Department of Microbiology and Immunology

  • United States

Organization profile

Organization profile

The faculty of the Department of Microbiology and Immunology at Penn State College of Medicine are known for their major contributions in molecular and structural virology, viral pathogenesis and viral and tumor immunology. Members of the faculty have attained national and international recognition for their research endeavors, as evidenced by their outstanding record of scientific publications, membership and leadership roles on national scientific review committees and advisory panels, appointments on editorial boards of leading virology and immunology journals and strong extramural grant funding.

Departmental graduates have been highly successful in obtaining postdoctoral positions in leading laboratories at major research centers and establishing rewarding careers as scientific investigators and educators.

Studies of microorganisms and their interactions with host cells, as well as the immune system, are generating knowledge used to conquer human disease and also providing answers to many of the major scientific questions confronting molecular and cellular biologists. Virology, immunology, oncology and metabolic diseases are broad research areas being pursued by various members of the department, with research opportunities available to explore interactions of viruses with host cells and organisms, virus replication and assembly, viral latency and reactivation and innate and adaptive immune responses in host defense, autoimmunity and mucosal immunity and inflammation.

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    Photo of Ryan Hobbs

    Ryan Hobbs, PhD

    Person: Academic


    Research Output

    Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells

    Kim, Y. S., Gupta Vallur, P., Jones, V. M., Worley, B. L., Shimko, S., Shin, D. H., Crawford, L. T. C., Chen, C. W., Aird, K. M., Abraham, T., Shepherd, T. G., Warrick, J. I., Lee, N. Y., Phaeton, R., Mythreye, K. & Hempel, N., Feb 20 2020, In : Oncogene. 39, 8, p. 1619-1633 15 p.

    Research output: Contribution to journalArticle

  • Open Access
  • Open Access
  • Type II but not type I IFN signaling is indispensable for TLR7-promoted development of autoreactive B cells and systemic autoimmunity

    Chodisetti, S. B., Fike, A. J., Domeier, P. P., Singh, H., Choi, N. M., Corradetti, C., Kawasawa, Y. I., Cooper, T. K., Caricchio, R. & Rahman, Z. S. M., Feb 15 2020, In : Journal of Immunology. 204, 4, p. 796-809 14 p.

    Research output: Contribution to journalArticle

  • 17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner

    Fuentes, N., Nicoleau, M., Cabello, N., Montes, D., Zomorodi, N., Chroneos, Z. C. & Silveyra, P., Nov 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 317, 5, p. L702-L716

    Research output: Contribution to journalArticle

  • Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

    Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C. P., May 2019, In : Lung Cancer. 131, p. 58-61 4 p.

    Research output: Contribution to journalArticle

  • A global scientific strategy to cure hepatitis B

    Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors, Jul 2019, In : The Lancet Gastroenterology and Hepatology. 4, 7, p. 545-558 14 p.

    Research output: Contribution to journalComment/debate

  • 20 Scopus citations

    Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

    Bazewicz, C. G., Dinavahi, S. S., Schell, T. D. & Robertson, G. P., Jan 2019, In : Immunology. 156, 1, p. 47-55 9 p.

    Research output: Contribution to journalReview article

  • 7 Scopus citations

    Asymmetry in icosahedral viruses

    Goetschius, D. J., Parrish, C. R. & Hafenstein, S., Jun 2019, In : Current Opinion in Virology. 36, p. 67-73 7 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    A trip down memory lane with Retrovirology

    Benkirane, M., Berkhout, B., Borrow, P., Fassati, A., Fujii, M., Garcia-Martinez, J. V., Margolis, D., Nijhuis, M., Parent, L., Strebel, K., Venter, F., Kirchhoff, F., Lever, A., Ross, S. & Mak, J., Aug 21 2019, In : Retrovirology. 16, 1, 22.

    Research output: Contribution to journalReview article

    Open Access