Center for Statistical Genetics

  • United States

Research Output 1982 2019

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Review article
2019

A unified mapping framework of multifaceted pharmacodynamic responses to hypertension interventions

Wang, Q., Gan, J., Wei, K., Berceli, S. A., Gragnoli, C. & Wu, R., Mar 1 2019, In : Drug Discovery Today. 24, 3, p. 883-889 7 p.

Research output: Contribution to journalReview article

Quantitative Trait Loci
Blood Pressure
Hypertension
Pharmaceutical Preparations
Patient Rights
1 Citation (Scopus)

Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome

Postolache, T. T., del Bosque-Plata, L., Jabbour, S., Vergare, M., Wu, R. & Gragnoli, C., Apr 1 2019, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 186-203 18 p.

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Comorbidity
Schizophrenia
Major Depressive Disorder
Genes
1 Citation (Scopus)

Nutritional status in chronic spinal cord injury: a systematic review and meta-analysis

Farkas, G. J., Pitot, M. A., Berg, A. & Gater, D., Jan 1 2019, In : Spinal Cord. 57, 1, p. 3-17 15 p.

Research output: Contribution to journalReview article

United States Department of Agriculture
Nutritional Status
Spinal Cord Injuries
Meta-Analysis
Confidence Intervals
6 Citations (Scopus)

Risk Factors for Elbow and Shoulder Injuries in Adolescent Baseball Players: A Systematic Review

Norton, R., Honstad, C., Joshi, R., Silvis, M., Chinchilli, V. & Dhawan, A., Mar 1 2019, In : American Journal of Sports Medicine. 47, 4, p. 982-990 9 p.

Research output: Contribution to journalReview article

Baseball
Elbow
Arm Injuries
Fatigue
Arm
2018
3 Citations (Scopus)

Mapping genes for drug chronotherapy

Wei, K., Wang, Q., Gan, J., Zhang, S., Ye, M., Gragnoli, C. & Wu, R., Nov 1 2018, In : Drug Discovery Today. 23, 11, p. 1883-1888 6 p.

Research output: Contribution to journalReview article

Drug Chronotherapy
Chromosome Mapping
Pharmaceutical Preparations
Genes
Genome-Wide Association Study
2017
12 Citations (Scopus)

Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition

Wang, Q., Gosik, K., Xing, S., Jiang, L., Sun, L., Chinchilli, V. & Wu, R., Mar 1 2017, In : Physics of Life Reviews. 20, p. 126-137 12 p.

Research output: Contribution to journalReview article

game theory
Game Theory
Methylation
embryos
Game theory
1 Citation (Scopus)

Landscaping Crossover Interference Across a Genome

Sun, L., Wang, J., Sang, M., Jiang, L., Zhao, B., Cheng, T., Zhang, Q. & Wu, R., Oct 1 2017, In : Trends in Plant Science. 22, 10, p. 894-907 14 p.

Research output: Contribution to journalReview article

landscaping
crossover interference
genome
chromosomes
meiosis
15 Citations (Scopus)

Plant grafting: how genetic exchange promotes vascular reconnection

Wang, J., Jiang, L. & Wu, R., Apr 1 2017, In : New Phytologist. 214, 1, p. 56-65 10 p.

Research output: Contribution to journalReview article

vascular tissues
scions
grafting (plants)
phenotypic variation
blood vessels
2016

Editorial

Li, R., Oct 1 2016, In : Annals of Statistics. 44, 5, p. 1817-1820 4 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Integrating Evolutionary Game Theory into Mechanistic Genotype-Phenotype Mapping

Zhu, X., Jiang, L., Ye, M., Sun, L., Gragnoli, C. & Wu, R., May 1 2016, In : Trends in Genetics. 32, 5, p. 256-268 13 p.

Research output: Contribution to journalReview article

Game Theory
Genotype
Phenotype
Genetic Selection
Quantitative Trait Loci
2015
25 Citations (Scopus)

An overview of the prediction of protein DNA-binding sites

Si, J., Zhao, R. & Wu, R., Mar 6 2015, In : International journal of molecular sciences. 16, 3, p. 5194-5215 22 p.

