Department of Cellular and Molecular Physiology

  • United States

Research Output

2020

Angiotensin-(1-7) Attenuates Protein O-GlcNAcylation in the Retina by EPAC/Rap1-Dependent Inhibition of O-GlcNAc Transferase

Dierschke, S. K., Toro, A. L., Barber, A. J., Arnold, A. C. & Dennis, M. D., Feb 7 2020, In : Investigative ophthalmology & visual science. 61, 2, 1 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Association of SNP–SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure

Gandhi, C., Chen, C., Wu, R., Yang, L., Thorenoor, N., Thomas, N., DiAngelo, S., Spear, D., Keim, G., Yehya, N. & Floros, J., Apr 20 2020, In : Journal of Clinical Medicine. 9, 4, p. 1183

Research output: Contribution to journalArticle

Open Access

Author Correction: Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells (Scientific Reports, (2019), 9, 1, (9683), 10.1038/s41598-019-46160-5)

Cheng, D., Zhao, Y., Zhang, F., Zhang, J., Wang, S. & Zhu, J., Dec 1 2020, In : Scientific reports. 10, 1, 1181.

Research output: Contribution to journalComment/debate

Open Access

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

Research output: Contribution to journalArticle

Differentiation of Adipose Tissue–Derived CD34+/CD31− Cells into Endothelial Cells In Vitro

Forghani, A., Koduru, S. V., Chen, C., Leberfinger, A. N., Ravnic, D. J. & Hayes, D. J., Mar 1 2020, In : Regenerative Engineering and Translational Medicine. 6, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Donor surfactant protein A2 polymorphism and lung transplant survival

D'Ovidio, F., Floros, J., Aramini, B., Lederer, D., DiAngelo, S. L., Arcasoy, S., Sonett, J. R., Robbins, H., Shah, L., Costa, J. & Urso, A., Mar 1 2020, In : European Respiratory Journal. 55, 3, 1900618.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease

Stine, J., Xu, D., Schmitz, K., Sciamanna, C. & Kimball, S. R., Jan 1 2020, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Exhortation to lose weight prior to complex ventral hernia repair: Nudge or noodge?

Ssentongo, P., DeLong, C. G., Ssentongo, A. E., Pauli, E. M. & Soybel, D. I., Jan 2020, In : American Journal of Surgery. 219, 1, p. 136-139 4 p.

Research output: Contribution to journalArticle

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

Koscsó, B., Kurapati, S., Rodrigues, R. R., Nedjic, J., Gowda, K., Shin, C., Soni, C., Ashraf, A. Z., Purushothaman, I., Palisoc, M., Xu, S., Sun, H., Chodisetti, S. B., Lin, E., Mack, M., Imamura, Y., He, P., Rahman, Z. S. M., Aifantis, I., Shulzhenko, N. & 2 others, Morgun, A. & Bogunovic, M., Jan 1 2020, In : Science Immunology. 5, 46, eaax0062.

Research output: Contribution to journalArticle

Open Access

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Feb 6 2020, In : Oncogene. 39, 6, p. 1302-1317 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer

Zhao, T., Jin, F., Xiao, D., Wang, H., Huang, C., Wang, X., Gao, S., Liu, J., Yang, S. & Hao, J., Jan 1 2020, In : Theranostics. 10, 9, p. 4088-4100 13 p.

Research output: Contribution to journalArticle

Open Access

Intracellular vesicle clusters are organelles that synthesize extracellular vesicle-associated cargo proteins in yeast

Winters, C. M., Hong-Brown, L. Q. & Chiang, H. L., Feb 28 2020, In : Journal of Biological Chemistry. 295, 9, p. 2650-2663 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure

Stump, C. L., Feehan, R. P., Jordan, T., Shantz, L. M. & Nowotarski, S. L., Feb 1 2020, In : Amino Acids. 52, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M. & Potier-Cartereau, M., Jan 15 2020, In : European Journal of Medicinal Chemistry. 186, 111854.

Research output: Contribution to journalArticle

Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia

Yan, B., Chen, Q., Xu, J., Li, W., Xu, B. & Qiu, Y., Jul 1 2020, In : Leukemia. 34, 7, p. 1816-1827 12 p.

Research output: Contribution to journalArticle

Open Access

Oxidative Stress and Microvessel Barrier Dysfunction

He, P., Talukder, M. A. H. & Gao, F., May 27 2020, In : Frontiers in Physiology. 11, 472.

Research output: Contribution to journalReview article

Open Access

PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC

Wang, X., Li, X., Wei, X., Jiang, H., Lan, C., Yang, S., Wang, H., Yang, Y., Tian, C., Xu, Z., Zhang, J., Hao, J. & Ren, H., Dec 1 2020, In : Signal Transduction and Targeted Therapy. 5, 1, 38.

Research output: Contribution to journalArticle

Open Access

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

Yoast, R. E., Emrich, S. M., Zhang, X., Xin, P., Johnson, M. T., Fike, A. J., Walter, V., Hempel, N., Yule, D. I., Sneyd, J., Gill, D. L. & Trebak, M., May 15 2020, In : Nature communications. 11, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

Miller, W. P., Sunilkumar, S., Giordano, J. F., Toro, A. L., Barber, A. J. & Dennis, M. D., May 22 2020, In : Journal of Biological Chemistry. 295, 21, p. 7350-7361 12 p.

Research output: Contribution to journalArticle

Open Access

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Zhao, B., Liu, P., Fukumoto, T., Nacarelli, T., Fatkhutdinov, N., Wu, S., Lin, J., Aird, K. M., Tang, H. Y., Liu, Q., Speicher, D. W. & Zhang, R., Dec 1 2020, In : Nature communications. 11, 1, 908.

