Department of Biochemistry and Molecular Biology

  • United States

Research Output 1969 2019

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2019

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson-Kennedy, P. S., Deneke, E., Vrana, K., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V., Ang, K., Wang, Y., Xiao, X., De Carlo, F., Van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

Chirasani, V. R., Xu, L., Addis, H. G., Pasek, D. A., Dokholyan, N., Meissner, G. & Yamaguchi, N., Aug 1 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C358-C365

Research output: Contribution to journalArticle

Central Core Myopathy
Ryanodine Receptor Calcium Release Channel
Skeletal Muscle
Binding Sites
Mutation

Activation of Wnt signaling promotes olaparib resistant ovarian cancer

Yamamoto, T. M., McMellen, A., Watson, Z. L., Aguilera, J., Ferguson, R., Nurmemmedov, E., Thakar, T., Moldovan, G-L., Kim, H., Cittelly, D. M., Joglar, A. M., Brennecke, E. P., Wilson, H., Behbakht, K., Sikora, M. J. & Bitler, B. G., Oct 1 2019, In : Molecular Carcinogenesis. 58, 10, p. 1770-1782 13 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Ovarian Diseases
Recombinational DNA Repair
Cell Line

An R package for model fitting, model selection and the simulation for longitudinal data with dropout missingness

Xu, C., Li, Z., Xue, Y., Zhang, L. & Wang, M., Oct 21 2019, In : Communications in Statistics: Simulation and Computation. 48, 9, p. 2812-2829 18 p.

Research output: Contribution to journalArticle

Drop out
Model Fitting
Longitudinal Data
Model Selection
Weighted Estimating Equations
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Polymorphism
Inflammatory Bowel Diseases
5 Citations (Scopus)

Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents

He, F., Berg, A., Imamura, Y., Bixler, E., Fernandez-Mendoza, J., Whitsel, E. A. & Liao, D., Dec 1 2019, In : Scientific reports. 9, 1, 2079.

Research output: Contribution to journalArticle

DNA Methylation
Body Mass Index
Obesity
Genes
Pediatric Obesity
1 Citation (Scopus)

Association between inflammatory cytokine levels and anemia during Plasmodium falciparum and Plasmodium vivax infections in Mangaluru: A Southwestern Coastal Region of India

Punnath, K., Dayanand, K. K., Chandrashekhar, V. N., Achur, R. N., Kakkilaya, S. B., Ghosh, S. K., Kumari, S. N. & Gowda, C., Jul 1 2019, In : Tropical Parasitology. 9, 2, p. 98-107 10 p.

Research output: Contribution to journalArticle

Plasmodium vivax
Plasmodium falciparum
Malaria
Anemia
India
1 Citation (Scopus)

Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies

Sarker, M., Lee, H. T., Mei, L., Krokhotin, A., de los Reyes, S. E., Yen, L., Costantini, L. M., Griffith, J., Dokholyan, N., Alushin, G. M. & Campbell, S. L., Apr 5 2019, In : Journal of Molecular Biology. 431, 8, p. 1604-1618 15 p.

Research output: Contribution to journalArticle

Vinculin
Cardiomyopathies
Actins
Mutation
Dimerization
1 Citation (Scopus)

Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
bladder
Polymerase chain reaction
Urinary Bladder Neoplasms
cancer
1 Citation (Scopus)

Circulating microRNAs in plasma among men with low-grade and high-grade prostate cancer at prostate biopsy

McDonald, A., Vira, M., Walter, V., Shen, J., Raman, J., Sanda, M. G., Patil, D. & Taioli, E., Jun 15 2019, In : Prostate. 79, 9, p. 961-968 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Prostatic Neoplasms
Biopsy
Neoplasm Grading
Prostate-Specific Antigen
1 Citation (Scopus)

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Ding, Y., Vanselow, D. J., Yakovlev, M. A., Katz, S. R., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V., Ang, K., Wang, Y., Xiao, X., Carlo, F. D., Van Rossum, D. B., Riviere, P. L. & Cheng, K., May 1 2019, In : eLife. 8, e44898.

Research output: Contribution to journalArticle

Open Access
Zebrafish
X-Rays
Tissue
X rays
Brain

Computationally Guided Design of Single-Chain Variable Fragment Improves Specificity of Chimeric Antigen Receptors

Krokhotin, A., Du, H., Hirabayashi, K., Popov, K., Kurokawa, T., Wan, X., Ferrone, S., Dotti, G. & Dokholyan, N., Dec 20 2019, In : Molecular Therapy - Oncolytics. 15, p. 30-37 8 p.

