Cancer Institute, Mechanisms of Carcinogenesis &ndash; Research Output

1977

13 Citations (Scopus)

A convenient synthesis of α-substituted β-lactams

Manhas, M. S., Chawla, H. P. S., Amin, S. & Bose, A. K., Jun 1 1977, In : Synthesis (Germany). 1977, 6, p. 407-409 3 p.

Research output: Contribution to journal › Article

Lactams

39 Citations (Scopus)

A new chemical synthesis of 2-amino-(N-d-ribofuranosyl)acetamide 5′-phosphate

Chettur, G. & Benkovic, S., Jan 1 1977, In : Carbohydrate Research. 56, 1, p. 75-86 12 p.

Research output: Contribution to journal › Article

Phosphoribosylglycinamide Formyltransferase

Phosphates

Phosphorylation

Anhydrides

Glycine

3 Citations (Scopus)

Cyclic AMP-binding proteins in normal and virus-transformed fibroblasts

Wigglesworth, N. M., Mastro, A. M., Bourne, H. R. & Rozengurt, E., Apr 30 1977, In : Archives of Biochemistry and Biophysics. 180, 2, p. 258-263 6 p.

Research output: Contribution to journal › Article

Fibroblasts

Viruses

Cyclic AMP Receptors

Cyclic AMP

Carrier Proteins

14 Citations (Scopus)

Heterocyclic compounds; IX. A facile synthesis of methaqualone and analogs

Manhas, M. S., Amin, S. & Rao, V. V., May 1 1977, In : Synthesis (Germany). 1977, 5, p. 309-310 2 p.

Research output: Contribution to journal › Article

Methaqualone

Heterocyclic Compounds

6 Citations (Scopus)

Novel Phosphonothioate Substrates for Phosphodiesterases

Dudman, N. P. & Benkovic, S., Jan 1 1977, In : Journal of the American Chemical Society. 99, 18, p. 6113-6115 3 p.

Research output: Contribution to journal › Article

Organothiophosphorus Compounds

Phosphoric Diester Hydrolases

Substrates

2 Citations (Scopus)

Phorbol esters and the mixed lymphocyte response

Mastro, A. M., Krupa, T. & Mueller, G. C., Jan 1 1977, In : Journal of Cell Biology. 75, 2 II

Research output: Contribution to journal › Article

Phorbol Esters

Lymphocytes

40 Citations (Scopus)

Studies on models for tetrahydrofolic acid. 8. Hydrolysis and methoxyaminolysis of amidines

Burdick, B. A., Benkovic, P. A. & Benkovic, S., Jan 1 1977, In : Journal of the American Chemical Society. 99, 17, p. 5716-5725 10 p.

Research output: Contribution to journal › Article

Amidines

Isomers

Hydrolysis

Thermodynamics

Kinetics

1976

12 Citations (Scopus)

Annelation of imines to β-lactams at low temperatures

Manhas, M. S., Amin, S., Ram, B. & Bose, A. K., Oct 1 1976, In : Synthesis (Germany). 1976, 10, p. 689-690 2 p.

Research output: Contribution to journal › Article

Imines

beta-Lactams

Temperature

Lactams

12 Citations (Scopus)

Heterocyclic compounds. VII. Synthesis of thiadiazasteroid analogs

Manhas, M. S., Rao, V. V. & Amin, S., Jan 1 1976, In : Journal of Heterocyclic Chemistry. 13, 4, p. 821-824 4 p.

Research output: Contribution to journal › Article

Heterocyclic Compounds

Lactams

Steroids

Derivatives

Cyclization

7 Citations (Scopus)

Phosphoproteins of the cell surface as generated by endogenous or exogenous proteins kinase: Stability of the ³²P-labelled product

Kinzel, V., Kübler, D., Mastro, A. M. & Rozengurt, E., May 20 1976, In : BBA - Protein Structure. 434, 1, p. 281-285 5 p.

