Organization profile

Organization profile

The Mechanisms of Carcinogenesis research program of Penn State Cancer Institute investigates the mechanisms of carcinogenesis induced by viruses, chemicals and environmental/dietary agents through basic research.

Novel carcinogenic mechanisms identified by the program are applied toward the prevention and treatment of human cancers in collaboration with the Cancer Control research program and the Next-Generation Therapies program. 

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  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Profiles

    Research Output

    An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

    Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  • Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

    Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

    Research output: Contribution to journalArticle

  • Change is Good: What is New for ToxSci?

    Peters, J. M., Jan 1 2020, In : Toxicological Sciences. 173, 1, p. 1-2 2 p.

    Research output: Contribution to journalEditorial

    1 Scopus citations

    Composite score analysis for unsupervised comparison and network visualization of metabolomics data

    Kellogg, J. J., Kvalheim, O. M. & Cech, N. B., Jan 25 2020, In : Analytica Chimica Acta. 1095, p. 38-47 10 p.

    Research output: Contribution to journalArticle

  • Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

    Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

    Research output: Contribution to journalArticle

  • Customized Prevention Trials Could Resolve the Controversy of the Effects of Omega-3 Fatty Acids on Cancer

    El-Bayoumy, K. & Manni, A., Feb 17 2020, In : Nutrition and cancer. 72, 2, p. 183-186 4 p.

    Research output: Contribution to journalComment/debate

  • 1 Scopus citations

    Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

    Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

    Research output: Contribution to journalArticle

  • Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

    Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

    Research output: Contribution to journalArticle

  • Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes

    Li, H., Zhang, Q., Shuman, L., Kaag, M., Raman, J. D., Merrill, S., DeGraff, D. J., Warrick, J. I. & Chen, G., Dec 1 2020, In : Scientific reports. 10, 1, 1439.

    Research output: Contribution to journalArticle

    Open Access
  • Gastrointestinal hypoalgesia in inflammatory bowel disease

    Coates, M. D., Soriano, C., Dalessio, S., Stuart, A., Walter, V., Koltun, W., Bernasko, N., Tinsley, A., Clarke, K. & Williams, E. D., Jan 1 2020, In : Annals of Gastroenterology. 33, 1, p. 45-52 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • Projects

    Activities

    • 3 Oral presentation

    Prizes

    Junior Faculty Research Scholar Award

    Ryan Hobbs (Recipient), Nicholas Graziane (Recipient), Hyun Jin Kwun (Recipient) & Jonathan Stine (Recipient), 2018

    Prize

    Outstanding Collaborative Research Award

    Karam El-Bayoumy (Recipient), Andrea Manni (Recipient), John Richie (Recipient), Jiangang (Jason) Liao (Recipient), John Patrick Vanden Heuvel (Recipient), Laurence Demers (Recipient), James Dillard (Recipient) & Connie Jo Rogers (Recipient), 2016

    Prize