Organization profile

Organization profile

The Next-Generation Therapies research program at Penn State Cancer Institute discovers and characterizes novel agents and pathways; translates these discoveries through innovative, preclinical proof-of-principle studies; and provides more effective cancer therapies to patients. 

Program members also collaborate with colleagues in biomedical engineering at Penn State University Park, as well as with Cancer Control research program members, regarding the role of exercise in treatment outcomes for cancer patients. Additional collaborations involve work with the Mechanisms of Carcinogenesis research program on the identification of genomic markers in metastatic melanoma as potential markers of response.

Fingerprint Dive into the research topics where Cancer Institute, Next-Generation Therapies is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

  • Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Profiles

    Research Output

  • An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract

    Ramisetti, S. R., Oña-Ruales, J. O., Wise, S. A., Amin, S. & Sharma, A. K., Jan 1 2020, In : Polycyclic Aromatic Compounds. 40, 1, p. 88-98 11 p.

    Research output: Contribution to journalArticle

  • A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors

    Santana, V. M., Sahr, N., Tatevossian, R. G., Jia, S., Campagne, O., Sykes, A., Stewart, C. F., Furman, W. L. & McGregor, L. M., Jan 1 2020, (Accepted/In press) In : Cancer.

    Research output: Contribution to journalArticle

  • A rewiring model of intratumoral interaction networks

    Sang, M., Rice, S., Jiang, L., Liu, X., Gragnoli, C., Belani, C. P. & Wu, R., 2020, In : Computational and Structural Biotechnology Journal. 18, p. 45-51 7 p.

    Research output: Contribution to journalReview article

    Open Access
  • Cellular signaling and epigenetic regulation of gene expression in leukemia

    Gowda, C., Song, C., Ding, Y., Iyer, S., Dhanyamraju, P. K., McGrath, M., Bamme, Y., Soliman, M., Kane, S., Payne, J. L. & Dovat, S., Jan 2020, In : Advances in Biological Regulation. 75, 100665.

    Research output: Contribution to journalReview article

    Open Access
  • Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia

    Pearson, J. M., Tan, S. F., Sharma, A., Annageldiyev, C., Fox, T. E., Abad, J. L., Fabrias, G., Desai, D., Amin, S., Wang, H. G., Cabot, M. C., Claxton, D. F., Kester, M., Feith, D. J. & Loughran, T. P., Jan 1 2020, In : Molecular Cancer Research. 18, 3, p. 352-363 12 p.

    Research output: Contribution to journalArticle

  • Clinical trials for deep brain stimulation: Current state of affairs

    Harmsen, I. E., Elias, G. J. B., Beyn, M. E., Boutet, A., Pancholi, A., Germann, J., Mansouri, A., Lozano, C. S. & Lozano, A. M., Mar 1 2020, In : Brain Stimulation. 13, 2, p. 378-385 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • Comparative effectiveness of surgery versus external beam radiation with/without brachytherapy in high-risk localized prostate cancer

    Yin, M., Zhao, J., Monk, P., Martin, D., Folefac, E., Joshi, M., Jin, N., Mortazavi, A., Verschraegen, C. & Clinton, S., Jan 1 2020, In : Cancer medicine. 9, 1, p. 27-34 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

    Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

    Research output: Contribution to journalArticle

  • Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents

    Dinavahi, S. S., Gowda, R., Bazewicz, C. G., Battu, M. B., Lin, J. M., Chitren, R. J., Pandey, M. K., Amin, S., Robertson, G. P. & Gowda, K., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111962.

    Research output: Contribution to journalArticle

  • Activities

    • 3 Oral presentation

    From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

    Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
    Sep 27 2017

    Activity: Talk typesOral presentation

    Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

    Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
    Jul 5 2017

    Activity: Talk typesOral presentation

    Prizes

    Best Doctors in America

    Edward Fox (Recipient), Karl Clebak (Recipient) & Paul Juliano (Recipient), 2016

    Prize

    Innovator of the Year

    Deb Kelly (Recipient), 2019

    Prize

    Outstanding Collaborative Research Award

    Karam El-Bayoumy (Recipient), Andrea Manni (Recipient), John Richie (Recipient), Jiangang (Jason) Liao (Recipient), John Patrick Vanden Heuvel (Recipient), Laurence Demers (Recipient), James Dillard (Recipient) & Connie Jo Rogers (Recipient), 2016

    Prize

  • Session Chair

    Deb Kelly (Recipient), 2017

    Prize: Other distinction

    Vice Chair

    Deb Kelly (Recipient), 2019

    Prize: Other distinction