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2020

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

Research output: Contribution to journalArticle

Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

Research output: Contribution to journalArticle

Composite score analysis for unsupervised comparison and network visualization of metabolomics data

Kellogg, J. J., Kvalheim, O. M. & Cech, N. B., Jan 25 2020, In : Analytica Chimica Acta. 1095, p. 38-47 10 p.

Research output: Contribution to journalArticle

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

Research output: Contribution to journalArticle

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticle

Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

Research output: Contribution to journalArticle

Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes

Li, H., Zhang, Q., Shuman, L., Kaag, M., Raman, J. D., Merrill, S., DeGraff, D. J., Warrick, J. I. & Chen, G., Dec 1 2020, In : Scientific reports. 10, 1, 1439.

Research output: Contribution to journalArticle

Open Access

Gastrointestinal hypoalgesia in inflammatory bowel disease

Coates, M. D., Soriano, C., Dalessio, S., Stuart, A., Walter, V., Koltun, W., Bernasko, N., Tinsley, A., Clarke, K. & Williams, E. D., Jan 1 2020, In : Annals of Gastroenterology. 33, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Open Access

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Feb 6 2020, In : Oncogene. 39, 6, p. 1302-1317 16 p.

Research output: Contribution to journalArticle

IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer

Zhao, T., Jin, F., Xiao, D., Wang, H., Huang, C., Wang, X., Gao, S., Liu, J., Yang, S. & Hao, J., Jan 1 2020, In : Theranostics. 10, 9, p. 4088-4100 13 p.

Research output: Contribution to journalArticle

Open Access

Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure

Stump, C. L., Feehan, R. P., Jordan, T., Shantz, L. M. & Nowotarski, S. L., Feb 1 2020, In : Amino Acids. 52, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In : Metabolites. 10, 1, 1.

Research output: Contribution to journalArticle

Open Access

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Das, N. K., Schwartz, A. J., Barthel, G., Inohara, N., Liu, Q., Sankar, A., Hill, D. R., Ma, X., Lamberg, O., Schnizlein, M. K., Arqués, J. L., Spence, J. R., Nunez, G., Patterson, A. D., Sun, D., Young, V. B. & Shah, Y. M., Jan 7 2020, In : Cell Metabolism. 31, 1, p. 115-130.e6

Research output: Contribution to journalArticle

2 Scopus citations
Open Access

PCB126 blocks the thermogenic beiging response of adipocytes

Gourronc, F. A., Perdew, G. H., Robertson, L. W. & Klingelhutz, A. J., Mar 1 2020, In : Environmental Science and Pollution Research. 27, 9, p. 8897-8904 8 p.

Research output: Contribution to journalArticle

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

Zhang, L., Rimal, B., Nichols, R. G., Tian, Y., Smith, P. B., Hatzakis, E., Chang, S. C., Butenhoff, J. L., Peters, J. M. & Patterson, A. D., Feb 15 2020, In : Toxicology. 431, 152365.

Research output: Contribution to journalArticle

Report from the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges

Warrick, J. I., Knowles, M. A., Yves, A., Van Der Kwast, T., Grignon, D. J., Kristiansen, G., Egevad, L., Hartmann, A. & Cheng, L., Jan 1 2020, (Accepted/In press) In : American Journal of Surgical Pathology.

Research output: Contribution to journalArticle

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In : Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticle

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase

Shin, Y., Hedglin, M. & Murakami, K. S., Feb 28 2020, In : Nucleic acids research. 48, 4, p. 2144-2155 12 p.

Research output: Contribution to journalArticle

Open Access
Open Access

The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells

Weissenrieder, J. S., Reed, J. L., Green, M. V., Moldovan, G. L., Koubek, E. J., Neighbors, J. D. & Hohl, R. J., Jan 1 2020, In : Pharmacology. 105, 1-2, p. 19-27 9 p.

Research output: Contribution to journalArticle

Open Access

The microbiome modulating activity of bile acids

Tian, Y., Gui, W., Koo, I., Smith, P. B., Allman, E. L., Nichols, R. G., Rimal, B., Cai, J., Liu, Q. & Patterson, A. D., Jan 1 2020, (Accepted/In press) In : Gut microbes.

Research output: Contribution to journalArticle

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

Bruno, P. M., Lu, M., Dennis, K. A., Inam, H., Moore, C. J., Sheehe, J., Elledge, S. J., Hemann, M. T. & Pritchard, J. R., Feb 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4053-4060 8 p.

Research output: Contribution to journalArticle

2019

2-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase

Boehr, A. K., Arnold, J. J., Oh, H. S., Cameron, C. E. & Boehr, D. D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 45, p. 16897-16907 11 p.

