Department of Biochemistry and Molecular Biology

Websitehttps://med.psu.edu/biochemistry

Postal addressShow on map
United States

The Department of Biochemistry and Molecular Biology at Penn State College of Medicine strives to marry the increasingly powerful tools of genomics and computational biology with the classic approaches of biochemistry and molecular biology to reveal fundamental processes of biology and to convert those discoveries into treatments that improve the well-being of patients.

Cesar Aliaga, MS
- Department of Biochemistry and Molecular Biology - Senior Research Associate
Person: Academic
19942021
Maria Bewley, PhD
- Penn State College of Medicine - Senior Scientific Director, Core Facilities
- Department of Biochemistry and Molecular Biology - Associate Professor
Person: Academic
19852021
James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Department of Otolaryngology - Head and Neck Surgery - Professor
- Institute for Personalized Medicine - Director
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
19752022
Laura Carrel, MA, PhD
- Department of Biochemistry and Molecular Biology - Associate Professor
- Huck Institutes of the Life Sciences
Person: Academic
19912022
Kun-Ming Chen, PhD, MS
- Department of Biochemistry and Molecular Biology - Associate Professor
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
20042021
Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
- Institute for Computational and Data Sciences (ICDS)
- Cancer Institute, Next-Generation Therapies
Person: Academic
19842022
Gary Clawson, MS, PhD, MD
- Department of Pathology and Laboratory Medicine - Professor Emeritus
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Professor Emeritus
- Penn State Cancer Institute
- Materials Research Institute (MRI)
- Cancer Institute, Next-Generation Therapies
Person: Academic
19772021
Arunangshu Das, MSc, PhD
- Department of Biochemistry and Molecular Biology - Assistant Professor
Person: Academic
19972016
David Degraff, PhD
- Department of Pathology and Laboratory Medicine - Associate Professor
- Division of Experimental Pathology
- Department of Urology - Associate Professor
- Department of Biochemistry and Molecular Biology - Associate Professor
- Penn State Cancer Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
20072022
Nikolay Dokholyan, PhD, MS
- Department of Pharmacology - G. Thomas Passananti Professor and Vice Chair for Research
- Department of Biochemistry and Molecular Biology - Professor
- Penn State Clinical and Translational Science Institute (CTSI) - Associate Director
- Penn State Cancer Institute
- Penn State Neuroscience Institute
- Cancer Institute, Next-Generation Therapies
Person: Academic
19942022

158885 Citations
167 h-index
2498 Article
190 Review article
63 Comment/debate
40 Chapter
More

AlphaFold illuminates half of the dark human proteins
Binder, J. L., Berendzen, J., Stevens, A. O., He, Y., Wang, J., Dokholyan, N. V. & Oprea, T. I., Jun 2022, In: Current Opinion in Structural Biology. 74, 102372.
Research output: Contribution to journal › Review article › peer-review

Open Access
2 Scopus citations
Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE
Gao, G. F., Liu, D., Zhan, X. & Li, B., Dec 2022, In: BMC Biology. 20, 1, 191.
Research output: Contribution to journal › Article › peer-review

Open Access
Anhydrous Nucleic Acid Nanoparticles for Storage and Handling at Broad Range of Temperatures
Tran, A. N., Chandler, M., Halman, J., Beasock, D., Fessler, A., McKeough, R. Q., Lam, P. A., Furr, D. P., Wang, J., Cedrone, E., Dobrovolskaia, M. A., Dokholyan, N. V., Trammell, S. R. & Afonin, K. A., Apr 1 2022, In: Small. 18, 13, 2104814.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Antiemetic effects of baclofen in a shrew model of postoperative nausea and vomiting: Whole-transcriptome analysis in the nucleus of the solitary tract
Konno, D., Sugino, S., Shibata, T. F., Misawa, K., Imamura-Kawasawa, Y., Suzuki, J., Kido, K., Nagasaki, M. & Yamauchi, M., Jun 2022, In: CNS Neuroscience and Therapeutics. 28, 6, p. 922-931 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability
Ganapathy, A. S., Saha, K., Suchanec, E., Singh, V., Verma, A., Yochum, G., Koltun, W., Nighot, M., Ma, T. & Nighot, P., 2022, In: Autophagy. 18, 9, p. 2086-2103 18 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Association of dietary sulfur amino acid intake with mortality from diabetes and other causes
Dong, Z., Gao, X., Chinchilli, V. M., Sinha, R., Muscat, J., Winkels, R. & Richie, J. P., Feb 2022, In: European Journal of Nutrition. 61, 1, p. 289-298 10 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Association of Spinal Cord Stimulator Implantation with Persistent Opioid Use in Patients with Postlaminectomy Syndrome
Vu, T. N., Khunsriraksakul, C., Vorobeychik, Y., Liu, A., Sauteraud, R., Shenoy, G., Liu, D. J. & Cohen, S. P., 2022, (Accepted/In press) In: JAMA network open. e2145876.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes (Nature, (2020), 583, 7818, (699-710), 10.1038/s41586-020-2493-4)
The ENCODE Project Consortium, May 12 2022, In: Nature. 605, 7909, p. E3
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
Author Correction: Perspectives on ENCODE (Nature, (2020), 583, 7818, (693-698), 10.1038/s41586-020-2449-8)
The ENCODE Project Consortium, May 12 2022, In: Nature. 605, 7909, p. E4
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale
Yakovlev, M. A., Vanselow, D. J., Ngu, M. S., Zaino, C. R., Katz, S. R., Ding, Y., Parkinson, D., Wang, S. Y., Ang, K. C., La Riviere, P. & Cheng, K. C., Mar 1 2022, In: Journal of Synchrotron Radiation. 29, p. 505-514 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access