Research output: Contribution to journalArticle

Open Access
Open Access

Zoledronic Acid Improves Muscle Function in Healthy Mice Treated with Chemotherapy

Hain, B. A., Jude, B., Xu, H., Smuin, D. M., Fox, E. J., Elfar, J. C. & Waning, D. L., Feb 1 2020, In : Journal of Bone and Mineral Research. 35, 2, p. 368-381 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. L. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation

Qiu, S., Liu, T., Piao, C., Wang, Y., Wang, K., Zhou, Y., Cai, L., Zheng, S., Lan, F. & Du, J., Mar 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1687-1697 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study

Macneill, C., De Guzman, G. S., Lupo, K., Umstead, T., Phelps, D. & Floros, J., Jan 1 2019, In : Journal of Lower Genital Tract Disease. 23, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

Woods, J. J., Nemani, N., Shanmughapriya, S., Kumar, A., Zhang, M., Nathan, S. R., Thomas, M., Carvalho, E., Ramachandran, K., Srikantan, S., Stathopulos, P. B., Wilson, J. J. & Madesh, M., Jan 23 2019, In : ACS Central Science. 5, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Waning, D. L., Guise, T. A. & Mohammad, K. S., Jan 8 2019, In : Cell Metabolism. 29, 1, p. 6-8 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Bioprinting functional tissues

Leberfinger, A. N., Dinda, S., Wu, Y., Koduru, S. V., Ozbolat, V., Ravnic, D. J. & Ozbolat, I. T., Sep 1 2019, In : Acta Biomaterialia. 95, p. 32-49 18 p.

Research output: Contribution to journalReview article

11 Scopus citations

Blockade of MCU-Mediated Ca 2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In : Cell Reports. 26, 13, p. 3709-3725.e7

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Ca2+ channels in cancer

Gautier, M., Trebak, M., Fleig, A., Vandier, C. & Ouadid-Ahidouch, H., Dec 2019, In : Cell Calcium. 84, 102083.

Research output: Contribution to journalEditorial

Ca2+ homeostasis and cancer

Gautier, M., Trebak, M., Fleig, A., Vandier, C. & Ouadid-Ahidouch, H., Dec 2019, In : Cell Calcium. 84, 102084.

Research output: Contribution to journalEditorial

Calcium signalling in T cells

Trebak, M. & Kinet, J. P., Mar 1 2019, In : Nature Reviews Immunology. 19, 3, p. 154-169 16 p.

Research output: Contribution to journalReview article

35 Scopus citations

Cellular Based Strategies for Microvascular Engineering

Koduru, S. V., Leberfinger, A. N., Pasic, D., Forghani, A., Lince, S., Hayes, D. J., Ozbolat, I. T. & Ravnic, D. J., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 218-240 23 p.

Research output: Contribution to journalReview article

5 Scopus citations

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Shanmughapriya, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. & Drosatos, K., Feb 2019, In : Journal of Molecular and Cellular Cardiology. 127, p. 232-245 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Chronic treatment with multi-kinase inhibitors causes differential toxicities on skeletal and cardiac muscles

Huot, J. R., Essex, A. L., Gutierrez, M., Barreto, R., Wang, M., Waning, D. L., Plotkin, L. I. & Bonetto, A., Apr 2019, In : Cancers. 11, 4, 571.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Closing the therapeutic loop

Campbell, K. S., Yengo, C. M., Lee, L. C., Kotter, J., Sorrell, V. L., Guglin, M. & Wenk, J. F., Mar 15 2019, In : Archives of Biochemistry and Biophysics. 663, p. 129-131 3 p.

Research output: Contribution to journalReview article

4 Scopus citations

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C. M., Feb 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. L. & Trebak, M., Apr 19 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium

Diwakar, B. T., Yoast, R., Nettleford, S., Qian, F., Lee, T. J., Berry, S., Huffnagle, I., Rossi, R. M., Trebak, M., Paulson, R. F. & Prabhu, K. S., Nov 1 2019, In : FASEB Journal. 33, 11, p. 12838-12852 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure

Wang, G., Umstead, T. M., Hu, S., Mikerov, A. N., Phelps, D. S. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 561.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
1 Scopus citations

Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil

Tang, W., Unrath, W. C., Desetty, R. & Yengo, C. M., Nov 15 2019, In : Journal of Biological Chemistry. 294, 46, p. 17314-17325 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dust mite induces leukocyte exosomes with proinflammatory effects toward airway epithelial cells

Lambert, K. A., Hsu, M. H., Laryea, Z. C., Zhao, Y., Roff, A. N., Sundstrom, J. M. & Ishmael, F. T., Jul 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 315-317 3 p.

Research output: Contribution to journalArticle

Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells

Cheng, D., Zhao, Y., Zhang, F., Zhang, J., Wang, S. & Zhu, J., Dec 1 2019, In : Scientific reports. 9, 1, 9683.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evidence for a role for sestrin1 in mediating leucine-induced activation of mtorc1 in skeletal muscle

Xu, D., Shimkus, K. L., Lacko, H. A., Kutzler, L., Jefferson, L. S. & Kimball, S. R., May 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E817-E828

Research output: Contribution to journalArticle

8 Scopus citations

Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions

Podany, A., Rauchut, J., Wu, T., Kawasawa, Y. I., Wright, J., Lamendella, R., Soybel, D. I. & Kelleher, S. L., Feb 1 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800947.

Research output: Contribution to journalArticle

5 Scopus citations

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations