Research Output 1963 2020

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Article
2019
Open Access
parasites
Ants
metabolites
Metabolites
muscles
12 Citations (Scopus)

Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin

Cook, E. C., Featherston, E. R., Showalter, S. A. & Cotruvo, Jr., J. A., Jan 15 2019, In : Biochemistry. 58, 2, p. 120-125 6 p.

Research output: Contribution to journalArticle

Methylobacterium extorquens
Lanthanoid Series Elements
EF Hand Motifs
Rare earth elements
Metals

Structure and function of an unusual flavodoxin from the domain Archaea

Prakash, D., Iyer, P. R., Suharti, S., Walters, K. A., Santiago-Martinez, M. G., Golbeck, J. H., Murakami, K. S. & Ferry, J. G., Dec 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 25917-25922 6 p.

Research output: Contribution to journalArticle

Flavodoxin
Archaea
Ferredoxins
Acetates
Methanosarcina
2 Citations (Scopus)

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Buj, R., Chen, C. W., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., Navaratnarajah, M., Zhang, G., Doan, M. T., Jiang, H., Zaleski, M., Kutzler, L., Lacko, H., Lu, Y., Mills, G. B., Gowda, R., Robertson, G. P., Warrick, J. I., Herlyn, M., Imamura, Y. & 4 others, Kimball, S. R., DeGraff, D. J., Snyder, N. W. & Aird, K. M., Aug 20 2019, In : Cell Reports. 28, 8, p. 1971-1980.e8

Research output: Contribution to journalArticle

Open Access
Nucleotides
Metabolism
Carcinogenesis
Up-Regulation
Neoplasms

Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal-Line Semimetals

Boukhvalov, D. W., Edla, R., Cupolillo, A., Fabio, V., Sankar, R., Zhu, Y., Mao, Z., Hu, J., Torelli, P., Chiarello, G., Ottaviano, L. & Politano, A., 2019, In : Advanced Functional Materials. 29, 18

Research output: Contribution to journalArticle

Metalloids
Chemical reactivity
metalloids
reactivity
Atoms

Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer

Dahl, E. S., Buj, R., Leon, K. E., Newell, J. M., Imamura, Y., Bitler, B. G., Snyder, N. W. & Aird, K. M., Aug 1 2019, In : Molecular Cancer Research. 17, 8, p. 1710-1720 11 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Therapeutics
Neoplasms
Epigenomics

The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages

Saha, P., Xiao, X., Yeoh, B. S., Chen, Q., Katkere, B., Kirimanjeswara, G. S. & Vijay-Kumar, M., May 4 2019, In : Gut Microbes. 10, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

Enterobactin
Siderophores
Salmonella
Iron
Macrophages

The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells

Matthews, S. M., Eshelman, M. A., Berg, A. S., Koltun, W. A. & Yochum, G. S., Feb 2019, In : PloS one. 14, 2, e0212850.

Research output: Contribution to journalArticle

Open Access
Crohn disease
Polymorphism
Gene expression
Crohn Disease
single nucleotide polymorphism
1 Citation (Scopus)

The diverse contributions of fucose linkages in cancer

Keeley, T. S., Yang, S. & Lau, E., Sep 2019, In : Cancers. 11, 9, 1241.

Research output: Contribution to journalArticle

Open Access
Fucose
Polysaccharides
Biological Phenomena
Post Translational Protein Processing
Neoplasms

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Bao, L., Festa, F., Freet, C. S., Lee, J. P., Hirschler-Laszkiewicz, I. M., Chen, S. J., Keefer, K. A., Wang, H. G., Patterson, A. D., Cheung, J. Y. & Miller, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 14132.

Research output: Contribution to journalArticle

Open Access
Transient Receptor Potential Channels
Ion Channels
Cell Survival
NADP
NAD
6 Citations (Scopus)

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

Xu, M., Almasi, S., Yang, Y., Yan, C., Sterea, A. M., Rizvi Syeda, A. K., Shen, B., Richard Derek, C., Huang, P., Gujar, S., Wang, J., Zong, W. X., Trebak, M., El Hiani, Y. & Dong, X. P., May 2019, In : Cell Calcium. 79, p. 80-88 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Drug Delivery Systems
Tumor Microenvironment
Down-Regulation
Adenosine Triphosphate

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access
deoxyguanosine kinase
Neoplastic Stem Cells
Neoplasms
Lung Neoplasms
AMP-Activated Protein Kinases

The multiple roles of the unfolded protein response regulator IRE1α in cancer

Chalmers, F., Mogre, S., Son, J., Blazanin, N. & Glick, A. B., Jan 1 2019, In : Molecular Carcinogenesis. 58, 9, p. 1623-1630 8 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Inositol
Endoplasmic Reticulum Stress
Enzymes
Endoplasmic Reticulum

The remote allosteric control of Orai channel gating

Zhou, Y., Nwokonko, R. M., Baraniak, J. H., Trebak, M., Lee, K. P. K. & Gill, D. L., Aug 30 2019, In : PLoS biology. 17, 8, e3000413.