Research output: Contribution to journalArticle

Open Access
Single-Chain Antibodies
Antigen Receptors
T-Cell Antigen Receptor
Peptides
Antibody Specificity

Conductance-Based Biophysical Distinction and Microfluidic Enrichment of Nanovesicles Derived from Pancreatic Tumor Cells of Varying Invasiveness

Moore, J. H., Varhue, W. B., Su, Y. H., Linton, S. S., Farmehini, V., Fox, T. E., Matters, G., Kester, M. & Swami, N. S., Aug 20 2019, In : Analytical chemistry. 91, 16, p. 10424-10431 8 p.

Research output: Contribution to journalArticle

Microfluidics
Tumors
Cells
Lipids
Fluidity
2 Citations (Scopus)

Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations

Brodie, N. I., Popov, K. I., Petrotchenko, E. V., Dokholyan, N. V. & Borchers, C. H., Mar 2019, In : PLoS computational biology. 15, 3, e1006859.

Research output: Contribution to journalArticle

Open Access
Synucleins
Discrete Dynamics
molecular dynamics
protein structure
Molecular Dynamics Simulation
4 Citations (Scopus)

Dietary sugar silences a colonization factor in a mammalian gut symbiont

Townsend, G. E., Han, W., Schwalm, N. D., Raghavan, V., Barry, N. A., Goodman, A. L. & Groisman, E. A., Jan 2 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 1, p. 233-238 6 p.

Research output: Contribution to journalArticle

Dietary Sucrose
Fructose
Glucose
Diet
Food

Differential impact of co-expressed SP-A1/SP-A2 protein on AM miRNome; Sex differences

Thorenoor, N., Imamura, Y., Gandhi, C., Zhang, X. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, AUG, 1960.

Research output: Contribution to journalArticle

Open Access
Alveolar Macrophages
varespladib methyl
Sex Characteristics
Pulmonary Surfactant-Associated Protein A
Oxidative Stress
4 Citations (Scopus)

Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

Liu, Z., Yee, P. P., Wei, Y., Liu, Z., Imamura, Y. & Li, W., Mar 1 2019, In : Journal of Cell Science. 132, 5, jcs225714.

Research output: Contribution to journalArticle

Open Access
Glioma
Carcinogenesis
Neoplasms
Glioblastoma
Growth

Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences

Krokhotin, A., Sarker, M., Sevilla, E. A., Costantini, L. M., Griffith, J. D., Campbell, S. L. & Dokholyan, N., Oct 1 2019, In : Structure. 27, 10, p. 1527-1536.e3

Research output: Contribution to journalArticle

Vinculin
Actins
Protein Isoforms
Actin Cytoskeleton
Point Mutation

Dust mite induces leukocyte exosomes with proinflammatory effects toward airway epithelial cells

Lambert, K. A., Hsu, M. H., Laryea, Z. C., Zhao, Y., Roff, A. N., Sundstrom, J. & Ishmael, F., Jul 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 315-317 3 p.

Research output: Contribution to journalArticle

Exosomes
Mites
Dust
Leukocytes
Epithelial Cells

Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms

Teissier, A., Le Magueresse, C., Olusakin, J., Andrade da Costa, B. L. S., De Stasi, A. M., Bacci, A., Imamura Kawasawa, Y., Vaidya, V. A. & Gaspar, P., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Oligodendroglia
Psychological Stress
Prefrontal Cortex
Neurons
Immediate-Early Genes
Open Access
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Aerosols
Tobacco Products
Carcinogens
Open Access
Reminder Systems
Educational Technology
Educational Measurement
educational technology
Medical Education
N'-nitrosonornicotine
Oral Leukoplakia
Tobacco
Tongue
Carcinogens

Empirical-likelihood-based criteria for model selection on marginal analysis of longitudinal data with dropout missingness

Chen, C., Shen, B., Zhang, L., Xue, Y. & Wang, M., Sep 1 2019, In : Biometrics. 75, 3, p. 950-965 16 p.

Research output: Contribution to journalArticle

dropouts
Information Criterion
Empirical Likelihood
Drop out
Longitudinal Data

Engineering proteins for allosteric control by light or ligands

Dagliyan, O., Dokholyan, N. & Hahn, K. M., Jun 1 2019, In : Nature Protocols. 14, 6, p. 1863-1883 21 p.

Research output: Contribution to journalArticle

Protein Engineering
Ligands
Light
Guanine
Sirolimus

Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells

Naldiga, S., Ji, S., Thomforde, J., Nicolae, C. M., Lee, M., Zhang, Z., Moldovan, G. L., Tretyakova, N. Y. & Basu, A. K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 27, p. 10619-10627 9 p.

Research output: Contribution to journalArticle

Cells
Peptides
Mutation
DNA
Plasmids
1 Citation (Scopus)

Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions

Podany, A., Rauchut, J., Wu, T., Imamura, Y., Wright, J., Lamendella, R., Soybel, D. & Kelleher, S. L., Feb 1 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800947.