Research output: Contribution to journal › Article

Protein Stability

Phosphoproteins

Threonine

Cell membranes

Protein Kinases

14 Citations (Scopus)

Studies on lactams. Part 45. Some carbocyclic analogues of cephalosporin

Bose, A. K., Amin, S., Kapur, J. C. & Manhas, M. S., Dec 1 1976, In : Journal of the Chemical Society, Perkin Transactions 1. 20, p. 2193-2197 5 p.

Research output: Contribution to journal › Article

Lactams

Cephalosporins

Chlorides

Imines

Penicillin G

24 Citations (Scopus)

α-Substituted β-Lactams Via A Convenient Annelation Of Imines

Manhas, M. S., Lai, B., Amin, S. & Bose, A. K., Jan 1 1976, In : Synthetic Communications. 6, 6, p. 435-441 7 p.

Research output: Contribution to journal › Article

Imines

beta-Lactams

1975

47 Citations (Scopus)

[60] Fructose-1,6-diphosphatase from Rabbit Liver

Ulm, E. H., Pogell, B. M., deMaine, M. M., Libby, C. B. & Benkovic, S., Jan 1 1975, In : Methods in Enzymology. 42, C, p. 369-374 6 p.

Research output: Contribution to journal › Article

Fructose-Bisphosphatase

Spectrophotometry

Adenosine Monophosphate

Edetic Acid

Chromatography

35 Citations (Scopus)

Catalysis of Phosphoryl Group Transfer. The Role of Divalent Metal Ions in the Hydrolysis of Lactic Acid O-Phenyl Phosphate and Salicylic Acid O-Aryl Phosphates

Steffens, J. J., Siewers, I. J. & Benkovic, S., Jun 1 1975, In : Biochemistry. 14, 11, p. 2431-2440 10 p.

Research output: Contribution to journal › Article

Salicylic Acid

Catalysis

Metal ions

Hydrolysis

Lactic Acid

Frontiers in chemistry day: Oxygen bicentennial symposium

Benkovic, S., 1975, In : Journal of Chemical Education. 52, 2, p. 15-20 6 p.

Research output: Contribution to journal › Article

chemistry

Oxygen

21 Citations (Scopus)

The anomeric form of D fructose 1,6 biphosphate used as substrate in the muscle and yeast aldolase reactions

Schray, K. J., Fishbein, R., Bullard, W. P. & Benkovic, S., 1975, In : Journal of Biological Chemistry. 250, 13, p. 4883-4887 5 p.

Research output: Contribution to journal › Article

Fructose-Bisphosphate Aldolase

Fructose

Yeast

Muscle

Yeasts

8 Citations (Scopus)

The Anomeric Specificity of Yeast Pyruvate Kinase toward Activation by D-Fructose l,6-Bisphosphatete

Fishbein, R., Benkovic, P. A. & Benkovic, S., Sep 1 1975, In : Biochemistry. 14, 18, p. 4060-4063 4 p.

Research output: Contribution to journal › Article

Pyruvate Kinase

Fructose

Yeast

Yeasts

Chemical activation

1974

7 Citations (Scopus)

A stereospecific synthesis of β-alkoxy-β-lactams (1)

Bose, A. K., Kapur, J. C., Amin, S. & Manhas, M. S., Jan 1 1974, In : Tetrahedron Letters. 15, 22, p. 1917-1920 4 p.

Research output: Contribution to journal › Article

beta-Lactams

alkoxyl radical

10 Citations (Scopus)

Iodination of plasma membrane proteins of BHK cells in different growth states

Mastro, A. M., Beer, C. T. & Mueller, G. C., May 30 1974, In : BBA - Biomembranes. 352, 1, p. 38-51 14 p.

Research output: Contribution to journal › Article

Halogenation

Cell membranes

Blood Proteins

Membrane Proteins

Cell Membrane

17 Citations (Scopus)

Studies on Models for Tetrahydrofolic Acid. V.A Kinetically Significant Transport Process in General Base Catalyzed Aminolysis of a Formamidine

Bullard, W. P., Farina, L. J., Farina, P. R. & Benkovic, S., Nov 1 1974, In : Journal of the American Chemical Society. 96, 23, p. 7295-7302 8 p.