1 Not started
12 Active
77 Finished

Variants underlying sex bias in Systemic Lupus Erythematosus
Carrel, L. & Liu, D. D.
National Institute of Allergy and Infectious Diseases
11/1/21 → 10/31/22
Project: Research project
Discovery of functionally selective dopamine ligands for age-related cognitive decline
Yang, Y., Mailman, R. & Dokholyan, N.
National Institute on Aging
6/1/21 → 5/31/24
Project: Research project
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Nicolae, C. & Nicolae, C. M.
National Cancer Institute
2/1/21 → 1/31/23
Project: Research project
Translational Studies on Electronic Cigarette-derived Oxidants and their Long-term Pulmonary Effects
Richie, J., Sinha, R., Sinha, R. R. & Sinha, R.
National Heart, Lung, and Blood Institute
7/1/20 → 6/30/23
Project: Research project
Regulation of Cell Intrinsic Immunity in Bladder Cancer
Degraff, D.
Congressionally Directed Medical Research Programs
1/1/20 → …
Project: Research project
The role of DNA damage tolerance pathways in human cells
Bielinsky, A. A., Moldovan, G., Moldovan, G. G. L. & Moldovan, G.
National Institute of General Medical Sciences
8/14/19 → 5/31/23
Project: Research project
The four dimensions of nucleosome chain folding
Grigoryev, S.
National Science Foundation
8/1/19 → 7/31/23
Project: Research project
Identification and Characterization of a Novel Posttranslational Modification of Merlin in Tumor Suppression
Li, W.
Congressionally Directed Medical Research Programs
1/1/17 → …
Project: Research project
The Role of Mono-ADP-Ribosylation by PARP14 in Radioresistance
Moldovan, G. G. L. & Moldovan, G.
National Institute of Environmental Health Sciences
2/1/16 → 12/31/22
Project: Research project
The PCNA-PARI Pathway of Genome Stability in Cancer
Moldovan, G.
Congressionally Directed Medical Research Programs
1/1/14 → …
Project: Research project

3 Oral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker) & D Vanselow (Speaker)
Sep 27 2017
Activity: Talk types › Oral presentation
Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)
Nov 4 2017
Activity: Talk types › Oral presentation
Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker) & PJ La Riviere (Speaker)
Jul 5 2017
Activity: Talk types › Oral presentation

40 Under 40
Festa, F. (Recipient), 2013
Prize: Honorary award
AAAS Fellow
Cheng, Keith (Recipient), 2020
Prize
Basic Science Career Mentor Award
Liu, Dajiang (Recipient), 2021
Prize
Basic Science Master Career Mentor Award
Dovat, Sinisa (Recipient), 2018
Prize
Basil O’Connor Starter Scholar Research Award
Dokholyan, Nikolay (Recipient), 2004
Prize
Career Citation Milestone Award - D (500) Club
Broach, James (Recipient), Coates, Matthew (Recipient), Duffy, C. (Recipient), Gardner, Andrew (Recipient), Gill, Donald (Recipient), Helm, Klaus (Recipient), Kimball, Scot (Recipient), Leslie, Douglas (Recipient), Lipton, Allan (Recipient), Ma, Thomas (Recipient), Naccarelli, Gerald (Recipient), Schmitz, Kathryn (Recipient), Siedlecki, Christopher (Recipient), Stoute, Jose (Recipient), Tombran-Tink, J. (Recipient) & Wang, Hong-Gang (Recipient), 2020
Prize
Career Citation Milestone Award - D (500) Club
Barber, Alistair (Recipient), Belani, Chandra (Recipient), Bixler, E. (Recipient), Eslinger, Paul (Recipient), Imamura, Y. (Recipient), Legro, Richard (Recipient), Mailman, Richard (Recipient), Schiff, S. (Recipient), Vgontzas, Alexandros (Recipient) & Wang, Hong-Gang (Recipient), 2019
Prize
Career Citation Milestone Award - D (500) Club
Bixler, E. (Recipient) & Cheng, Keith (Recipient), 2016
Prize
Career Citation Milestone Award - M (1000) Club
Barnstable, Colin (Recipient) & Broach, James (Recipient), 2017
Prize
Career Citation Milestone Award - M (1000) Club
Carrel, Laura (Recipient), Cheng, Keith (Recipient) & Chin, Thomas (Recipient), 2020
Prize