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66 Scopus citations

Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: Central role of epithelial-derived MMP

Castaneda, F. E., Walia, B., Kumar, M. V., Patel, N. R., Roser, S., Kolachala, V. L., Rojas, M., Wang, L., Oprea, G., Garg, P., Gewirtz, A. T., Roman, J., Merlin, D. & Sitaraman, S. V., Jan 1 2005, In : Gastroenterology. 129, 6, p. 1991-2008 18 p.

Research output: Contribution to journalArticle

175 Scopus citations

Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis

Chandrasekharan, B., Bala, V., Kolachala, V. L., Vijay-Kumar, M., Jones, D., Gewirtz, A. T., Sitaraman, S. V. & Srinivasan, S., Oct 1 2008, In : PloS one. 3, 10, e3304.

Research output: Contribution to journalArticle

41 Scopus citations

Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma

Glick, A. B., Lee, M. M., Darwiche, N., Kulkarni, A. B., Karlsson, S. & Yuspa, S. H., Oct 15 1994, In : Genes and Development. 8, 20, p. 2429-2440 12 p.

Research output: Contribution to journalArticle

133 Scopus citations
62 Scopus citations

Targeted disruption of peroxisomal proliferator-activated receptor β (δ) results in distinct gender differences in mouse brain phospholipid and esterified FA levels

Rosenberger, T. A., Hovda, J. T. & Peters, J. M., Jan 1 2002, In : Lipids. 37, 5, p. 495-500 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Targeted immunotherapy for non-small cell lung cancer

Vasekar, M., Liu, X., Zheng, H. & Belani, C., May 10 2014, In : World Journal of Clinical Oncology. 5, 2, p. 39-47 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Targeted overexpression of ornithine decarboxylase enhances β-adrenergic agonist-induced cardiac hypertrophy

Shantz, L., Feith, D. J. & Pegg, A., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Targeted repression of AXIN2 and MYC gene expression using designer TALEs

Rennoll, S. A., Scott, S. A. & Yochum, G., Apr 18 2014, In : Biochemical and Biophysical Research Communications. 446, 4, p. 1120-1125 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia

Marie, Y. S., Toulon, A., Paus, R., Maubec, E., Cherfa, A., Grossin, M., Descamps, V., Clemessy, M., Gasc, J. M., Peuchmaur, M., Glick, A., Farman, N. & Jaisser, F., Sep 2007, In : American Journal of Pathology. 171, 3, p. 846-860 15 p.

Research output: Contribution to journalArticle

50 Scopus citations

Targeting Akt3 signaling in malignant melanoma using isoselenocyanates

Sharma, A., Sharma, A. K., Madhunapantula, S. V., Desai, D., Huh, S. J., Mosca, P., Amin, S. & Robertson, G. P., Mar 1 2009, In : Clinical Cancer Research. 15, 5, p. 1674-1685 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer

Doerr, F., George, J., Schmitt, A., Beleggia, F., Rehkämper, T., Hermann, S., Walter, V., Weber, J. P., Thomas, R. K., Wittersheim, M., Büttner, R., Persigehl, T. & Christian Reinhardt, H., Dec 1 2017, In : Scientific reports. 7, 1, 15511.

Research output: Contribution to journalArticle

14 Scopus citations

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

Song, C., Gowda, C., Pan, X., Ding, Y., Tong, Y., Tan, B. H., Wang, H., Muthusami, S., Ge, Z., Sachdev, M., Amin, S. G., Desai, D., Gowda, K., Gowda, R., Robertson, G. P., Schjerven, H., Muschen, M., Payne, K. J. & Dovat, S., Oct 8 2015, In : Blood. 126, 15, p. 1813-1822 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. D., Tong, H., Henry, M. D. & Hohl, R. J., Aug 25 2015, In : Clinical and Experimental Metastasis. 32, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

Thomas, Z. I., Gibson, W., Sexton, J. Z., Aird, K. M., Ingram, S. M., Aldrich, A., Lyerly, H. K., Devi, G. R. & Williams, K. P., May 10 2011, In : British Journal of Cancer. 104, 10, p. 1575-1586 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer

Dahl, E. S., Buj, R., Leon, K. E., Newell, J. M., Imamura, Y., Bitler, B. G., Snyder, N. W. & Aird, K. M., Aug 1 2019, In : Molecular Cancer Research. 17, 8, p. 1710-1720 11 p.

Research output: Contribution to journalArticle

Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAFV600E inhibitors

Kim, T. W., Havighurst, T., Kim, K. M., Albertini, M., Xu, Y. G. & Spiegelman, V. S., May 2018, In : Molecular Carcinogenesis. 57, 5, p. 678-683 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
94 Scopus citations

Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ 12-PGJ 2 through covalent binding to Cys 1438

Ravindra, K. C., Narayan, V., Lushington, G. H., Peterson, B. R. & Prabhu, K. S., Feb 20 2012, In : Chemical research in toxicology. 25, 2, p. 337-347 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons

Smith, L. E., Denissenko, M. F., Bennett, W. P., Li, H., Amin, S., Tang, M. S. & Pfeifer, G. P., May 17 2000, In : Journal of the National Cancer Institute. 92, 10, p. 803-811 9 p.