Research output: Contribution to journalReview article

Binding sites
DNA
deoxyribonucleic acid
Binding Sites
proteins
14 Citations (Scopus)

A selective overview of feature screening for ultrahigh-dimensional data

Liu, J. Y., Zhong, W. & Li, R., Oct 29 2015, In : Science China Mathematics. 58, 10

Research output: Contribution to journalReview article

Screening
High-dimensional Data
Variable Selection
Biomedical Imaging
Penalized Least Squares
26 Citations (Scopus)

Computational prediction of RNA-binding proteins and binding sites

Si, J., Cui, J., Cheng, J. & Wu, R., Nov 3 2015, In : International journal of molecular sciences. 16, 11, p. 26303-26317 15 p.

Research output: Contribution to journalReview article

RNA-Binding Proteins
Binding sites
RNA
Protein Binding
Binding Sites
23 Citations (Scopus)

Mapping complex traits as a dynamic system

Sun, L. & Wu, R., Jan 1 2015, In : Physics of Life Reviews. 13, p. 155-185 31 p.

Research output: Contribution to journalReview article

Endophenotypes
Quantitative Trait Loci
DNA sequences
Biological systems
Machinery
35 Citations (Scopus)

Metabolic reprogramming and dysregulated metabolism: Cause, consequence and/or enabler of environmental carcinogenesis?

Brooks Robey, R., Weisz, J., Kuemmerle, N., Salzberg, A. C., Berg, A., Brown, D. G., Kubik, L., Palorini, R., Al-Mulla, F., Al-Temaimi, R., Colacci, A., Mondello, C., Raju, J., Woodrick, J., Ivana Scovassi, A., Singh, N., Vaccari, M., Roy, R., Forte, S., Memeo, L. & 10 others, Salem, H. K., Amedei, A., Hamid, R. A., Williams, G. P., Lowe, L., Meyer, J., Martin, F. L., Bisson, W. H., Chiaradonna, F. & Ryan, E. P., Jun 1 2015, In : Carcinogenesis. 36, p. S203-S231

Research output: Contribution to journalReview article

Carcinogenesis
Neoplasms
Toxicology
Gene Expression
2014
4 Citations (Scopus)

Systems mapping of genes controlling chemotherapeutic drug efficiency for cancer stem cells

Wu, W., Feng, S., Wang, Y., Wang, N., Hao, H. & Wu, R., Jan 1 2014, In : Drug Discovery Today. 19, 8, p. 1125-1130 6 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Chromosome Mapping
Pharmaceutical Preparations
Neoplasms
Genetic Association Studies
2013
12 Citations (Scopus)

A dynamic framework for quantifying the genetic architecture of phenotypic plasticity

Wang, Z., Pang, X., Lv, Y., Xu, F., Zhou, T., Li, X., Feng, S., Li, J., Li, Z. & Wu, R., Jan 1 2013, In : Briefings in Bioinformatics. 14, 1, p. 82-95 14 p., bbs009.

Research output: Contribution to journalReview article

Plasticity
Quantitative Trait Loci
Dynamic models
Genes
Genotype
8 Citations (Scopus)

Delivering systems pharmacogenomics towards precision medicine through mathematics

Wang, Y., Wang, N., Wang, J., Wang, Z. & Wu, R., Jun 30 2013, In : Advanced Drug Delivery Reviews. 65, 7, p. 905-911 7 p.

Research output: Contribution to journalReview article

Precision Medicine
Mathematics
Pharmacogenetics
Biomarkers
Pharmaceutical Preparations
1 Citation (Scopus)

Statistical resolution of missing longitudinal data in clinical pharmacogenomics

Wang, Z., Li, H., Wang, J., Li, J. & Wu, R., Jun 30 2013, In : Advanced Drug Delivery Reviews. 65, 7, p. 980-986 7 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Pharmaceutical Preparations
Precision Medicine
Statistical Models
Haplotypes
4 Citations (Scopus)

Stochastic modeling of systems mapping in pharmacogenomics

Wang, Z., Luo, J., Fu, G., Wang, Z. & Wu, R., Jun 30 2013, In : Advanced Drug Delivery Reviews. 65, 7, p. 912-917 6 p.