Research output: Contribution to journalArticle

Open Access
Remote control
calcium
Molecules
Cell membranes
Ion Channels

Tissue-specific gene expression during productive human papillomavirus 16 infection of cervical, foreskin, and tonsil epithelium

Chatterjee, S., Kang, S. D., Alam, S., Salzberg, A. C., Milici, J., Van Der Burg, S. H., Freeman, W. & Meyers, C., Sep 1 2019, In : Journal of virology. 93, 17, e00915-19.

Research output: Contribution to journalArticle

Human papillomavirus 16
Foreskin
Papillomavirus Infections
tonsils
Palatine Tonsil
2 Citations (Scopus)

Transferrin receptor binds virus capsid with dynamic motion

Lee, H., Callaway, H. M., Cifuente, J. O., Bator, C. M., Parrish, C. R. & Hafenstein, S. L., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20462-20471 10 p.

Research output: Contribution to journalArticle

Open Access
Canine Parvovirus
Transferrin Receptors
Capsid
Viruses
Dog Diseases

Tristetraprolin targets Nos2 expression in the colonic epithelium

Eshelman, M. A., Matthews, S. M., Schleicher, E. M., Fleeman, R. M., Kawasawa, Y. I., Stumpo, D. J., Blackshear, P. J., Koltun, W. A., Ishmael, F. T. & Yochum, G. S., Dec 1 2019, In : Scientific reports. 9, 1, 14413.

Research output: Contribution to journalArticle

Open Access
Tristetraprolin
Epithelium
Epithelial Cells
3' Untranslated Regions
Colitis

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation

Miller, B. A., Wang, J. F., Song, J., Zhang, X. Q., Hirschler-Laszkiewicz, I., Shanmughapriya, S., Tomar, D., Rajan, S., Feldman, A. M., Madesh, M., Sheu, S. S. & Cheung, J. Y., Sep 2019, In : Journal of Cellular Physiology. 234, 9, p. 15048-15060 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Phosphorylation
Energy Metabolism
Muscle Cells
Wounds and Injuries
2 Citations (Scopus)

Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma

Liu, J., Jiang, W., Zhao, K., Wang, H., Zhou, T., Bai, W., Wang, X., Zhao, T., Huang, C., Gao, S., Qin, T., Yu, W., Yang, B., Li, X., Fu, D., Tan, W., Yang, S., Ren, H. & Hao, J., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 656-673 18 p.

Research output: Contribution to journalArticle

Open Access
Adenocarcinoma
Neoplasms
Therapeutics
Tumor Microenvironment
Granulocyte-Macrophage Colony-Stimulating Factor

Two types of poor immunological responder showing distinct responses to long-term HAART

Kong, Y., Tian, Y., Hao, Y., Chong, X., Xiao, J., Yang, D., Song, C., Han, J., Dai, G., Zhang, F., Zheng, H., Zhao, H. & Zeng, H., Sep 2019, In : International Journal of Infectious Diseases. 86, p. 178-187 10 p.

Research output: Contribution to journalArticle

Open Access
Highly Active Antiretroviral Therapy
T-Lymphocytes
Neopterin
T-Lymphocyte Subsets
Regulatory T-Lymphocytes

Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden

Parekh, N. J., Krouse, T. E., Reider, I. E., Hobbs, R. P., Ward, B. M. & Norbury, C. C., Jan 1 2019, In : PLoS pathogens. 15, 10, e1007778.

Research output: Contribution to journalArticle

Open Access
Interferon Type I
Vaccinia virus
Viral Load
Virus Replication
Viruses
4 Citations (Scopus)

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid

Sun, L., Lee, H., Thibaut, H. J., Lanko, K., Rivero-Buceta, E., Bator, C., Martinez-Gualda, B., Dallmeier, K., Delang, L., Leyssen, P., Gago, F., San-Felix, A., Hafenstein, S., Mirabelli, C. & Neyts, J., Jan 1 2019, In : PLoS pathogens. 15, 5, e1007760.

Research output: Contribution to journalArticle

Open Access
Dendrimers
Enterovirus
Capsid
Tryptophan
Enterovirus Infections
6 Citations (Scopus)

Vitamin D is required for ILC3 derived IL-22 and protection from Citrobacter rodentium infection

Lin, Y. D., Arora, J., Diehl, K., Bora, S. A. & Cantorna, M. T., Jan 1 2019, In : Frontiers in immunology. 10, JAN

Research output: Contribution to journalArticle

Citrobacter rodentium
Vitamin D
Infection
interleukin-22

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon

Cantorna, M. T., Lin, Y. D., Arora, J., Bora, S., Tian, Y., Nichols, R. G. & Patterson, A. D., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Regulatory T-Lymphocytes
Vitamin D
Colon
Colitis
2 Citations (Scopus)

VPS37A directs ESCRT recruitment for phagophore closure

Takahashi, Y., Liang, X., Hattori, T., Tang, Z., He, H., Chen, H., Liu, X., Abraham, T., Imamura-Kawasawa, Y., Buchkovich, N. J., Young, M. M. & Wang, H. G., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3336-3354 19 p.

