, p. 16891-16898 8 p.

Research output: Contribution to journalArticle

Mutation
Survival
Neoplasms
Confidence Intervals
Exome
2 Citations (Scopus)

Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3

Selvam, S. P., Roth, B. M., Nganga, R., Kim, J., Cooley, M. A., Helke, K., Smith, C. D. & Ogretmen, B., Jan 1 2018, In : Journal of Biological Chemistry. 293, 25, p. 9784-9800 17 p.

Research output: Contribution to journalArticle

Telomere
Caspase 3
Association reactions
Apoptosis
Telomerase
21 Citations (Scopus)

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice

Kokolus, K. M., Zhang, Y., Sivik, J. M., Schmeck, C., Zhu, J., Repasky, E. A., Drabick, J. J. & Schell, T. D., Mar 4 2018, In : OncoImmunology. 7, 3, e1405205.

Research output: Contribution to journalArticle

Immunotherapy
Melanoma
Adrenergic Receptors
Survival
Interleukin-2