Department of Biochemistry and Molecular Biology

Websitehttps://med.psu.edu/biochemistry

Postal address
United States

Organization profile

The Department of Biochemistry and Molecular Biology at Penn State College of Medicine strives to marry the increasingly powerful tools of genomics and computational biology with the classic approaches of biochemistry and molecular biology to reveal fundamental processes of biology and to convert those discoveries into treatments that improve the well-being of patients.

Cesar Aliaga, MS
- Department of Biochemistry and Molecular Biology - Senior Research Associate
Person: Academic
19942021
Maria Bewley, PhD
- Department of Biochemistry and Molecular Biology - Associate Professor
Person: Academic
19922020
James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Department of Otolaryngology - Head and Neck Surgery - Professor
- Institute for Personalized Medicine - Director
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
19752021
Laura Carrel, MA, PhD
- Department of Biochemistry and Molecular Biology - Associate Professor
- Huck Institutes of the Life Sciences
Person: Academic
19912020
Kun-Ming Chen, PhD, MS
- Department of Biochemistry and Molecular Biology - Associate Professor
- Cancer Institute, Mechanisms of Carcinogenesis
- Penn State Cancer Institute
Person: Academic
20042021
Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Cancer Institute, Next-Generation Therapies
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
Person: Academic
19842021
Gary Clawson, MS, PhD, MD
- Department of Pathology and Laboratory Medicine - Professor Emeritus
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Professor Emeritus
- Cancer Institute, Next-Generation Therapies
- Penn State Cancer Institute
- Materials Research Institute (MRI)
Person: Academic
19772019
Arunangshu Das, MSc, PhD
- Department of Biochemistry and Molecular Biology - Assistant Professor
Person: Academic
19972016
Nikolay Dokholyan, PhD, MS
- Department of Pharmacology - G. Thomas Passananti Professor and Vice Chair for Research
- Department of Biochemistry and Molecular Biology - Professor
- Penn State Cancer Institute
- Penn State Neuroscience Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
19942021
Keri Donaldson, MD, MS
- Department of Biochemistry and Molecular Biology - Assistant Professor
- Department of Public Health Sciences - Assistant Professor
- Institute for Personalized Medicine
Person: Academic
20102019

141901 Citations
161 h-Index
2293 Article
168 Review article
57 Comment/debate
34 Chapter
More

Abdominal pain in quiescent inflammatory bowel disease
Coates, M. D., Johri, A., Gorrepati, V. S., Maheshwari, P., Dalessio, S., Walter, V., Stuart, A., Koltun, W., Bernasko, N., Tinsley, A., Williams, E. D. & Clarke, K., Jan 2021, In: International Journal of Colorectal Disease. 36, 1, p. 93-102 10 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Acquired antibody responses against merozoite surface protein-1₁₉ antigen during Plasmodium falciparum and P.vivax infections in South Indian city of Mangaluru
Punnath, K., Dayanand, K. K., Midya, V., Chandrashekar, V. N., Achur, R. N., Kakkilaya, S. B., Ghosh, S. K., Kumari, S. N. & Gowda, D. C., Mar 2021, In: Journal of Parasitic Diseases. 45, 1, p. 176-190 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis
Chen, Y. C., Dinavahi, S. S., Feng, Q., Gowda, R., Ramisetti, S., Xia, X., LaPenna, K. B., Chirasani, V. R., Cho, S. H., Hafenstein, S. L., Battu, M. B., Berg, A., Sharma, A. K., Kirchhausen, T., Dokholyan, N. V., Amin, S., He, P. & Robertson, G. P., May 28 2021, In: Cancer Letters. 506, p. 107-119 13 p.
Research output: Contribution to journal › Article › peer-review
Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants
Piltonen, M., Krokhotin, A., Parisien, M., Bérubé, P., Djambazian, H., Sladek, R., Dokholyan, N. V., Shabalina, S. A. & Diatchenko, L., Jul 2021, In: Cellular and Molecular Neurobiology. 41, 5, p. 1039-1055 17 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Dominguez, L., Shea, J. E., Dokholyan, N. V., de Simone, A., Ma, B., Nussinov, R., Najafi, S., Ngo, S. T., Loquet, A., Chiricotto, M., Ganguly, P., McCarty, J., Li, M. S., Hall, C. & 14 others, Wang, Y., Miller, Y., Melchionna, S., Habenstein, B., Timr, S., Chen, J., Hnath, B., Strodel, B., Kayed, R., Lesné, S., Wei, G., Sterpone, F., Doig, A. J. & Derreumaux, P., Feb 24 2021, In: Chemical Reviews. 121, 4, p. 2545-2647 103 p.
Research output: Contribution to journal › Review article › peer-review
35 Scopus citations
An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy
Ye, Y., Tyndall, E. R., Bui, V., Tang, Z., Shen, Y., Jiang, X., Flanagan, J. M., Wang, H. G. & Tian, F., Dec 2021, In: Nature communications. 12, 1, 374.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D₂ receptor-dependent, manner
Weissenrieder, J. S., Reed, J. L., Moldovan, G. L., Johnson, M. T., Trebak, M., Neighbors, J. D., Mailman, R. B. & Hohl, R. J., Jun 2021, In: Pharmacology Research and Perspectives. 9, 3, e00689.
Research output: Contribution to journal › Article › peer-review