Research output: Contribution to journalArticle

255 Scopus citations

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Targeting RRM2 and mutant BRAF is a novel combinatorial strategy for melanoma

Fatkhutdinov, N., Sproesser, K., Krepler, C., Liu, Q., Brafford, P. A., Herlyn, M., Aird, K. M. & Zhang, R., Sep 1 2016, In : Molecular Cancer Research. 14, 9, p. 767-775 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis

Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J. D., Hohl, R. & Carter, A. B., Jun 27 2015, In : Free Radical Biology and Medicine. 86, p. 47-56 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Targeting the pregnane X receptor using microbial metabolite mimicry

Dvořák, Z., Kopp, F., Costello, C. M., Kemp, J. S., Li, H., Vrzalová, A., Štěpánková, M., Bartoňková, I., Jiskrová, E., Poulíková, K., Vyhlídalová, B., Nordstroem, L. U., Karunaratne, C. V., Ranhotra, H. S., Mun, K. S., Naren, A. P., Murray, I. A., Perdew, G. H., Brtko, J., Toporova, L. & 22 others, Schön, A., Wallace, W. G., Walton, W. G., Redinbo, M. R., Sun, K., Beck, A., Kortagere, S., Neary, M. C., Chandran, A., Vishveshwara, S., Cavalluzzi, M. M., Lentini, G., Cui, J. Y., Gu, H., March, J. C., Chatterjee, S., Matson, A., Wright, D., Flannigan, K. L., Hirota, S. A., Sartor, R. B. & Mani, S., Apr 7 2020, In : EMBO Molecular Medicine. 12, 4, e11621.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication

Yoo, M. H., Xu, X. M., Carlson, B. A., Patterson, A. D., Gladyshev, V. N. & Hatfield, D. L., Oct 31 2007, In : PloS one. 2, 10, e1112.

Research output: Contribution to journalArticle

90 Scopus citations

Targeting Tumour Proliferation with a Small-Molecule Inhibitor of AICAR Transformylase Homodimerization

Spurr, I. B., Birts, C. N., Cuda, F., Benkovic, S. J., Blaydes, J. P. & Tavassoli, A., Jul 23 2012, In : ChemBioChem. 13, 11, p. 1628-1634 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeting β-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells

Tang, W., Li, Y., Yu, D., Thomas-Tikhonenko, A., Spiegelman, V. & Fuchs, S. Y., Mar 1 2005, In : Cancer Research. 65, 5, p. 1904-1908 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases

Parvatiyar, K., Barber, G. N. & Harhaj, E. W., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 14999-15009 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

TAX1BP1 restrains virus-induced apoptosis by facilitating itch-mediated degradation of the mitochondrial adaptor MAVS

Choi, Y. B., Shembade, N., Parvatiyar, K., Balachandran, S. & Harhaj, E. W., Jan 1 2017, In : Molecular and cellular biology. 37, 1, e00422-16.

Research output: Contribution to journalArticle

12 Scopus citations

T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis

Rogers, H., Wang, L., Yu, X., Alnaeeli, M., Cui, K., Zhao, K., Bieker, J. J., Prchal, J., Huang, S., Weksler, B. & Noguchi, C. T., Oct 26 2012, In : Journal of Biological Chemistry. 287, 44, p. 36720-36731 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8+ T-cell exhaustion and poor clinical outcome in AML patients

Kong, Y., Zhu, L., Schell, T. D., Zhang, J., Claxton, D. F., Ehmann, W. C., Rybka, W. B., George, M. R., Zeng, H. & Zheng, H., Jun 15 2016, In : Clinical Cancer Research. 22, 12, p. 3057-3066 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

T-cell Immunoglobulin and ITIM Domain Contributes to CD8 + T-cell Immunosenescence

Song, Y., Wang, B., Song, R., Hao, Y., Wang, D., Li, Y., Jiang, Y., Xu, L., Ma, Y., Zheng, H., Kong, Y. & Zeng, H., Apr 2018, In : Aging cell. 17, 2, e12716.

