Research Output 1989 2019

Article
136 Citations (Scopus)

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome

Brunner, M., Peng, X., Gong, X. L., Ren, X. Q., Ziv, O., Choi, B. R., Mathur, R., Hajjiri, M., Odening, K. E., Steinberg, E., Folco, E. J., Pringa, E., Centracchio, J., Macharzina, R. R., Donahay, T., Schofield, L., Rana, N., Kirk, M., Mitchell, G. F., Poppas, A. & 2 others, Zehender, M. & Koren, G., Jun 2 2008, In : Journal of Clinical Investigation. 118, 6, p. 2246-2259 14 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Sudden Death
Cardiac Arrhythmias
Sudden Cardiac Death
Rabbits
21 Citations (Scopus)

Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent

Chen, K-M., Guttenplan, J. B., Zhang, S. M., Aliaga, C., Cooper, T., Sun, Y-W., Deltondo, J., Kosinska, W., Sharma, A., Jiang, K., Bruggeman, R., Ahn, K., Amin, S. & El-Bayoumy, K., Sep 15 2013, In : International Journal of Cancer. 133, 6, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

Environmental Pollutants
Smoke
Tobacco
Carcinogenesis
Tongue
2 Citations (Scopus)
Environmental Pollutants
Metabolites
Rats
Breast
Human Mammary Glands
8 Citations (Scopus)

Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury

Besecker, E. M., Deiter, G. M., Pironi, N., Cooper, T. K. & Holmes, G. M., Jan 1 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 312, 1, p. R146-R156

Research output: Contribution to journalArticle

Spinal Cord Injuries
Blood Vessels
Inflammation
Superior Mesenteric Artery
Hypotension
10 Citations (Scopus)

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

Hens, J. R., Sinha, I., Perodin, F., Cooper, T., Sinha, R., Plummer, J., Perrone, C. E. & Orentreich, D., Jun 3 2016, In : BMC Cancer. 16, 1, 349.

Research output: Contribution to journalArticle

Nude Mice
Methionine
Cell Cycle
Breast Neoplasms
Diet
33 Citations (Scopus)

Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat

Maddineni, S., Nichenametla, S., Sinha, R., Wilson, R. & Richie, J., Jul 25 2013, In : Experimental Biology and Medicine. 238, 4, p. 392-399 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Methionine
Oxidation-Reduction
Glutathione
Rats
10 Citations (Scopus)

Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits

Peng, X., Max Lang, C. & Kreider, J. W., Jan 1995, In : Virus Research. 35, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

Cottontail rabbit papillomavirus
Methylation
Rabbits
Skin
DNA
17 Citations (Scopus)

Midazolam enhances the analgesic properties of dexmedetomidine in the rat

Boehm, C. A., Carney, E. L., Tallarida, R. J. & Wilson, R. P., Nov 2010, In : Veterinary Anaesthesia and Analgesia. 37, 6, p. 550-556 7 p.

Research output: Contribution to journalArticle

dexmedetomidine
Dexmedetomidine
analgesic effect
Midazolam
Analgesics
10 Citations (Scopus)

Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue

Cladel, N. M., Budgeon, L. R., Balogh, K. K., Cooper, T., Hu, J. & Christensen, N., Jan 15 2016, In : Virology. 488, p. 73-80 8 p.

Research output: Contribution to journalArticle

Mouth Mucosa
Tongue
Nude Mice
Papillomavirus Infections
Infection

Multiple complex congenital malformations in a rabbit kit (Oryctolagus cuniculi)

Booth, J., Peng, X., Baccon, J. & Cooper, T., Aug 1 2013, In : Comparative Medicine. 63, 4, p. 342-347 6 p.