Open Access
Aptamer-targeted calcium phosphosilicate nanoparticles for effective imaging of pancreatic and prostate cancer
Abraham, T., McGovern, C. O., Linton, S. S., Wilczynski, Z., Adair, J. H. & Matters, G. L., 2021, In: International Journal of Nanomedicine. 16, p. 2297-2309 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Bacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort
for the Efraim investigators and the Nine-I study group, Aug 2021, In: Journal of Critical Care. 64, p. 114-119 6 p.
Research output: Contribution to journal › Article › peer-review
Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis
Patrick, M. T., Stuart, P. E., Zhang, H., Zhao, Q., Yin, X., He, K., Zhou, X. J., Mehta, N. N., Voorhees, J. J., Boehnke, M., Gudjonsson, J. E., Nair, R. P., Handelman, S. K., Elder, J. T., Liu, D. J. & Tsoi, L. C., Jun 2021, In: Journal of Investigative Dermatology. 141, 6, p. 1493-1502 10 p.
Research output: Contribution to journal › Article › peer-review
3 Scopus citations

6 Active
45 Finished

The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Nicolae, C.
National Cancer Institute
2/1/21 → 1/30/22
Project: Research project
High-throughput surveillance of gut mucosal polysaccharides
Townsend, G. E.
National Institute of Allergy and Infectious Diseases
2/1/21 → 1/31/22
Project: Research project
The role of DNA damage tolerance pathways in human cells
Moldovan, G., Bielinsky, A. K., MOLDOVAN, G. L. & Bielinsky, A. K.
National Institute of General Medical Sciences
8/14/19 → 5/31/22
Project: Research project
Metabolic activation of nitroarenes and Nrf2-Keap1
El-Bayoumy, K. & Penning, T.
National Institute of Environmental Health Sciences
5/8/19 → 4/30/22
Project: Research project
Chemoprevention by Black Raspberry of Oral Cancer Induced by Tobacco Carcinogens: Translational Studies
El-Bayoumy, K.
National Cancer Institute
4/1/13 → 1/31/22
Project: Research project
Genotoxicity and Repair of Tobacco-Specific Nitrosamine DNA Adducts
Spratt, T. & SPRATT, T.
National Institute of Environmental Health Sciences
7/20/12 → 5/31/22
Project: Research project
Nuclear AXIN2 and Colorectal Cancer
Yochum, G.
National Cancer Institute
7/1/19 → 6/30/20
Project: Research project
Cellular responses to exogenous and endogenous assault
Spratt, T.
National Institute of Environmental Health Sciences
7/1/19 → 6/30/20
Project: Research project
Targeting Rab6-km23-1-mediated compartmentalized trafficking as a novel therapeutic approach to Alzheimers Disease
Mulder, K. & LIOTTA, L. A.
National Institute on Aging
8/15/18 → 5/31/21
Project: Research project
Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
Chen, K. & Chen, K. M.
National Institute of Environmental Health Sciences
9/15/13 → 8/31/17
Project: Research project

3 Oral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017
Activity: Talk types › Oral presentation
Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017
Activity: Talk types › Oral presentation
Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017
Activity: Talk types › Oral presentation

