Organization profile

Organization profile

The Next-Generation Therapies research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients. 

Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.

Fingerprint Dive into the research topics where Cancer Institute, Next-Generation Therapies is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.


    Research Output

    A Deep Learning approach to Photoacoustic Wavefront Localization in Deep-Tissue Medium

    Johnstonbaugh, K., Agrawal, S., Durairaj, D. A., Fadden, C., Dangi, A., Karri, S. P. K. & Kothapalli, S. R., Jan 1 2020, (Accepted/In press) In : IEEE transactions on ultrasonics, ferroelectrics, and frequency control.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis

    Li, Y., Liao, Z., Luo, H., Benyoucef, A., Kang, Y., Lai, Q., Dovat, S., Miller, B., Chepelev, I., Li, Y., Zhao, K., Brand, M. & Huang, S., Apr 6 2020, In : Nucleic acids research. 48, 6, p. 3119-3133 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating

    Casey, J. S., Arrizabalaga, J. H., Abu-Laban, M., Becca, J. C., Rose, B. J., Strickland, K. T., Bursavich, J. B., McCann, J. S., Pacheco, C. N., Jessen, L., Attaluri, A. & Hayes, D. J., Jul 1 2020, In : Journal of Colloid And Interface Science. 571, p. 348-355 8 p.

    Research output: Contribution to journalArticle

  • A modular approach to neonatal whole-brain photoacoustic imaging

    Dangi, A., Roy, K., Agrawal, S., Chen, H., Ashok, A., Wible, C., Osman, M., Pratap, R. & Kothapalli, S. R., Jan 1 2020, Photons Plus Ultrasound: Imaging and Sensing 2020. Oraevsky, A. A. & Wang, L. V. (eds.). SPIE, 1124057. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11240).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • A multistage murine breast cancer model reveals long-lived premalignant clones refractory to parity-induced protection

    Li, S., Gestl, S. A. & Gunther, E. J., Jan 1 2020, In : Cancer Prevention Research. 13, 2, p. 173-183 11 p.

    Research output: Contribution to journalArticle

  • Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny

    Patel, N. J., Hogan, K. J., Rizk, E., Stewart, K., Madrid, A., Vadakkadath Meethal, S., Alisch, R., Borth, L., Papale, L. A., Ondoma, S., Gorges, L. R., Weber, K., Lake, W., Bauer, A., Hariharan, N., Kuehn, T., Cook, T., Keles, S., Newton, M. A. & Iskandar, B. J., Apr 1 2020, In : Molecular Neurobiology. 57, 4, p. 2048-2071 24 p.

    Research output: Contribution to journalArticle

  • An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

    Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  • A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors

    Santana, V. M., Sahr, N., Tatevossian, R. G., Jia, S., Campagne, O., Sykes, A., Stewart, C. F., Furman, W. L. & McGregor, L. M., Apr 15 2020, In : Cancer. 126, 8, p. 1749-1757 9 p.

    Research output: Contribution to journalArticle

  • A Photoacoustic Imaging Device Using Piezoelectric Micromachined Ultrasound Transducers (PMUTs)

    Dangi, A., Cheng, C. Y., Agrawal, S., Tiwari, S., Datta, G. R., Benoit, R. R., Pratap, R., Trolier-Mckinstry, S. & Kothapalli, S. R., Apr 2020, In : IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 67, 4, p. 801-809 9 p., 8915732.

    Research output: Contribution to journalArticle

  • A rewiring model of intratumoral interaction networks

    Sang, M., Rice, S., Jiang, L., Liu, X., Gragnoli, C., Belani, C. P. & Wu, R., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 45-51 7 p.

    Research output: Contribution to journalReview article

    Open Access
  • Activities

    • 3 Oral presentation

    From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

    Keith Cheng (Speaker), , Y Ding (Speaker), , SR Katz (Speaker), , AY Lin (Speaker), , D van Rossum (Speaker), & D Vanselow (Speaker)

    Sep 27 2017

    Activity: Talk typesOral presentation

    Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

    Keith Cheng (Speaker), , Y Ding (Speaker), , AY Lin (Speaker), , M Yakovlev (Speaker), , D Vanselow (Speaker), , X Xin (Speaker), , S Katz (Speaker), , D Vanselow (Speaker), & PJ La Riviere (Speaker)

    Jul 5 2017

    Activity: Talk typesOral presentation


    Best Doctors in America

    Fox, Edward (Recipient), Clebak, Karl (Recipient) & Juliano, Paul (Recipient), 2016


    Innovator of the Year

    Deb Kelly (Recipient), 2019


    ORAU Travel Grant

    Hempel, Nadine (Recipient), 2017


    Outstanding Collaborative Research Award

    El-Bayoumy, Karam (Recipient), Manni, Andrea (Recipient), Richie, John (Recipient), Liao, Jiangang (Jason) (Recipient), Vanden Heuvel, John Patrick (Recipient), Laurence Demers (Recipient), Dillard, James (Recipient) & Rogers, Connie Jo (Recipient), 2016


  • Session Chair

    Deb Kelly (Recipient), 2017

    Prize: Other distinction