Organization profile

Organization profile

The Next-Generation Therapies research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients. 

Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.

Fingerprint Dive into the research topics where Cancer Institute, Next-Generation Therapies is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Neoplasms Medicine & Life Sciences
Non-Small Cell Lung Carcinoma Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cells Chemical Compounds
Iron Medicine & Life Sciences
Lung Neoplasms Medicine & Life Sciences
Growth Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Research Output 1965 2020

Parity
Breast
Clone Cells
Breast Neoplasms
Carcinogenesis

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

Research output: Contribution to journalArticle

Coal Tar
Coal tar
Aromatization
Polycyclic Aromatic Hydrocarbons
Liquid chromatography

A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors

Santana, V. M., Sahr, N., Tatevossian, R. G., Jia, S., Campagne, O., Sykes, A., Stewart, C. F., Furman, W. L. & McGregor, L. M., Jan 1 2020, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

Neoplasms
Sirolimus
Maximum Tolerated Dose
Blood Cells
Bevacizumab

A rewiring model of intratumoral interaction networks

Sang, M., Rice, S., Jiang, L., Liu, X., Gragnoli, C., Belani, C. P. & Wu, R., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 45-51 7 p.

Research output: Contribution to journalReview article

Open Access
Tumors
Neoplasms
Cells
Blueprints
Game theory

Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer

Yin, M., Zhao, J., Monk, P., Martin, D., Folefac, E., Joshi, M., Jin, N., Mortazavi, A., Verschraegen, C. & Clinton, S., Jan 1 2020, In : Cancer medicine. 9, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Open Access
Brachytherapy
Prostatic Neoplasms
Radiation
Survival
Radiotherapy

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Antineoplastic Agents
Protein Isoforms
Poisons
Cells

Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent

Dinavahi, S. S., Gowda, R., Gowda, K., Bazewicz, C. G., Chirasani, V. R., Battu, M. B., Berg, A., Dokholyan, N. V., Amin, S. & Robertson, G. P., Feb 1 2020, In : Molecular cancer therapeutics. 19, 2, p. 447-459 13 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Protein Isoforms
Poisons
Neoplasms
Melanoma

Dose-dependent effect of aerobic exercise on inflammatory biomarkers in a randomized controlled trial of women at high risk of breast cancer

Haley, J. S., Hibler, E. A., Zhou, S., Schmitz, K. H. & Sturgeon, K. M., Jan 15 2020, In : Cancer. 126, 2, p. 329-336 8 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Biomarkers
Exercise
Breast Neoplasms
Interleukin-12

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Feb 6 2020, In : Oncogene. 39, 6, p. 1302-1317 16 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Urinary Bladder Neoplasms
Urothelium
Inborn Genetic Diseases
DNA

Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant

Dandoy, C. E., Kim, S., Chen, M., Ahn, K. W., Ardura, M. I., Brown, V., Chhabra, S., Diaz, M. A., Dvorak, C., Farhadfar, N., Flagg, A., Ganguly, S., Hale, G. A., Hashmi, S. K., Hematti, P., Martino, R., Nishihori, T., Nusrat, R., Olsson, R. F., Rotz, S. J. & 5 others, Sung, A. D., Perales, M. A., Lindemans, C. A., Komanduri, K. V. & Riches, M. L., Jan 3 2020, In : JAMA network open. 3, 1, p. e1918668

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Transplants
Incidence
Wounds and Injuries
Infection

Activities 2017 2017

  • 3 Oral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation

Prizes

Best Doctors in America

Edward Fox (Recipient) & Karl Clebak (Recipient), 2016

Prize

Innovator of the Year

Deb Kelly (Recipient), 2019

Prize

Outstanding Collaborative Research Award

Karam El-Bayoumy (Recipient), Andrea Manni (Recipient), John Richie (Recipient), Jiangang (Jason) Liao (Recipient), John Patrick Vanden Heuvel (Recipient), Laurence Demers (Recipient), James Dillard (Recipient) & Connie Jo Rogers (Recipient), 2016

Prize

Estrogen Receptor Modulators
Omega-3 Fatty Acids
Breast Neoplasms
Research

Session Chair

Deb Kelly (Recipient), 2017

Prize: Other distinction

Vice Chair

Deb Kelly (Recipient), 2019

Prize: Other distinction