Organization profile

Organization profile

The Mechanisms of Carcinogenesis research program of Penn State Cancer Institute investigates the mechanisms of carcinogenesis induced by viruses, chemicals and environmental/dietary agents through basic research.

Novel carcinogenic mechanisms identified by the program are applied toward the prevention and treatment of human cancers in collaboration with the Cancer Control research program and the Experimental Therapeutics research program. 

Fingerprint Dive into the research topics where Cancer Institute, Mechanisms of Carcinogenesis is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Proteins Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
DNA Medicine & Life Sciences
Peroxisome Proliferator-Activated Receptors Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Genes Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Genome Medicine & Life Sciences

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Profiles

Research Output 1963 2020

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

Alkaloids
Modulators
Cells
Breast Neoplasms
Derivatives

2-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase

Boehr, A. K., Arnold, J. J., Oh, H. S., Cameron, C. E. & Boehr, D. D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 45, p. 16897-16907 11 p.

Research output: Contribution to journalArticle

RNA Replicase
RNA Viruses
Viral RNA
Viruses
Catalytic Domain

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K. C., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

Acceptability of electronic nicotine delivery systems (ENDS) among HIV positive smokers

Yingst, J., Foulds, J., Zurlo, J., Steinberg, M. B., Eissenberg, T. & Du, P., Jan 1 2019, (Accepted/In press) In : AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV.

Research output: Contribution to journalArticle

Nicotine
nicotine
HIV
electronics
Acquired Immunodeficiency Syndrome
2 Citations (Scopus)

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data

Sharma, A. K., Sormanni, P., Ahmed, N., Ciryam, P., Friedrich, U. A., Kramer, G. & O'Brien, E. P., Jan 1 2019, In : PLoS computational biology. 15, 5, e1007070.

Research output: Contribution to journalArticle

Open Access
Chemical Kinetics
Elongation
Profiling
ribosomes
Stem cells
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome

Muku, G. E., Murray, I. A. & Perdew, G. H., Oct 1 2019, In : Current Pharmacology Reports. 5, 5, p. 319-331 13 p.

Research output: Contribution to journalReview article

Aryl Hydrocarbon Receptors
Homeostasis
Chemical activation
Ligands
Gastrointestinal Microbiome

Acute Invasive Fungal Rhinosinusitis: Frozen Section Histomorphology and Diagnosis with PAS Stain

Crist, H., Hennessy, M., Hodos, J., McGinn, J., White, B., Payne, S. & Warrick, J., Sep 1 2019, In : Head and Neck Pathology. 13, 3, p. 318-326 9 p.

Research output: Contribution to journalArticle

Frozen Sections
Fungi
Coloring Agents
Periodic Acid-Schiff Reaction
Biopsy

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Sumanth, M. S., Abhilasha, K. V., Jacob, S. P., Chaithra, V. H., Basrur, V., Willard, B., McIntyre, T. M., Prabhu, K. S. & Marathe, G. K., Sep 2019, In : Immunobiology. 224, 5, p. 672-680 9 p.

Research output: Contribution to journalArticle

Acute-Phase Proteins
Sepsis
Glycoproteins
Ligands
Acids

Projects 2012 2023

DNA-Directed DNA Polymerase
DNA
DNA Replication
Mutation
Neoplasms

Activities 2005 2016

  • 3 Oral presentation