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The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

van der Linden, L., Vives-Adrián, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A. M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Pürstinger, G., Coutard, B., Canard, B., Boehr, D. D., Arnold, J. J., Cameron, C. E. & 3 others, Verdaguer, N., Neyts, J. & van Kuppeveld, F. J. M., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-23 23 p., e1004733.

Research output: Contribution to journalArticle

18 Scopus citations

The role of apoptosis in the modulation of colon carcinogenesis by dietary fat and by the organoselenium compound 1,4-phenylenebis(methylene) selenocyanate

Samaha, H. S., Hamid, R., El-Bayoumy, K., Rao, C. V. & Reddy, B. S., Oct 18 1997, In : Cancer Epidemiology Biomarkers and Prevention. 6, 9, p. 699-704 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

The role of canonical transient receptor potential 7 in B-cell receptor-activated channels

Lievremont, J. P., Numaga, T., Vazquez, G., Lemonnier, L., Hara, Y., Mori, E., Trebak, M., Moss, S. E., Bird, G. S., Mori, Y. & Putney, J. W., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35346-35351 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

The role of chaperone proteins in the aryl hydrocarbon receptor core complex

Petrulis, J. R. & Perdew, G. H., Sep 20 2002, In : Chemico-Biological Interactions. 141, 1-2, p. 25-40 16 p.

Research output: Contribution to journalArticle

203 Scopus citations

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: Studies of distal mutants of dihydrofolate reductase

Wang, L., Goodey, N. M., Benkovic, S. J. & Kohen, A., Aug 29 2006, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 361, 1472, p. 1307-1315 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

The role of evolutionary intermediates in the host adaptation of canine parvovirus

Stucker, K. M., Pagan, I., Cifuente, J. O., Kaelber, J. T., Lillie, T. D., Hafenstein, S., Holmes, E. C. & Parrish, C. R., Feb 1 2012, In : Journal of virology. 86, 3, p. 1514-1521 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

The Role of Human Dicer-dsRBD in Processing Small Regulatory RNAs

Wostenberg, C., Lary, J. W., Sahu, D., Acevedo, R., Quarles, K. A., Cole, J. L. & Showalter, S. A., Dec 13 2012, In : PloS one. 7, 12, e51829.

Research output: Contribution to journalArticle

30 Scopus citations

The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans

El-Bayoumy, K., Sharma, C., Louis, Y. M., Reddy, B. & Hecht, S. S., Jul 1983, In : Cancer Letters. 19, 3, p. 311-316 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

The role of kupffer cell oxidant production in early ethanol-induced liver disease

Wheeler, M. D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G. E., Gäbele, E., Rusyn, I., Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B. U., Smutney, O. M., Connor, H. D., Mason, R. P., Goyert, S. M., Peters, J. M., Gonzalez, F. J., Samulski, R. J. & 1 others, Thurman, R. G., Dec 15 2001, In : Free Radical Biology and Medicine. 31, 12, p. 1544-1549 6 p.

Research output: Contribution to journalArticle

201 Scopus citations

The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Patterson, A. D., Lanz, C., Gonzalez, F. J. & Idle, J. R., May 1 2010, In : Mass Spectrometry Reviews. 29, 3, p. 503-521 19 p.

Research output: Contribution to journalArticle

38 Scopus citations

The role of nitric oxide on DNA damage induced by benzene metabolites

Melikian, A. A., Chen, K. M., Li, H., Sodum, R., Fiala, E. & El-Bayoumy, K., May 1 2008, In : Oncology reports. 19, 5, p. 1331-1337 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of the human papillomavirus type 18 E7 oncoprotein during the complete viral life cycle

McLaughlin-Drubin, M. E., Bromberg-White, J. L. & Meyers, C., Jul 20 2005, In : Virology. 338, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

The role of the NKG2D immunoreceptor in immune cell activation and natural killing

Jamieson, A. M., Diefenbach, A., McMahon, C. W., Xiong, N., Carlyle, J. R. & Raulet, D. H., Jan 1 2002, In : Immunity. 17, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

459 Scopus citations

The role of UVR and Vitamin D on T cells and inflammatory bowel disease

Bora, S. & Cantorna, M. T., Jan 1 2017, In : Photochemical and Photobiological Sciences. 16, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

The role of vitamin D and vitamin D receptor in immunity to Leishmania major infection

Whitcomb, J. P., Deagostino, M., Ballentine, M., Fu, J., Tenniswood, M., Welsh, J., Cantorna, M. & McDowell, M. A., Jan 5 2012, In : Journal of Parasitology Research. 2012, 134645.

Research output: Contribution to journalArticle

20 Scopus citations

The roles of social domains, behavioral risk, health care resources, and chlamydia in spatial clusters of US cervical cancer mortality: Not all the clusters are the same

Du, P., Lemkin, A., Kluhsman, B., Chen, J., Roth, R. E., Maceachren, A., Meyers, C., Zurlo, J. & Lengerich, E., Oct 1 2010, In : Cancer Causes and Control. 21, 10, p. 1669-1683 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

The RON receptor tyrosine kinase: A key regulator of inflammation and cancer progression

Wang, X. & Giblin, P. H., Oct 15 2013, In : Critical Reviews in Immunology. 33, 6, p. 549-574 26 p.

Research output: Contribution to journalArticle

11 Scopus citations

The RON receptor tyrosine kinase regulates IFN-γ production and responses in innate immunity

Wilson, C. B., Ray, M., Lutz, M., Sharda, D., Xu, J. & Hankey, P. A., Aug 15 2008, In : Journal of Immunology. 181, 4, p. 2303-2310 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Yu, S., Allen, J. N., Dey, A., Zhang, L., Balandaram, G., Kennett, M. J., Xia, M., Xiong, N., Peters, J. M., Patterson, A. D. & Giblin, P. H., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 256-265 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The safety of two Bacillus probiotic strains for human use

Sorokulova, I. B., Pinchuk, I. V., Denayrolles, M., Osipova, I. G., Huang, J. M., Cutting, S. M. & Urdaci, M. C., Apr 1 2008, In : Digestive Diseases and Sciences. 53, 4, p. 954-963 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally

García-Molinero, V., García-Martínez, J., Reja, R., Furió-Tarí, P., Antúnez, O., Vinayachandran, V., Conesa, A., Pugh, B. F., Pérez-Ortín, J. E. & Rodríguez-Navarro, S., Mar 29 2018, In : Epigenetics and Chromatin. 11, 1, 13.

Research output: Contribution to journalArticle

4 Scopus citations
20 Scopus citations

The Sequence Dependence of Human Nucleotide Excision Repair Efficiencies of Benzo[a]pyrene-derived DNA Lesions: Insights into the Structural Factors that Favor Dual Incisions

Kropachev, K., Kolbanovskii, M., Cai, Y., Rodríguez, F., Kolbanovskii, A., Liu, Y., Zhang, L., Amin, S., Patel, D., Broyde, S. & Geacintov, N. E., Mar 13 2009, In : Journal of Molecular Biology. 386, 5, p. 1193-1203 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
16 Scopus citations

The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells

Kemp, K. L., Lin, Z., Zhao, F., Gao, B., Song, J., Zhang, K. & Fang, D., Nov 15 2013, In : Journal of Biological Chemistry. 288, 46, p. 33272-33282 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

The small RING finger protein Z drives arenavirus budding: Implications for antiviral strategies

Perez, M., Craven, R. C. & De la Torre, J. C., Oct 28 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 22, p. 12978-12983 6 p.

Research output: Contribution to journalArticle

243 Scopus citations

The S-Oxalin, N-acetyl-S-oxalylcysteamine, inhibits lymphocyte proliferation, IL-2 production and utilization

Grove, D. S., Crowl, C. V., Hamilton, G. A. & Mastro, A. M., May 15 1996, In : Biochemical and Biophysical Research Communications. 222, 2, p. 505-511 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

The state of antibody catalysis

Smithrud, D. B. & Benkovic, S., Jan 1 1997, In : Current Opinion in Biotechnology. 8, 4, p. 459-466 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

The STIM1-binding site nexus remotely controls Orai1 channel gating

Zhou, Y., Cai, X., Loktionova, N. A., Wang, X., Nwokonko, R. M., Wang, X., Wang, Y., Rothberg, B. S., Trebak, M. & Gill, D. L., Dec 8 2016, In : Nature communications. 7, 13725.

Research output: Contribution to journalArticle

34 Scopus citations

The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization

Mo, P. & Yang, S., Jan 1 2018, In : Frontiers in Bioscience - Landmark. 23, 7, p. 1241-1256 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer

Zhuang, Z., Yoder, B. L., Burgers, P. M. J. & Benkovic, S. J., Feb 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 8, p. 2546-2551 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
39 Scopus citations

The Suprabasal Expression of α6ß4 Integrin Is Associated with a High Risk for Malignant Progression in Mouse Skin Carcinogenesis

Tennenbaum, T., Weiner, A. K., Belanger, A. J., Glick, A. B., Hennings, H. & Yuspa, S. H., Oct 1993, In : Cancer Research. 53, 20, p. 4803-4810 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

Nishimura, Y., McLaughlin, N. P., Pan, J., Goldstein, S., Hafenstein, S., Shimizu, H., Winkler, J. D. & Bergelson, J. M., Jan 1 2015, In : PLoS pathogens. 11, 10, e1005184.

