Research Output 1963 2019

2019

2-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase

Boehr, A. K., Arnold, J. J., Oh, H. S., Cameron, C. E. & Boehr, D. D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 45, p. 16897-16907 11 p.

Research output: Contribution to journalArticle

RNA Replicase
RNA Viruses
Viral RNA
Viruses
Catalytic Domain
5 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

Acceptability of electronic nicotine delivery systems (ENDS) among HIV positive smokers

Yingst, J., Foulds, J., Zurlo, J., Steinberg, M. B., Eissenberg, T. & Du, P., Jan 1 2019, (Accepted/In press) In : AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV.

Research output: Contribution to journalArticle

Nicotine
nicotine
HIV
electronics
Acquired Immunodeficiency Syndrome
2 Citations (Scopus)

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data

Sharma, A. K., Sormanni, P., Ahmed, N., Ciryam, P., Friedrich, U. A., Kramer, G. & O'Brien, E. P., Jan 1 2019, In : PLoS computational biology. 15, 5, e1007070.

Research output: Contribution to journalArticle

Open Access
Chemical Kinetics
Elongation
Profiling
ribosomes
Stem cells
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Activation of the Ah Receptor Modulates Gastrointestinal Homeostasis and the Intestinal Microbiome

Muku, G. E., Murray, I. A. & Perdew, G. H., Oct 1 2019, In : Current Pharmacology Reports. 5, 5, p. 319-331 13 p.

Research output: Contribution to journalReview article

Aryl Hydrocarbon Receptors
Homeostasis
Chemical activation
Ligands
Gastrointestinal Microbiome

Acute Invasive Fungal Rhinosinusitis: Frozen Section Histomorphology and Diagnosis with PAS Stain

Crist, H., Hennessy, M., Hodos, J., McGinn, J., White, B., Payne, S. & Warrick, J., Sep 1 2019, In : Head and Neck Pathology. 13, 3, p. 318-326 9 p.

Research output: Contribution to journalArticle

Frozen Sections
Fungi
Coloring Agents
Periodic Acid-Schiff Reaction
Biopsy

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Sumanth, M. S., Abhilasha, K. V., Jacob, S. P., Chaithra, V. H., Basrur, V., Willard, B., McIntyre, T. M., Prabhu, K. S. & Marathe, G. K., Sep 2019, In : Immunobiology. 224, 5, p. 672-680 9 p.

Research output: Contribution to journalArticle

Acute-Phase Proteins
Sepsis
Glycoproteins
Ligands
Acids

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C., May 1 2019, In : Lung Cancer. 131, p. 58-61 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Interleukin-6
T-Lymphocytes
Population
STAT1 Transcription Factor
15 Citations (Scopus)

A global scientific strategy to cure hepatitis B

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors, Jul 2019, In : The Lancet Gastroenterology and Hepatology. 4, 7, p. 545-558 14 p.

Research output: Contribution to journalComment/debate

Hepatitis B
Hepatitis B virus
Virus Diseases
Chronic Hepatitis B
Circular DNA
4 Citations (Scopus)

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. D. & Robertson, G. P., Jan 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance
1 Citation (Scopus)

Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity

Cantorna, M. T-A., Rogers, C. J. & Arora, J., Jul 1 2019, In : Trends in Endocrinology and Metabolism. 30, 7, p. 459-466 8 p.

Research output: Contribution to journalReview article

Vitamin D
Immunity
Inflammatory Bowel Diseases
Infection
T-Lymphocytes
1 Citation (Scopus)

Aluminum oxide free-standing thin films to enable nitrogen edge soft X-ray scattering

Ye, D., Rongpipi, S., Litofsky, J. H., Lee, Y., Culp, T. E., Yoo, S. H., Jackson, T. N., Wang, C., Gomez, E. W. & Gomez, E. D., Mar 1 2019, In : MRS Communications. 9, 1, p. 224-228 5 p.

Research output: Contribution to journalArticle

Aluminum Oxide
X ray scattering
Nitrogen
Aluminum
X rays

A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition

Elcheva, I., Sneed, M., Frazee, S., Liu, Z., Zhu, J., Wood, T., Hendrickson, S., Oehler, C., Garcia, B. & Spiegelman, V. S., Dec 2019, In : Toxicology in Vitro. 61, 104622.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cytotoxicity
Toxicity
GATA2 Transcription Factor
Screening
1 Citation (Scopus)

A random subset implementation of weighted quantile sum (WQSRS) regression for analysis of high-dimensional mixtures

Curtin, P., Kellogg, J., Cech, N. & Gennings, C., Jan 1 2019, (Accepted/In press) In : Communications in Statistics: Simulation and Computation.

Research output: Contribution to journalArticle

Quantile
High-dimensional
Regression
Subset
Specificity
1 Citation (Scopus)

A review of analytical platforms for accurate bile acid measurement

Dutta, M., Cai, J., Gui, W. & Patterson, A. D., Jul 19 2019, In : Analytical and Bioanalytical Chemistry. 411, 19, p. 4541-4549 9 p.