40 Under 40
Festa, Fernanda (Recipient), 2013
Prize: Honorary award
Basic Science Career Mentor Award
Liu, Dajiang (Recipient), 2021
Prize
Basic Science Master Career Mentor Award
Dovat, Sinisa (Recipient), 2018
Prize
Basil O’Connor Starter Scholar Research Award
Dokholyan, Nikolay (Recipient), 2004
Prize
Career Citation Milestone Award - D (500) Club
Bixler, E. (Recipient) & Cheng, Keith (Recipient), 2016
Prize
Career Citation Milestone Award - D (500) Club
Broach, James (Recipient), Coates, Matthew (Recipient), Duffy, Charles (Recipient), Gardner, Andrew (Recipient), Gill, Donald (Recipient), Helm, Klaus (Recipient), Kimball, Scot (Recipient), Leslie, Douglas (Recipient), Lipton, Allan (Recipient), Ma, Thomas (Recipient), Naccarelli, Gerald (Recipient), Schmitz, Kathryn (Recipient), Siedlecki, Christopher (Recipient), Stoute, Jose (Recipient), Tombran-Tink, J. (Recipient) & Wang, Hong-Gang (Recipient), 2020
Prize
Career Citation Milestone Award - D (500) Club
Barber, Alistair (Recipient), Belani, Chandra (Recipient), Bixler, E. (Recipient), Eslinger, Paul (Recipient), Imamura, Yuka (Recipient), Legro, Richard (Recipient), Mailman, Richard (Recipient), Schiff, Steven (Recipient), Vgontzas, Alexandros (Recipient) & Wang, Hong-Gang (Recipient), 2019
Prize
Career Citation Milestone Award - M (1000) Club
Barnstable, Colin (Recipient) & Broach, James (Recipient), 2017
Prize
Career Citation Milestone Award - M (1000) Club
Carrel, Laura (Recipient), Cheng, Keith (Recipient) & Chin, Thomas (Recipient), 2020
Prize
Dean's Award for Excellence in Teaching
Aprile, Bettina (Recipient), Aumiller, Betsy B. (Recipient), Berkey, Franklin (Recipient), Bonavia, Anthony (Recipient), Booth, Jennifer (Recipient), Brennan, K. (Recipient), Browning, Kirsteen (Recipient), Buchkovich, Nicholas (Recipient), Butt, Fauzia K. (Recipient), Carrel, Laura (Recipient), Choe, Angela (Recipient), Clarke, Sheila (Recipient), Coleman, Melissa (Recipient), Dalke, Katharine (Recipient), Devaraj, Tara (Recipient), Duryea, Stacey (Recipient), Enama, Joseph (Recipient), Evey, Loren (Recipient), Finch, Elizabeth (Recipient), Fischer, Michelle (Recipient), Gallo, Robert (Recipient), Gavigan, Patrick (Recipient), Ghaffari, Gisoo (Recipient), Go, Pauline (Recipient), Grana, Jennifer (Recipient), Greensmith, James (Recipient), Grogan, James (Recipient), Hajnal, Andras (Recipient), Helm, Matthew (Recipient), Hempel, N. (Recipient), Hussein, Rezhan (Recipient), Imamura, Fumiaki (Recipient), Jain, Rohit (Recipient), Jeganathan, Nimalan (Recipient), Kelle, Angela (Recipient), Kumar, Ashutosh (Recipient), Kwun, Hyun Jin (Recipient), Lang, Charles (Recipient), Lutzkanin, Andrew (Recipient), Martin, Kathryn (Recipient), McGarrity, Thomas (Recipient), McHale, Katie (Recipient), McLaughlin, Patricia (Recipient), Mormando, Charles (Recipient), Nguyen, Joseph (Recipient), Nickolich, Myles (Recipient), Ouyang, Tao (Recipient), Pachuski, Justin (Recipient), Polimera, Hyma (Recipient), Potochny, Evelyn (Recipient), Rakszawski, Kevin L. (Recipient), Reyes, Lilia (Recipient), Sankoorikal, Binu-john (Recipient), Shantz, Lisa (Recipient), Singh, Madhavi (Recipient), Songdej, Natthapol (Recipient), Spotts, Ryan (Recipient), Swigart, Alison (Recipient), Varner, Malina (Recipient), Verma, Navin (Recipient), Walter, Vonn (Recipient), Wang, Che-Yen "Joseph" (Recipient), Warfield, Dennis (Recipient) & Wilson, Meghan N. (Recipient), 2021
Prize