Research Output 1963 2020

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2017
5 Citations (Scopus)

Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase i study

Squiquera, L., Taxman, D. J., Brendle, S. A., Torres, R., Sulley, J., Hodge, T., Christensen, N. & Sidransky, D., Jan 1 2017, In : Antiviral Therapy. 22, 3, p. 247-255 9 p.

Research output: Contribution to journalArticle

Warts
Cultured Cells
Antiviral Agents
Cottontail rabbit papillomavirus
Endoribonucleases
1 Citation (Scopus)

Reduced competitive repopulation capacity of multipotential hematopoietic stem cells in the bone marrow of friend virus-infected Fv2-resistant mice

Epperly, M. W., Zhang, X., Fisher, R., Hou, W., Franicola, D., Shields, D., Quickel, M., Hankey-Giblin, P., Wang, H. & Greenberger, J. S., May 1 2017, In : In Vivo. 31, 3, p. 313-320 8 p.

Research output: Contribution to journalArticle

Friend murine leukemia virus
Hematopoietic Stem Cells
Stem cells
Viruses
Bone
8 Citations (Scopus)

Reduced total serum bilirubin levels are associated with ulcerative colitis

Schieffer, K. M., Bruffy, S. M., Rauscher, R., Koltun, W. A., Yochum, G. S. & Gallagher, C. J., Jun 2017, In : PloS one. 12, 6, e0179267.

Research output: Contribution to journalArticle

colitis
bilirubin
Ulcerative Colitis
Bilirubin
Crohn disease
1 Citation (Scopus)

Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells

Qin, Q., Lauver, M., Maru, S., Lin, E. & Lukacher, A. E., Feb 1 2017, In : Virology. 502, p. 198-205 8 p.

Research output: Contribution to journalArticle

Polyomavirus Infections
Polyomavirus
Viruses
T-Lymphocytes
Viral Load
9 Citations (Scopus)

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA

Hedglin, M. & Benkovic, S. J., Apr 4 2017, In : Biochemistry. 56, 13, p. 1824-1835 12 p.

Research output: Contribution to journalArticle

Replication Protein A
Single-Stranded DNA
Clamping devices
Proliferating Cell Nuclear Antigen
DNA
5 Citations (Scopus)

RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma

Kim, T. W., Havighurst, T., Kim, K. M., Hebbring, S. J., Ye, Z., Aylward, J., Keles, S., Xu, Y. G. & Spiegelman, V. S., Mar 1 2017, In : Journal of Investigative Dermatology. 137, 3, p. 772-775 4 p.

Research output: Contribution to journalArticle

Neoplasm RNA
Proto-Oncogene Proteins c-myc
RNA-Binding Proteins
Epithelial Cells
3 Citations (Scopus)
DNA Primase
Bacteriophage T4
Recycling
DNA Replication
Holoenzymes
11 Citations (Scopus)

RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis

Schieffer, K. M., Choi, C. S., Emrich, S., Harris, L., Deiling, S., Karamchandani, D. M., Salzberg, A., Kawasawa, Y. I., Yochum, G. S. & Koltun, W. A., Sep 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 3, p. G277-G284

Research output: Contribution to journalArticle

Diverticulitis
Immune System
RNA
Diverticulum
Sigmoid Colon
16 Citations (Scopus)

Role of megakaryocytes in breast cancer metastasis to bone

Jackson, W., Sosnoski, D. M., Ohanessian, S. E., Chandler, P., Mobley, A., Meisel, K. D. & Mastro, A. M., Apr 15 2017, In : Cancer Research. 77, 8, p. 1942-1954 13 p.

Research output: Contribution to journalArticle

Megakaryocytes
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Extramedullary Hematopoiesis
6 Citations (Scopus)

Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer

Morad, S. A. F., Davis, T. S., MacDougall, M. R., Tan, S. F., Feith, D. J., Desai, D. H., Amin, S. G., Kester, M., Loughran, T. P. & Cabot, M. C., Apr 15 2017, In : Biochemical Pharmacology. 130, p. 21-33 13 p.

