Department of Microbiology and Immunology

  • United States

Research Output

2016

Malignant melanoma—The cradle of anti-neoplastic immunotherapy

Koller, K. M., Wang, W., Schell, T. D., Cozza, E. M., Kokolus, K. M., Neves, R. I., Mackley, H. B., Pameijer, C., Leung, A., Anderson, B., Mallon, C. A., Robertson, G. & Drabick, J. J., Oct 1 2016, In : Critical Reviews in Oncology/Hematology. 106, p. 25-54 30 p.

Research output: Contribution to journalReview article

15 Scopus citations

Marginal zinc intake reduces the protective effect of lactation on mammary gland carcinogenesis in a DMBA-induced tumor model in mice

Bostanci, Z., Mack, R. P., Enomoto, L. M., Alam, S., Brown, A., Neumann, C., Soybel, D. I. & Kelleher, S. L., Mar 2016, In : Oncology reports. 35, 3, p. 1409-1416 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Melanoma immunotherapy in mice using genetically engineered pluripotent stem cells

Haque, M., Song, J., Fino, K., Sandhu, P., Wang, Y., Ni, B., Fang, D. & Song, J., Jan 1 2016, In : Cell Transplantation. 25, 5, p. 811-827 17 p., 17.

Research output: Contribution to journalArticle

6 Scopus citations

Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs

Li, F., Cheng, L., Murphy, C. M., Reszka-Blanco, N. J., Wu, Y., Chi, L., Hu, J. & Su, L., Nov 7 2016, In : Scientific reports. 6, 36483.

Research output: Contribution to journalArticle

16 Scopus citations

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

Han, K. J., Foster, D., Harhaj, E. W., Dzieciatkowska, M., Hansen, K. & Liu, C. W., Apr 1 2016, In : Human molecular genetics. 25, 7, p. 1392-1405 14 p., ddw021.

Research output: Contribution to journalArticle

10 Scopus citations

Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue

Cladel, N. M., Budgeon, L. R., Balogh, K. K., Cooper, T., Hu, J. & Christensen, N., Jan 15 2016, In : Virology. 488, p. 73-80 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

MRI contrast agent for targeting glioma: Interleukin-13 labeled liposome encapsulating gadolinium-DTPA

Liu, X., Madhankumar, A. B., Miller, P. A., Duck, K. A., Hafenstein, S., Rizk, E., Slagle-Webb, B., Sheehan, J. M., Connor, J. R. & Yang, Q. X., May 1 2016, In : Neuro-oncology. 18, 5, p. 691-699 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Near-atomic resolution structure of a highly neutralizing fab bound to canine parvovirus

Organtini, L. J., Lee, H., Iketani, S., Huang, K., Ashley, R. E., Makhov, A. M., Conway, J. F., Parrish, C. R. & Hafenstein, S., Jan 1 2016, In : Journal of virology. 90, 21, p. 9733-9742 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Novel immunotherapies for hematological malignancies

Vasekar, M., Rizvi, S., Liu, X., Vrana, K. E. & Zheng, H., Aug 1 2016, In : Current Molecular Pharmacology. 9, 3, p. 264-271 8 p.

Research output: Contribution to journalReview article

9 Scopus citations

Phosphorylation of the brome mosaic virus capsid regulates the timing of viral infection

Hoover, H. S., Wang, J. C. Y., Middleton, S., Ni, P., Zlotnick, A., Vaughan, R. C. & Cheng Kao, C., Jan 1 2016, In : Journal of virology. 90, 17, p. 7748-7760 13 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Reducing Ribosome Biosynthesis Promotes Translation during Low Mg2+ Stress

Pontes, M. H., Yeom, J. & Groisman, E. A., Nov 3 2016, In : Molecular cell. 64, 3, p. 480-492 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Role of autophagy in the regulation of epithelial cell junctions

Nighot, P. & Ma, T., Jul 2 2016, In : Tissue Barriers. 4, 3, e1171284.

Research output: Contribution to journalReview article

11 Scopus citations

Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

Fu, K., Sun, X., Wier, E. M., Hodgson, A., Hobbs, R. P. & Wan, F., Dec 20 2016, In : eLife. 5, DECEMBER2016, e21957.

Research output: Contribution to journalArticle

4 Scopus citations

Severe Babesia microti Infection in an Immunocompetent Host in Pennsylvania

Genda, J., Negron, EA., Lotfipour, M., Balabhadra, S., Desai, D., Craft, D. & Katzman, M., Aug 22 2016, In : Journal of Investigative Medicine High Impact Case Reports. 4, 3

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E., Feb 1 2016, In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Contribution to journalShort survey

Single mutations in the VP2 300 loop region of the three-fold spike of the carnivore parvovirus capsid can determine host range

Allison, A. B., Organtini, L. J., Zhang, S., Hafenstein, S. L., Holmes, E. C. & Parrish, C. R., Jan 1 2016, In : Journal of virology. 90, 2, p. 753-767 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity

Haque, M., Song, J., Fino, K., Sandhu, P., Song, X., Lei, F., Zheng, S., Ni, B., Fang, D. & Song, J., Feb 5 2016, In : Scientific reports. 6, 20588.