Research output: Contribution to journalArticle

Holoprosencephaly
Gastroschisis
congenital abnormalities
Teratogens
Oryctolagus cuniculus
28 Citations (Scopus)

Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer

Guttenplan, J. B., Kosinska, W., Zhao, Z. L., Chen, K. M., Aliaga, C., Deltondo, J., Cooper, T., Sun, Y. W., Zhang, S. M., Jiang, K., Bruggeman, R., Sharma, A. K., Amin, S., Ahn, K. & El-Bayoumy, K., Jun 15 2012, In : International Journal of Cancer. 130, 12, p. 2783-2790 8 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Mutagenesis
Mouth
Carcinogenesis
Squamous Cell Carcinoma
1 Citation (Scopus)

Mycotic Thromboses in Sheep Implanted with Biomedical Cardiac Devices

Wilson, R. P. & Griffith, J. W., Dec 1 1997, In : Laboratory Animal Science. 47, 5, p. 554-556 3 p.

Research output: Contribution to journalArticle

Heart Valve Prosthesis Implantation
Sheep Diseases
Mucormycosis
sheep diseases
Mucor
12 Citations (Scopus)

Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

Biermann, J., Wu, K., Odening, K. E., Asbach, S., Koren, G., Peng, X., Zehender, M., Bode, C. & Brunner, M., Jan 10 2011, In : European Journal of Pharmacology. 650, 1, p. 309-316 8 p.

Research output: Contribution to journalArticle

Romano-Ward Syndrome
Nicorandil
Rabbits
Heart Rate
Action Potentials
36 Citations (Scopus)

Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome

Ziv, O., Morales, E., Song, Y. K., Peng, X., Odening, K. E., Buxton, A. E., Karma, A., Koren, G. & Choi, B. R., Oct 1 2009, In : Journal of Physiology. 587, 19, p. 4661-4680 20 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Action Potentials
Rabbits
Cardiac Arrhythmias
Architectural Accessibility
6 Citations (Scopus)

Ototoxicity of carboplatin delivered locally in a monkey brainstem

Carey, J. P., Cooper, T., Jallo, G. I., Carson, B. S. & Guarnieri, M., Nov 1 2005, In : International journal of toxicology. 24, 6, p. 443-449 7 p.

Research output: Contribution to journalArticle

Carboplatin
Vestibular Hair Cells
Brain Stem
Haplorhini
Cells
1 Citation (Scopus)

Outbreak of Abdominal Distension and Obstipation in a C57BL/6J Experimental Autoimmune Encephalomyelitis Study

Koya, V., Campbell, A. M., McLaughlin, P., Tewari, D., Wilson, R. & Cooper, T., May 1 2012, In : Veterinary Pathology. 49, 3, p. 528-531 4 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
encephalitis
Disease Outbreaks
Clostridium difficile
Fecal Impaction
11 Citations (Scopus)

Ovine skin-recirculating γδ T cells express IFN-γ and IL-17 and exit tissue independently of CCR7

Geherin, S. A., Lee, M. H., Wilson, R. P. & Debes, G. F., Sep 1 2013, In : Veterinary Immunology and Immunopathology. 155, 1-2, p. 87-97 11 p.

Research output: Contribution to journalArticle

Interleukin-17
skin (animal)
Sheep
T-lymphocytes
T-Lymphocytes
1 Citation (Scopus)

Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

Cladel, N. M., Jiang, P., Li, J. J., Peng, X., Cooper, T. K., Majerciak, V., Balogh, K. K., Meyer, T. J., Brendle, S. A., Budgeon, L. R., Shearer, D. A., Munden, R., Cam, M., Vallur, R., Christensen, N. D., Zheng, Z. M. & Hu, J., Jan 1 2019, In : Emerging Microbes and Infections. 8, 1, p. 1108-1121 14 p.

Research output: Contribution to journalArticle

Open Access
Papillomavirus Infections
Animal Models
Infection
Neoplasms
Stomach
48 Citations (Scopus)

Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization

Odening, K. E., Hyder, O., Chaves, L., Schofield, L., Brunner, M., Kirk, M., Zehender, M., Peng, X. & Koren, G., Dec 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 6, p. H2264-H2272

Research output: Contribution to journalArticle

Romano-Ward Syndrome
Pharmacogenetics
Anesthetics
Isoflurane
Genotype
22 Citations (Scopus)

Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits

Bentzen, B. H., Bahrke, S., Wu, K., Larsen, A. P., Odening, K. E., Franke, G., Vańs Gravesande, K. S., Biermann, J., Peng, X., Koren, G., Zehender, M., Bode, C., Grunnet, M. & Brunner, M., Feb 1 2011, In : Journal of Cardiovascular Pharmacology. 57, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

pamidronate
Romano-Ward Syndrome
Pharmacology
Rabbits
Action Potentials
9 Citations (Scopus)

Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice

You, H., Gao, T., Raup-Konsavage, W. M., Cooper, T. K., Bronson, S. K., Reeves, W. B. & Awad, A. S., Mar 1 2017, In : Kidney International. 91, 3, p. 671-682 12 p.

Research output: Contribution to journalArticle

CCR Receptors
Podocytes
Kidney
Diabetic Nephropathies
Wounds and Injuries
2 Citations (Scopus)

Practicing handoffs early: Applying a clinical framework in the anatomy laboratory

Lazarus, M. D., Dos Santos, J. A., Haidet, P. M. & Whitcomb, T. L., Oct 1 2016, In : Anatomical sciences education. 9, 5, p. 476-487 12 p.

Research output: Contribution to journalArticle

Anatomy
Students
Learning
Clinical Competence
Teaching

Presumptive spontaneous lysosomal storage-like disease in a Crl:CD1(ICR) mouse

Hernon, K. M., Whitcomb, T. L., Davis, L. & Cooper, T. K., Feb 2017, In : Comparative Medicine. 67, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

Lysosomal Storage Diseases
Inbred ICR Mouse
Cholesterol Ester Storage Disease
Periodic Acid
Viscera
6 Citations (Scopus)

Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)

Cooper, T. K., Murray, K. N., Spagnoli, S. & Spitsbergen, J. M., Mar 16 2015, In : Veterinary Pathology. 52, 2, p. 388-392 5 p.

Research output: Contribution to journalArticle

Chordoma
Zebrafish
Danio rerio
neoplasms
lesions (animal)
2 Citations (Scopus)
Adoptive Immunotherapy
Brain Neoplasms
T-Lymphocytes
Recurrence
Whole-Body Irradiation
65 Citations (Scopus)
Cottontail rabbit papillomavirus
Viral Genes
Firearms
Vaccination
rabbits
12 Citations (Scopus)
Cottontail rabbit papillomavirus
DNA Vaccines
Papillomavirus Infections
recombinant vaccines
epitopes
13 Citations (Scopus)

Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury

Awad, A. S., Gao, T., Gvritishvili, A., You, H., Liu, Y., Cooper, T. K., Brian Reeves, W. & Tombran-Tink, J., Sep 15 2013, In : American Journal of Physiology - Renal Physiology. 305, 6, p. F891-F900

Research output: Contribution to journalArticle

Kidney
Peptides
Wounds and Injuries
pigment epithelium-derived factor
Puromycin Aminonucleoside
1 Citation (Scopus)
Biomarkers
Adenoma
Proteomics
Hyperplasia
Lung
5 Citations (Scopus)

Reinitiated expression of EJras transgene in targeted epidermal cells of transgenic rabbits by cottontail rabbit papillomavirus infection

Peng, X., Griffith, J. W. & Lang, C. M., Oct 10 2001, In : Cancer Letters. 171, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Cottontail rabbit papillomavirus
Papillomavirus Infections
Transgenes
Rabbits
Keratoacanthoma
3 Citations (Scopus)

S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion

Shi, C., Cooper, T. K., Mccloskey, D. E., Glick, A. B., Shantz, L. M. & Feith, D. J., Jul 1 2012, In : Carcinogenesis. 33, 7, p. 1310-1318 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Keratin-5
Polyamines
Skin
Doxycycline
28 Citations (Scopus)

Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus

Cladel, N. M., Budgeon, L. R., Cooper, T. K., Balogh, K. K., Hu, J. & Christensen, N. D., Aug 1 2013, In : Journal of virology. 87, 16, p. 9391-9395 5 p.