Research output: Contribution to journalArticle

Open Access
Endosomal Sorting Complexes Required for Transport
Clustered Regularly Interspaced Short Palindromic Repeats
Multivesicular Bodies
Ubiquitin
Epidermal Growth Factor Receptor

Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration

Hao, S., Matsui, Y., Lai, Z. C. & Paulson, R. F., Dec 2019, In : Experimental Hematology. 80, p. 42-54.e4

Research output: Contribution to journalArticle

Erythropoiesis
Regeneration
Erythrocytes
Glutamine
Transcriptome

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

Pajtler, K. W., Wei, Y., Okonechnikov, K., Silva, P. B. G., Vouri, M., Zhang, L., Brabetz, S., Sieber, L., Gulley, M., Mauermann, M., Wedig, T., Mack, N., Imamura Kawasawa, Y., Sharma, T., Zuckermann, M., Andreiuolo, F., Holland, E., Maass, K., Körkel-Qu, H., Liu, H. K. & 13 others, Sahm, F., Capper, D., Bunt, J., Richards, L. J., Jones, D. T. W., Korshunov, A., Chavez, L., Lichter, P., Hoshino, M., Pfister, S. M., Kool, M., Li, W. & Kawauchi, D., Dec 1 2019, In : Nature communications. 10, 1, 3914.

Research output: Contribution to journalArticle

Open Access
NFI Transcription Factors
Ependymoma
subgroups
Carcinogenesis
Fusion reactions
2020

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

Research output: Contribution to journalArticle

Coal Tar
Coal tar
Aromatization
Polycyclic Aromatic Hydrocarbons
Liquid chromatography

Change is Good: What is New for ToxSci?

Peters, J. M., Jan 1 2020, In : Toxicological sciences : an official journal of the Society of Toxicology. 173, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Composite score analysis for unsupervised comparison and network visualization of metabolomics data

Kellogg, J. J., Kvalheim, O. M. & Cech, N. B., Jan 25 2020, In : Analytica Chimica Acta. 1095, p. 38-47 10 p.

Research output: Contribution to journalArticle

Metabolomics
Hydrastis
Principal Component Analysis
visualization
Visualization

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Antineoplastic Agents
Protein Isoforms
Poisons
Cells

Gastrointestinal hypoalgesia in inflammatory bowel disease

Coates, M. D., Soriano, C., Dalessio, S., Stuart, A., Walter, V., Koltun, W., Bernasko, N., Tinsley, A., Clarke, K. & Williams, E. D., Jan 1 2020, In : Annals of Gastroenterology. 33, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Open Access
Inflammatory Bowel Diseases
Pain
Tertiary Care Centers
Fistula
Opiate Alkaloids

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Feb 6 2020, In : Oncogene. 39, 6, p. 1302-1317 16 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Urinary Bladder Neoplasms
Urothelium
Inborn Genetic Diseases
DNA

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

Alkaloids
Modulators
Cells
Breast Neoplasms
Derivatives

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In : Metabolites. 10, 1, 1.

Research output: Contribution to journalArticle

Open Access
Organic pollutants
Body Weight
Lipopolysaccharides
Aryl Hydrocarbon Receptors
Glutamic Acid

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Das, N. K., Schwartz, A. J., Barthel, G., Inohara, N., Liu, Q., Sankar, A., Hill, D. R., Ma, X., Lamberg, O., Schnizlein, M. K., Arqués, J. L., Spence, J. R., Nunez, G., Patterson, A. D., Sun, D., Young, V. B. & Shah, Y. M., Jan 7 2020, In : Cell Metabolism. 31, 1, p. 115-130.e6

Research output: Contribution to journalArticle

Homeostasis
Iron
Intestinal Absorption
Iron Overload
Micronutrients

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

Zhang, L., Rimal, B., Nichols, R. G., Tian, Y., Smith, P. B., Hatzakis, E., Chang, S. C., Butenhoff, J. L., Peters, J. M. & Patterson, A. D., Feb 15 2020, In : Toxicology. 431, 152365.

Research output: Contribution to journalArticle

Homeostasis
Metabolome
Metabolism
Genes
perfluorooctane sulfonic acid

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

Muku, G. E., Kusnadi, A., Kuzu, G., Tanos, R., Murray, I. A., Gowda, K., Amin, S. & Perdew, G. H., Feb 1 2020, In : Laboratory Investigation. 100, 2, p. 250-264 15 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Aryl Hydrocarbon Receptors
Cholesterol
Ligands
Genes

The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells

Weissenrieder, J. S., Reed, J. L., Green, M. V., Moldovan, G. L., Koubek, E. J., Neighbors, J. D. & Hohl, R. J., Jan 1 2020, In : Pharmacology. 105, 1-2, p. 19-27 9 p.

Research output: Contribution to journalArticle

Open Access
Remoxipride
Dopamine D2 Receptors
Thioridazine
Glioblastoma
Pimozide