Research output: Contribution to journal › Article

Amidines

Proton transfer

Acids

Catalysis

Amines

132 Citations (Scopus)

Synergistic action of phorbol esters in mitogen-activated bovine lymphocytes

Mastro, A. M. & Mueller, G. C., Jan 1 1974, In : Experimental Cell Research. 88, 1, p. 40-46 7 p.

Research output: Contribution to journal › Article

Phorbol Esters

Mitogens

Lymphocytes

Phytohemagglutinins

Concanavalin A

1973

25 Citations (Scopus)

Effect of divalent metal ions on the intramolecular nucleophilic catalysis of phosphate diester hydrolysis

Steffens, J. J., Sampson, E. J., Siewers, I. J. & Benkovic, S., Feb 1 1973, In : Journal of the American Chemical Society. 95, 3, p. 936-938 3 p.

Research output: Contribution to journal › Article

Catalysis

Metal ions

Hydrolysis

Phosphates

Metals

112 Citations (Scopus)

Enrichment of cell types from the rat adenohypophysis by sedimentation at unit gravity

Hymer, W. C., Evans, W. H., Kraicer, J., Mastro, A., Davis, J. & Griswold, E., Jan 1 1973, In : Endocrinology. 92, 1, p. 275-287 13 p.

Research output: Contribution to journal › Article

Anterior Pituitary Gland

Gravitation

Cell Separation

Thyrotrophs

Lactotrophs

12 Citations (Scopus)

Internal Return of Caged Geminate Radicals from 9-azophenyl-2-bromo-9-methylfluorene. Viscosity-Dependent Rotation of Caged Radicals

Steffens, J. J., Sampson, E. J., Siewers, I. J. & Benkovic, S., Feb 1 1973, In : Journal of the American Chemical Society. 95, 3, p. 938-939 2 p.

Research output: Contribution to journal › Article

Viscosity

9-methylfluorene

20 Citations (Scopus)

Intramolecular and Divalent Metal Ion Catalysis. The Hydrolytic Mechanism of O-Phenyl N-(Glycyl)phosphoramidate

Sampson, E. J., Fedor, J., Benkovic, P. A. & Benkovic, S., Apr 1 1973, In : Journal of Organic Chemistry. 38, 7, p. 1301-1306 6 p.

Research output: Contribution to journal › Article

Catalysis

Metal ions

Hydrolysis

Phosphates

Hydroxylamine

41 Citations (Scopus)

Studies On Models For The Tetrahydrofolic Acid. IV. Reactions Of Amines With Formamidinium Tetrahydroquinoxaline Analogs

Benkovic, S., Barrows, T. H. & Farina, P. R., Dec 1 1973, In : Journal of the American Chemical Society. 95, 25, p. 8414-8420 7 p.

Research output: Contribution to journal › Article

Amines

Acids

Kinetics

Protonation

Thermodynamics

15 Citations (Scopus)

The effects of age and oestrone treatment on DNA polymerase activity in anterior pituitary glands of male rats

Mastro, A. & Hymer, W. C., Jan 1 1973, In : Journal of Endocrinology. 59, 1, p. 107-119 13 p.

Research output: Contribution to journal › Article

Anterior Pituitary Gland

Estrone

DNA-Directed DNA Polymerase

DNA

Deoxyribonucleosides

1972

1 Citation (Scopus)

An Active-Site Titrant for Arylsulfate Sulfohydrolase

Benkovic, S. & Fedor, J. M., Dec 1 1972, In : Journal of the American Chemical Society. 94, 25, p. 8928-8929 2 p.

Research output: Contribution to journal › Article

Arylsulfatases

Sulfatases

Nitrophenols

Oxalates

Phenols

16 Citations (Scopus)

Chapter 1 Hydrolytic Reactions of Inorganic Esters

Benkovic, S., Dec 1 1972, In : Comprehensive Chemical Kinetics. 10, C, p. 1-56 56 p.

Research output: Contribution to journal › Article

esters

Esters

42 Citations (Scopus)

Heterocyclic Compounds. 4.f Synthesis and Antiinflammatory Activity of Some Substituted Thienopyrimidones

Manhas, M. S., Sharma, S. D. & Amin, S., Jan 1 1972, In : Journal of Medicinal Chemistry. 15, 1, p. 106-107 2 p.