Research output: Contribution to journalArticle

13 Scopus citations

Structural biology: A picornavirus unlike the others

Hafenstein, S., Oct 26 2016, In : Nature Microbiology. 1, 11, 16217.

Research output: Contribution to journalShort survey

Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

Chandler, P., Kochupurakkal, B. S., Alam, S., Richardson, A. L., Soybel, D. I. & Kelleher, S. L., Jan 5 2016, In : Molecular Cancer. 15, 1, 2.

Research output: Contribution to journalArticle

25 Scopus citations

Susceptibility of HPV16 and 18 to high level disinfectants indicated for semi-critical ultrasound probes

Ryndock, E., Robison, R. & Meyers, C., Jun 1 2016, In : Journal of Medical Virology. 88, 6, p. 1076-1080 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8+ T-cell exhaustion and poor clinical outcome in AML patients

Kong, Y., Zhu, L., Schell, T. D., Zhang, J., Claxton, D. F., Ehmann, W. C., Rybka, W. B., George, M. R., Zeng, H. & Zheng, H., Jun 15 2016, In : Clinical Cancer Research. 22, 12, p. 3057-3066 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

TGF-β-induced regulatory t cells directly suppress b cell responses through a noncytotoxic mechanism

Xu, A., Liu, Y., Chen, W., Wang, J., Xue, Y., Huang, F., Rong, L., Lin, J., Liu, D., Yan, M., Li, Q. Z., Li, B., Song, J., Olsen, N. & Zheng, S. G., May 1 2016, In : Journal of Immunology. 196, 9, p. 3631-3641 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Xu, Y., Zhao, F., Qiu, Q., Chen, K., Wei, J., Kong, Q., Gao, B., Melo-Cardenas, J., Zhang, B., Zhang, J., Song, J., Zhang, D. D., Zhang, J., Fan, Y., Li, H. & Fang, D., Jul 15 2016, In : Nature communications. 7, 12073.

Research output: Contribution to journalArticle

9 Scopus citations

The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs

Lee, H., Shingler, K. L., Organtini, L. J., Ashley, R. E., Makhov, A. M., Conway, J. F. & Hafenstein, S., Aug 2016, In : Science Advances. 2, 8, e1501929.

Research output: Contribution to journalArticle

30 Scopus citations

The Use of Filter-Purified Merozoites to Assess Anti-Merozoite Immunity

Biryukov, S. & Stoute, J. A., Dec 1 2016, In : EBioMedicine. 14, p. 11-12 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Al-Sadi, R., Guo, S., Ye, D., Rawat, M. & Ma, T. Y., May 1 2016, In : American Journal of Pathology. 186, 5, p. 1151-1165 15 p.

Research output: Contribution to journalArticle

56 Scopus citations
Open Access
5 Scopus citations

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Schietinger, A., Philip, M., Krisnawan, V. E., Chiu, E. Y., Delrow, J. J., Basom, R. S., Lauer, P., Brockstedt, D. G., Knoblaugh, S. E., Hämmerling, G. J., Schell, T. D., Garbi, N. & Greenberg, P. D., Jan 1 2016, In : Immunity. 45, 2, p. 389-401 13 p.

Research output: Contribution to journalArticle

134 Scopus citations

Type I interferons regulate the magnitude and functionality of mouse polyomavirus-specific CD8 T cells in a virus strain- dependent manner

Qin, Q., Shwetank, Frost, E. L., Maru, S. & Lukacher, A. E., May 1 2016, In : Journal of virology. 90, 10, p. 5187-5199 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Using a Novel Partitivirus in Pseudogymnoascus destructans to Understand the Epidemiology of White-Nose Syndrome

Thapa, V., Turner, G. G., Hafenstein, S., Overton, B. E., Vanderwolf, K. J. & Roossinck, M. J., Dec 27 2016, In : PLoS pathogens. 12, 12, e1006076.

