Research output per year
Research output per year
Organization profile
Organization profile
The Next-Generation Therapies research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients.
Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.
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Profiles
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Dawit Aregawi, MD
- Department of Neurosurgery - Assistant Professor
- Cancer Institute, Next-Generation Therapies
- Penn State Cancer Institute
Person: Academic
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Anilchandra Attaluri
- School of Science, Engineering & Technology (Harrisburg) - Assistant Professor of Mechanical Engineering
- Cancer Institute, Next-Generation Therapies
- Penn State Cancer Institute
Person: Academic
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James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Department of Otolaryngology - Head and Neck Surgery - Professor
- Institute for Personalized Medicine - Director
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Cancer Institute, Next-Generation Therapies
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
Person: Academic
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Karen Choi, MD
- Department of Otolaryngology - Head and Neck Surgery - Assistant Professor
- Cancer Institute, Next-Generation Therapies
- Penn State Cancer Institute
Person: Academic
Research output
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A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications
Tang, S., Chi, K., Xu, H., Yong, Q., Yang, J. & Catchmark, J. M., Jan 15 2021, In: Carbohydrate Polymers. 252, 117123.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis
Chen, Y. C., Dinavahi, S. S., Feng, Q., Gowda, R., Ramisetti, S., Xia, X., LaPenna, K. B., Chirasani, V. R., Cho, S. H., Hafenstein, S. L., Battu, M. B., Berg, A., Sharma, A. K., Kirchhausen, T., Dokholyan, N. V., Amin, S., He, P. & Robertson, G. P., May 28 2021, In: Cancer Letters. 506, p. 107-119 13 p.Research output: Contribution to journal › Article › peer-review
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Acupuncture for Cancer-Related Anorexia: a Review of the Current Evidence
Liu, W., Lopez, G., Narayanan, S., Qdaisat, A., Geng, Y., Zhou, S., Spano, M., Underwood, S., Eclache, M. G., Dev, R., Dalal, S., Bruera, E. & Cohen, L., Jul 2021, In: Current oncology reports. 23, 7, 82.Research output: Contribution to journal › Review article › peer-review
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Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants
Piltonen, M., Krokhotin, A., Parisien, M., Bérubé, P., Djambazian, H., Sladek, R., Dokholyan, N. V., Shabalina, S. A. & Diatchenko, L., Jul 2021, In: Cellular and Molecular Neurobiology. 41, 5, p. 1039-1055 17 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A male patient with pseudobulbar affect caused by post-traumatic normal pressure hydrocephalus successfully managed with ventriculoperitoneal shunt
Gigliotti, M. J., Pooshpas, P., Patel, N. & Rizk, E. B., Mar 2021, In: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 23, 100916.Research output: Contribution to journal › Article › peer-review
Open Access -
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Dominguez, L., Shea, J. E., Dokholyan, N. V., de Simone, A., Ma, B., Nussinov, R., Najafi, S., Ngo, S. T., Loquet, A., Chiricotto, M., Ganguly, P., McCarty, J., Li, M. S., Hall, C. & 14 others, , Feb 24 2021, In: Chemical Reviews. 121, 4, p. 2545-2647 103 p.Research output: Contribution to journal › Review article › peer-review
35 Scopus citations -
An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning
Mansouri, A., Germann, J., Boutet, A., Elias, G. J. B., Karmur, B., Neudorfer, C., Loh, A., McAndrews, M. P., Ibrahim, G. M., Lozano, A. M. & Valiante, T. A., Dec 2021, In: Scientific reports. 11, 1, 4686.Research output: Contribution to journal › Article › peer-review
Open Access -
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
Lindskrog, S. V., Prip, F., Lamy, P., Taber, A., Groeneveld, C. S., Birkenkamp-Demtröder, K., Jensen, J. B., Strandgaard, T., Nordentoft, I., Christensen, E., Sokac, M., Birkbak, N. J., Maretty, L., Hermann, G. G., Petersen, A. C., Weyerer, V., Grimm, M. O., Horstmann, M., Sjödahl, G., Höglund, M. & 27 others, , Dec 2021, In: Nature communications. 12, 1, 2301.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy
Ye, Y., Tyndall, E. R., Bui, V., Tang, Z., Shen, Y., Jiang, X., Flanagan, J. M., Wang, H. G. & Tian, F., Dec 2021, In: Nature communications. 12, 1, 374.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
A novel clinically relevant graft-versus-leukemia model in humanized mice
Jia, B., Zhao, C., Bayerl, M., Shike, H., Claxton, D. F., Ehmann, W. C., Mineishi, S., Schell, T. D., Zheng, P., Zhang, Y., Shultz, L. D., Prabhu, K. S., Paulson, R. F. & Zheng, H., 2021, (Accepted/In press) In: Journal of Leukocyte Biology.Research output: Contribution to journal › Article › peer-review
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Multimodal Image-Guided Intervention System for Lung-Cancer Diagnosis and Staging
8/24/10 → 12/31/21
Project: Research project
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REGULATION OF APICAL ENDOCYTOSIS BY ARF6 AND PLD
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
4/1/99 → 3/31/02
Project: Research project
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Activities
- 3 Oral presentation
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From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017Activity: Talk types › Oral presentation
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Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017Activity: Talk types › Oral presentation
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Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017Activity: Talk types › Oral presentation
Prizes
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American Orthopaedic Association C. Howard Hatcher Pathology Fellowship Award
Fox, Edward (Recipient), 2001
Prize
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Bausch & Lomb Science Award for Outstanding Achievement in Chemistry
Fox, Edward (Recipient), 1987
Prize
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Best Doctors in America
Fox, Edward (Recipient), Clebak, Karl (Recipient), Juliano, Paul (Recipient) & McGinn, Johnathan (Recipient), 2016
Prize
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Outstanding Collaborative Research Team
El-Bayoumy, Karam (Recipient), Manni, Andrea (Recipient), Richie, John (Recipient), Liao, Jiangang "Jason" (Recipient), Vanden Heuvel, John Patrick (Recipient), Demers, Laurence (Recipient), Dillard, James (Recipient) & Rogers, Connie Jo (Recipient), 2016
Prize
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