Research output: Contribution to journalArticle

Ceramides
P-Glycoprotein
Glycosylation
Tamoxifen
Neoplasms
1 Citation (Scopus)
Chlamydia
Gonorrhea
Sexually Transmitted Diseases
Young Adult
Age Groups
1 Citation (Scopus)

Selective opioid growth factor receptor antagonists based on a stilbene isostere

Stockdale, D. P., Titunick, M. B., Biegler, J. M., Reed, J. L., Hartung, A. M., Wiemer, D. F., McLaughlin, P. J. & Neighbors, J. D., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 16, p. 4464-4474 11 p.

Research output: Contribution to journalArticle

Stilbenes
Amides
Isomers
Opioid Analgesics
Intercellular Signaling Peptides and Proteins
1 Citation (Scopus)

Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages

Dhanjal, N. I. K., Sharma, S., Prabhu, K. S. & Tejo Prakash, N., Nov 2 2017, In : Food and Agricultural Immunology. 28, 6, p. 1374-1392 19 p.

Research output: Contribution to journalArticle

Selenium
lipopolysaccharides
selenium
Triticum
Lipopolysaccharides
8 Citations (Scopus)

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers

Dulin, D., Arnold, J. J., van Laar, T., Oh, H. S., Lee, C., Perkins, A. L., Harki, D. A., Depken, M., Cameron, C. E. & Dekker, N. H., Oct 24 2017, In : Cell Reports. 21, 4, p. 1063-1076 14 p.

Research output: Contribution to journalArticle

RNA Replicase
Nucleotides
Throughput
Ribonucleotides
Antiviral Agents
13 Citations (Scopus)

Single-Cell Virology: On-Chip Investigation of Viral Infection Dynamics

Guo, F., Li, S., Caglar, M. U., Mao, Z., Liu, W., Woodman, A., Arnold, J. J., Wilke, C. O., Huang, T. J. & Cameron, C. E., Nov 7 2017, In : Cell Reports. 21, 6, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

Virology
Virus Diseases
Microfluidics
Kinetics
Population

SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

Hengst, J., Dick, T. E., Sharma, A., Doi, K., Hegde, S., Tan, S. F., Geffert, L., Fox, T. E., Sharma, A. K., Desai, D., Amin, S., Kester, M., Loughran, T. P., Paulson, R., Claxton, D., Wang, H-G. & Yun, J., 2017, In : Cancer Translational Medicine. 3, 4, p. 109-121

Research output: Contribution to journalArticle

2 Citations (Scopus)
Parasite Load
T-cells
Malaria
Molecules
Malaria control
10 Citations (Scopus)

Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

Jin, S., Su, H., Tran, N. T., Song, J., Lu, S. S., Li, Y., Huang, S., Abdel-Wahab, O., Liu, Y. & Zhao, X., May 2017, In : PloS one. 12, 5, e0175523.

Research output: Contribution to journalArticle

alternative splicing
Alternative Splicing
RNA splicing
Transcription Factors
transcription factors
5 Citations (Scopus)

Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women

Manni, A., Richie, J. P., Schetter, S. E., Calcagnotto, A., Trushin, N., Aliaga, C. & El-Bayoumy, K., Jun 1 2017, In : European Journal of Clinical Nutrition. 71, 6, p. 762-765 4 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Omega-3 Fatty Acids
Breast Neoplasms
Body Mass Index
Biomarkers
22 Citations (Scopus)

Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis

Molodtsov, V., Scharf, N. T., Stefan, M. A., Garcia, G. A. & Murakami, K. S., Mar 1 2017, In : Molecular Microbiology. 103, 6, p. 1034-1045 12 p.

Research output: Contribution to journalArticle

Bacterial RNA
DNA-Directed RNA Polymerases
Mycobacterium tuberculosis
Tuberculosis
Mutation
15 Citations (Scopus)

Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain

Portz, B., Lu, F., Gibbs, E. B., Mayfield, J. E., Rachel Mehaffey, M., Zhang, Y. J., Brodbelt, J. S., Showalter, S. A. & Gilmour, D. S., May 12 2017, In : Nature communications. 8, 15231.

