Organization profile

Organization profile

The Experimental Therapeutics research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients. 

Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Population Health and Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.

Fingerprint Dive into the research topics where Cancer Institute, Next-Generation Therapies is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Neoplasms Medicine & Life Sciences
Non-Small Cell Lung Carcinoma Medicine & Life Sciences
Proteins Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Cells Chemical Compounds
Iron Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Growth Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Research Output 1965 2020

An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

Research output: Contribution to journalArticle

Coal Tar
Coal tar
Aromatization
Polycyclic Aromatic Hydrocarbons
Liquid chromatography

A rewiring model of intratumoral interaction networks

Sang, M., Rice, S., Jiang, L., Liu, X., Gragnoli, C., Belani, C. P. & Wu, R., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 45-51 7 p.

Research output: Contribution to journalReview article

Open Access
Tumors
Neoplasms
Cells
Blueprints
Game theory

Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer

Yin, M., Zhao, J., Monk, P., Martin, D., Folefac, E., Joshi, M., Jin, N., Mortazavi, A., Verschraegen, C. & Clinton, S., Jan 1 2020, In : Cancer medicine. 9, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Open Access
Brachytherapy
Prostatic Neoplasms
Radiation
Survival
Radiotherapy

Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Antineoplastic Agents
Protein Isoforms
Poisons
Cells

Dose-dependent effect of aerobic exercise on inflammatory biomarkers in a randomized controlled trial of women at high risk of breast cancer

Haley, J. S., Hibler, E. A., Zhou, S., Schmitz, K. H. & Sturgeon, K. M., Jan 15 2020, In : Cancer. 126, 2, p. 329-336 8 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Biomarkers
Exercise
Breast Neoplasms
Interleukin-12

Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant

Dandoy, C. E., Kim, S., Chen, M., Ahn, K. W., Ardura, M. I., Brown, V., Chhabra, S., Diaz, M. A., Dvorak, C., Farhadfar, N., Flagg, A., Ganguly, S., Hale, G. A., Hashmi, S. K., Hematti, P., Martino, R., Nishihori, T., Nusrat, R., Olsson, R. F., Rotz, S. J. & 5 others, Sung, A. D., Perales, M. A., Lindemans, C. A., Komanduri, K. V. & Riches, M. L., Jan 3 2020, In : JAMA network open. 3, 1, p. e1918668

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Transplants
Incidence
Wounds and Injuries
Infection

km23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells

Raza, A., Pandey, M. S., Jin, Q. & Mulder, K. M., Jan 1 2020, In : Cell Biology International. 44, 1, p. 155-165 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Dyneins
Colorectal Neoplasms
Transforming Growth Factors

Lesion Network Mapping Analysis Identifies Potential Cause of Postoperative Depression in a Case of Cingulate Low-Grade Glioma

Mansouri, A., Boutet, A., Elias, G., Germann, J., Yan, H., Babu, H., Lozano, A. M. & Valiante, T. A., Jan 2020, In : World neurosurgery. 133, p. 278-282 5 p.

Research output: Contribution to journalArticle

Glioma
Depression
Neoplasms
Major Depressive Disorder
Seizures

Ligand-induced disorder-to-order transitions characterized by structural proteomics and molecular dynamics simulations

Makepeace, K. A. T., Brodie, N. I., Popov, K. I., Gudavicius, G., Nelson, C. J., Petrotchenko, E. V., Dokholyan, N. V. & Borchers, C. H., Jan 16 2020, In : Journal of Proteomics. 211, 103544.

Research output: Contribution to journalArticle

Open Access
Molecular Dynamics Simulation
Proteomics
Molecular dynamics
Ligands
Computer simulation

Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes

Al-Holou, W. N., Hodges, T. R., Everson, R. G., Freeman, J., Zhou, S., Suki, D., Rao, G., Ferguson, S. D., Heimberger, A. B., McCutcheon, I. E., Prabhu, S. S., Lang, F. F., Weinberg, J. S., Wildrick, D. M. & Sawaya, R., Jan 1 2020, In : Neurosurgery. 86, 1, p. 112-121 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Multivariate Analysis
Neoplasms
Propensity Score
Analysis of Variance

Activities 2017 2017

  • 3 Oral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation