Department of Cellular and Molecular Physiology

  • United States

Research Output 1965 2019

2019
2 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation

Qiu, S., Liu, T., Piao, C., Wang, Y., Wang, K., Zhou, Y., Cai, L., Zheng, S., Lan, F. & Du, J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Open Access
Inflammation
AMP-Activated Protein Kinases
Liver
Wounds and Injuries
Neoplasms

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study

Macneill, C., De Guzman, G. S., Lupo, K., Umstead, T., Phelps, D. & Floros, J., Jan 1 2019, In : Journal of Lower Genital Tract Disease. 23, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

Surface-Active Agents
Mucous Membrane
Anti-Inflammatory Agents
Lipids
Cytokines
3 Citations (Scopus)

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Santhanam, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Madesh, M., Jan 23 2019, In : ACS Central Science. 5, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Open Access
Calcium
Signal transduction
Mutagenesis
Ruthenium
Poisons

A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Waning, D., Guise, T. A. & Mohammad, K. S., Jan 8 2019, In : Cell Metabolism. 29, 1, p. 6-8 3 p.

Research output: Contribution to journalShort survey

Bone Neoplasms
Connexins
Bone and Bones
Neoplasm Metastasis
Neoplasms
2 Citations (Scopus)

Bioprinting functional tissues

Leberfinger, A. N., Dinda, S., Wu, Y., Koduru, S., Ozbolat, V., Ravnic, D. & Ozbolat, I. T., Sep 1 2019, In : Acta Biomaterialia. 95, p. 32-49 18 p.

Research output: Contribution to journalReview article

Bioprinting
Tissue
Transplants
Mechanics
Cell Count

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Santhanam, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
AMP-Activated Protein Kinases
Lipid Metabolism
Lipids
Liver
Homeostasis
12 Citations (Scopus)

Calcium signalling in T cells

Trebak, M. & Kinet, J. P., Mar 1 2019, In : Nature Reviews Immunology. 19, 3, p. 154-169 16 p.

Research output: Contribution to journalReview article

Calcium Signaling
T-Lymphocytes
Immunity
Cell Membrane
Lymphocytes
1 Citation (Scopus)

Cellular Based Strategies for Microvascular Engineering

Koduru, S., Leberfinger, A. N., Pasic, D., Forghani, A., Lince, S., Hayes, D. J., Ozbolat, I. T. & Ravnic, D., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 218-240 23 p.

Research output: Contribution to journalReview article

Blood Vessels
Tissue Engineering
Microvessels
Microtechnology
Microfluidics
3 Citations (Scopus)

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Santhanam, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 1 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Punctures
Cardiac Myocytes
Ligation
Reactive Oxygen Species
Alcohol Drinking
Muscle
Skeletal Muscle
Alcohols
Muscles

Chronic treatment with multi-kinase inhibitors causes differential toxicities on skeletal and cardiac muscles

Huot, J. R., Essex, A. L., Gutierrez, M., Barreto, R., Wang, M., Waning, D., Plotkin, L. I. & Bonetto, A., Apr 1 2019, In : Cancers. 11, 4, 571.

Research output: Contribution to journalArticle

Open Access
Myocardium
Skeletal Muscle
Phosphotransferases
Muscles
Cachexia
1 Citation (Scopus)

Closing the therapeutic loop

Campbell, K. S., Yengo, C., Lee, L. C., Kotter, J., Sorrell, V. L., Guglin, M. & Wenk, J. F., Mar 15 2019, In : Archives of Biochemistry and Biophysics. 663, p. 129-131 3 p.

Research output: Contribution to journalReview article

Therapeutics

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Myosins
Mutation
Kinetics
Adenosine Triphosphatases
Conformations

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure

Wang, G., Umstead, T. M., Hu, S., Mikerov, A. N., Phelps, D. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 561.

Research output: Contribution to journalArticle

Open Access
Ozone
Klebsiella pneumoniae
Bronchoalveolar Lavage
Proteome
varespladib methyl

Differential impact of co-expressed SP-A1/SP-A2 protein on AM miRNome; Sex differences

Thorenoor, N., Imamura, Y., Gandhi, C. K., Zhang, X. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, AUG, 1960.

