Department of Cellular and Molecular Physiology

  • United States

Organization profile

Organization profile

The Department of Cellular and Molecular Physiology at Penn State College of Medicine provides outstanding training opportunities for graduate students and postdoctoral fellows interested in pursuing a career in the cellular, molecular and/or metabolic aspects of physiology. The department offers a faculty of international reputation along with modern, well-equipped laboratories in a beautiful setting conducive to outstanding academic achievement and research productivity.

The research laboratories of individual department faculty members encompass a total of approximately 22,000 square feet. These facilities are well-equipped with modern analytical instruments.

The service activities of the faculty include membership and leadership on the committees of the University and on peer review committees at the national and international levels. Department members serve as editor or associate editor of the major journals in their areas of expertise. Several additional department members serve on major editorial boards including those of the American Journal of Physiology, the Journal of Biological Chemistry, the Biochemical Journal and the International Journal of Biochemistry and Cell Biology. Service in advisory groups and national study sections is also extensive.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Proteins Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Rats Chemical Compounds
Polyamines Medicine & Life Sciences
Liver Medicine & Life Sciences
Ornithine Decarboxylase Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Spermine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Photo of Alistair Barber
19892019
Photo of Sarah Bronson

Sarah Bronson, PhD

Person: Academic

19912017
No photo of Vincent Chau
19672017
No photo of Michael Dennis
20072019
Photo of Donald Gill
19812020

Research Output 1965 2019

1 Citation (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation

Qiu, S., Liu, T., Piao, C., Wang, Y., Wang, K., Zhou, Y., Cai, L., Zheng, S., Lan, F. & Du, J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Open Access
Inflammation
AMP-Activated Protein Kinases
Liver
Wounds and Injuries
Neoplasms

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study

Macneill, C., De Guzman, G. S., Lupo, K., Umstead, T., Phelps, D. & Floros, J., Jan 1 2019, In : Journal of Lower Genital Tract Disease. 23, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Mucous Membrane
Anti-Inflammatory Agents
Lipids
Cytokines

A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Waning, D., Guise, T. A. & Mohammad, K. S., Jan 8 2019, In : Cell Metabolism. 29, 1, p. 6-8 3 p.

Research output: Contribution to journalShort survey

Bone Neoplasms
Connexins
Bone and Bones
Neoplasm Metastasis
Neoplasms
7 Citations (Scopus)

Calcium signalling in T cells

Trebak, M. & Kinet, J. P., Mar 1 2019, In : Nature Reviews Immunology. 19, 3, p. 154-169 16 p.

Research output: Contribution to journalReview article

Calcium Signaling
T-Lymphocytes
Immunity
Cell Membrane
Lymphocytes

Chronic treatment with multi-kinase inhibitors causes differential toxicities on skeletal and cardiac muscles

Huot, J. R., Essex, A. L., Gutierrez, M., Barreto, R., Wang, M., Waning, D., Plotkin, L. I. & Bonetto, A., Apr 1 2019, In : Cancers. 11, 4, 571.

Research output: Contribution to journalArticle

Open Access
Myocardium
Skeletal Muscle
Phosphotransferases
Muscles
Cachexia
1 Citation (Scopus)

Closing the therapeutic loop

Campbell, K. S., Yengo, C., Lee, L. C., Kotter, J., Sorrell, V. L., Guglin, M. & Wenk, J. F., Mar 15 2019, In : Archives of Biochemistry and Biophysics. 663, p. 129-131 3 p.

Research output: Contribution to journalReview article

Therapeutics

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Myosins
Mutation
Kinetics
Adenosine Triphosphatases
Conformations

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure

Wang, G., Umstead, T. M., Hu, S., Mikerov, A. N., Phelps, D. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 561.

Research output: Contribution to journalArticle

Open Access
Ozone
Klebsiella pneumoniae
Bronchoalveolar Lavage
Proteome
varespladib methyl

Projects 1975 2023

Neoplasm Metastasis
Actin Cytoskeleton
Neoplasms
AMP-Activated Protein Kinases
fascin
Microvessels
Permeability
Reactive Oxygen Species
Nitric Oxide
Peroxynitrous Acid
Cardiac Myosins
Myosins
Cardiomyopathies
Mutation
Ventricular Myosins
Platinum
Ovarian Neoplasms
Nucleotides
Neoplastic Stem Cells
Mentors
Melanoma
Neoplasm Metastasis
Calcium
Neoplasms
Basement Membrane
Vascular Smooth Muscle
Smooth Muscle Myocytes
Smooth Muscle
Vascular Diseases
Hypertension
B-Lymphocytes
Calcium
Proteins
Molecular Probes
Protein Unfolding
Myosins
Calmodulin
X-Ray Diffraction
Muscles
Skeletal Muscle
Proteins
skeletal muscle
Protein Biosynthesis
Sirolimus