Research output: Contribution to journalArticle

DNA Virus Infections
tissue tropism
Tropism
DNA Viruses
Papillomaviridae
16 Citations (Scopus)

Septicemia and peritonitis in a colony of common marmosets (Callithrix jacchus) secondary to Klebsiella pneumoniae infection

Pisharath, H. R., Cooper, T. K., Brice, A. K., Cianciolo, R. E., Pistorio, A. L., Wachtman, L. M., Mankowski, J. L. & Newcomer, C. E., Jan 1 2005, In : Contemporary Topics in Laboratory Animal Science. 44, 1, p. 35-37 3 p.

Research output: Contribution to journalArticle

Klebsiella Infections
Callithrix
Callithrix jacchus
peritonitis
Klebsiella pneumoniae
3 Citations (Scopus)

Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test

Lafleur, R. A., Wilson, R. P., Morgan, D. J. & Henderson-Redmond, A. N., Jan 1 2018, In : Neuroreport. 29, 6, p. 447-452 6 p.

Research output: Contribution to journalArticle

Dronabinol
Pain Measurement
Sex Characteristics
Cannabinoids
Cannabinoid Receptors
24 Citations (Scopus)

Sex differences in the expression of lung inflammatory mediators in response to ozone

Cabello, N., Mishra, V., Sinha, U., Diangelo, S. L., Chroneos, Z. C., Ekpa, N. A., Cooper, T. K., Caruso, C. R. & Silveyra, P., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 10, p. L1150-L1163

Research output: Contribution to journalArticle

Ozone
Sex Characteristics
Lung
Bronchoalveolar Lavage Fluid
Interleukin-6

Short-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model

Kim, T. Y., Jeng, P., Hwang, J. M., Pfeiffer, Z., Patel, D., Cooper, L. L., Kossidas, K., Centracchio, J., Peng, X., Koren, G., Qu, Z. & Choi, B. R., Dec 1 2019, In : Scientific reports. 9, 1, 14849.

Research output: Contribution to journalArticle

Open Access
pamidronate
Long QT Syndrome
Action Potentials
Heart Rate
Rabbits
152 Citations (Scopus)

Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

Guan, Z., Peng, X. & Fang, J., Aug 20 2004, In : Brain research. 1018, 1, p. 38-47 10 p.

Research output: Contribution to journalArticle

Sleep Deprivation
Extracellular Signal-Regulated MAP Kinases
Hippocampus
Phosphorylation
Sleep
16 Citations (Scopus)

Sorafenib and quinacrine target anti-apoptotic protein MCL1: A poor prognostic marker in Anaplastic Thyroid Cancer (ATC)

Abdulghani, J., Gokare, P., Gallant, J. N., Dicker, D., Whitcomb, T., Cooper, T., Liao, J. J., Derr, J., Liu, J., Goldenberg, D., Finnberg, N. K. & El-Deiry, W. S., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6192-6203 12 p.

Research output: Contribution to journalArticle

Quinacrine
Apoptosis Regulatory Proteins
Thyroid Neoplasms
Anaplastic Thyroid Carcinoma
sorafenib
5 Citations (Scopus)

Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo

Bitzer, Z. T., Wopperer, A. L., Chrisfield, B. J., Tao, L., Cooper, T. K., Vanamala, J., Elias, R. J., Hayes, J. E. & Lambert, J. D., Feb 1 2017, In : Journal of Nutritional Biochemistry. 40, p. 201-208 8 p.

Research output: Contribution to journalArticle

Soybean Proteins
Dextran Sulfate
Inflammation
Caspase 1
Splenomegaly
10 Citations (Scopus)

Spatially discordant alternans and arrhythmias in tachypacing-induced cardiac myopathy in transgenic LQT1 rabbits: The importance of IKsand Ca2+ cycling

Lau, E., Kossidas, K., Kim, T. Y., Kunitomo, Y., Ziv, O., Zhen, S., Taylor, C., Schofield, L., Yammine, J., Liu, G., Peng, X., Qu, Z., Koren, G. & Choi, B. R., May 13 2015, In : PloS one. 10, 5, e0122754.