Research output: Contribution to journalArticle

Open Access
Alveolar Macrophages
varespladib methyl
Sex Characteristics
Pulmonary Surfactant-Associated Protein A
Oxidative Stress

Differentiation of Adipose Tissue–Derived CD34+/CD31− Cells into Endothelial Cells In Vitro

Forghani, A., Koduru, S., Chen, C., Leberfinger, A. N., Ravnic, D. & Hayes, D. J., Jan 1 2019, In : Regenerative Engineering and Translational Medicine.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Tissue
Vascular Endothelial Growth Factor A
Cells

Dust mite induces leukocyte exosomes with proinflammatory effects toward airway epithelial cells

Lambert, K. A., Hsu, M. H., Laryea, Z. C., Zhao, Y., Roff, A. N., Sundstrom, J. & Ishmael, F., Jul 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 315-317 3 p.

Research output: Contribution to journalArticle

Exosomes
Mites
Dust
Leukocytes
Epithelial Cells

Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells

Cheng, D., Zhao, Y., Zhang, F., Zhang, J., Wang, S. & Zhu, J., Dec 1 2019, In : Scientific reports. 9, 1, 9683.

Research output: Contribution to journalArticle

Open Access
Telomerase
Genes
Telomere Homeostasis
Fibroblasts
Alleles
TOR Serine-Threonine Kinases
Autophagy
Muscle
Skeletal Muscle
Ethanol

Evidence for a role for sestrin1 in mediating leucine-induced activation of mtorc1 in skeletal muscle

Xu, D., Shimkus, K. L., Lacko, H. A., Kutzler, L., Jefferson, L. J. & Kimball, S., May 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E817-E828

Research output: Contribution to journalArticle

Leucine
Skeletal Muscle
Cell Culture Techniques
Amino Acids
Oral Administration
1 Citation (Scopus)

Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions

Podany, A., Rauchut, J., Wu, T., Imamura, Y., Wright, J., Lamendella, R., Soybel, D. & Kelleher, S. L., Feb 1 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800947.

Research output: Contribution to journalArticle

Zinc
neonates
Oxidative Stress
oxidative stress
zinc

Exhortation to lose weight prior to complex ventral hernia repair: Nudge or noodge?

Ssentongo, P., DeLong, C. G., Ssentongo, A. E., Pauli, E. & Soybel, D., Jan 1 2019, In : American Journal of Surgery.

Research output: Contribution to journalArticle

Ventral Hernia
Herniorrhaphy
Body Mass Index
Weights and Measures
Hernia

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
Oxidative Phosphorylation
Actin Cytoskeleton
Actins
Lung Neoplasms
Physiological Stress

Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

Alhothali, M., Mathew, M., Iyer, G., Lawrence, H. R., Yang, S., Chellappan, S. & Padmanabhan, J., May 16 2019, In : International journal of molecular sciences. 20, 10

Research output: Contribution to journalArticle

Open Access
Fendiline
combat
Therapeutic Uses
Tumors
tumors

H2O2-induced microvessel barrier dysfunction: the interplay between reactive oxygen species, nitric oxide, and peroxynitrite

Zhou, X., Qian, Y., Yuan, D., Feng, Q. & He, P., Jan 1 2019, In : Physiological reports. 7, 16, PHY214206.

Research output: Contribution to journalArticle

Open Access
Peroxynitrous Acid
Microvessels
Reactive Oxygen Species
Nitric Oxide
Permeability
1 Citation (Scopus)

Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors

Lu, F., Sun, J., Zheng, Q., Li, J., Hu, Y., Yu, P., He, H., Zhao, Y., Wang, X., Yang, S. & Cheng, H., Mar 1 2019, In : Journal of Cell Science. 132, 6, 224923.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Biosensing Techniques
Calmodulin
Melanoma
Interviews
1 Citation (Scopus)

Increased circulating microparticles in streptozotocin-induced diabetes propagate inflammation contributing to microvascular dysfunction

Feng, Q., Stork, C. J., Xu, S., Yuan, D., Xia, X., LaPenna, K. B., Guo, G., Sun, H., Xu, L., Siedlecki, C., Brundage, K. M., Sheaffer, N., Schell, T. & He, P., Feb 1 2019, In : Journal of Physiology. 597, 3, p. 781-798 18 p.