Research output: Contribution to journalArticle

10 Scopus citations

TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells

Eshelman, M. A., Shah, M., Raup-Konsavage, W. M., Rennoll, S. A. & Yochum, G. S., Jun 3 2017, In : Biochemical and Biophysical Research Communications. 487, 3, p. 716-722 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation

De Witte, M. A., Bendle, G. M., Van Den Boom, M. D., Coccoris, M., Schell, T. D., Tevethia, S. S., Van Tinteren, H., Mesman, E. M., Song, J. Y. & Schumacher, T. N. M., Aug 15 2008, In : Journal of Immunology. 181, 4, p. 2563-2571 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
8 Scopus citations

Telbivudine treatment corrects HBV-induced epigenetic alterations in liver cells of patients with chronic hepatitis B

Tian, Y., Ni, D., Yang, W., Zhang, Y., Zhao, K., Song, J., Mao, Q., Tian, Z., van Velkinburgh, J. C., Yang, D., Wu, Y. & Ni, B., Jan 1 2014, In : Carcinogenesis. 35, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability

Damerla, R. R., Knickelbein, K. E., Kepchia, D., Jackson, A., Armitage, B. A., Eckert, K. A. & Opresko, P. L., Nov 10 2010, In : DNA Repair. 9, 11, p. 1119-1129 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Temperature- and field-driven spin reorientations in triple-layer ruthenate Sr4Ru3O10

Zhu, M., Li, P. G., Wang, Y., Cao, H. B., Tian, W., Zhang, H. D., Phelan, B. D., Mao, Z. Q. & Ke, X., 2018, In : Scientific reports. 8, 1

Research output: Contribution to journalArticle

4 Scopus citations

Template/primer requirements and single nucleotide incorporation by Hepatitis C virus nonstructural protein 5B polymerase

Zhong, W., Ferrari, E., Lesburg, C. A., Maag, D., Ghosh, S. K. B., Cameron, C. E., Lau, J. Y. N. & Hong, Z., Jan 1 2000, In : Journal of virology. 74, 19, p. 9134-9143 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Temporal and spatial expression of the E5a protein during the differentiation-dependent life cycle of human papillomavirus type 31b

Mayer, T. J. & Meyers, C., Sep 1 1998, In : Virology. 248, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Temporal gene regulation of the channel catfish virus (Ictalurid herpesvirus 1)

Huang, S. & Hanson, L. A., Mar 1 1998, In : Journal of virology. 72, 3, p. 1910-1917 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Temporal impact of substrate mechanics on differentiation of human embryonic stem cells to cardiomyocytes

Hazeltine, L. B., Badur, M. G., Lian, X., Das, A., Han, W. & Palecek, S. P., Feb 2014, In : Acta Biomaterialia. 10, 2, p. 604-612 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Temporally overlapped but uncoupled motions in dihydrofolate reductase catalysis

Liu, C. T., Wang, L., Goodey, N. M., Hanoian, P. & Benkovic, S. J., Aug 13 2013, In : Biochemistry. 52, 32, p. 5332-5334 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Temporal usage of multiple promoters during the life cycle of human papillomavirus type 31b

Ozbun, M. A. & Meyers, C., Apr 1 1998, In : Journal of virology. 72, 4, p. 2715-2722 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., Nazha, A., Chen, L., Yao, B., Liu, C., Chen, S., Weeks, O., Ni, H., Phillips, B. L., Huang, S., Wang, J. & 8 others, He, C., Li, G. M., Radivoyevitch, T., Aifantis, I., MacIejewski, J. P., Yang, F. C., Jin, P. & Xu, M., Jan 1 2017, In : Nature communications. 8, 15102.

Research output: Contribution to journalArticle

33 Scopus citations

Tetrasomy is induced by human papillomavirus type 18 e7 gene expression in keratinocyte raft cultures

Southern, S. A., Noya, F., Meyers, C., Broker, T. R., Chow, L. T. & Herrington, C. S., Jun 15 2001, In : Cancer Research. 61, 12, p. 4858-4863 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

TFIIA regulates TBP and TFIID dimers

Coleman, R. A., Taggart, A. K. P., Burma, S., Chicca, J. J. & Pugh, B. F., Sep 1999, In : Molecular cell. 4, 3, p. 451-457 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

TGFΒ1-induced inflammation in premalignant epidermal squamous lesions requires IL-17

Mohammed, J., Ryscavage, A., Perez-Lorenzo, R., Gunderson, A. J., Blazanin, N. & Glick, A. B., Sep 1 2010, In : Journal of Investigative Dermatology. 130, 9, p. 2295-2303 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

TGFβ1-induced expression of caldesmon mediates epithelial–mesenchymal transition

Nalluri, S. M., O'Connor, J. W., Virgi, G. A., Stewart, S. E., Ye, D. & Gomez, E. W., May 2018, In : Cytoskeleton. 75, 5, p. 201-212 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity

Mohammed, J., Gunderson, A. J., Khong, H. H., Koubek, R. D., Udey, M. C. & Glick, A. B., Jan 2013, In : Journal of Investigative Dermatology. 133, 1, p. 135-143 9 p.

Research output: Contribution to journalArticle

14 Scopus citations