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The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

Luongo, T. S., Lambert, J. P., Yuan, A., Zhang, X., Gross, P., Song, J., Shanmughapriya, S., Gao, E., Jain, M., Houser, S. R., Koch, W. J., Cheung, J. Y., Madesh, M. & Elrod, J. W., Jul 7 2015, In : Cell Reports. 12, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Open Access
134 Scopus citations

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

Luongo, T. S., Lambert, J. P., Gross, P., Nwokedi, M., Lombardi, A. A., Shanmughapriya, S., Carpenter, A. C., Kolmetzky, D., Gao, E., Van Berlo, J. H., Tsai, E. J., Molkentin, J. D., Chen, X., Madesh, M., Houser, S. R. & Elrod, J. W., May 4 2017, In : Nature. 545, 7652, p. 93-97 5 p.

Research output: Contribution to journalArticle

77 Scopus citations
20 Scopus citations

The molecular basis of the human serum paraoxonase activity polymorphism

Humbert, R., Adler, D. A., Disteche, C. M., Hassett, C., Omiecinski, C. J. & Furlong, C. E., Jan 1 1993, In : Nature Genetics. 3, 1, p. 73-76 4 p.

Research output: Contribution to journalArticle

720 Scopus citations

The mouse and human Ah receptor differ in recognition of LXXLL motifs

Flaveny, C., Reen, R. K., Kusnadi, A. & Perdew, G. H., Mar 15 2008, In : Archives of Biochemistry and Biophysics. 471, 2, p. 215-223 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

The mouse papillomavirus infection model

Hu, J., Cladel, N. M., Budgeon, L. R., Balogh, K. K. & Christensen, N. D., Sep 2017, In : Viruses. 9, 9, 246.

Research output: Contribution to journalArticle

8 Scopus citations

The multiple roles of the unfolded protein response regulator IRE1α in cancer

Chalmers, F., Mogre, S., Son, J., Blazanin, N. & Glick, A. B., Jan 1 2019, In : Molecular Carcinogenesis. 58, 9, p. 1623-1630 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The mutator form of polymerase β with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

Opresko, P. L., Sweasy, J. B. & Eckert, K., Feb 24 1998, In : Biochemistry. 37, 8, p. 2111-2119 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

The Myc 3'wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract

Konsavage, W. M., Jin, G. & Yochum, G. S., Oct 1 2012, In : Molecular and cellular biology. 32, 19, p. 3891-3902 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The Myc 3' Wnt-responsive element suppresses colonic tumorigenesis

Konsavage, W. M. & Yochum, G. S., May 2014, In : Molecular and cellular biology. 34, 9, p. 1659-1669 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The MYC 3′ Wnt-responsive element drives oncogenic MYC expression in human colorectal cancer cells

Rennoll, S. A., Eshelman, M. A., Raup-Konsavage, W. M., Kawasawa, Y. I. & Yochum, G. S., May 23 2016, In : Cancers. 8, 5, 52.

Research output: Contribution to journalArticle

9 Scopus citations

The Myc 3′ Wnt responsive element regulates neutrophil recruitment after acute colonic injury in mice

Konsavage, W. M., Roper, J. N., Ishmael, F. T. & Yochum, G. S., Oct 1 2013, In : Digestive Diseases and Sciences. 58, 10, p. 2858-2867 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women

Carter, J. J., Koutsky, L. A., Wipf, G. C., Christensen, N. D., Lee, S. K., Kuypers, J., Kiviat, N. & Galloway, D. A., Jan 1 1996, In : Journal of Infectious Diseases. 174, 5, p. 927-936 10 p.

Research output: Contribution to journalArticle

258 Scopus citations

The NLRP4-DTX4 axis: A key suppressor of TBK1 and innate antiviral signaling

Charoenthongtrakul, S., Gao, L. & Harhaj, E. W., Nov 1 2012, In : Cellular and Molecular Immunology. 9, 6, p. 431-433 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs

Lee, H., Shingler, K. L., Organtini, L. J., Ashley, R. E., Makhov, A. M., Conway, J. F. & Hafenstein, S., Aug 2016, In : Science Advances. 2, 8, e1501929.

Research output: Contribution to journalArticle

30 Scopus citations

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access

The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe

Thakurta, A. G., Selvanathan, S. P., Patterson, A. D., Gopal, G. & Dhar, R., Jun 15 2007, In : Journal of Biological Chemistry. 282, 24, p. 17507-17516 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

Schneider, M., Hellerschmied, D., Schubert, T., Amlacher, S., Vinayachandran, V., Reja, R., Pugh, B. F., Clausen, T. & Köhler, A., Aug 27 2015, In : Cell. 162, 5, p. 1016-1028 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Zhu, B., Ferry, C. H., Markell, L. K., Blazanin, N., Glick, A. B., Gonzalez, F. J. & Peters, J. M., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 20102-20119 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

The Nucleotide Analog 2-Aminopurine as a Spectroscopic Probe of Nucleotide Incorporation by the Klenow Fragment of Escherichia coli Polymerase I and Bacteriophage T4 DNA Polymerase

West Frey, M., Sowers, L. C., Millar, D. P. & Benkovic, S., Jan 1 1995, In : Biochemistry. 34, 28, p. 9185-9192 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

The oligomeric T4 primase is the functional form during replication

Yang, J., Xi, J., Zhuang, Z. & Benkovic, S., Jul 8 2005, In : Journal of Biological Chemistry. 280, 27, p. 25416-25423 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes

Christensen, N. D., Kreider, J. W., Kan, N. C. & Diangelo, S. L., Apr 1991, In : Virology. 181, 2, p. 572-579 8 p.

Research output: Contribution to journalArticle

124 Scopus citations

The Orai1 store-operated calcium channel functions as a hexamer

Cai, X., Zhou, Y., Nwokonko, R. M., Loktionova, N. A., Wang, X., Xin, P., Trebak, M., Wang, Y. & Gill, D. L., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 25764-25775 12 p.

Research output: Contribution to journalArticle

44 Scopus citations
32 Scopus citations

The origin and development of nonlymphoid tissue CD103+ DCs

Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J., Yin, N., Bromberg, J., Lira, S. A., Stanley, E. R., Nussenzweig, M. & Merad, M., Dec 21 2009, In : Journal of Experimental Medicine. 206, 13, p. 3115-3130 16 p.

Research output: Contribution to journalArticle

488 Scopus citations

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3)

Laurenzana, E. M., Chen, T., Kannuswamy, M., Sell, B. E., Strom, S. C., Li, Y. & Omiecinski, C. J., Nov 1 2012, In : Molecular pharmacology. 82, 5, p. 918-928 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Coleman, J. D., Prabhu, K. S., Thompson, J. T., Reddy, P. S., Peters, J. M., Peterson, B. R., Reddy, C. C. & Vanden Heuvel, J. P., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1155-1164 10 p.

Research output: Contribution to journalArticle

72 Scopus citations

The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage

Gorbalenya, A. E., Pringle, F. M., Zeddam, J. L., Luke, B. T., Cameron, C. E., Kalmakoff, J., Hanzlik, T. N., Gordon, K. H. J. & Ward, V. K., Jan 1 2002, In : Journal of Molecular Biology. 324, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

134 Scopus citations

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

Iwafuchi-Doi, M., Donahue, G., Kakumanu, A., Watts, J. A., Mahony, S., Pugh, B. F., Lee, D., Kaestner, K. H. & Zaret, K. S., Apr 7 2016, In : Molecular cell. 62, 1, p. 79-91 13 p.

Research output: Contribution to journalArticle

108 Scopus citations

The PPARα-leukotriene B4 pathway to inflammation control

Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J. & Wahli, W., Nov 7 1996, In : Nature. 384, 6604, p. 39-43 5 p.

Research output: Contribution to journalArticle

1139 Scopus citations

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

Bruno, P. M., Lu, M., Dennis, K. A., Inam, H., Moore, C. J., Sheehe, J., Elledge, S. J., Hemann, M. T. & Pritchard, J. R., Feb 25 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 8, p. 4053-4060 8 p.

Research output: Contribution to journalArticle

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU

Kline, C. L. B. & Irby, R. B., Dec 1 2011, In : Apoptosis. 16, 12, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

Zhao, H., French, J. B., Fang, Y. & Benkovic, S. J., May 6 2013, In : Chemical Communications. 49, 40, p. 4444-4452 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

The Q-rich Subdomain of the Human Ah Receptor Transactivation Domain Is Required for Dioxin-mediated Transcriptional Activity

Kumar, M. B., Ramadoss, P., Reen, R. K., Vanden Heuvel, J. P. & Perdew, G. H., Nov 9 2001, In : Journal of Biological Chemistry. 276, 45, p. 42302-42310 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Therapeutic effect of vitamin d supplementation in a pilot study of crohn's patients

Yang, L., Weaver, V., Smith, J. P., Bingaman, S., Hartman, T. J. & Cantorna, M. T., Nov 18 2013, In : Clinical and Translational Gastroenterology. 4, e33.

