Research Output per year
Organization profile
Organization profile
The Next-Generation Therapies research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients.
Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.
Fingerprint Dive into the research topics where Cancer Institute, Next-Generation Therapies is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Neoplasms
Medicine & Life Sciences
Non-Small Cell Lung Carcinoma
Medicine & Life Sciences
Therapeutics
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Cells
Chemical Compounds
Iron
Medicine & Life Sciences
Lung Neoplasms
Medicine & Life Sciences
Growth
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Profiles
James Hansell Adair, PhD
- Materials Science and Engineering - Professor
- Department of Pharmacology - Professor
- Materials Research Institute (MRI)
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Reka Z. Albert, PhD
- Physics - Distinguished Professor
- Institute for Computational and Data Sciences (ICDS)
- Huck Institutes of the Life Sciences
- Materials Research Institute (MRI)
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Marco Archetti
- Huck Institutes of the Life Sciences
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Dawit Aregawi, MD
- Department of Neurosurgery - Assistant Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Anilchandra Attaluri
- School of Science, Engineering & Technology (Harrisburg) - Assistant Professor of Mechanical Engineering
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Chandra Belani, MD
- Department of Medicine - Professor
- Division of Hematology and Oncology
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Institute for Personalized Medicine
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Valerie Brown, MD, PhD
- Department of Pediatrics - Professor
- Division of Hematology and Oncology
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
- Cancer Institute, Next-Generation Therapies
Person: Academic
Karen Choi, MD
- Department of Otolaryngology - Head and Neck Surgery - Assistant Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Research Output 1965 2020
A Multistage Murine Breast Cancer Model Reveals Long-Lived Premalignant Clones Refractory to Parity-Induced Protection
Li, S., Gestl, S. A. & Gunther, E. J., Feb 1 2020, In : Cancer prevention research (Philadelphia, Pa.). 13, 2, p. 173-184 12 p.Research output: Contribution to journal › Article
Parity
Breast
Clone Cells
Breast Neoplasms
Carcinogenesis
An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract
Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.Research output: Contribution to journal › Article
Coal Tar
Coal tar
Aromatization
Polycyclic Aromatic Hydrocarbons
Liquid chromatography
A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors
Santana, V. M., Sahr, N., Tatevossian, R. G., Jia, S., Campagne, O., Sykes, A., Stewart, C. F., Furman, W. L. & McGregor, L. M., Jan 1 2020, (Accepted/In press) In : Cancer.Research output: Contribution to journal › Article
Neoplasms
Sirolimus
Maximum Tolerated Dose
Blood Cells
Bevacizumab
A rewiring model of intratumoral interaction networks
Sang, M., Rice, S., Jiang, L., Liu, X., Gragnoli, C., Belani, C. P. & Wu, R., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 45-51 7 p.Research output: Contribution to journal › Review article
Open Access
Tumors
Neoplasms
Cells
Blueprints
Game theory
Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer
Yin, M., Zhao, J., Monk, P., Martin, D., Folefac, E., Joshi, M., Jin, N., Mortazavi, A., Verschraegen, C. & Clinton, S., Jan 1 2020, In : Cancer medicine. 9, 1, p. 27-34 8 p.Research output: Contribution to journal › Article
Open Access
Brachytherapy
Prostatic Neoplasms
Radiation
Survival
Radiotherapy
Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents
Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.Research output: Contribution to journal › Article
Aldehyde Dehydrogenase
Antineoplastic Agents
Protein Isoforms
Poisons
Cells
Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent
Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.Research output: Contribution to journal › Article
Aldehyde Dehydrogenase
Protein Isoforms
Poisons
Neoplasms
Melanoma
Dose-dependent effect of aerobic exercise on inflammatory biomarkers in a randomized controlled trial of women at high risk of breast cancer
Haley, J. S., Hibler, E. A., Zhou, S., Schmitz, K. H. & Sturgeon, K. M., Jan 15 2020, In : Cancer. 126, 2, p. 329-336 8 p.Research output: Contribution to journal › Article
Randomized Controlled Trials
Biomarkers
Exercise
Breast Neoplasms
Interleukin-12
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer
Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Feb 6 2020, In : Oncogene. 39, 6, p. 1302-1317 16 p.Research output: Contribution to journal › Article
Loss of Heterozygosity
Urinary Bladder Neoplasms
Urothelium
Inborn Genetic Diseases
DNA
Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant
Dandoy, C. E., Kim, S., Chen, M., Ahn, K. W., Ardura, M. I., Brown, V., Chhabra, S., Diaz, M. A., Dvorak, C., Farhadfar, N., Flagg, A., Ganguly, S., Hale, G. A., Hashmi, S. K., Hematti, P., Martino, R., Nishihori, T., Nusrat, R., Olsson, R. F., Rotz, S. J. & 5 others, , Jan 3 2020, In : JAMA network open. 3, 1, p. e1918668Research output: Contribution to journal › Article
Open Access
Hematopoietic Stem Cells
Transplants
Incidence
Wounds and Injuries
Infection
Activities 2017 2017
- 3 Oral presentation
Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)Nov 4 2017
Activity: Talk types › Oral presentation
Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)Jul 5 2017
Activity: Talk types › Oral presentation
From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)Sep 27 2017
Activity: Talk types › Oral presentation
Prizes
American Orthopaedic Association C. Howard Hatcher Pathology Fellowship Award
Edward Fox (Recipient), 2001
Prize
Bausch & Lomb Science Award for Outstanding Achievement in Chemistry
Edward Fox (Recipient), 1987
Prize
Outstanding Collaborative Research Award
Karam El-Bayoumy (Recipient), Andrea Manni (Recipient), John Richie (Recipient), Jiangang (Jason) Liao (Recipient), John Patrick Vanden Heuvel (Recipient), Laurence Demers (Recipient), James Dillard (Recipient) & Connie Jo Rogers (Recipient), 2016
Prize
Estrogen Receptor Modulators
Omega-3 Fatty Acids
Breast Neoplasms
Research