Research output: Contribution to journalReview article

Bile Acids and Salts
Clinical laboratories
Intestinal Diseases
Molecules
Liquid chromatography
5 Citations (Scopus)

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Madesh, M., Jan 23 2019, In : ACS Central Science. 5, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Open Access
Calcium
Signal transduction
Mutagenesis
Ruthenium
Poisons
1 Citation (Scopus)

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents

Asymmetry in icosahedral viruses

Goetschius, D. J., Parrish, C. R. & Hafenstein, S., Jun 1 2019, In : Current Opinion in Virology. 36, p. 67-73 7 p.

Research output: Contribution to journalReview article

Leviviridae
Genome
Viruses
Picornaviridae
Capsid Proteins

A trip down memory lane with Retrovirology

Benkirane, M., Berkhout, B., Borrow, P., Fassati, A., Fujii, M., Garcia-Martinez, J. V., Margolis, D., Nijhuis, M., Parent, L., Strebel, K., Venter, F., Kirchhoff, F., Lever, A., Ross, S. & Mak, J., Aug 21 2019, In : Retrovirology. 16, 1, 22.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., de Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, G., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 71.

Research output: Contribution to journalComment/debate

Open Access
Molecular Medicine
Licensure
Medicine
Rabbits
4 Citations (Scopus)

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation

Tian, Y., Cai, J., Gui, W., Nichols, R. G., Koo, I., Zhang, J., Anitha, M. & Patterson, A. D., Feb 1 2019, In : Drug Metabolism and Disposition. 47, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

Berberine
Bacteria
choloylglycine hydrolase
Metabolomics
Bile Acids and Salts
1 Citation (Scopus)

Biomimetic Separation of Transport and Matrix Functions in Lamellar Block Copolymer Channel-Based Membranes

Lang, C., Ye, D., Song, W., Yao, C., Tu, Y. M., Capparelli, C., Lanasa, J. A., Hickner, M. A., Gomez, E. W., Gomez, E. D., Hickey, III, R. J. & Kumar, M., Jul 23 2019, In : ACS nano. 13, 7, p. 8292-8302 11 p.

Research output: Contribution to journalArticle

biomimetics
Biomimetics
block copolymers
Block copolymers
Aquaporins

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Lipid Metabolism
Lipids
Liver
Homeostasis
2 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models

Ca2+ channels in cancer

Gautier, M., Trebak, M., Fleig, A., Vandier, C. & Ouadid-Ahidouch, H., Dec 2019, In : Cell Calcium. 84, 102083.

Research output: Contribution to journalEditorial

Neoplasms

Ca2+ homeostasis and cancer

Gautier, M., Trebak, M., Fleig, A., Vandier, C. & Ouadid-Ahidouch, H., Dec 2019, In : Cell Calcium. 84, 102084.

Research output: Contribution to journalEditorial

Homeostasis
Neoplasms
13 Citations (Scopus)

Calcium signalling in T cells

Trebak, M. & Kinet, J. P., Mar 1 2019, In : Nature Reviews Immunology. 19, 3, p. 154-169 16 p.

Research output: Contribution to journalReview article

Calcium Signaling
T-Lymphocytes
Immunity
Cell Membrane
Lymphocytes
2 Citations (Scopus)

Cancer and the dopamine D2 receptor: A pharmacological perspective

Weissenrieder, J. S., Neighbors, J., Mailman, R. & Hohl, R., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalReview article

Dopamine D2 Receptors
Pharmacology
Neoplasms
Ligands
Drug Therapy
7 Citations (Scopus)

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

Hu, J., Lin, Y. Y., Chen, P. J., Watashi, K. & Wakita, T., Jan 1 2019, In : Gastroenterology. 156, 2, p. 338-354 17 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepatitis B virus
Animal Models
Pharmaceutical Preparations
Cell Culture Techniques
1 Citation (Scopus)

Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
bladder
Polymerase chain reaction
Urinary Bladder Neoplasms
cancer
1 Citation (Scopus)

Characterizing protein-DNA binding event subtypes in ChIP-exo data

Yamada, N., Lai, W., Farrell, N., Pugh, B. F. & Mahony, S. A., Mar 15 2019, In : Bioinformatics. 35, 6, p. 903-913 11 p.

Research output: Contribution to journalArticle

DNA-binding Protein
Chromatin Immunoprecipitation
Chromatin
DNA-Binding Proteins
DNA
4 Citations (Scopus)

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Santhanam, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 1 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Punctures
Cardiac Myocytes
Ligation
Reactive Oxygen Species
2 Citations (Scopus)

Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)

Ebad-Allah, J., Afonso, J. F., M., K., Hu, J., Zhu, Y. L., Mao, Z. Q., J., K. & Kuntscher, C. A., 2019, In : Physical Review B. 99, 12

Research output: Contribution to journalArticle

metalloids
pressure effects
conductivity
corrugating
interlayers
1 Citation (Scopus)

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Nakada, E. M., Bhakta, N. R., Korwin-Mihavics, B. R., Kumar, A., Chamberlain, N., Bruno, S. R., Chapman, D. G., Hoffman, S. M., Daphtary, N., Aliyeva, M., Irvin, C. G., Dixon, A. E., Woodruff, P. G., Amin, S., Poynter, M. E., Desai, D. H. & Anathy, V., Jan 1 2019, In : JCI Insight. 4, 9, e98101.

