Organization profile

Organization profile

The Mechanisms of Carcinogenesis research program of Penn State Cancer Institute investigates the mechanisms of carcinogenesis induced by viruses, chemicals and environmental/dietary agents through basic research.

Novel carcinogenic mechanisms identified by the program are applied toward the prevention and treatment of human cancers in collaboration with the Cancer Control research program and the Experimental Therapeutics research program. 

Fingerprint Dive into the research topics where Cancer Institute, Mechanisms of Carcinogenesis is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Proteins Medicine & Life Sciences
DNA Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Peroxisome Proliferator-Activated Receptors Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Genes Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Enzymes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Research Output 1963 2019

2 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium
1 Citation (Scopus)

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data

Sharma, A. K., Sormanni, P., Ahmed, N., Ciryam, P., Friedrich, U. A., Kramer, G. & O'Brien, Jr., E. P., Jan 1 2019, In : PLoS computational biology. 15, 5, e1007070.

Research output: Contribution to journalArticle

Open Access
Chemical Kinetics
Elongation
Profiling
ribosomes
Stem cells
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome

Muku, G. E., Murray, I. A. & Perdew, G. H., Oct 1 2019, In : Current Pharmacology Reports. 5, 5, p. 319-331 13 p.

Research output: Contribution to journalReview article

Aryl Hydrocarbon Receptors
Homeostasis
Chemical activation
Ligands
Gastrointestinal Microbiome

Acute Invasive Fungal Rhinosinusitis: Frozen Section Histomorphology and Diagnosis with PAS Stain

Crist, H., Hennessy, M., Hodos, J., McGinn, J., White, B., Payne, S. & Warrick, J., Sep 1 2019, In : Head and Neck Pathology. 13, 3, p. 318-326 9 p.

Research output: Contribution to journalArticle

Frozen Sections
Fungi
Coloring Agents
Periodic Acid-Schiff Reaction
Biopsy

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Sumanth, M. S., Abhilasha, K. V., Jacob, S. P., Chaithra, V. H., Basrur, V., Willard, B., McIntyre, T. M., Prabhu, K. S. & Marathe, G. K., Sep 1 2019, In : Immunobiology. 224, 5, p. 672-680 9 p.

Research output: Contribution to journalArticle

Acute-Phase Proteins
Sepsis
Glycoproteins
Ligands
Acids

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C., May 1 2019, In : Lung Cancer. 131, p. 58-61 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Interleukin-6
T-Lymphocytes
Population
STAT1 Transcription Factor
10 Citations (Scopus)

A global scientific strategy to cure hepatitis B

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors, Jul 1 2019, In : The Lancet Gastroenterology and Hepatology. 4, 7, p. 545-558 14 p.

Research output: Contribution to journalComment/debate

Hepatitis B
Hepatitis B virus
Virus Diseases
Chronic Hepatitis B
Circular DNA
4 Citations (Scopus)

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance

Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity

Cantorna, M. T-A., Rogers, C. J. & Arora, J., Jul 1 2019, In : Trends in Endocrinology and Metabolism. 30, 7, p. 459-466 8 p.

Research output: Contribution to journalReview article

Vitamin D
Immunity
Inflammatory Bowel Diseases
Infection
T-Lymphocytes

Projects 2012 2023

DNA-Directed DNA Polymerase
DNA
DNA Replication
Mutation
Neoplasms

Activities 2005 2016

  • 3 Oral presentation