Research output: Contribution to journalArticle

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K. C., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Acceptability of electronic nicotine delivery systems (ENDS) among HIV positive smokers

Yingst, J., Foulds, J., Zurlo, J., Steinberg, M. B., Eissenberg, T. & Du, P., Jan 1 2019, (Accepted/In press) In : AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV.

Research output: Contribution to journalArticle

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data

Sharma, A. K., Sormanni, P., Ahmed, N., Ciryam, P., Friedrich, U. A., Kramer, G. & O'Brien, E. P., Jan 1 2019, In : PLoS computational biology. 15, 5, e1007070.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Acute Invasive Fungal Rhinosinusitis: Frozen Section Histomorphology and Diagnosis with PAS Stain

Crist, H., Hennessy, M., Hodos, J., McGinn, J., White, B., Payne, S. & Warrick, J. I., Sep 1 2019, In : Head and Neck Pathology. 13, 3, p. 318-326 9 p.

Research output: Contribution to journalArticle

Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses

Sumanth, M. S., Abhilasha, K. V., Jacob, S. P., Chaithra, V. H., Basrur, V., Willard, B., McIntyre, T. M., Prabhu, K. S. & Marathe, G. K., Sep 2019, In : Immunobiology. 224, 5, p. 672-680 9 p.

Research output: Contribution to journalArticle

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C. P., May 2019, In : Lung Cancer. 131, p. 58-61 4 p.

Research output: Contribution to journalArticle

Aluminum oxide free-standing thin films to enable nitrogen edge soft X-ray scattering

Ye, D., Rongpipi, S., Litofsky, J. H., Lee, Y., Culp, T. E., Yoo, S. H., Jackson, T. N., Wang, C., Gomez, E. W. & Gomez, E. D., Mar 1 2019, In : MRS Communications. 9, 1, p. 224-228 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition

Elcheva, I., Sneed, M., Frazee, S., Liu, Z., Zhu, J., Wood, T., Hendrickson, S., Oehler, C., Garcia, B. & Spiegelman, V. S., Dec 2019, In : Toxicology in Vitro. 61, 104622.

Research output: Contribution to journalArticle

A random subset implementation of weighted quantile sum (WQSRS) regression for analysis of high-dimensional mixtures

Curtin, P., Kellogg, J., Cech, N. & Gennings, C., Jan 1 2019, (Accepted/In press) In : Communications in Statistics: Simulation and Computation.

Research output: Contribution to journalArticle

2 Scopus citations

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Madesh, M., Jan 23 2019, In : ACS Central Science. 5, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A. K., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation

Tian, Y., Cai, J., Gui, W., Nichols, R. G., Koo, I., Zhang, J., Anitha, M. & Patterson, A. D., Feb 2019, In : Drug Metabolism and Disposition. 47, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Biomimetic Separation of Transport and Matrix Functions in Lamellar Block Copolymer Channel-Based Membranes

Lang, C., Ye, D., Song, W., Yao, C., Tu, Y. M., Capparelli, C., Lanasa, J. A., Hickner, M. A., Gomez, E. W., Gomez, E. D., Hickey, R. J. & Kumar, M., Jul 23 2019, In : ACS nano. 13, 7, p. 8292-8302 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M. M., Chen, H., Hohl, R. J. & Mailman, R. B., Mar 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

Hu, J., Lin, Y. Y., Chen, P. J., Watashi, K. & Wakita, T., Jan 2019, In : Gastroenterology. 156, 2, p. 338-354 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Characterizing protein-DNA binding event subtypes in ChIP-exo data

Yamada, N., Lai, W. K. M., Farrell, N., Pugh, B. F. & Mahony, S., Mar 15 2019, In : Bioinformatics. 35, 6, p. 903-913 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Shanmughapriya, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)

Ebad-Allah, J., Afonso, J. F., M., K., Hu, J., Zhu, Y. L., Mao, Z. Q., J., K. & Kuntscher, C. A., 2019, In : Physical Review B. 99, 12

Research output: Contribution to journalArticle

5 Scopus citations

Circulating microRNAs in plasma among men with low-grade and high-grade prostate cancer at prostate biopsy

McDonald, A. C., Vira, M., Walter, V., Shen, J., Raman, J. D., Sanda, M. G., Patil, D. & Taioli, E., Jun 15 2019, In : Prostate. 79, 9, p. 961-968 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits

Lucas, A. M., Palmiero, N. E., McGuigan, J., Passero, K., Zhou, J., Orie, D., Ritchie, M. D. & Hall, M. A., Dec 18 2019, In : Frontiers in Genetics. 10, 1240.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations