Research Output

Filter
Article

The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs

Lee, H., Shingler, K. L., Organtini, L. J., Ashley, R. E., Makhov, A. M., Conway, J. F. & Hafenstein, S., Aug 2016, In : Science Advances. 2, 8, e1501929.

Research output: Contribution to journalArticle

30 Scopus citations

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe

Thakurta, A. G., Selvanathan, S. P., Patterson, A. D., Gopal, G. & Dhar, R., Jun 15 2007, In : Journal of Biological Chemistry. 282, 24, p. 17507-17516 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

Schneider, M., Hellerschmied, D., Schubert, T., Amlacher, S., Vinayachandran, V., Reja, R., Pugh, B. F., Clausen, T. & Köhler, A., Aug 27 2015, In : Cell. 162, 5, p. 1016-1028 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Zhu, B., Ferry, C. H., Markell, L. K., Blazanin, N., Glick, A. B., Gonzalez, F. J. & Peters, J. M., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 20102-20119 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

The Nucleotide Analog 2-Aminopurine as a Spectroscopic Probe of Nucleotide Incorporation by the Klenow Fragment of Escherichia coli Polymerase I and Bacteriophage T4 DNA Polymerase

West Frey, M., Sowers, L. C., Millar, D. P. & Benkovic, S., Jan 1 1995, In : Biochemistry. 34, 28, p. 9185-9192 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

The oligomeric T4 primase is the functional form during replication

Yang, J., Xi, J., Zhuang, Z. & Benkovic, S., Jul 8 2005, In : Journal of Biological Chemistry. 280, 27, p. 25416-25423 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes

Christensen, N. D., Kreider, J. W., Kan, N. C. & Diangelo, S. L., Apr 1991, In : Virology. 181, 2, p. 572-579 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

The Orai1 store-operated calcium channel functions as a hexamer

Cai, X., Zhou, Y., Nwokonko, R. M., Loktionova, N. A., Wang, X., Xin, P., Trebak, M., Wang, Y. & Gill, D. L., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 25764-25775 12 p.

Research output: Contribution to journalArticle

46 Scopus citations
33 Scopus citations

The origin and development of nonlymphoid tissue CD103+ DCs

Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J., Yin, N., Bromberg, J., Lira, S. A., Stanley, E. R., Nussenzweig, M. & Merad, M., Dec 21 2009, In : Journal of Experimental Medicine. 206, 13, p. 3115-3130 16 p.

Research output: Contribution to journalArticle

498 Scopus citations

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3)

Laurenzana, E. M., Chen, T., Kannuswamy, M., Sell, B. E., Strom, S. C., Li, Y. & Omiecinski, C. J., Nov 1 2012, In : Molecular pharmacology. 82, 5, p. 918-928 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Coleman, J. D., Prabhu, K. S., Thompson, J. T., Reddy, P. S., Peters, J. M., Peterson, B. R., Reddy, C. C. & Vanden Heuvel, J. P., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1155-1164 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage

Gorbalenya, A. E., Pringle, F. M., Zeddam, J. L., Luke, B. T., Cameron, C. E., Kalmakoff, J., Hanzlik, T. N., Gordon, K. H. J. & Ward, V. K., Jan 1 2002, In : Journal of Molecular Biology. 324, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

138 Scopus citations

The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia

Annageldiyev, C., Tan, S. F., Thakur, S., Dhanyamraju, P. K., Ramisetti, S. R., Bhadauria, P., Schick, J., Zeng, Z., Sharma, V., Dunton, W., Dovat, S., Desai, D., Zheng, H., Feith, D. J., Loughran, T. P., Amin, S., Sharma, A. K., Claxton, D. & Sharma, A., Apr 1 2020, In : Frontiers in Oncology. 10, 393.

Research output: Contribution to journalArticle

Open Access

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H. & Zaret, K. S., Apr 7 2016, In : Molecular cell. 62, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

114 Scopus citations

The PPARα-leukotriene B4 pathway to inflammation control

Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J. & Wahli, W., Nov 7 1996, In : Nature. 384, 6604, p. 39-43 5 p.

Research output: Contribution to journalArticle

1147 Scopus citations

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

Bruno, P. M., Lu, M., Dennis, K. A., Inam, H., Moore, C. J., Sheehe, J., Elledge, S. J., Hemann, M. T. & Pritchard, J. R., Feb 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4053-4060 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Kline, C. L. B. & Irby, R. B., Dec 1 2011, In : Apoptosis. 16, 12, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

Zhao, H., French, J. B., Fang, Y. & Benkovic, S. J., May 6 2013, In : Chemical Communications. 49, 40, p. 4444-4452 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

The Q-rich Subdomain of the Human Ah Receptor Transactivation Domain Is Required for Dioxin-mediated Transcriptional Activity

Kumar, M. B., Ramadoss, P., Reen, R. K., Vanden Heuvel, J. P. & Perdew, G. H., Nov 9 2001, In : Journal of Biological Chemistry. 276, 45, p. 42302-42310 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Therapeutic effect of vitamin d supplementation in a pilot study of crohn's patients

Yang, L., Weaver, V., Smith, J. P., Bingaman, S., Hartman, T. J. & Cantorna, M. T., Nov 18 2013, In : Clinical and Translational Gastroenterology. 4, e33.

Research output: Contribution to journalArticle

108 Scopus citations

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

Liao, A., Broeg, K., Fox, T., Tan, S. F., Watters, R., Shah, M. V., Zhang, L. Q., Li, Y., Ryland, L., Yang, J., Aliaga, C., Dewey, A., Rogers, A., Loughran, K., Hirsch, L., Jarbadan, N. R., Baab, K. T., Liao, J., Wang, H. G., Kester, M. & 4 others, Desai, D., Amin, S., Loughran, T. P. & Liu, X., Sep 8 2011, In : Blood. 118, 10, p. 2793-2800 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity

Klatt, A., Zhang, Z., Kalantari, P., Hankey, P. A., Gilmour, D. S. & Henderson, A. J., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1670-1677 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

The regulation of erythropoiesis by selenium in mice

Kaushal, N., Hegde, S., Lumadue, J., Paulson, R. F. & Prabhu, K. S., Apr 15 2011, In : Antioxidants and Redox Signaling. 14, 8, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

The regulation of foxP3-expressing regulatory T cells

Haque, R., Lei, F., Xiong, X. & Song, J., Dec 2011, In : Endocrine, Metabolic and Immune Disorders - Drug Targets. 11, 4, p. 334-346 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

The relationships between XPC binding to conformationally diverse DNA adducts and their excision by the human NER system: Is there a correlation?

Lee, Y. C., Cai, Y., Mu, H., Broyde, S., Amin, S., Chen, X., Min, J. H. & Geacintov, N. E., Jul 2014, In : DNA Repair. 19, p. 55-63 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

The remote allosteric control of Orai channel gating

Zhou, Y., Nwokonko, R. M., Baraniak, J. H., Trebak, M., Lee, K. P. K. & Gill, D. L., Aug 30 2019, In : PLoS biology. 17, 8, e3000413.

Research output: Contribution to journalArticle

Open Access

The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation

Wu, L., Zee, B. M., Wang, Y., Garcia, B. A. & Dou, Y., Jul 8 2011, In : Molecular cell. 43, 1, p. 132-144 13 p.

Research output: Contribution to journalArticle

93 Scopus citations
7 Scopus citations

Thermodynamic and structural determinants of differential pdx1 binding to elements from the insulin and IAPP promoters

Bastidas, M. & Showalter, S. A., Sep 23 2013, In : Journal of Molecular Biology. 425, 18, p. 3360-3377 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Thermodynamic perspective on the dock-lock growth mechanism of amyloid fibrils

O'Brien, E. P., Okamoto, Y., Straub, J. E., Brooks, B. R. & Thirumalai, D., Oct 29 2009, In : Journal of Physical Chemistry B. 113, 43, p. 14421-14430 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides

De Silva, A. D., Boesteanu, A., Song, R., Nagy, N., Harhaj, E., Harding, C. V. & Joyce, S., Jan 1 1999, In : Journal of Immunology. 163, 8, p. 4413-4420 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Thermospray high‐performance liquid chromatography/mass spectrometric determination of cyclosporins

Abián, J., Stone, A., Morrow, M. G., Creer, M. H., Fink, L. M. & Lay, J. O., Nov 1992, In : Rapid Communications in Mass Spectrometry. 6, 11, p. 684-689 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain

Shengjuler, D., Chan, Y. M., Sun, S., Moustafa, I. M., Li, Z. L., Gohara, D. W., Buck, M., Cremer, P. S., Boehr, D. D. & Cameron, C. E., Dec 5 2017, In : Structure. 25, 12, p. 1875-1886.e7

Research output: Contribution to journalArticle

4 Scopus citations

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

te Velthuis, A. J. W., Arnold, J. J., Cameron, C. E., van den Worm, S. H. E. & Snijder, E. J., Oct 29 2009, In : Nucleic acids research. 38, 1, p. 203-214 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

van der Linden, L., Vives-Adrián, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A. M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Pürstinger, G., Coutard, B., Canard, B., Boehr, D. D., Arnold, J. J., Cameron, C. E. & 3 others, Verdaguer, N., Neyts, J. & van Kuppeveld, F. J. M., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-23 23 p., e1004733.

Research output: Contribution to journalArticle

23 Scopus citations

The role of apoptosis in the modulation of colon carcinogenesis by dietary fat and by the organoselenium compound 1,4-phenylenebis(methylene) selenocyanate

Samaha, H. S., Hamid, R., El-Bayoumy, K., Rao, C. V. & Reddy, B. S., Oct 18 1997, In : Cancer Epidemiology Biomarkers and Prevention. 6, 9, p. 699-704 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

The role of canonical transient receptor potential 7 in B-cell receptor-activated channels

Lievremont, J. P., Numaga, T., Vazquez, G., Lemonnier, L., Hara, Y., Mori, E., Trebak, M., Moss, S. E., Bird, G. S., Mori, Y. & Putney, J. W., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35346-35351 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

The role of chaperone proteins in the aryl hydrocarbon receptor core complex

Petrulis, J. R. & Perdew, G. H., Sep 20 2002, In : Chemico-Biological Interactions. 141, 1-2, p. 25-40 16 p.

Research output: Contribution to journalArticle

205 Scopus citations

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: Studies of distal mutants of dihydrofolate reductase

Wang, L., Goodey, N. M., Benkovic, S. J. & Kohen, A., Aug 29 2006, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 361, 1472, p. 1307-1315 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

The role of evolutionary intermediates in the host adaptation of canine parvovirus

Stucker, K. M., Pagan, I., Cifuente, J. O., Kaelber, J. T., Lillie, T. D., Hafenstein, S., Holmes, E. C. & Parrish, C. R., Feb 1 2012, In : Journal of virology. 86, 3, p. 1514-1521 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

Wostenberg, C., Lary, J. W., Sahu, D., Acevedo, R., Quarles, K. A., Cole, J. L. & Showalter, S. A., Dec 13 2012, In : PloS one. 7, 12, e51829.

Research output: Contribution to journalArticle

30 Scopus citations

The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans

El-Bayoumy, K., Sharma, C., Louis, Y. M., Reddy, B. & Hecht, S. S., Jul 1983, In : Cancer Letters. 19, 3, p. 311-316 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

The role of kupffer cell oxidant production in early ethanol-induced liver disease

Wheeler, M. D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G. E., Gäbele, E., Rusyn, I., Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B. U., Smutney, O. M., Connor, H. D., Mason, R. P., Goyert, S. M., Peters, J. M., Gonzalez, F. J., Samulski, R. J. & 1 others, Thurman, R. G., Dec 15 2001, In : Free Radical Biology and Medicine. 31, 12, p. 1544-1549 6 p.

Research output: Contribution to journalArticle

201 Scopus citations

The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Patterson, A. D., Lanz, C., Gonzalez, F. J. & Idle, J. R., May 1 2010, In : Mass Spectrometry Reviews. 29, 3, p. 503-521 19 p.

Research output: Contribution to journalArticle

39 Scopus citations

The role of nitric oxide on DNA damage induced by benzene metabolites

Melikian, A. A., Chen, K. M., Li, H., Sodum, R., Fiala, E. & El-Bayoumy, K., May 1 2008, In : Oncology reports. 19, 5, p. 1331-1337 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of the human papillomavirus type 18 E7 oncoprotein during the complete viral life cycle

McLaughlin-Drubin, M. E., Bromberg-White, J. L. & Meyers, C., Jul 20 2005, In : Virology. 338, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

The role of the NKG2D immunoreceptor in immune cell activation and natural killing

Jamieson, A. M., Diefenbach, A., McMahon, C. W., Xiong, N., Carlyle, J. R. & Raulet, D. H., Jan 1 2002, In : Immunity. 17, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

466 Scopus citations

The role of UVR and Vitamin D on T cells and inflammatory bowel disease

Bora, S. & Cantorna, M. T., Jan 1 2017, In : Photochemical and Photobiological Sciences. 16, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

10 Scopus citations