Research output: Contribution to journalArticle

RNA Polymerase III
Phosphorylation
RNA Polymerase II
Drosophila melanogaster
Consensus Sequence
1 Citation (Scopus)

Structural model of the tubular assembly of the rous sarcoma virus capsid protein

Jeon, J., Qiao, X., Hung, I., Mitra, A. K., Desfosses, A., Huang, D., Gorkov, P. L., Craven, R. C., Kingston, R. L., Gan, Z., Zhu, F. & Chen, B., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 2006-2013 8 p.

Research output: Contribution to journalArticle

Rous sarcoma virus
Capsid
Structural Models
Capsid Proteins
Viruses
31 Citations (Scopus)

Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C60-Secondary Ion Mass Spectrometry

Tian, H., Six, D. A., Krucker, T., Leeds, J. A. & Winograd, N., May 2 2017, In : Analytical chemistry. 89, 9, p. 5050-5057 8 p.

Research output: Contribution to journalArticle

Secondary ion mass spectrometry
Tetracycline
Bacteria
Anti-Bacterial Agents
Imaging techniques

Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain

Gibbs, E. B., Laremore, T. N., Usher, G. A., Portz, B., Cook, E. C. & Showalter, S. A., Nov 7 2017, In : Biophysical journal. 113, 9, p. 1909-1911 3 p.

Research output: Contribution to journalArticle

RNA Polymerase III
Peptide Elongation Factors
RNA Polymerase II
Positive Transcriptional Elongation Factor B
Substrate Specificity
20 Citations (Scopus)

Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model

Li, G., Liu, D., Cooper, T., Kimchi, E. T., Qi, X., Avella, D. M., Li, N., Yang, Q., Kester, M., Rountree, C. B., Kaifi, J. T., Cole, D. J., Rockey, D. C., Schell, T. & Staveley-O'Carroll, K. F., Jan 1 2017, In : Journal of Hepatology. 66, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Neoplasms
Neoplasm Antigens
T-Lymphocytes
Programmed Cell Death 1 Receptor
8 Citations (Scopus)

Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer

Liu, D., Li, G., Avella, D. M., Kimchi, E. T., Kaifi, J. T., Rubinstein, M. P., Camp, E. R., Rockey, D. C., Schell, T. D. & Staveley-O'Carroll, K. F., Sep 20 2017, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Liver Neoplasms
Neoplasm Antigens
Neoplasms
T-Lymphocytes
20 Citations (Scopus)

Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis

Miles, J. P., Zou, J., Kumar, M. V., Pellizzon, M., Ulman, E., Ricci, M., Gewirtz, A. T. & Chassaing, B., Jul 1 2017, In : Inflammatory bowel diseases. 23, 7, p. 1133-1143 11 p.

Research output: Contribution to journalArticle

Fat-Restricted Diet
Dextran Sulfate
High Fat Diet
Colitis
Inulin
8 Citations (Scopus)

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

Reilly, J. E., Neighbors, J. D. & Hohl, R. J., Nov 2 2017, In : Cancer Biology and Therapy. 18, 11, p. 872-882 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prostatic Neoplasms
Neoplasm Metastasis
Tumor Burden
Farnesyltranstransferase
9 Citations (Scopus)

TAX1BP1 restrains virus-induced apoptosis by facilitating itch-mediated degradation of the mitochondrial adaptor MAVS

Choi, Y. B., Shembade, N., Parvatiyar, K., Balachandran, S. & Harhaj, E. W., Jan 1 2017, In : Molecular and cellular biology. 37, 1, e00422-16.