Research output: Contribution to journalReview article

Pharmacogenetics
Precision Medicine
Pharmaceutical Preparations
Drug Design
Pharmacology
4 Citations (Scopus)

Systems mapping of metabolic genes through control theory

Liu, G., Kong, L., Wang, Z., Wang, C. & Wu, R., Jun 30 2013, In : Advanced Drug Delivery Reviews. 65, 7, p. 918-928 11 p.

Research output: Contribution to journalReview article

Chromosome Mapping
Quantitative Trait Loci
Phenotype
Metabolic Networks and Pathways
Genotype

Theoretical Biology and Medical Modelling: Ensuring continued growth and future leadership

Nishiura, H., Rietman, E. A. & Wu, R., Jul 16 2013, In : Theoretical Biology and Medical Modelling. 10, 1, 43.

Research output: Contribution to journalReview article

Leadership
Biology
Growth
Modeling
Mathematical Biology
27 Citations (Scopus)

Variation in the transcriptional response of threatened coral larvae to elevated temperatures

Polato, N. R., Altman, N. S. & Baums, I. B., Mar 1 2013, In : Molecular Ecology. 22, 5, p. 1366-1382 17 p.

Research output: Contribution to journalReview article

Anthozoa
Larva
corals
coral
larva
2012
2 Citations (Scopus)

A pattern-mixture model for haplotype analysis of longitudinal traits with non-ignorable dropout

Li, H. & Wu, R., Jan 1 2012, In : Statistica Sinica. 22, 1, p. 337-357 21 p.

Research output: Contribution to journalReview article

Pattern-mixture Model
Haplotype
Drop out
Dobutamine
Model
8 Citations (Scopus)

Key observations from the NHLBI Asthma Clinical Research Network

Szefler, S. J., Chinchilli, V., Israel, E., Denlinger, L. C., Lemanske, R. F., Calhoun, W. & Peters, S. P., Jan 1 2012, In : Thorax. 67, 5, p. 450-455 6 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Asthma
Research
Clinical Trials
Leukotriene Antagonists
2011
18 Citations (Scopus)

A conceptual framework for pharmacodynamic genome-wide association studies in pharmacogenomics

Wu, R., Tong, C., Wang, Z., Mauger, D., Tantisira, K., Szefler, S. J., Chinchilli, V. & Israel, E., Oct 1 2011, In : Drug Discovery Today. 16, 19-20, p. 884-890 7 p.

Research output: Contribution to journalReview article

Genome-Wide Association Study
Pharmacogenetics
Pharmaceutical Preparations
Genetic Testing
Genetic Association Studies
124 Citations (Scopus)
Public Health
Smoking
Tobacco Products
Electronic Cigarettes
Smoking Cessation
6 Citations (Scopus)

How to compute which genes control drug resistance dynamics

Guo, Y., Luo, J., Wang, J., Wang, Y. & Wu, R., Apr 1 2011, In : Drug Discovery Today. 16, 7-8, p. 339-344 6 p.

Research output: Contribution to journalReview article

Virus Diseases
Drug Resistance
Viruses
Viral Drug Resistance
Genes
9 Citations (Scopus)

Measures of agreement and concordance with clinical research applications

Landis, J. R., King, T., Choi, J. W., Chinchilli, V. & Koch, G. G., Dec 1 2011, In : Statistics in Biopharmaceutical Research. 3, 2, p. 185-209 25 p.

Research output: Contribution to journalReview article

Concordance
Correlation coefficient
Research
Longitudinal Studies
Research Design
2010
11 Citations (Scopus)

Designs for linkage analysis and association studies of complex diseases.

Cui, Y., Li, G., Li, S. & Wu, R., Nov 9 2010, In : Methods in molecular biology (Clifton, N.J.). 620, p. 219-242 24 p.

Research output: Contribution to journalReview article

Genomics
Genomic Imprinting
Gene Expression
Genetic Linkage
Chromosome Mapping
30 Citations (Scopus)

Mapping genes for plant structure, development and evolution: functional mapping meets ontology

He, Q., Berg, A., Li, Y., Vallejos, C. E. & Wu, R., Jan 1 2010, In : Trends in Genetics. 26, 1, p. 39-46 8 p.