Research output: Contribution to journalArticle

Experimental Diabetes Mellitus
Inflammation
Microvessels
Phosphatidylserines
Blood Vessels
5 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Glioblastoma
Amlodipine
Calcium
Growth

Jumonji C demethylases in cellular senescence

Leon, K. E. & Aird, K., Jan 1 2019, In : Genes. 10, 1, 33.

Research output: Contribution to journalReview article

Cell Aging
Histones
Gene Expression
Enzyme Induction
Cell Cycle Checkpoints

Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure

Stump, C. L., Feehan, R. P., Jordan, T., Shantz, L. & Nowotarski, S. L., Jan 1 2019, (Accepted/In press) In : Amino Acids.

Research output: Contribution to journalArticle

Raptors
Ornithine Decarboxylase
Keratinocytes
RNA Stability
Messenger RNA

LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation

Huang, C., Li, Y., Li, Z., Xu, Y., Li, N., Ge, Y., Dong, J., Chang, A., Zhao, T., Wang, X., Wang, H., Yang, S., Xie, K., Hao, J. & Ren, H., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 4091-4103 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Pancreatic Neoplasms
Cell Survival
Oxygen
Glucose

Major effect of oxidative stress on the Male, but not female, SP-A1 type II cell miRNome

Noutsios, G. T., Thorenoor, N., Zhang, X., Phelps, D., Umstead, T. M., Durrani, F. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, JULY, 1514.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Oxidative Stress
varespladib methyl
Pulmonary Surfactant-Associated Protein A
Messenger RNA

Milk-derived miRNA profiles elucidate molecular pathways that underlie breast dysfunction in women with common genetic variants in SLC30A2

Kelleher, S. L., Gagnon, A., Rivera, O. C., Hicks, S., Carney, M. C. & Alam, S., Dec 1 2019, In : Scientific reports. 9, 1, 12686.

Research output: Contribution to journalArticle

Open Access
MicroRNAs
Milk
Breast
Lactation
Human Mammary Glands

MiR-204 regulates type 1 IP 3 R to control vascular smooth muscle cell contractility and blood pressure

Gabani, M., Liu, J., Ait-Aissa, K., Koval, O., Kim, Y. R., Castañeda, D., Vikram, A., Jacobs, J. S., Grumbach, I., Trebak, M., Irani, K. & Kassan, M., Jun 1 2019, In : Cell Calcium. 80, p. 18-24 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Pressure
Angiotensin II
Mesenteric Arteries
1 Citation (Scopus)

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes

Cheung, J. Y., Gordon, J., Wang, J. F., Song, J., Zhang, X. Q., Prado, F. J., Santhanam, S., Rajan, S., Tomar, D., Tahrir, F. G., Gupta, M. K., Knezevic, T., Merabova, N., Kontos, C. D., McClung, J. M., Klotman, P. E., Madesh, M., Khalili, K. & Feldman, A. M., Apr 1 2019, In : Journal of Cellular Physiology. 234, 4, p. 4432-4444 13 p.

Research output: Contribution to journalArticle

Viruses
Cardiac Myocytes
Muscle Cells
Transgenic Mice
HIV-1
8 Citations (Scopus)

NAD + metabolism governs the proinflammatory senescence-associated secretome

Nacarelli, T., Lau, L., Fukumoto, T., Zundell, J., Fatkhutdinov, N., Wu, S., Aird, K., Iwasaki, O., Kossenkov, A. V., Schultz, D., Noma, K. I., Baur, J. A., Schug, Z., Tang, H. Y., Speicher, D. W., David, G. & Zhang, R., Mar 1 2019, In : Nature Cell Biology. 21, 3, p. 397-407 11 p.

Research output: Contribution to journalArticle

NAD
Phenotype
Nicotinamide Phosphoribosyltransferase
High Mobility Group Proteins
Neoplasms

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1 dependent mitochondrial dysfunction in the retina

Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Imamura, Y., Salzberg, A. C., Kimball, S., Jefferson, L. J. & Dennis, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5508-5520 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Retina
Messenger RNA
Ribosomes
Eukaryotic Initiation Factors
1 Citation (Scopus)

ORAI channels in cellular remodeling of cardiorespiratory disease

Johnson, M. & Trebak, M., May 1 2019, In : Cell Calcium. 79, p. 1-10 10 p.

Research output: Contribution to journalReview article

Ion Channels
Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease
Smooth Muscle
Atherosclerosis
Open Access
Libellula
Odonata
Parasitic Diseases
flight muscles
dragonfly
1 Citation (Scopus)

Porous tissue strands: Avascular building blocks for scalable tissue fabrication

Wu, Y., Hospodiuk, M., Peng, W., Gudapati, H., Neuberger, T., Koduru, S., Ravnic, D. & Ozbolat, I. T., Jan 1 2019, In : Biofabrication. 11, 1, 015009.

Research output: Contribution to journalArticle

Tissue
Fabrication
Porosity
Cartilage
Self assembly

Postoperative hyperglycemia in patients undergoing cytoreductive surgery and HIPEC: A cohort study

DiSano, J. A., Wischhusen, J., Schaefer, E. W., Dessureault, S., Wong, J., Soybel, D. & Pameijer, C. R., Apr 1 2019, In : International Journal of Surgery. 64, p. 5-9 5 p.

Research output: Contribution to journalArticle

Hyperglycemia
Cohort Studies
Length of Stay
Neoplasms
Emergencies
1 Citation (Scopus)

REDD1 activates a ROS-generating feedback loop in the retina of diabetic mice

Miller, W. P., Toro, A. L., Barber, A. & Dennis, M., May 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 6, p. 2369-2379 11 p.

Research output: Contribution to journalArticle

Open Access
Retina
Reactive Oxygen Species
Cysteine
Mitochondrial Membrane Potential
Hydrogen Peroxide

Resistin directly inhibits bacterial killing in neutrophils

Miller, L., Singbartl, K., Chroneos, Z., Ruiz-Velasco, V., Lang, C. & Bonavia, A., May 30 2019, In : Intensive Care Medicine Experimental. 7, 30

Research output: Contribution to journalArticle

Open Access

Role of p90RSK in kidney and other diseases

Lin, L., White, S. A. & Hu, K., Feb 2 2019, In : International journal of molecular sciences. 20, 4, 972.

Research output: Contribution to journalReview article

Open Access
kidney diseases
Ribosomal Protein S6 Kinases
Kidney Diseases
activation
effectors
1 Citation (Scopus)

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

Kuskovsky, R., Buj, R., Xu, P., Hofbauer, S., Doan, M. T., Jiang, H., Bostwick, A., Mesaros, C., Aird, K. & Snyder, N. W., Mar 1 2019, In : Analytical Biochemistry. 568, p. 65-72 8 p.

Research output: Contribution to journalArticle

Deoxyribonucleotides
Liquid chromatography
Liquid Chromatography
Isotopes
Dilution

STIM1 is a precise thermo-sensor in skin

Nwokonko, R. M., Zhou, Y. & Gill, D., Apr 1 2019, In : Cell Research. 29, 4, p. 259-260 2 p.

Research output: Contribution to journalComment/debate

Skin
2 Citations (Scopus)

Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules

Li, J., Liu, H., Raval, M. H., Wan, J., Yengo, C., Liu, W. & Zhang, M., Sep 3 2019, In : Structure. 27, 9, p. 1366-1374.e3

Research output: Contribution to journalArticle

Protein Binding
Tail
Tandem Repeat Sequences
Proteins
Ankyrins

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Buj, R., Chen, C. W., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., Navaratnarajah, M., Zhang, G., Doan, M. T., Jiang, H., Zaleski, M., Kutzler, L., Lacko, H., Lu, Y., Mills, G. B., Gowda, R., Robertson, G., Warrick, J., Herlyn, M., Imamura, Y. & 4 others, Kimball, S., Degraff, D., Snyder, N. W. & Aird, K., Jan 1 2019, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Open Access
Nucleotides
Metabolism
Carcinogenesis
Up-Regulation
Neoplasms