Department of Microbiology and Immunology

  • United States

Organization profile

Organization profile

The faculty of the Department of Microbiology and Immunology at Penn State College of Medicine are known for their major contributions in molecular and structural virology, viral pathogenesis and viral and tumor immunology. Members of the faculty have attained national and international recognition for their research endeavors, as evidenced by their outstanding record of scientific publications, membership and leadership roles on national scientific review committees and advisory panels, appointments on editorial boards of leading virology and immunology journals and strong extramural grant funding.

Departmental graduates have been highly successful in obtaining postdoctoral positions in leading laboratories at major research centers and establishing rewarding careers as scientific investigators and educators.

Studies of microorganisms and their interactions with host cells, as well as the immune system, are generating knowledge used to conquer human disease and also providing answers to many of the major scientific questions confronting molecular and cellular biologists. Virology, immunology, oncology and metabolic diseases are broad research areas being pursued by various members of the department, with research opportunities available to explore interactions of viruses with host cells and organisms, virus replication and assembly, viral latency and reactivation and innate and adaptive immune responses in host defense, autoimmunity and mucosal immunity and inflammation.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

T-Lymphocytes Medicine & Life Sciences
Virion Medicine & Life Sciences
Capsid Medicine & Life Sciences
Cottontail rabbit papillomavirus Medicine & Life Sciences
Proteins Medicine & Life Sciences
Viruses Medicine & Life Sciences
Papillomaviridae Agriculture & Biology
Rous sarcoma virus Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Photo of Ryan Hobbs

Ryan Hobbs, PhD

Person: Academic

20082018

Research Output 1977 2019

Advanced NSCLC patients with high IL-6 levels have altered peripheral T cell population and signaling

Rice, S. J., Liu, X., Zhang, J., Jia, B., Zheng, H. & Belani, C., May 1 2019, In : Lung Cancer. 131, p. 58-61 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Interleukin-6
T-Lymphocytes
Population
STAT1 Transcription Factor
1 Citation (Scopus)

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance

Asymmetry in icosahedral viruses

Goetschius, D. J., Parrish, C. R. & Hafenstein, S., Jun 1 2019, In : Current Opinion in Virology. 36, p. 67-73 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

Hu, J., Lin, Y. Y., Chen, P. J., Watashi, K. & Wakita, T., Jan 1 2019, In : Gastroenterology. 156, 2, p. 338-354 17 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepatitis B virus
Animal Models
Pharmaceutical Preparations
Cell Culture Techniques

Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)

Ebad-Allah, J., Afonso, J. F., M., K., Hu, J., Zhu, Y. L., Mao, Z. Q., J., K. & Kuntscher, C. A., 2019, In : Physical Review B. 99, 12

Research output: Contribution to journalArticle

metalloids
pressure effects
conductivity
corrugating
interlayers

Downregulation of CD73 associates with T cell exhaustion in AML patients

Kong, Y., Jia, B., Zhao, C., Claxton, D., Sharma, A., Annageldiyev, C., Fotos, J., Zeng, H., Paulson, R., Prabhu, K. S. & Zheng, H., Apr 24 2019, In : Journal of Hematology and Oncology. 12, 1, 40.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Down-Regulation
T-Lymphocytes
Adenosine
Neoplasms
1 Citation (Scopus)
Open Access
Acute Myeloid Leukemia
T-Lymphocytes
Leukemia
Transcription Factors
Induction Chemotherapy
1 Citation (Scopus)

Examination and reconstruction of three ancient endogenous parvovirus capsid protein gene remnants found in rodent genomes

Callaway, H. M., Subramanian, S., Urbina, C. A., Barnard, K. N., Dick, R. A., Bator, C. M., Hafenstein, S., Gifford, R. J. & Parrish, C. R., Mar 1 2019, In : Journal of virology. 93, 6, e01542-18.

Research output: Contribution to journalArticle

Parvovirus
Protoparvovirus
Capsid Proteins
coat proteins
capsid
1 Citation (Scopus)

Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1

Xu, J., Liu, H., Yang, Y., Wang, X., Liu, P., Li, Y., Meyers, C., Banerjee, N. S., Wang, H. K., Cam, M., Lu, W., Chow, L. T., Xie, X., Zhu, J. & Zheng, Z. M., Jan 29 2019, In : mBio. 10, 1

Research output: Contribution to journalArticle

RNA-Binding Proteins
Genome
Uterine Cervical Neoplasms
p16 Genes
DNA Replication

Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation

Carmichael, J. C., Starkey, J., Zhang, D., Sarfo, A., Chadha, P., Wills, J. & Han, J., Jan 15 2019, In : Virology. 527, p. 64-76 13 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Product Packaging
Giant Cells
Glycoproteins
Proteins

Projects 1978 2023

Non-Receptor Type 1 Protein Tyrosine Phosphatase
Human Herpesvirus 1
Simplexvirus
Herpesviridae
Antibody Formation
Endosomal Sorting Complexes Required for Transport
Cytomegalovirus
Viruses
Membranes
Capsid
Inflammatory Bowel Diseases
Antigen-Presenting Cells
Macrophages
T-Lymphocytes
Anti-Inflammatory Agents
Enteric Nervous System
Mucosal Immunity
Immune System
Macrophages
Gastrointestinal Tract
Polyomavirus
Demyelinating Diseases
Progressive Multifocal Leukoencephalopathy
Oligodendroglia
T-Lymphocytes
Epstein-Barr Virus Infections
Human Herpesvirus 4
Epithelium
Infection
Viruses
Mouth Neoplasms
Epigenomics
Acquired Immunodeficiency Syndrome
MicroRNAs
Mouth Diseases
Hepadnaviridae
Nucleocapsid
Hepatitis B virus
RNA-Directed DNA Polymerase
Reverse Transcription

VIRUSES AND CANCER

Meyers, C., Isom, H. C., Courtney, R. & Lukacher, A.

National Institutes of Health

5/6/947/31/22

Project: Research project

Allergy and Immunology
Virology
Viruses
Neoplasms
Retroviridae