Research output: Contribution to journalReview article

Plant Structures
Plant Development
Chromosome Mapping
Quantitative Trait Loci
Internal-External Control
2009
4 Citations (Scopus)

Computing genetic imprinting expressed by haplotypes.

Cheng, Y., Berg, A., Wu, S., Li, Y. & Wu, R., Jan 1 2009, In : Methods in molecular biology (Clifton, N.J.). 573, p. 189-212 24 p.

Research output: Contribution to journalReview article

Genomic Imprinting
Haplotypes
Genome
Genes
Gene Regulatory Networks
11 Citations (Scopus)

Genetic dissection of complex endosperm traits

Wang, X., Xu, C., Wu, R. & Larkins, B. A., Jul 1 2009, In : Trends in Plant Science. 14, 7, p. 391-398 8 p.

Research output: Contribution to journalReview article

endosperm
epigenetics
genetic techniques and protocols
raw materials
quantitative trait loci
3 Citations (Scopus)

Network models for dissecting plant development by functional mapping

Wu, S., Yap, J. S., Li, Y., Li, Q., Fu, G., Li, J., Das, K., Berg, A., Zeng, Y. & Wu, R., Sep 1 2009, In : Current Bioinformatics. 4, 3, p. 183-187 5 p.

Research output: Contribution to journalReview article

Plant Development
Network Model
Growth and Development
Proteins
Biological Phenomena
4 Citations (Scopus)

Penn state hershey - Center for pediatric cardiovascular research: Guest editorial

Undar, A., Pauliks, L., Clark, J., Zahn, J., Rosenberg, G., Kunselman, A., Sun, Q., Pekkan, K., Saliba, K., Carney, E., Thomas, N., Freeman, W., Vrana, K., El-Banayosy, A., Ural, S., Wilson, R., Umstead, T. M., Floros, J., Phelps, D., Weiss, W. & 15 others, Snyder, A., Yang, S., Kimatian, S., Cyran, S., Chinchilli, V., Guan, Y., Rider, A., Haines, N., Rogerson, A., Alkan-Bozkaya, T., Akcevin, A., Sun, K., Wang, S., Cun, L. & Myers, J., Nov 1 2009, In : Artificial organs. 33, 11, p. 883-887 5 p.

Research output: Contribution to journalReview article

Pediatrics
Research
Perfusion
Students
National Heart, Lung, and Blood Institute (U.S.)
2008
2 Citations (Scopus)

Modeling the genetic control of HIV-1 dynamics after highly active antiretroviral therapy

Ma, C. X., Li, Y. & Wu, R., May 1 2008, In : Current Genomics. 9, 3, p. 208-211 4 p.

Research output: Contribution to journalReview article

Highly Active Antiretroviral Therapy
HIV-1
HIV
Drug Design
Statistical Models
15 Citations (Scopus)

Rejoinder: One-step sparse estimates in nonconcave penalized likelihood models

Zou, H. & Li, R., Aug 1 2008, In : Annals of Statistics. 36, 4, p. 1561-1566 6 p.

Research output: Contribution to journalReview article

Penalized Likelihood
Estimate
Model
2007
8 Citations (Scopus)

A general quantitative genetic model for haplotyping a complex trait in humans

Wu, S., Yang, J., Wang, C. & Wu, R., Aug 1 2007, In : Current Genomics. 8, 5, p. 343-350 8 p.

Research output: Contribution to journalReview article

Genetic Models
Haplotypes
Single Nucleotide Polymorphism
Diploidy
Uncertainty
14 Citations (Scopus)
Meta-Analysis
Asthma
Publication Bias
Causality
Placebos
37 Citations (Scopus)
National Heart, Lung, and Blood Institute (U.S.)
Asthma
Clinical Trials
Guidelines
Research
8 Citations (Scopus)

Mapping nucleotide sequences that encode complex binary disease traits with HapMap

Cui, Y., Fu, W., Sun, K., Romero, R. & Wu, R., Aug 1 2007, In : Current Genomics. 8, 5, p. 307-322 16 p.

