Department of Biochemistry and Molecular Biology

  • United States

Organization profile

Organization profile

The Department of Biochemistry and Molecular Biology at Penn State College of Medicine strives to marry the increasingly powerful tools of genomics and computational biology with the classic approaches of biochemistry and molecular biology to reveal fundamental processes of biology and to convert those discoveries into treatments that improve the well-being of patients.

Fingerprint Dive into the research topics where Department of Biochemistry and Molecular Biology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Proteins Medicine & Life Sciences
Genes Medicine & Life Sciences
DNA Medicine & Life Sciences
Mutation Medicine & Life Sciences
Yeasts Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

No photo of Cesar Aliaga

Cesar Aliaga, MS

Person: Academic

19942018
No photo of Maria Bewley
19922017
No photo of Paula Dalessio
19932014
No photo of Arunangshu Das
19972016
Photo of Nikolay Dokholyan
19942021

Research Output 1969 2020

De novo resonance assignment of the transmembrane domain of LR11/SorLA in E. coli membranes

Ding, X., Fu, R. & Tian, F., Jan 2020, In : Journal of Magnetic Resonance. 310, 106639.

Research output: Contribution to journalArticle

Escherichia coli
membranes
proteins
Membranes
Membrane Proteins

Ligand-induced disorder-to-order transitions characterized by structural proteomics and molecular dynamics simulations

Makepeace, K. A. T., Brodie, N. I., Popov, K. I., Gudavicius, G., Nelson, C. J., Petrotchenko, E. V., Dokholyan, N. V. & Borchers, C. H., Jan 16 2020, In : Journal of Proteomics. 211, 103544.

Research output: Contribution to journalArticle

Open Access
Molecular Dynamics Simulation
Proteomics
Molecular dynamics
Ligands
Computer simulation

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K. C., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

Chirasani, V. R., Xu, L., Addis, H. G., Pasek, D. A., Dokholyan, N. V., Meissner, G. & Yamaguchi, N., Aug 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C358-C365

Research output: Contribution to journalArticle

Central Core Myopathy
Ryanodine Receptor Calcium Release Channel
Skeletal Muscle
Binding Sites
Mutation

Activation of Wnt signaling promotes olaparib resistant ovarian cancer

Yamamoto, T. M., McMellen, A., Watson, Z. L., Aguilera, J., Ferguson, R., Nurmemmedov, E., Thakar, T., Moldovan, G-L., Kim, H., Cittelly, D. M., Joglar, A. M., Brennecke, E. P., Wilson, H., Behbakht, K., Sikora, M. J. & Bitler, B. G., Oct 1 2019, In : Molecular Carcinogenesis. 58, 10, p. 1770-1782 13 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Ovarian Diseases
Recombinational DNA Repair
Cell Line
12 Citations (Scopus)

Allostery in Its Many Disguises: From Theory to Applications

Wodak, S. J., Paci, E., Dokholyan, N. V., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., Hamm, P., Stote, R. H., Eberhardt, J., Chebaro, Y., Dejaegere, A., Cecchini, M., Changeux, J. P., Bolhuis, P. G., Vreede, J., Faccioli, P. & 19 others, Orioli, S., Ravasio, R., Yan, L., Brito, C., Wyart, M., Gkeka, P., Rivalta, I., Palermo, G., McCammon, J. A., Panecka-Hofman, J., Wade, R. C., Di Pizio, A., Niv, M. Y., Nussinov, R., Tsai, C. J., Jang, H., Padhorny, D., Kozakov, D. & McLeish, T., Apr 2 2019, In : Structure. 27, 4, p. 566-578 13 p.

Research output: Contribution to journalReview article

Allosteric Regulation
Biological Phenomena
Education
Drug Design
Signal Transduction

An R package for model fitting, model selection and the simulation for longitudinal data with dropout missingness

Xu, C., Li, Z., Xue, Y., Zhang, L. & Wang, M., Oct 21 2019, In : Communications in Statistics: Simulation and Computation. 48, 9, p. 2812-2829 18 p.

Research output: Contribution to journalArticle

Drop out
Model Fitting
Longitudinal Data
Model Selection
Weighted Estimating Equations
1 Citation (Scopus)
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Polymorphism
Inflammatory Bowel Diseases
5 Citations (Scopus)

Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents

He, F., Berg, A., Imamura, Y., Bixler, E., Fernandez-Mendoza, J., Whitsel, E. A. & Liao, D., Dec 1 2019, In : Scientific reports. 9, 1, 2079.

Research output: Contribution to journalArticle

DNA Methylation
Body Mass Index
Obesity
Genes
Pediatric Obesity
2 Citations (Scopus)

Association between inflammatory cytokine levels and anemia during Plasmodium falciparum and Plasmodium vivax infections in Mangaluru: A Southwestern Coastal Region of India

Punnath, K., Dayanand, K. K., Chandrashekhar, V. N., Achur, R. N., Kakkilaya, S. B., Ghosh, S. K., Kumari, S. N. & Gowda, C., Jul 1 2019, In : Tropical Parasitology. 9, 2, p. 98-107 10 p.

Research output: Contribution to journalArticle

Plasmodium vivax
Plasmodium falciparum
Malaria
Anemia
India

Projects 1981 2023

Autophagy
Lipids
Membranes
Heart Neoplasms
Structural Models
Amyloid beta-Protein Precursor
Alzheimer Disease
Amyloid
Protein Transport
Therapeutics
Health
Bioinformatics
Statistics
Information science
Big data
Nitrosamines
DNA Adducts
Tobacco
Oligodeoxyribonucleotides
Smoke
chronic illness
career
Disease
student
experience
Yeasts
Food
Transcription Factors
Metabolome
Growth
Membranes
Lipids
Bacillus subtilis
Recognition (Psychology)
Capsid Proteins
Adenocarcinoma
Actins
Neoplasm Metastasis
Cell Movement
Pancreatic Stellate Cells

Activities 2017 2017

  • 3 Oral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation