Research Output per year
Organization profile
Organization profile
The Department of Biochemistry and Molecular Biology at Penn State College of Medicine strives to marry the increasingly powerful tools of genomics and computational biology with the classic approaches of biochemistry and molecular biology to reveal fundamental processes of biology and to convert those discoveries into treatments that improve the well-being of patients.
Fingerprint Dive into the research topics where Department of Biochemistry and Molecular Biology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Proteins
Medicine & Life Sciences
Genes
Medicine & Life Sciences
DNA
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Yeasts
Medicine & Life Sciences
Chromatin
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Plasmodium falciparum
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Profiles
Cesar Aliaga, MS
- Department of Biochemistry and Molecular Biology - Senior Research Associate
Person: Academic
Maria Bewley, PhD
- Department of Biochemistry and Molecular Biology - Associate Professor
Person: Academic
James Broach, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor and Chair
- Institute for Personalized Medicine
- Penn State Cancer Institute
- Cancer Institute, Experimental Therapeutics
Person: Academic
Laura Carrel, MA, PhD
- Department of Biochemistry and Molecular Biology - Associate Professor
- Huck Institutes of the Life Sciences
Person: Academic
Kun-Ming Chen, PhD, MS
- Department of Biochemistry and Molecular Biology - Associate Professor
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
Keith Cheng, MD, PhD
- Department of Pathology and Laboratory Medicine - Distinguished Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Department of Pharmacology - Distinguished Professor
- Penn State Cancer Institute
- Huck Institutes of the Life Sciences
- Cancer Institute, Experimental Therapeutics
Person: Academic
Gary Clawson, MS, PhD, MD
- Department of Pathology and Laboratory Medicine - Professor
- Division of Experimental Pathology
- Department of Biochemistry and Molecular Biology - Professor
- Penn State Cancer Institute
- Materials Research Institute (MRI)
- Cancer Institute, Experimental Therapeutics
Person: Academic
Paula Dalessio, MS, PhD
- Department of Biochemistry and Molecular Biology - Assistant Professor
Person: Academic
Arunangshu Das, MSc, PhD
- Department of Biochemistry and Molecular Biology - Assistant Professor
Person: Academic
Nikolay Dokholyan, PhD, MS
- Department of Pharmacology - G. Thomas Passananti Professor and Vice Chair for Research
- Department of Biochemistry and Molecular Biology - G. Thomas Passananti Professor
- Cancer Institute, Experimental Therapeutics
- Penn State Cancer Institute
Person: Academic
Research Output 1969 2019
6
Citations
(Scopus)
Allostery in Its Many Disguises: From Theory to Applications
Wodak, S. J., Paci, E., Dokholyan, N., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., Hamm, P., Stote, R. H., Eberhardt, J., Chebaro, Y., Dejaegere, A., Cecchini, M., Changeux, J. P., Bolhuis, P. G., Vreede, J., Faccioli, P. & 19 others, , Apr 2 2019, In : Structure. 27, 4, p. 566-578 13 p.Research output: Contribution to journal › Review article
Allosteric Regulation
Biological Phenomena
Education
Drug Design
Signal Transduction
A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme
Gonzalez-Lopez, E., Kawasawa-Imamura, Y., Zhang, L., Huang, X., Koltun, W., Coates, M. & Vrana, K., Feb 1 2019, In : PloS one. 14, 2, e0210175.Research output: Contribution to journal › Article
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Polymorphism
Inflammatory Bowel Diseases
4
Citations
(Scopus)
Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents
He, F., Berg, A., Imamura, Y., Bixler, E., Fernandez-Mendoza, J., Whitsel, E. A. & Liao, D., Dec 1 2019, In : Scientific reports. 9, 1, 2079.Research output: Contribution to journal › Article
DNA Methylation
Body Mass Index
Obesity
Genes
Pediatric Obesity
13
Citations
(Scopus)
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
23andMe Research Team, HUNT All-In Psychiatry, Liu, M., Jiang, Y., Wedow, R., Li, Y., Brazel, D. M., Chen, F., Datta, G., Davila-Velderrain, J., McGuire, D., Tian, C., Zhan, X., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P. & 32 others, , Feb 1 2019, In : Nature Genetics. 51, 2, p. 237-244 8 p.Research output: Contribution to journal › Letter
Tobacco Use
Alcohols
Tobacco Use Cessation
Genetic Association Studies
Synaptic Transmission