Research output: Contribution to journalArticle

107 Scopus citations

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

Liao, A., Broeg, K., Fox, T., Tan, S. F., Watters, R., Shah, M. V., Zhang, L. Q., Li, Y., Ryland, L., Yang, J., Aliaga, C., Dewey, A., Rogers, A., Loughran, K., Hirsch, L., Jarbadan, N. R., Baab, K. T., Liao, J., Wang, H. G., Kester, M. & 4 others, Desai, D., Amin, S., Loughran, T. P. & Liu, X., Sep 8 2011, In : Blood. 118, 10, p. 2793-2800 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity

Klatt, A., Zhang, Z., Kalantari, P., Hankey, P. A., Gilmour, D. S. & Henderson, A. J., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1670-1677 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

The regulation of erythropoiesis by selenium in mice

Kaushal, N., Hegde, S., Lumadue, J. A., Paulson, R. & Prabhu, K. S., Apr 15 2011, In : Antioxidants and Redox Signaling. 14, 8, p. 1403-1412 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

The regulation of foxP3-expressing regulatory T cells

Haque, R., Lei, F., Xiong, X. & Song, J., Dec 2011, In : Endocrine, Metabolic and Immune Disorders - Drug Targets. 11, 4, p. 334-346 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

The relationships between XPC binding to conformationally diverse DNA adducts and their excision by the human NER system: Is there a correlation?

Lee, Y. C., Cai, Y., Mu, H., Broyde, S., Amin, S., Chen, X., Min, J. H. & Geacintov, N. E., Jul 2014, In : DNA Repair. 19, p. 55-63 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

The remote allosteric control of Orai channel gating

Zhou, Y., Nwokonko, R. M., Baraniak, J. H., Trebak, M., Lee, K. P. K. & Gill, D. L., Aug 30 2019, In : PLoS biology. 17, 8, e3000413.

Research output: Contribution to journalArticle

Open Access

The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation

Wu, L., Zee, B. M., Wang, Y., Garcia, B. A. & Dou, Y., Jul 8 2011, In : Molecular cell. 43, 1, p. 132-144 13 p.

Research output: Contribution to journalArticle

92 Scopus citations
7 Scopus citations

Thermodynamic and structural determinants of differential pdx1 binding to elements from the insulin and IAPP promoters

Bastidas, M. & Showalter, S. A., Sep 23 2013, In : Journal of Molecular Biology. 425, 18, p. 3360-3377 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

Thermodynamic perspective on the dock-lock growth mechanism of amyloid fibrils

O'Brien, E. P., Okamoto, Y., Straub, J. E., Brooks, B. R. & Thirumalai, D., Oct 29 2009, In : Journal of Physical Chemistry B. 113, 43, p. 14421-14430 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides

De Silva, A. D., Boesteanu, A., Song, R., Nagy, N., Harhaj, E., Harding, C. V. & Joyce, S., Jan 1 1999, In : Journal of Immunology. 163, 8, p. 4413-4420 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Thermospray high‐performance liquid chromatography/mass spectrometric determination of cyclosporins

Abián, J., Stone, A., Morrow, M. G., Creer, M. H., Fink, L. M. & Lay, J. O., Nov 1992, In : Rapid Communications in Mass Spectrometry. 6, 11, p. 684-689 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain

Shengjuler, D., Chan, Y. M., Sun, S., Moustafa, I. M., Li, Z. L., Gohara, D. W., Buck, M., Cremer, P. S., Boehr, D. D. & Cameron, C. E., Dec 5 2017, In : Structure. 25, 12, p. 1875-1886.e7

Research output: Contribution to journalArticle

4 Scopus citations

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

te Velthuis, A. J. W., Arnold, J. J., Cameron, C. E., van den Worm, S. H. E. & Snijder, E. J., Oct 29 2009, In : Nucleic acids research. 38, 1, p. 203-214 12 p.

Research output: Contribution to journalArticle

52 Scopus citations