Department of Microbiology and Immunology

  • United States

Organization profile

Organization profile

The faculty of the Department of Microbiology and Immunology at Penn State College of Medicine are known for their major contributions in molecular and structural virology, viral pathogenesis and viral and tumor immunology. Members of the faculty have attained national and international recognition for their research endeavors, as evidenced by their outstanding record of scientific publications, membership and leadership roles on national scientific review committees and advisory panels, appointments on editorial boards of leading virology and immunology journals and strong extramural grant funding.

Departmental graduates have been highly successful in obtaining postdoctoral positions in leading laboratories at major research centers and establishing rewarding careers as scientific investigators and educators.

Studies of microorganisms and their interactions with host cells, as well as the immune system, are generating knowledge used to conquer human disease and also providing answers to many of the major scientific questions confronting molecular and cellular biologists. Virology, immunology, oncology and metabolic diseases are broad research areas being pursued by various members of the department, with research opportunities available to explore interactions of viruses with host cells and organisms, virus replication and assembly, viral latency and reactivation and innate and adaptive immune responses in host defense, autoimmunity and mucosal immunity and inflammation.

Fingerprint Dive into the research topics where Department of Microbiology and Immunology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

T-Lymphocytes Medicine & Life Sciences
Virion Medicine & Life Sciences
Capsid Medicine & Life Sciences
Cottontail rabbit papillomavirus Medicine & Life Sciences
Viruses Medicine & Life Sciences
Proteins Medicine & Life Sciences
Papillomaviridae Agriculture & Biology
Rous sarcoma virus Medicine & Life Sciences

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Profiles

Photo of Ryan Hobbs

Ryan Hobbs, PhD

Person: Academic

20082019

Research Output 1977 2019

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C., May 1 2019, In : Lung Cancer. 131, p. 58-61 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Interleukin-6
T-Lymphocytes
Population
STAT1 Transcription Factor
6 Citations (Scopus)

A global scientific strategy to cure hepatitis B

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors, Jul 1 2019, In : The Lancet Gastroenterology and Hepatology. 4, 7, p. 545-558 14 p.

Research output: Contribution to journalComment/debate

Hepatitis B
Hepatitis B virus
Virus Diseases
Chronic Hepatitis B
Circular DNA
3 Citations (Scopus)

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance

Asymmetry in icosahedral viruses

Goetschius, D. J., Parrish, C. R. & Hafenstein, S., Jun 1 2019, In : Current Opinion in Virology. 36, p. 67-73 7 p.

Research output: Contribution to journalReview article

Leviviridae
Genome
Viruses
Picornaviridae
Capsid Proteins

A trip down memory lane with Retrovirology

Benkirane, M., Berkhout, B., Borrow, P., Fassati, A., Fujii, M., Garcia-Martinez, J. V., Margolis, D., Nijhuis, M., Parent, L., Strebel, K., Venter, F., Kirchhoff, F., Lever, A., Ross, S. & Mak, J., Aug 21 2019, In : Retrovirology. 16, 1, 22.

Research output: Contribution to journalReview article

Open Access

Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., de Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, G., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., Jul 1 2019, In : Experimental and Molecular Medicine. 51, 7, 71.

Research output: Contribution to journalComment/debate

Open Access
Molecular Medicine
Licensure
Medicine
Rabbits
3 Citations (Scopus)

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

Hu, J., Lin, Y. Y., Chen, P. J., Watashi, K. & Wakita, T., Jan 1 2019, In : Gastroenterology. 156, 2, p. 338-354 17 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepatitis B virus
Animal Models
Pharmaceutical Preparations
Cell Culture Techniques
1 Citation (Scopus)

Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)

Ebad-Allah, J., Afonso, J. F., M., K., Hu, J., Zhu, Y. L., Mao, Z. Q., J., K. & Kuntscher, C. A., 2019, In : Physical Review B. 99, 12

Research output: Contribution to journalArticle

metalloids
pressure effects
conductivity
corrugating
interlayers

CryoEM reconstruction approaches to resolve asymmetric features

Goetschius, D. J., Lee, H. & Hafenstein, S., Jan 1 2019, Advances in Virus Research. Rey, F. A. (ed.). Academic Press Inc., p. 73-91 19 p. (Advances in Virus Research; vol. 105).

Research output: Chapter in Book/Report/Conference proceedingChapter

Viruses
Capsid
Life Cycle Stages
Genome
Proteins
Human herpesvirus 1
Human Herpesvirus 1
cells
Proteins
proteins

Projects 1978 2023

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Human Herpesvirus 1
Simplexvirus
Herpesviridae
Antibody Formation
Endosomal Sorting Complexes Required for Transport
Cytomegalovirus
Viruses
Membranes
Capsid
Polyomavirus
Demyelinating Diseases
Progressive Multifocal Leukoencephalopathy
Oligodendroglia
T-Lymphocytes
Epstein-Barr Virus Infections
Human Herpesvirus 4
Epithelium
Infection
Viruses
Hepadnaviridae
Nucleocapsid
Hepatitis B virus
RNA-Directed DNA Polymerase
Reverse Transcription

VIRUSES AND CANCER

Meyers, C., Isom, H. C., Courtney, R. & Lukacher, A.

National Institutes of Health

5/6/947/31/22

Project: Research project

Allergy and Immunology
Virology
Viruses
Neoplasms
Retroviridae
Interferons
Antiviral Agents
Immunity
Vaccinia virus
Interferon Receptors