Research output: Contribution to journal › Article

Pyrimidinones

Heterocyclic Compounds

Thiophenes

Lethal Dose 50

Oral Administration

28 Citations (Scopus)

Magnetic resonance studies of the anomeric distribution and manganese binding properties of fructose phosphates

Benkovic, S., Engle, J. L. & Mildvan, A. S., May 26 1972, In : Biochemical and Biophysical Research Communications. 47, 4, p. 852-858 7 p.

Research output: Contribution to journal › Article

Magnetic resonance

Manganese

Fructose

Magnetic Resonance Spectroscopy

Phosphates

36 Citations (Scopus)

Studies on Models for Tetrahydrofolic Acid. III. Hydrolytic Interconversions of the Tetrahydroquinoxaline Analogs at the Formate Level of Oxidation

Benkovic, S., Bullard, W. P. & Benkovic, P. A., Oct 1 1972, In : Journal of the American Chemical Society. 94, 21, p. 7542-7549 8 p.

Research output: Contribution to journal › Article

formic acid

Buffers

Oxidation

Kinetics

Acids

1971

Thiophene Analogues of Peedianwridcne

Bost, A. K., Han ha, M. S., Sharme, S. O., Amin, S. G. & Chawla, H. P. S., Jan 1 1971, In : Synthetic Communications. 1, 1, p. 33-36 4 p.

Research output: Contribution to journal › Article

Thiophenes

1970

27 Citations (Scopus)

DNA synthesis in the anterior pituitary of the male rat: Effect of castration and photoperiod

Hymer, W. C., Mastro, A. M. & Griswold, E., Jan 1 1970, In : Science. 167, 3925, p. 1629-1631 3 p.

Research output: Contribution to journal › Article

Castration

Photoperiod

Anterior Pituitary Gland

Basophils

DNA

33 Citations (Scopus)

Organic and Biological Chemistry: Studies on Models for Tetrahydrofolic Acid. II. Additional Observations on the Mechanism for Condensation of Formaldehyde with Tetrahydroquinoxaline Analogs

Benkovic, S., Benkovic, P. A. & Chrzanowski, R., Feb 1 1970, In : Journal of the American Chemical Society. 92, 3, p. 523-528 6 p.

Research output: Contribution to journal › Article

Imidazolidines

Organic Chemistry

Catalysis

Dehydration

Formaldehyde

25 Citations (Scopus)

Studies in Sulfate Esters. V. The Mechanism of Hydrolysis of Phenyl Phosphosulfate, a Model System for 3′-Phosphoadenosine 5′-Phosphosulfate

Benkovic, S. & Hevey, R. C., Aug 1 1970, In : Journal of the American Chemical Society. 92, 16, p. 4971-4977 7 p.

Research output: Contribution to journal › Article

Phosphoadenosine Phosphosulfate

Sulfates

Hydrolysis

Esters

Adenosine Phosphosulfate

1969

18 Citations (Scopus)

DNA synthesis in adult rat anterior pituitary glands in organ culture

Mastro, A. M., Hymer, W. C. & Therrien, C. D., Jan 1 1969, In : Experimental Cell Research. 54, 3, p. 407-414 8 p.

Research output: Contribution to journal › Article

Anterior Pituitary Gland

Organ Culture Techniques

Thymidine

DNA

Basophils

22 Citations (Scopus)

DNA synthesis in the rat anterior pituitary: an electron microscope radioautographic study.

Mastro, A., Shelton, E. & Hymer, W. C., Dec 1969, In : The Journal of cell biology. 43, 3, p. 626-629 4 p.

Research output: Contribution to journal › Article

Cytoplasmic Granules

Tritium

Pituitary Gland

Autoradiography

Electron Microscopy

22 Citations (Scopus)

Kinetic Detection of the Imminium Cation in Formaldehyde-Amine Condensations in Neutral Aqueous Solution

Benkovic, S., Benkovic, P. A. & Comfort, D. R., Jan 1 1969, In : Journal of the American Chemical Society. 91, 7, p. 1860-1861 2 p.