Brexanolone, a neurosteroid antidepressant, vindicates the gabaergic deficit hypothesis of depression and may foster resilience [version 1; peer review: 4 approved]
Luscher, B. & Möhler, H., Jan 1 2019, In : F1000Research. 8, 751.Research output: Contribution to journal › Review article
Open Access
Pregnanolone
Peer Review
Antidepressive Agents
Neurotransmitter Agents
Depression
Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies
Sarker, M., Lee, H. T., Mei, L., Krokhotin, A., de los Reyes, S. E., Yen, L., Costantini, L. M., Griffith, J., Dokholyan, N., Alushin, G. M. & Campbell, S. L., Apr 5 2019, In : Journal of Molecular Biology. 431, 8, p. 1604-1618 15 p.Research output: Contribution to journal › Article
Vinculin
Cardiomyopathies
Actins
Mutation
Dimerization
Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems
Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J., Wu, X. R., Kaag, M. G., Raman, J. & Degraff, D., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.Research output: Contribution to journal › Article
Open Access
Histone Deacetylases
bladder
Polymerase chain reaction
Urinary Bladder Neoplasms
cancer
Circulating microRNAs in plasma among men with low-grade and high-grade prostate cancer at prostate biopsy
McDonald, A., Vira, M., Walter, V., Shen, J., Raman, J., Sanda, M. G., Patil, D. & Taioli, E., Jun 15 2019, In : Prostate. 79, 9, p. 961-968 8 p.Research output: Contribution to journal › Article
MicroRNAs
Prostatic Neoplasms
Biopsy
Neoplasm Grading
Prostate-Specific Antigen
Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations
Brodie, N. I., Popov, K. I., Petrotchenko, E. V., Dokholyan, N. & Borchers, C. H., Mar 1 2019, In : PLoS computational biology. 15, 3, e1006859.Research output: Contribution to journal › Article
Open Access
Synucleins
Discrete Dynamics
molecular dynamics
protein structure
Molecular Dynamics Simulation
2
Citations
(Scopus)
Dietary sugar silences a colonization factor in a mammalian gut symbiont
Townsend, G. E., Han, W., Schwalm, N. D., Raghavan, V., Barry, N. A., Goodman, A. L. & Groisman, E. A., Jan 2 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 1, p. 233-238 6 p.Research output: Contribution to journal › Article
Dietary Sucrose
Fructose
Glucose
Diet
Food
Projects 1981 2023
Structural and Molecular Basis of Human ATG3 Activation and Regulation for LC3 Lipid Conjugation in Autophagy
1/15/19 → 12/31/22
Project: Research project
Autophagy
Lipids
Membranes
Heart Neoplasms
Structural Models
Targeting Rab6-km23-1-mediated compartmentalized trafficking as a novel therapeutic approach to Alzheimers Disease
Mulder, K. & Liotta, L. A.
8/15/18 → 5/31/20
Project: Research project
Amyloid beta-Protein Precursor
Alzheimer Disease
Amyloid
Protein Transport
Therapeutics
Visualization, modeling and validation of chromatin interaction data
1/8/18 → 12/31/22
Project: Research project
Visualization
Genes
Throughput
Transcription factors
Computational methods
Impact of genetic variants on gene regulation and 3D genome organization in human diseases
9/1/17 → 7/31/22
Project: Research project
Genome
Genes
Chromatin
Single Nucleotide Polymorphism
Deoxyribonucleases
Penn State Biomedical Big Data to Knowledge (B2D2K) Training Program
Honavar, V. G., Ritchie, M. D., Li, R., Ritchie, M. D. & Broach, J.
4/1/16 → 3/31/21
Project: Research project
Health
Bioinformatics
Statistics
Information science
Big data
Membranes
Lipids
Bacillus subtilis
Recognition (Psychology)
Capsid Proteins
Genotoxicity and Repair of Tobacco-Specific Nitrosamine DNA Adducts
7/20/12 → 5/31/23
Project: Research project
Nitrosamines
DNA Adducts
Tobacco
Oligodeoxyribonucleotides
Smoke
Preparing for research careers related to diabetes, digestive &kidney diseases
Matters, G., Matters, G., Reeves, W. B. & Bond, J.
6/1/07 → 2/28/22
Project: Research project
chronic illness
career
Disease
student
experience
Yeasts
Food
Transcription Factors
Metabolome
Growth
Activities 2017 2017
- 3 Oral presentation
From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics
Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)Sep 27 2017
Activity: Talk types › Oral presentation
Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish
Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)Jul 5 2017
Activity: Talk types › Oral presentation
Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)
Keith Cheng (Speaker)Nov 4 2017
Activity: Talk types › Oral presentation
Prizes
Michael Hooker Distinguished Professor in Biochemistry and Biophysics
Nikolay Dokholyan (Recipient), 2013
Prize