Department of Cellular and Molecular Physiology

  • United States

Organization profile

Organization profile

The Department of Cellular and Molecular Physiology at Penn State College of Medicine provides outstanding training opportunities for graduate students and postdoctoral fellows interested in pursuing a career in the cellular, molecular and/or metabolic aspects of physiology. The department offers a faculty of international reputation along with modern, well-equipped laboratories in a beautiful setting conducive to outstanding academic achievement and research productivity.

The research laboratories of individual department faculty members encompass a total of approximately 22,000 square feet. These facilities are well-equipped with modern analytical instruments.

The service activities of the faculty include membership and leadership on the committees of the University and on peer review committees at the national and international levels. Department members serve as editor or associate editor of the major journals in their areas of expertise. Several additional department members serve on major editorial boards including those of the American Journal of Physiology, the Journal of Biological Chemistry, the Biochemical Journal and the International Journal of Biochemistry and Cell Biology. Service in advisory groups and national study sections is also extensive.

Fingerprint Dive into the research topics where Department of Cellular and Molecular Physiology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Proteins Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Rats Chemical Compounds
Polyamines Medicine & Life Sciences
Liver Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Ornithine Decarboxylase Medicine & Life Sciences
Spermine Medicine & Life Sciences

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Profiles

Photo of Alistair Barber
19892019
Photo of Sarah Bronson

Sarah Bronson, PhD

Person: Academic

19912017
No photo of Michael Dennis
20072019
Photo of Donald Gill
19812020

Research Output 1965 2019

2 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation

Qiu, S., Liu, T., Piao, C., Wang, Y., Wang, K., Zhou, Y., Cai, L., Zheng, S., Lan, F. & Du, J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Open Access
Inflammation
AMP-Activated Protein Kinases
Liver
Wounds and Injuries
Neoplasms

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study

Macneill, C., De Guzman, G. S., Lupo, K., Umstead, T., Phelps, D. & Floros, J., Jan 1 2019, In : Journal of Lower Genital Tract Disease. 23, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Mucous Membrane
Anti-Inflammatory Agents
Lipids
Cytokines

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Santhanam, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Madesh, M., Jan 23 2019, In : ACS Central Science. 5, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Open Access
Ruthenium Compounds
Ruthenium compounds
Signal transduction
Biochemistry
Mitochondria

A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Waning, D., Guise, T. A. & Mohammad, K. S., Jan 8 2019, In : Cell Metabolism. 29, 1, p. 6-8 3 p.

Research output: Contribution to journalShort survey

Bone Neoplasms
Connexins
Bone and Bones
Neoplasm Metastasis
Neoplasms
1 Citation (Scopus)

Bioprinting functional tissues

Leberfinger, A. N., Dinda, S., Wu, Y., Koduru, S., Ozbolat, V., Ravnic, D. & Ozbolat, I. T., Jan 1 2019, (Accepted/In press) In : Acta Biomaterialia.

Research output: Contribution to journalArticle

Bioprinting
Tissue
Transplants
Mechanics
Cell Count

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Santhanam, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Metabolic Diseases
Medical problems
Lipid Metabolism
Phosphoric Monoester Hydrolases
12 Citations (Scopus)

Calcium signalling in T cells

Trebak, M. & Kinet, J. P., Mar 1 2019, In : Nature Reviews Immunology. 19, 3, p. 154-169 16 p.

Research output: Contribution to journalReview article

Calcium Signaling
T-Lymphocytes
Immunity
Cell Membrane
Lymphocytes

Cellular Based Strategies for Microvascular Engineering

Koduru, S., Leberfinger, A. N., Pasic, D., Forghani, A., Lince, S., Hayes, D. J., Ozbolat, I. T. & Ravnic, D., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 218-240 23 p.

Research output: Contribution to journalReview article

Blood Vessels
Tissue Engineering
Microvessels
Microtechnology
Microfluidics

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Santhanam, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 1 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Punctures
Cardiac Myocytes
Ligation
Reactive Oxygen Species

Projects 1975 2023

Neoplasm Metastasis
Actin Cytoskeleton
Neoplasms
AMP-Activated Protein Kinases
fascin
Microvessels
Permeability
Reactive Oxygen Species
Nitric Oxide
Peroxynitrous Acid
Cardiac Myosins
Myosins
Cardiomyopathies
Mutation
Ventricular Myosins
Platinum
Ovarian Neoplasms
Nucleotides
Neoplastic Stem Cells
Mentors
Melanoma
Neoplasm Metastasis
Calcium
Neoplasms
Basement Membrane
Vascular Smooth Muscle
Smooth Muscle Myocytes
Smooth Muscle
Vascular Diseases
Hypertension
B-Lymphocytes
Calcium
Proteins
Molecular Probes
Protein Unfolding
Myosins
Calmodulin
X-Ray Diffraction
Muscles

REGULATION OF SKELETAL MUSCLE METABOLISM

Jefferson, L. "., Jefferson, L. ". & Kimball, S.

National Institutes of Health

9/1/774/30/22

Project: Research project

Skeletal Muscle
Proteasome Endopeptidase Complex
Proteins
Leucine
Phosphorylation
MicroRNAs
Muscle Cells
Blood Vessels
Ion Channels
Cardiac Myocytes