Research output: Contribution to journalArticle

RNA Virus Infections
Apoptosis
Viruses
Sendai virus
Virus Activation
7 Citations (Scopus)

TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells

Eshelman, M. A., Shah, M., Raup-Konsavage, W. M., Rennoll, S. A. & Yochum, G. S., Jun 3 2017, In : Biochemical and Biophysical Research Communications. 487, 3, p. 716-722 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
TCF Transcription Factors
Gene expression
Colorectal Neoplasms
Cells
8 Citations (Scopus)
Virus Diseases
T-Lymphocytes
Brain
Antigens
Epitopes
28 Citations (Scopus)

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., Nazha, A., Chen, L., Yao, B., Liu, C., Chen, S., Weeks, O., Ni, H., Phillips, B. L., Huang, S., Wang, J. & 8 others, He, C., Li, G. M., Radivoyevitch, T., Aifantis, I., MacIejewski, J. P., Yang, F. C., Jin, P. & Xu, M., Jan 1 2017, In : Nature communications. 8, 15102.

Research output: Contribution to journalArticle

stem cells
mutations
Hematopoietic Stem Cells
Stem cells
Hematologic Neoplasms
7 Citations (Scopus)

The histone acetyltransferase Gcn5 positively regulates T Cell activation

Gao, B., Kong, Q., Zhang, Y., Yun, C., Dent, S. Y. R., Song, J., Zhang, D. D., Wang, Y., Li, X. & Fang, D., May 15 2017, In : Journal of Immunology. 198, 10, p. 3927-3938 12 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
T-Lymphocytes
Proteins
Interleukin-2
Autoimmune Experimental Encephalomyelitis
9 Citations (Scopus)

The joint effect of air pollution exposure and copy number variation on risk for autism

Kim, D., Volk, H., Girirajan, S., Pendergrass, S., Hall, M. A., Verma, S. S., Schmidt, R. J., Hansen, R. L., Ghosh, D., Ludena-Rodriguez, Y., Kim, K., Ritchie, M. D., Hertz-Picciotto, I. & Selleck, S. B., Sep 2017, In : Autism Research. 10, 9, p. 1470-1480 11 p.

Research output: Contribution to journalArticle

Air Pollution
Autistic Disorder
Ozone
Air Pollutants
Environmental Exposure
8 Citations (Scopus)

The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients

Schieffer, K. M., Sabey, K., Wright, J. R., Toole, D. R., Drucker, R., Tokarev, V., Harris, L. R., Deiling, S., Eshelman, M. A., Hegarty, J. P., Yochum, G. S., Koltun, W. A., Lamendella, R. & Stewart, D. B., Dec 1 2017, In : Scientific reports. 7, 1, 8467.

Research output: Contribution to journalArticle

Diverticulitis
Sigmoid Colon
Ecosystem
Sigmoid Diseases
Diverticulum
71 Citations (Scopus)

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

Luongo, T. S., Lambert, J. P., Gross, P., Nwokedi, M., Lombardi, A. A., Shanmughapriya, S., Carpenter, A. C., Kolmetzky, D., Gao, E., Van Berlo, J. H., Tsai, E. J., Molkentin, J. D., Chen, X., Madesh, M., Houser, S. R. & Elrod, J. W., May 4 2017, In : Nature. 545, 7652, p. 93-97 5 p.

Research output: Contribution to journalArticle

Homeostasis
Cell Death
Heart Failure
Gene Transfer Techniques
Tamoxifen
7 Citations (Scopus)

The mouse papillomavirus infection model

Hu, J., Cladel, N. M., Budgeon, L. R., Balogh, K. K. & Christensen, N. D., Sep 2017, In : Viruses. 9, 9, 246.

Research output: Contribution to journalArticle

Papillomavirus Infections
Laboratory Animals
Immunocompromised Host
Infection
Disease Progression
4 Citations (Scopus)

The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain

Shengjuler, D., Chan, Y. M., Sun, S., Moustafa, I., Li, Z. L., Gohara, D. W., Buck, M., Cremer, P. S., Boehr, D. D. & Cameron, C. E., Dec 5 2017, In : Structure. 25, 12, p. 1875-1886.e7

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Poliovirus
Phosphatidylinositols
Binding Sites
RNA
9 Citations (Scopus)

The role of UVR and Vitamin D on T cells and inflammatory bowel disease

Bora, S. & Cantorna, M. T-A., Jan 1 2017, In : Photochemical and Photobiological Sciences. 16, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

calciferol
T-cells
Vitamin D
Ultraviolet radiation
ultraviolet radiation
9 Citations (Scopus)

TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells

Nguyen, J. Q. & Irby, R. B., Jan 2 2017, In : Cancer Biology and Therapy. 18, 1, p. 16-25 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Colonic Neoplasms
Cisplatin
prostate apoptosis response-4 protein
Neoplasms
7 Citations (Scopus)

Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases

Yang, X., Liu, X., Musser, D. M., Moustafa, I. M., Arnold, J. J., Cameron, C. E. & Boehr, D. D., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3810-3826 17 p.

Research output: Contribution to journalArticle

RNA Replicase
Viral RNA
Nucleotides
Structural dynamics
Poliovirus
30 Citations (Scopus)

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

Huang, C., Li, N., Li, Z., Chang, A., Chen, Y., Zhao, T., Li, Y., Wang, X., Zhang, W., Wang, Z., Luo, L., Shi, J., Yang, S., Ren, H. & Hao, J., Jan 1 2017, In : Nature communications. 8, 14035.

Research output: Contribution to journalArticle

interleukins
Interleukins
metastasis
Tumors
Adenocarcinoma
5 Citations (Scopus)

UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication

Huang, P. N., Jheng, J. R., Arnold, J. J., Wang, J. R., Cameron, C. E. & Shih, S. R., May 2017, In : PLoS pathogens. 13, 5, e1006375.

Research output: Contribution to journalArticle

Enterovirus
Viral RNA
Unfolded Protein Response
Virulence
RNA Virus Infections
9 Citations (Scopus)

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

Uchida, A., Murugesapillai, D., Kastner, M., Wang, Y., Lodeiro, M. F., Prabhakar, S., Oliver, G. V., Arnold, J. J., Maher, L. J., Williams, M. C. & Cameron, C. E., Jul 26 2017, In : eLife. 6, e27283.

Research output: Contribution to journalArticle

Transcription
Mitochondrial DNA
Tail
Chemical activation
Transcription Initiation Site
5 Citations (Scopus)

UVC radiation as an effective disinfectant method to inactivate human papillomaviruses

Meyers, C., Milici, J. & Robison, R., Oct 2017, In : PloS one. 12, 10, e0187377.

Research output: Contribution to journalArticle

Papillomaviridae
Disinfectants
disinfectants
ultraviolet radiation
Disinfection
15 Citations (Scopus)

VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells

Aragon-Sanabria, V., Pohler, S. E., Eswar, V. J., Bierowski, M., Gomez, E. W. & Dong, C., Apr 10 2017, In : Scientific reports. 7, 45835.

Research output: Contribution to journalArticle

Endothelium
Endothelial Cells
Neoplasms
Adherens Junctions
Cell Movement
4 Citations (Scopus)

Viral DNA replication orientation and hnrnps regulate transcription of the human papillomavirus 18 late promoter

Wang, X., Liu, H., Ge, H., Ajiro, M., Sharma, N. R., Meyers, C., Morozov, P., Tuschl, T., Klar, A., Court, D. & Zhenga, Z. M., May 1 2017, In : mBio. 8, 3, e00713-17.

Research output: Contribution to journalArticle

Human papillomavirus 18
Viral DNA
DNA Replication
Heterogeneous-Nuclear Ribonucleoproteins
Keratinocytes
17 Citations (Scopus)

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling

Reichardt, F., Chassaing, B., Nezami, B. G., Li, G., Tabatabavakili, S., Mwangi, S., Uppal, K., Liang, B., Vijay-Kumar, M., Jones, D., Gewirtz, A. T. & Srinivasan, S., Mar 1 2017, In : Journal of Physiology. 595, 5, p. 1831-1846 16 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Lipopolysaccharides
Fatty Acids
Dysbiosis
Nonesterified Fatty Acids
3 Citations (Scopus)

X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway

Murakami, K. S., Shin, Y., Turnbough, C. L. & Molodtsov, V., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8211-8216 6 p.

Research output: Contribution to journalArticle

X-Rays
RNA
Thermus thermophilus
Enzymes
DNA-Directed RNA Polymerases