Research output: Contribution to journalArticle

Zinc
neonates
Oxidative Stress
oxidative stress
zinc
5 Citations (Scopus)

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour, Brazel, D. M., Jiang, Y., Hughey, J. M., Turcot, V., Zhan, X., Gong, J., Batini, C., Weissenkampen, J. D., Liu, M. Z., Surendran, P., Young, R., Barnes, D. R., Nielsen, S. F., Rasheed, A., Samuel, M., Zhao, W., Kontto, J., Perola, M. & 32 others, Caslake, M., de Craen, A. J. M., Trompet, S., Uria-Nickelsen, M., Malarstig, A., Reily, D. F., Hoek, M., Vogt, T., Jukema, J. W., Sattar, N., Ford, I., Packard, C. J., Alam, D. S., Majumder, A. A. S., Di Angelantonio, E., Chowdhury, R., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., EPIC-CVD Consortium, C., Frossard, P., Nordestgaard, B. G., Saleheen, D., Danesh, J., Butterworth, A. S. & Liu, D., Jun 1 2019, In : Biological Psychiatry. 85, 11, p. 946-955 10 p.

Research output: Contribution to journalArticle

Exome
Meta-Analysis
Smoking
Alcohols
Phenotype
2 Citations (Scopus)

Gene Expression Subtype Predicts Nodal Metastasis and Survival in Human Papillomavirus–Negative Head and Neck Cancer

Zevallos, J. P., Mazul, A. L., Walter, V. & Hayes, D. N., Jan 1 2019, In : Laryngoscope. 129, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Squamous Cell Carcinoma
Neoplasm Metastasis
Gene Expression
Survival

Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels

Wu, Z., Huo, Q., Ren, L., Dong, F., Feng, M., Wang, Y., Bai, Y., Luscher, B., Li, S. T., Wang, G. L., Long, C., Wang, Y., Wu, G. & Chen, G., May 15 2019, In : Molecular Brain. 12, 1, 50.

Research output: Contribution to journalArticle

Open Access
Seizures
Brain
Newborn Animals
Knockout Mice
Anticonvulsants

Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks

Li, J., Li, Y., Li, W., Luo, H., Xi, Y., Dong, S., Gao, M., Xu, P., Zhang, B., Liang, Y., Zou, Q., Hu, X., Peng, L., Zou, D., Wang, T., Yang, H., Jiang, C., Peng, S., Wu, F. & Yu, W., Feb 2019, In : Genome research. 29, 2, p. 270-280 11 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Methylation
Genome
Neoplasms
GC Rich Sequence

HBV induces different responses of the hepatocytes and oval cells during HBV-related hepatic cirrhosis

Zhang, L., Chen, Y., Zhang, L., Wang, M., Chang, D. L., Wan, W. W., Zhang, B. X., Zhang, W. G. & Chen, X. P., Feb 28 2019, In : Cancer Letters. 443, p. 47-55 9 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Liver Cirrhosis
Hepatocytes
Transgenic Mice
Fibrosis

Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive

Edvardson, S., Nicolae, C. M., Noh, G. J., Burton, J. E., Punzi, G., Shaag, A., Bischetsrieder, J., De Grassi, A., Pierri, C. L., Elpeleg, O. & Moldovan, G. L., Jan 3 2019, In : American Journal of Human Genetics. 104, 1, p. 179-185 7 p.

Research output: Contribution to journalArticle

Failure to Thrive
Microcephaly
Brain Diseases
Blindness
Protein Unfolding
1 Citation (Scopus)

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Luo, H., Sobh, A., Vulpe, C. D., Brewer, E., Dovat, S., Qiu, Y. & Huang, S., Mar 31 2019, In : Journal of visualized experiments : JoVE. 145

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Chromatin
Screening
Genes
Gene Expression
1 Citation (Scopus)

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Epigenomics
Chromatin
Cell Differentiation

Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke

Janicki, P., Eyileten, C., Ruiz-Velasco, V., Pordzik, J., Czlonkowska, A., Kurkowska-Jastrzebska, I., Sugino, S., Imamura, Y., Mirowska-Guzel, D. & Postula, M., Apr 1 2019, In : Molecular medicine reports. 19, 4, p. 3263-3272 10 p.

Research output: Contribution to journalArticle

Platelets
Genes
Stroke
Quality control
Blood Platelets
4 Citations (Scopus)

Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells

Zhang, L., Cheng, F., Wei, Y., Zhang, L., Guo, D., Wang, B. & Li, W., Apr 11 2019, In : Oncogene. 38, 15, p. 2788-2799 12 p.