Research output: Contribution to journalArticle

pamidronate
muscular diseases
arrhythmia
Muscular Diseases
Cardiac Arrhythmias
9 Citations (Scopus)

Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus)

Cooper, T. K., Adelsohn, D. & Gilbertson, S. R., May 1 2006, In : Veterinary Pathology. 43, 3, p. 377-380 4 p.

Research output: Contribution to journalArticle

Oryctolagus cuniculus
rabbits
Rabbits
Keratin-18
Epithelioid Cells
3 Citations (Scopus)

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

Cooper, T. K., Griffith, J. W., Chroneos, Z. C., Izer, J. M., Willing, L. B. & Peng, X., Jan 1 2017, In : Veterinary Pathology. 54, 1, p. 178-187 10 p.

Research output: Contribution to journalArticle

Oryctolagus cuniculus
lesions (animal)
rabbits
lungs
Rabbits
3 Citations (Scopus)

Strong and Specific Protective and Therapeutic Immunity Induced by Single HLA-A2.1 Restricted Epitope DNA Vaccine in Rabbits

Hu, J., Schell, T., Peng, X., Cladel, N. M., Balogh, K. K. & Christensen, N., Dec 14 2009, In : Procedia in Vaccinology. 1, 1, p. 4-14 11 p.

Research output: Contribution to journalArticle

DNA Vaccines
Epitopes
Immunity
Cottontail rabbit papillomavirus
Rabbits
20 Citations (Scopus)

Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model

Li, G., Liu, D., Cooper, T. K., Kimchi, E. T., Qi, X., Avella, D. M., Li, N., Yang, Q. X., Kester, M., Rountree, C. B., Kaifi, J. T., Cole, D. J., Rockey, D. C., Schell, T. D. & Staveley-O'Carroll, K. F., Jan 1 2017, In : Journal of Hepatology. 66, 1, p. 75-85 11 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Neoplasms
Neoplasm Antigens
T-Lymphocytes
Programmed Cell Death 1 Receptor

Systemic iron deficiency in a nonhuman primate model of endometriosis

Atkins, H. M., Appt, S. E., Taylor, R. N., Torres-Mendoza, Y., Lenk, E. E., Rosenthal, N. S. & Caudell, D. L., Aug 2018, In : Comparative Medicine. 68, 4, p. 298-307 10 p.

Research output: Contribution to journalArticle

Endometriosis
Primates
Iron
animal models
iron
3 Citations (Scopus)
students
rodents
learning
animal care
laboratory animals
2 Citations (Scopus)

Temporal variation in cellular proliferation during recornification of mouse tail skin

Wilson, R., McLaughlin, P., Lang, C. M. & Zagon, I., Jan 1 1998, In : Cell Proliferation. 31, 5-6, p. 191-201 11 p.

Research output: Contribution to journalArticle

Tail
Cell Proliferation
Skin
Wounds and Injuries
Epidermis
9 Citations (Scopus)

The Clinical Importance of Pulsatile Flow in Extracorporeal Life Support: The Penn State Health Approach

Undar, A., Wang, S., Izer, J., Clark, J., Kunselman, A., Patel, S., Shank, K., Profeta, E., Wilson, R. & Ostadal, P., Dec 1 2016, In : Artificial Organs. 40, 12, p. 1101-1104 4 p.

Research output: Contribution to journalArticle

Pulsatile Flow
Pulsatile flow
Extracorporeal Membrane Oxygenation
Left Ventricular Function
Respiratory Insufficiency
4 Citations (Scopus)
Pediatrics
Heart-Assist Devices
Left Ventricular Function
Animals
Animal Models
11 Citations (Scopus)

The effect of single agent oral fusaric acid (FA) on the growth of subcutaneously xenografted SCC-1 cells in a nude mouse model

Ruda, J. M., Beus, K. S., Hollenbeak, C. S., Wilson, R. & Stack, B. C., Sep 1 2006, In : Investigational New Drugs. 24, 5, p. 377-381 5 p.

Research output: Contribution to journalArticle

Fusaric Acid
Nude Mice
Growth
Tumor Burden
Neoplasms