Research output: Contribution to journal › Article

Formaldehyde

Amines

Cations

Condensation

Positive ions

47 Citations (Scopus)

Studies on Models for Tetrahydrofolic Acid. I. The Condensation of Formaldehyde with Tetrahydroquinoxaline Analogs

Benkovic, S., Benkovic, P. A. & Comfort, D. R., Sep 1 1969, In : Journal of the American Chemical Society. 91, 19, p. 5270-5279 10 p.

Research output: Contribution to journal › Article

Formaldehyde

Condensation

Carbon

Imidazolidines

Acids

1968

18 Citations (Scopus)

Metal Ion Catalysis of Phosphoryl Transfer from Phosphoenolpyruvate

Benkovic, S. & Schray, K. J., Nov 1 1968, In : Biochemistry. 7, 11, p. 4097-4102 6 p.

Research output: Contribution to journal › Article

Phosphoenolpyruvate

Catalysis

Mercury

Metal ions

Metals

15 Citations (Scopus)

Studies on Sulfate Esters. III. A Comparison of the Solvolyses of Salicyl Sulfate and Sulfur Trioxide

Benkovic, S. & Benkovic, P. A., Jan 1 1968, In : Journal of the American Chemical Society. 90, 10, p. 2646-2650 5 p.

Research output: Contribution to journal › Article

Isomers

Sulfates

Esters

Sulfur

Methanol

35 Citations (Scopus)

The Kinetics and Mechanisms of Phosphoenolpyruvate Hydrolysis

Benkovic, S. & Schray, K. J., Nov 1 1968, In : Biochemistry. 7, 11, p. 4090-4096 7 p.

Research output: Contribution to journal › Article

Phosphoenolpyruvate

Hydrolysis

Kinetics

Phosphates

Ketones

1967

21 Citations (Scopus)

Hydrolytic Mechanisms of Phosphoramidates of Aromatic Amino Acids

Benkovic, S. & Benkovic, P. A., Aug 1 1967, In : Journal of the American Chemical Society. 89, 18, p. 4714-4722 9 p.

Research output: Contribution to journal › Article

Aromatic Amino Acids

Carboxylic acids

Amino acids

Alcohols

Hydrolysis

1966

100 Citations (Scopus)

Studies on Sulfate Esters. I. Nucleophilic Reactions of Amines with p-Nitrophenyl Sulfate

Benkovic, S. & Benkovic, P. A., Jan 1 1966, In : Journal of the American Chemical Society. 88, 23, p. 5504-5511 8 p.

Research output: Contribution to journal › Article

Sulfates

Amines

Esters

Hydrolysis

Phosphates

24 Citations (Scopus)

Studies on Sulfate Esters. II. Carboxyl Group Catalysis in the Hydrolysis of Salicyl Sulfate

Benkovic, S., Jan 1 1966, In : Journal of the American Chemical Society. 88, 23, p. 5511-5515 5 p.

Research output: Contribution to journal › Article

Catalysis

Sulfates

Hydrolysis

Esters

Acids

1964

113 Citations (Scopus)

The Compensation in ΔH+ and ‡S+ Accompanying the Conversion of Lower Order Nucleophilic Displacement Reactions to Higher Order Catalytic Processes. The Temperature Dependence of the Hydrazinolysis and Imidazole-Catalyzed Hydrolysis of Substituted Phenyl Acetates

Bruice, T. C. & Benkovic, S., Feb 1 1964, In : Journal of the American Chemical Society. 86, 3, p. 418-426 9 p.

Research output: Contribution to journal › Article

Hydrolysis

Esters

hydrazine

Temperature

Nucleophiles

1963

85 Citations (Scopus)

A Comparison of the Bimolecular and Intramolecular Nucleophilic Catalysis of the Hydrolysis of Substituted Phenyl Acylates by the Dimethylamino Group

Bruice, T. C. & Benkovic, S., Jan 1 1963, In : Journal of the American Chemical Society. 85, 1, p. 1-8 8 p.

Research output: Contribution to journal › Article

Catalysis

Anions

Hydrolysis

Rate constants

Esters