Research output: Contribution to journalArticle

Glioma
Radiation
Catenins
Growth
Glioblastoma

Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase

Sapienza, P. J., Popov, K. I., Mowrey, D. D., Falk, B. T., Dokholyan, N. & Lee, A. L., Jul 30 2019, In : Biochemistry. 58, 30, p. 3302-3313 12 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Dimers
Catalytic Domain
Nuclear magnetic resonance
Magnetic Resonance Spectroscopy
13 Citations (Scopus)

Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]

Warrick, J., Sjödahl, G., Kaag, M. G., Raman, J., Merrill, S., Shuman, L., Chen, G., Walter, V. & Degraff, D., Jan 1 2019, In : European Urology. 75, 1, p. 18-22 5 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Neoplasms
Histology
Selection Bias
Carcinoma
2 Citations (Scopus)

Isolation and profiling of plasma microRNAs: Biomarkers for asthma and allergic rhinitis

Panganiban, R. P., Lambert, K. A., Hsu, M. H., Laryea, Z. & Ishmael, F., Jan 1 2019, In : Methods. 152, p. 48-54 7 p.

Research output: Contribution to journalArticle

Biomarkers
MicroRNAs
Blood
Asthma
Plasmas

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

Crowley, N., Magee, S. N., Feng, M., Jefferson, S. J., Morris, C. J., Dao, N. C., Brockway, D. F. & Luscher, B., May 1 2019, In : Neuropharmacology. 149, p. 35-44 10 p.

Research output: Contribution to journalArticle

Binge Drinking
Drinking Behavior
Ketamine
Synaptic Transmission
Drinking

km23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells

Raza, A., Pandey, M. S., Jin, Q. & Mulder, K., Jan 1 2019, (Accepted/In press) In : Cell Biology International.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Dyneins
Colorectal Neoplasms
Transforming Growth Factors

Limits in accuracy and a strategy of RNA structure prediction using experimental information

Wang, J., Williams, B., Chirasani, V. R., Krokhotin, A., Das, R. & Dokholyan, N., Jan 1 2019, In : Nucleic acids research. 47, 11, p. 5563-5572 10 p.

Research output: Contribution to journalArticle

Open Access
RNA
Structural Models
Computational Biology
1 Citation (Scopus)
Aspirin
Anti-Inflammatory Agents
Pharmaceutical Preparations
Ibuprofen
Ambulatory Surgical Procedures

Malarial anemia among pregnant women in the south-western coastal city of Mangaluru in India

Chandrashekar, V. N., Punnath, K., Dayanand, K. K., Achur, R. N., Kakkilaya, S. B., Jayadev, P., Kumari, S. N. & Gowda, C., Jan 1 2019, In : Informatics in Medicine Unlocked. 15, 100159.

Research output: Contribution to journalArticle

Open Access
Malaria
Anemia
Pregnant Women
India
Pregnancy

Malaria severity in Mangaluru city in the southwestern coastal region of India

Dayanand, K. K., Kishore, P., Chandrashekar, V., Achur, R. N., Ghosh, S. K., Kakkilaya, S. B., Kumari, S. N., Tiwari, S., Boloor, A., Devi, R. & Gowda, C., Jan 1 2019, In : American Journal of Tropical Medicine and Hygiene. 100, 2, p. 275-279 5 p.

Research output: Contribution to journalArticle

Malaria
India
Plasmodium falciparum
Plasmodium vivax
Vivax Malaria
2 Citations (Scopus)

Measuring the reproducibility and quality of Hi-C data

Yardımcı, G. G., Ozadam, H., Sauria, M. E. G., Ursu, O., Yan, K. K., Yang, T., Chakraborty, A., Kaul, A., Lajoie, B. R., Song, F., Zhan, Y., Ay, F., Gerstein, M., Kundaje, A., Li, Q., Taylor, J., Yue, F., Dekker, J. & Noble, W. S., Mar 19 2019, In : Genome biology. 20, 1, 57.

Research output: Contribution to journalArticle

reproducibility
Noise
Benchmarking
DNA Replication
Practice Guidelines
1 Citation (Scopus)

MedusaDock 2.0: Efficient and Accurate Protein-Ligand Docking with Constraints

Wang, J. & Dokholyan, N., Jun 24 2019, In : Journal of Chemical Information and Modeling. 59, 6, p. 2509-2515 7 p.

Research output: Contribution to journalArticle

Ligands
drug
Proteins
efficiency
energy
1 Citation (Scopus)

MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

Jiang, Y., Zhang, Y., Leung, J. Y., Fan, C., Popov, K. I., Su, S., Qian, J., Wang, X., Holtzhausen, A., Ubil, E., Xiang, Y., Davis, I., Dokholyan, N., Wu, G., Perou, C. M., Kim, W. Y., Earp, H. S. & Liu, P., Dec 1 2019, In : Nature communications. 10, 1, 1515.

Research output: Contribution to journalArticle

Open Access
phosphorylation
Phosphorylation
Chemical activation
retarding
activation
2 Citations (Scopus)

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S. & 31 others, Boehnke, M., Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A. & Liu, D., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome