Research Output per year
Organization profile
Organization profile
The Experimental Therapeutics research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients.
Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Population Health and Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.
Fingerprint Dive into the research topics where Cancer Institute, Next-Generation Therapies is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Neoplasms
Medicine & Life Sciences
Non-Small Cell Lung Carcinoma
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Therapeutics
Medicine & Life Sciences
Cells
Chemical Compounds
Iron
Medicine & Life Sciences
Opioid Analgesics
Medicine & Life Sciences
Growth
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Profiles
James Hansell Adair, PhD
- Materials Science and Engineering - Professor
- Department of Pharmacology - Professor
- Materials Research Institute (MRI)
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Reka Z. Albert, PhD
- Physics - Distinguished Professor
- Institute for Computational and Data Sciences (ICDS)
- Huck Institutes of the Life Sciences
- Materials Research Institute (MRI)
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Marco Archetti
- Huck Institutes of the Life Sciences
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Dawit Aregawi, MD
- Department of Neurosurgery - Assistant Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Anilchandra Attaluri
- School of Science, Engineering & Technology (Harrisburg) - Assistant Professor of Mechanical Engineering
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Chandra Belani, MD
- Department of Medicine - Professor
- Division of Hematology and Oncology
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Institute for Personalized Medicine
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Valerie Brown, MD, PhD
- Department of Pediatrics - Professor
- Division of Hematology and Oncology
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
- Cancer Institute, Next-Generation Therapies
Person: Academic
Karen Choi, MD
- Department of Otolaryngology - Head and Neck Surgery - Assistant Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
Research Output 1965 2020
A rewiring model of intratumoral interaction networks
Sang, M., Rice, S., Jiang, L., Liu, X., Gragnoli, C., Belani, C. P. & Wu, R., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 45-51 7 p.Research output: Contribution to journal › Review article
Open Access
Tumors
Neoplasms
Cells
Blueprints
Game theory
Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer
Yin, M., Zhao, J., Monk, P., Martin, D., Folefac, E., Joshi, M., Jin, N., Mortazavi, A., Verschraegen, C. & Clinton, S., Jan 1 2020, In : Cancer medicine. 9, 1, p. 27-34 8 p.Research output: Contribution to journal › Article
Open Access
Brachytherapy
Prostatic Neoplasms
Radiation
Survival
Radiotherapy
Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents
Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.Research output: Contribution to journal › Article
Aldehyde Dehydrogenase
Antineoplastic Agents
Protein Isoforms
Poisons
Cells
Dose-dependent effect of aerobic exercise on inflammatory biomarkers in a randomized controlled trial of women at high risk of breast cancer
Haley, J. S., Hibler, E. A., Zhou, S., Schmitz, K. H. & Sturgeon, K. M., Jan 15 2020, In : Cancer. 126, 2, p. 329-336 8 p.Research output: Contribution to journal › Article
Randomized Controlled Trials
Biomarkers
Exercise
Breast Neoplasms
Interleukin-12
Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant
Dandoy, C. E., Kim, S., Chen, M., Ahn, K. W., Ardura, M. I., Brown, V., Chhabra, S., Diaz, M. A., Dvorak, C., Farhadfar, N., Flagg, A., Ganguly, S., Hale, G. A., Hashmi, S. K., Hematti, P., Martino, R., Nishihori, T., Nusrat, R., Olsson, R. F., Rotz, S. J. & 5 others, , Jan 3 2020, In : JAMA network open. 3, 1, p. e1918668Research output: Contribution to journal › Article
Open Access
Hematopoietic Stem Cells
Transplants
Incidence
Wounds and Injuries
Infection
km23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells
Raza, A., Pandey, M. S., Jin, Q. & Mulder, K. M., Jan 1 2020, In : Cell Biology International. 44, 1, p. 155-165 11 p.Research output: Contribution to journal › Article
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Dyneins
Colorectal Neoplasms
Transforming Growth Factors
Lesion Network Mapping Analysis Identifies Potential Cause of Postoperative Depression in a Case of Cingulate Low-Grade Glioma
Mansouri, A., Boutet, A., Elias, G., Germann, J., Yan, H., Babu, H., Lozano, A. M. & Valiante, T. A., Jan 2020, In : World neurosurgery. 133, p. 278-282 5 p.Research output: Contribution to journal › Article
Glioma
Depression
Neoplasms
Major Depressive Disorder
Seizures
Ligand-induced disorder-to-order transitions characterized by structural proteomics and molecular dynamics simulations
Makepeace, K. A. T., Brodie, N. I., Popov, K. I., Gudavicius, G., Nelson, C. J., Petrotchenko, E. V., Dokholyan, N. V. & Borchers, C. H., Jan 16 2020, In : Journal of Proteomics. 211, 103544.Research output: Contribution to journal › Article
Open Access
Molecular Dynamics Simulation
Proteomics
Molecular dynamics
Ligands
Computer simulation
Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes
Al-Holou, W. N., Hodges, T. R., Everson, R. G., Freeman, J., Zhou, S., Suki, D., Rao, G., Ferguson, S. D., Heimberger, A. B., McCutcheon, I. E., Prabhu, S. S., Lang, F. F., Weinberg, J. S., Wildrick, D. M. & Sawaya, R., Jan 1 2020, In : Neurosurgery. 86, 1, p. 112-121 10 p.Research output: Contribution to journal › Article
Glioblastoma
Multivariate Analysis
Neoplasms
Propensity Score
Analysis of Variance
Postoperative chemotherapy and radiation improve survival following cardiac sarcoma resection
Hendriksen, B. S., Stahl, K. A., Hollenbeak, C. S., Taylor, M. D., Vasekar, M. K., Drabick, J. J., Conte, J. V., Soleimani, B. & Reed, M. F., Jan 1 2020, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.Research output: Contribution to journal › Article
Sarcoma
Radiation
Drug Therapy
Survival
Therapeutics
Activities 2017 2017
- 3 Oral presentation
Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)Jul 5 2017
Activity: Talk types › Oral presentation
Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)Nov 4 2017
Activity: Talk types › Oral presentation
From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)Sep 27 2017
Activity: Talk types › Oral presentation
Prizes
American Orthopaedic Association C. Howard Hatcher Pathology Fellowship Award
Edward Fox (Recipient), 2001
Prize
Bausch & Lomb Science Award for Outstanding Achievement in Chemistry
Edward Fox (Recipient), 1987
Prize