Research output: Contribution to journalArticle

17 Scopus citations

The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities

Nelson, S. W. & Benkovic, S. J., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 407-416 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

The T antigen locus of merkel cell polyomavirus downregulates human toll-like receptor 9 expression

Shahzad, N., Shuda, M., Gheit, T., Kwun, H. J., Cornet, I., Saidj, D., Zannetti, C., Hasan, U., Chang, Y., Moore, P. S., Accardi, R. & Tommasino, M., Dec 1 2013, In : Journal of virology. 87, 23, p. 13009-13019 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells

Mahon, B. D., Wittke, A., Weaver, V. & Cantorna, M. T., Aug 1 2003, In : Journal of cellular biochemistry. 89, 5, p. 922-932 11 p.

Research output: Contribution to journalArticle

315 Scopus citations

The TATA-binding protein and associated factors are components of pol III transcription factor TFIIIB

Taggart, A. K. P., Fisher, T. S. & Pugh, B. F., Dec 11 1992, In : Cell. 71, 6, p. 1015-1028 14 p.

Research output: Contribution to journalArticle

104 Scopus citations

The TCR γδ Repertoire and relative gene expression characteristics of T-ALL cases with biclonal malignant vδ1 and Vδ2 T cells

Zheng, H., Wang, X., Ma, Y., Xu, B., Chen, S., Yang, L., Wu, X., Przybylski, G. K., Huang, S., Ye, T. & Li, Y., Jan 1 2014, In : DNA and Cell Biology. 33, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes

Hogan, K. A., Ravindran, A., Podolsky, M. A. & Glick, A. B., Dec 1 2013, In : Cytokine. 64, 3, p. 652-659 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols

Trushin, N., Leder, G., El-Bayoumy, K., Hoffmann, D., Beger, H. G., Henne-Bruns, D., Ramadani, M. & Prokopczyk, B., Jul 1 2008, In : Langenbeck's Archives of Surgery. 393, 4, p. 571-579 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
41 Scopus citations

The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-β-mediated growth regulation

Ponnamperuma, R. M., King, K. E., Elsir, T., Glick, A. B., Wahl, G. M., Nister, M. & Weinberg, W. C., Oct 1 2009, In : Journal of Pathology. 219, 2, p. 263-274 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

The truncated form of the Epstein-Barr virus LMP-1 is dispensable or complimentable by the full-length form in virus infection and replication

Torii, T., Konishi, K., Sample, J. & Takada, K., Nov 25 1998, In : Virology. 251, 2, p. 273-278 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
57 Scopus citations

The type 1 diabetes resistance locus B10 Idd9.3 mediates impaired B-cell lymphopoiesis and implicates microRNA-34a in diabetes protection

Berry, G. J., Budgeon, L. R., Cooper, T., Christensen, N. & Waldner, H., Jan 1 2014, In : European Journal of Immunology. 44, 6, p. 1716-1727 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

The U4 antibody epitope on human papillomavirus 16 identified by cryo-electron microscopy

Guan, J., Bywaters, S. M., Brendle, S. A., Lee, H., Ashley, R. E., Christensen, N. D. & Hafenstein, S., Jan 1 2015, In : Journal of virology. 89, 23, p. 12108-12117 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

Shembade, N., Parvatiyar, K., Harhaj, N. S. & Harhaj, E. W., Mar 4 2009, In : EMBO Journal. 28, 5, p. 513-522 10 p.

Research output: Contribution to journalArticle

144 Scopus citations

The United States-Japan Workshop on: The role of nuclear receptors in carcinogenesis

Peters, J. M., Kato, S. & Gonzalez, F. J., Oct 1 2004, In : Molecular Carcinogenesis. 41, 2, p. 77-84 8 p.

Research output: Contribution to journalArticle

The upstream direct repeat sequence of prague a rous sarcoma virus is deficient in mediating efficient gag assembly and particle release

Simpson, S. B., Guo, W., Winistorfer, S. C., Craven, R. C. & Stoltzfus, C. M., Jul 20 1998, In : Virology. 247, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

17 Scopus citations