Research output: Contribution to journalReview article

HapMap Project
Genetic Association Studies
Single Nucleotide Polymorphism
Human Genome
Computer Simulation
72 Citations (Scopus)

The floral genome: an evolutionary history of gene duplication and shifting patterns of gene expression

Soltis, D. E., Ma, H., Frohlich, M. W., Soltis, P. S., Albert, V. A., Oppenheimer, D. G., Altman, N. S., Depamphilis, C. W. & Leebens-Mack, J., Aug 1 2007, In : Trends in Plant Science. 12, 8, p. 358-367 10 p.

Research output: Contribution to journalReview article

gene duplication
Angiospermae
gene expression
genome
genes
2006
13 Citations (Scopus)

Clustering periodic patterns of gene expression based on fourier approximations

Kim, B. R., Littell, R. C. & Wu, R., May 1 2006, In : Current Genomics. 7, 3, p. 197-203 7 p.

Research output: Contribution to journalReview article

Cluster Analysis
Gene Expression
Technology
cdc Genes
Periodicity
8 Citations (Scopus)

Detecting sequence-sequence interactions for complex diseases

Lin, M. & Wu, R., Mar 1 2006, In : Current Genomics. 7, 1, p. 59-72 14 p.

Research output: Contribution to journalReview article

HapMap Project
Haplotypes
Nucleotides
Quantitative Trait Loci
Single Nucleotide Polymorphism
1 Citation (Scopus)

Epistatic control of human obesity as revealed by linkage disequilibrium mapping: A report from the NHLBI-sponsored WISE study

Li, H., Wu, R., Lin, M., Terra, S. G., Pepine, C. J., McGorray, S. P., Johnson, B. D. & Johnson, J. A., Nov 1 2006, In : Current Genomics. 7, 7, p. 463-468 6 p.

Research output: Contribution to journalReview article

National Heart, Lung, and Blood Institute (U.S.)
Chromosome Mapping
Linkage Disequilibrium
Ischemia
Obesity
221 Citations (Scopus)

Opinion: Functional mapping - How to map and study the genetic architecture of dynamic complex traits

Wu, R. & Lin, M., Mar 1 2006, In : Nature Reviews Genetics. 7, 3, p. 229-237 9 p.

Research output: Contribution to journalReview article

Quantitative Trait Loci
Nucleotides
Gene Regulatory Networks
Genes
2004
23 Citations (Scopus)

Head Injury and Pulmonary Embolism: A Retrospective Report Based on the Pennsylvania Trauma Outcomes Study

Page, R. B., Spott, M. A., Krishnamurthy, S., Taleghani, C., Chinchilli, V., Kelly, D. F., Chandler, W. F., Marion, D. W. & Wilberger, J. E., Jan 1 2004, In : Neurosurgery. 54, 1, p. 143-149 7 p.

Research output: Contribution to journalReview article

Pulmonary Embolism
Craniocerebral Trauma
Outcome Assessment (Health Care)
Wounds and Injuries
Incidence
2003
24 Citations (Scopus)

Molecular Dissection of Allometry, Ontogeny, and Plasticity: A Genomic View of Developmental Biology

Wu, R., Ma, C. X., Lou, X. Y. & Casella, G., Jan 1 2003, In : BioScience. 53, 11, p. 1041-1047 7 p.

Research output: Contribution to journalReview article

Developmental Biology
allometry
ontogeny
Dissection
genomics
27 Citations (Scopus)

Quantitative trait loci of growth trajectories in Populus

Wu, R., Ma, C. X., Yang, M. C. K., Chang, M., Littell, R. C., Santra, U., Wu, S. S., Yin, T., Huang, M., Wang, M. & Casella, G., Feb 2003, In : Genetical Research. 81, 1, p. 51-64 14 p.

Research output: Contribution to journalReview article

Populus
Quantitative Trait Loci
Growth
Biological Phenomena
Genetic Linkage
2002
13 Citations (Scopus)

A unified framework for mapping quantitative trait loci in bivalent tetraoploids using single-dose restriction fragments: A case study from alfalfa

Ma, C. X., Casella, G., Shen, Z. J., Osborn, T. C. & Wu, R., Dec 1 2002, In : Genome research. 12, 12, p. 1974-1981 8 p.

Research output: Contribution to journalReview article

Medicago sativa
Quantitative Trait Loci
Chromosome Pairing
Polyploidy
Meiosis