Research output per year
Research output per year
Organization profile
The Next-Generation Therapies research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients.
Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.
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Profiles
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Dawit Aregawi, MD
- Department of Neurosurgery - Assistant Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Anilchandra Attaluri
- School of Science, Engineering & Technology (Harrisburg) - Assistant Professor of Mechanical Engineering
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
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James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Department of Otolaryngology - Head and Neck Surgery - Professor
- Institute for Personalized Medicine - Director
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
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Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
- Institute for Computational and Data Sciences (ICDS)
- Cancer Institute, Next-Generation Therapies
Person: Academic
Research output
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Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing
Wu, K., Fu, M., Zhao, Y., Gerhard, E., Li, Y., Yang, J. & Guo, J., Feb 2023, In: Bioactive Materials. 20, p. 93-110 18 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: Effects of 4-Aminopyridine
Lee, J., Talukder, M., Karuman, Z., Gurjar, A., Govindappa, P., Guddadarangaiah, J., Manto, K., Wandling, G., Hegarty, J., Waning, D. & Elfar, J., Feb 2023, In: Neural Regeneration Research. 18, 2, p. 439-444 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Smart bioadhesives for wound healing and closure
Zhu, J., Zhou, H., Gerhard, E. M., Zhang, S., Parra Rodríguez, F. I., Pan, T., Yang, H., Lin, Y., Yang, J. & Cheng, H., Jan 2023, In: Bioactive Materials. 19, p. 360-375 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
5-Aminolevulinic acid for enhanced surgical visualization of high-grade gliomas: a prospective, multicenter study
Schupper, A. J., Baron, R. B., Cheung, W., Rodriguez, J., Kalkanis, S. N., Chohan, M. O., Andersen, B. J., Chamoun, R., Nahed, B. V., Zacharia, B. E., Kennedy, J., Moulding, H. D., Zucker, L., Chicoine, M. R., Olson, J. J., Jensen, R. L., Sherman, J. H., Zhang, X., Price, G., Fowkes, M., & 4 others, Jun 2022, In: Journal of neurosurgery. 136, 6, p. 1525-1534 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Abdominopelvic MR to CT registration using a synthetic CT intermediate
Heo, J. U., Zhou, F., Jones, R., Zheng, J., Song, X., Qian, P., Baydoun, A., Traughber, M. S., Kuo, J. W., Helo, R. A., Thompson, C., Avril, N., DeVincent, D., Hunt, H., Gupta, A., Faraji, N., Kharouta, M. Z., Kardan, A., Bitonte, D., Langmack, C. B., & 11 others, 2022, (Accepted/In press) In: Journal of applied clinical medical physics.Research output: Contribution to journal › Article › peer-review
Open Access -
Accurate virus identification with interpretable Raman signatures by machine learning
Ye, J., Yeh, Y. T., Xue, Y., Wang, Z., Zhang, N., Liu, H., Zhang, K., Ricker, R. A., Yu, Z., Roder, A., Lopez, N. P., Organtini, L., Greene, W., Hafenstein, S., Lu, H., Ghedin, E., Terrones, M., Huang, S. & Huang, S. X., Jun 7 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 23, e2118836119.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A Comparative Study of Patients With Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Using CyberKnife and Linear Accelerator–Based Volumetric Modulated Arc Therapy
Deshpande, S. R., Grubb, W. R., Kharouta, M., Zhang, Y., Zheng, Y., Podder, T. K., Towe, C., Young, B., Machtay, M. & Biswas, T., May 1 2022, In: Practical Radiation Oncology. 12, 3, p. 200-209 10 p.Research output: Contribution to journal › Article › peer-review
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A comparison of end-of-life care patterns between older patients with both cancer and Alzheimer's disease and related dementias versus those with only cancer
Weng, X., Shen, C., Van Scoy, L. J., Boltz, M., Joshi, M. & Wang, L., 2022, (Accepted/In press) In: Journal of Geriatric Oncology.Research output: Contribution to journal › Article › peer-review
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A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling
Singh, A. P., Luo, H., Matur, M., Eshelman, M. A., Hamamoto, K., Sharma, A., Lesperance, J. & Huang, S., Jan 28 2022, In: Oncogene. 41, 5, p. 718-731 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications
Long, N. A., Golla, U., Sharma, A. & Claxton, D. F., Apr 2022, In: Stem Cell Reviews and Reports. 18, 4, p. 1211-1226 16 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations
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Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial
5/1/22 → 4/30/23
Project: Research project
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Collaborative Research: An implantable intracranial ultrasound stimulation for treating neurodiseases
8/15/21 → 7/31/24
Project: Research project
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Discovery of functionally selective dopamine ligands for age-related cognitive decline
Yang, Y., Mailman, R. & Dokholyan, N.
6/1/21 → 5/31/24
Project: Research project
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Collaborative Research: Infection mechanisms of bacteriophages targeting motile bacteria
6/1/21 → 5/31/24
Project: Research project
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Delineating novel mechanism of immune evasion in melanoma brain metastases
1/1/21 → …
Project: Research project
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RECODE: Real-time Monitoring, Modeling and Manipulation of Progenitor Co-differentiation in Heterotypic Cell Systems
Hayes, D. J., Wong, P. K. & Pritchard, J.
1/1/21 → 12/31/23
Project: Research project
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A portable photoacoustic imager for diagnosing vascular diseases
Kothapalli, S. & Kothapalli, S.
National Institute of Biomedical Imaging and Bioengineering
9/17/20 → 5/31/23
Project: Research project
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Sex-based Differences in Glioma
Lathia, J. J. D., Barnholtz-sloan, J. S., Berens, M. E., Connor, J., Connor, J. J. R., Luo, J. J., Rubin, J. J. B., Lathia, J. D., Luo, J., Berens, M. M. E. & Rubin, J. B.
9/14/20 → 6/30/23
Project: Research project
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Structural Studies of Human Papillomavirus
Hafenstein, S. & Hafenstein, S.
National Institute of Allergy and Infectious Diseases
8/13/20 → 7/31/23
Project: Research project
Activities
- 3 Oral presentation
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Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017Activity: Talk types › Oral presentation
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Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017Activity: Talk types › Oral presentation
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From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017Activity: Talk types › Oral presentation
Prizes
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American Orthopaedic Association C. Howard Hatcher Pathology Fellowship Award
Fox, Edward (Recipient), 2001
Prize
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Bausch & Lomb Science Award for Outstanding Achievement in Chemistry
Fox, Edward (Recipient), 1987
Prize
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Best Doctors in America
Fox, Edward (Recipient), Clebak, Karl (Recipient), Juliano, Paul (Recipient) & McGinn, Johnathan (Recipient), 2016
Prize
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Dean’s Award for Excellence in Teaching
Hollins, L. Claire (Recipient), Nisnevitch-Savarese, Zoulfira (Recipient), Read, Selina (Recipient), Rossi, John (Recipient), Royo, Marc (Recipient), Sarraf, Elie (Recipient), Shah, Bunty (Recipient), Moldovan, George-Lucian (Recipient), van Riggelen, Jan (Recipient), Shantz, Lisa (Recipient), Yengo, Christopher (Recipient), Booth, Jennifer (Recipient), Bates, Erica (Recipient), Schuster, Angel (Recipient), Clebak, Karl (Recipient), Daniels, Eldra W. (Recipient), Hays, Amy (Recipient), Hemerly, Nathan (Recipient), Thompson, Andrew (Recipient), George, Daniel (Recipient), Evey, Loren (Recipient), McLaughlin, Patricia (Recipient), Acharya, J. (Recipient), De Jesus, Sol (Recipient), O'Leary, Amber (Recipient), Wright, Tonya (Recipient), Cantore, William (Recipient), Pantanelli, Seth (Recipient), Millard, Roberta (Recipient), Updegrove, Gary F. (Recipient), Choi, Karen (Recipient), Darowish, Charles (Recipient), Dooley, Amy (Recipient), Hackman, Nicole (Recipient), Krawiec, Conrad (Recipient), Oji-Mmuo, Christiana (Recipient), Ryan, Sheryl (Recipient), Shedlock, Aaron (Recipient), Tunks, Robert (Recipient), Critchfield, Laura (Recipient), Bellon, Alfredo (Recipient), Dougherty, Kathleen (Recipient), Lagman, Jasmin (Recipient), Mahgoub, Yassir (Recipient), Dreibelbis, Tomi (Recipient), Richie, John (Recipient), Wang, Li (Recipient), Methratta, Sosamma (Recipient), Chauvin, Nancy (Recipient), Deutsch, Michael (Recipient), Kulaylat, Afif (Recipient), Paulishak, Melody (Recipient), Staszak, Ryan (Recipient) & MacDonald, Susan (Recipient), 2022
Prize
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Excellence in Career Mentoring Award
Waxmonsky, James (Recipient), Connor, James (Recipient), Pantanelli, Seth (Recipient) & Shen, Chan (Recipient), 2022
Prize
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