Research output: Contribution to journalArticle

10 Scopus citations

Viral DNA-dependent induction of innate immune response to hepatitis B virus in immortalized mouse hepatocytes

Cui, X., Clark, D. N., Liu, K., Xu, X. D., Guo, J. T. & Hu, J., Jan 1 2016, In : Journal of virology. 90, 1, p. 486-496 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2015

A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment

Lee, H., Brendle, S. A., Bywaters, S. M., Guan, J., Ashley, R. E., Yoder, J. D., Makhov, A. M., Conway, J. F., Christensen, N. D. & Hafenstein, S., Jan 1 2015, In : Journal of virology. 89, 2, p. 1428-1438 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Alteration of mature nucleocapsid and enhancement of covalently closed circular DNA formation by hepatitis B virus core mutants defective in complete-virion formation

Cui, X., Luckenbaugh, L., Bruss, V. & Hu, J., Jan 1 2015, In : Journal of virology. 89, 19, p. 10064-10072 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Analysis of erythrocyte invasion mechanisms of plasmodium falciparum clinical isolates across 3 malaria-endemic areas in Ghana

Mensah-Brown, H. E., Amoako, N., Abugri, J., Stewart, L. B., Agongo, G., Dickson, E. K., Ofori, M. F., Stoute, J. A., Conway, D. J. & Awandare, G. A., Oct 15 2015, In : Journal of Infectious Diseases. 212, 8, p. 1288-1297 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections

Cladel, N. M., Budgeon, L. R., Balogh, K. K., Cooper, T. K., Hu, J. & Christensen, N. D., Mar 24 2015, In : PloS one. 10, 3, e0120128.

Research output: Contribution to journalArticle

18 Scopus citations

Apolipoprotein E levels in pediatric patients undergoing cardiopulmonary bypass

Aĝirbaşli, M., Song, J., Lei, F., Wang, S., Kunselman, A. R., Clark, J. B., Myers, J. L. & Ündar, A., Jan 1 2015, In : Artificial organs. 39, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Aryl hydrocarbon receptor interacting protein targets IRF7 to suppress antiviral signaling and the induction of type I interferon

Zhou, Q., Lavorgna, A., Bowman, M., Hiscott, J. & Harhaj, E. W., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14729-14739 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Atomic Modeling of an Immature Retroviral Lattice Using Molecular Dynamics and Mutagenesis

Goh, B. C., Perilla, J. R., England, M. R., Heyrana, K. J., Craven, R. C. & Schulten, K., Aug 7 2015, In : Structure. 23, 8, p. 1414-1425 12 p., 3201.

Research output: Contribution to journalArticle

26 Scopus citations

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Nighot, P. K., Hu, C. A. A. & Ma, T. Y., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, p. 7234-7246 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance

Wong, E. B., Soni, C., Chan, A. Y., Domeier, P. P., Shwetank, Abraham, T., Limaye, N., Khan, T. N., Elias, M. J., Chodisetti, S. B., Wakeland, E. K. & Rahman, Z. S. M., May 1 2015, In : Journal of Immunology. 194, 9, p. 4130-4143 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
13 Scopus citations

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

Shuda, M., Velásquez, C., Cheng, E., Cordek, D. G., Kwun, H. J., Chang, Y. & Moore, P. S., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 5875-5882 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Cleavage of the HPV16 minor capsid protein L2 during virion morphogenesis ablates the requirement for cellular furin during de novo infection

Cruz, L., Biryukov, J., Conway, M. J. & Meyers, C., Nov 11 2015, In : Viruses. 7, 11, p. 5813-5830 18 p.

Research output: Contribution to journalArticle

11 Scopus citations
Open Access

Cutting edge: Resident memory CD8 T cells express high-affinity TCRs

Frost, E. L., Kersh, A. E., Evavold, B. D. & Lukacher, A. E., Oct 15 2015, In : Journal of Immunology. 195, 8, p. 3520-3524 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cytotoxic T lymphocytes in SV40 infections

Schell, T. D. & Tevethia, S. S., Jan 1 2015, In : Methods in Molecular Biology. 165, p. 243-256 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Deleted in breast cancer 1 suppresses B cell activation through RelB and is regulated by IKKα phosphorylation

Kong, S., Dong, H., Song, J., Thiruppathi, M., Prabhakar, B. S., Qiu, Q., Lin, Z., Chini, E., Zhang, B. & Fang, D., Oct 15 2015, In : Journal of Immunology. 195, 8, p. 3685-3693 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity

Soni, C., Domeier, P. P., Wong, E. B., Shwetank, Khan, T. N., Elias, M. J., Schell, S. L., Lukacher, A. E., Cooper, T. K. & Rahman, Z. S. M., Sep 1 2015, In : Journal of Autoimmunity. 63, p. 31-46 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?

Cui, X., McAllister, R., Boregowda, R., Sohn, J. A., Ledesma, F. C., Caldecott, K. W., Seeger, C. & Hu, J., Jun 16 2015, In : PloS one. 10, 6, e0128401.

Research output: Contribution to journalArticle

40 Scopus citations

Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy

Wyluda, E. J., Cheng, J., Schell, T. D., Haley, J. S., Mallon, C., Neves, R. I., Robertson, G., Sivik, J., Mackley, H., Talamo, G. & Drabick, J. J., Jan 1 2015, In : Cancer Biology and Therapy. 16, 5, p. 662-670 9 p.

Research output: Contribution to journalArticle

18 Scopus citations