Research output: Contribution to journalArticle

Open Access
Unfolded Protein Response
Transducers
Bile Acids and Salts
Allergens
Inflammation

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Neoplasm Metastasis
Survival
Antioxidants
Peritoneal Cavity

Continuing a Legacy: Adapting to Ensure the Bright Future of ToxSci

Peters, J. M., Jul 1 2019, In : Toxicological Sciences. 170, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Ensure

Coordinated Network Changes across the Catalytic Cycle of Alpha Tryptophan Synthase

O'Rourke, K. F., Sahu, D., Bosken, Y. K., D'Amico, R. N., Chang, C. E. A. & Boehr, D. D., Sep 3 2019, In : Structure. 27, 9, p. 1405-1415.e5

Research output: Contribution to journalArticle

Tryptophan Synthase
Proteins
Enzymes
Amino Acids
Molecular Dynamics Simulation
Open Access
Allergy and Immunology
Interleukin-1
Actins
Monocytes
Outcome Assessment (Health Care)

Cross Sectional Study and Risk Factors Analysis of Francisella tularensis in Soil Samples in Punjab Province of Pakistan

Muhammad, J., Rabbani, M., Shabbir, M. Z., Muhammad, K., Ghori, M. T., Chaudhry, H. R., Hassnain, Z. U., Jamil, T., Abbas, T., Chaudhry, M. H., Haisem-Ur-Rasool, M., Ali, M. A., Nisar, M., Kirimanjeswara, G. S. & Jayarao, B. M., Jan 1 2019, In : Frontiers in Cellular and Infection Microbiology. 9, APR, 089.

Research output: Contribution to journalArticle

Open Access
Francisella tularensis
Pakistan
Statistical Factor Analysis
Soil
Cross-Sectional Studies

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

Diwakar, B. T., Yoast, R., Nettleford, S., Qian, F., Lee, T. J., Berry, S., Huffnagle, I., Rossi, R. M., Trebak, M., Paulson, R. F. & Prabhu, K. S., Nov 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12838-12852 15 p.

Research output: Contribution to journalArticle

Macrophages
Lipopolysaccharides
Down-Regulation
Chemical activation
Prostaglandins

CryoEM reconstruction approaches to resolve asymmetric features

Goetschius, D. J., Lee, H. & Hafenstein, S., 2019, Advances in Virus Research. Rey, F. A. (ed.). Academic Press Inc., p. 73-91 19 p. (Advances in Virus Research; vol. 105).

Research output: Chapter in Book/Report/Conference proceedingChapter

Viruses
Capsid
Life Cycle Stages
Genome
Proteins

Customized Prevention Trials Could Resolve the Controversy of the Effects of Omega-3 Fatty Acids on Cancer

El-Bayoumy, K. & Manni, A., Jan 1 2019, (Accepted/In press) In : Nutrition and cancer.

Research output: Contribution to journalComment/debate

Omega-3 Fatty Acids
Fish Oils
Health Services Needs and Demand
Secondary Prevention
Neoplasms
2 Citations (Scopus)

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5261-5275 15 p.

Research output: Contribution to journalArticle

Sulfur
Isothiocyanates
Neoplasms
Organoselenium Compounds
Glucosinolates
2 Citations (Scopus)

Device characteristics of long term electronic cigarette users: A follow-up study

Yingst, J., Foulds, J., Veldheer, S. & Du, P., Apr 1 2019, In : Addictive Behaviors. 91, p. 238-243 6 p.

Research output: Contribution to journalArticle

Tobacco Products
Equipment and Supplies
Nicotine
Tobacco
Electronic Cigarettes
4 Citations (Scopus)

Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

Liu, Z., Yee, P. P., Wei, Y., Liu, Z., Imamura, Y. & Li, W., Mar 1 2019, In : Journal of Cell Science. 132, 5, jcs225714.

Research output: Contribution to journalArticle

Open Access
Glioma
Carcinogenesis
Neoplasms
Glioblastoma
Growth

Direct prediction of regulatory elements from partial data without imputation

Zhang, Y. & Mahony, S., Nov 1 2019, In : PLoS computational biology. 15, 11, p. e1007399

Research output: Contribution to journalArticle

Open Access
Imputation
segmentation
Genome
Segmentation
genome

DNA polymerases as chemotherapy targets: Promise and challenges

Eckert, K. A. & Barnes, R. P., Jan 1 2019, In : Oncotarget. 10, 6, p. 620-621 2 p.

Research output: Contribution to journalEditorial

DNA-Directed DNA Polymerase
Drug Therapy
2 Citations (Scopus)

Domain topology, stability, and translation speed determine mechanical force generation on the ribosome

Leininger, S. E., Trovato, F., Nissley, D. A. & O'Brien, Jr., E. P., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 12, p. 5523-5532 10 p.

Research output: Contribution to journalArticle

Ribosomes
Proteins
Statistical Models
Proteome
Phenotype