Organization profile

Organization profile

The Department of Pharmacology at Penn State College of Medicine is dedicated to teaching and research in the biomedical sciences. Its missions are to provide high-quality training of the next generation of scientists and physicians and to develop new diagnostic tests, medicines and delivery systems.

At its home in Hershey, Pennsylvania, the Department of Pharmacology occupies 20,000 square feet of state-of-the-art laboratory space in the Hershey Center for Applied Research, Penn State Cancer Institute and Penn State Institute for Personalized Medicine.

The faculty comprises more than 25 primary faculty members with an additional 20 joint faculty from clinical and basic science departments. Research ranges from cell and molecular studies of cancer, to biochemical/pharmacological investigation of nervous system function, to whole-animal studies of drug development.

As educational leaders in their fields, departmental faculty are involved in medical, graduate and allied health instruction and training.

We are assistant deans, course directors, textbook authors and PhD program directors. We are research scientists, endowed professors and entrepreneurs. We are Penn State.

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cells Chemical Compounds
Melanoma Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Epoxy Compounds Medicine & Life Sciences
Rats Chemical Compounds

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Profiles

Photo of Matthew Coates

Matthew Coates, MD, PhD

Person: Academic

20042019
Photo of Nikolay Dokholyan
19942021
Photo of John Ellis
19802019
Photo of Nicholas Graziane
20092018

Research Output 1964 2019

1 Citation (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation
1 Citation (Scopus)

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance
5 Citations (Scopus)

Allostery in Its Many Disguises: From Theory to Applications

Wodak, S. J., Paci, E., Dokholyan, N., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., Hamm, P., Stote, R. H., Eberhardt, J., Chebaro, Y., Dejaegere, A., Cecchini, M., Changeux, J. P., Bolhuis, P. G., Vreede, J., Faccioli, P. & 19 othersOrioli, S., Ravasio, R., Yan, L., Brito, C., Wyart, M., Gkeka, P., Rivalta, I., Palermo, G., McCammon, J. A., Panecka-Hofman, J., Wade, R. C., Di Pizio, A., Niv, M. Y., Nussinov, R., Tsai, C. J., Jang, H., Padhorny, D., Kozakov, D. & McLeish, T., Apr 2 2019, In : Structure. 27, 4, p. 566-578 13 p.

Research output: Contribution to journalReview article

Allosteric Regulation
Biological Phenomena
Education
Drug Design
Signal Transduction
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Polymorphism
Inflammatory Bowel Diseases

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents
1 Citation (Scopus)
DNA Methylation
Body Mass Index
Obesity
Genes
Pediatric Obesity
Shape optimization
Heat flux
Thermal load
Spacecraft
Physics
1 Citation (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models

Cancer and the Dopamine D2 Receptor: A Pharmacological Perspective

Weissenrieder, J. S., Neighbors, J., Mailman, R. & Hohl, R., Jul 1 2019, In : The Journal of pharmacology and experimental therapeutics. 370, 1, p. 111-126 16 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Pharmacology
Neoplasms
Ligands
Drug Therapy

Projects 1975 2024

Ovarian Neoplasms
Survival
Neoplasm Metastasis
Ascites
Neoplasms
gemcitabine
Pancreatic Neoplasms
Adenocarcinoma
Therapeutics
Heterografts
Castration
Deoxyglucose
Prostatic Neoplasms
Hexokinase
Toxicology
Molecular Probes
Dopamine D1 Receptors
Ligands
Single-Photon Emission-Computed Tomography
Catechols
Neurogenesis
Olfactory Bulb
Olfactory Receptor Neurons
Automatic Data Processing
Neurons
Allosteric Regulation
Protein Interaction Maps
Guanine
Proteins
Guanosine Triphosphate
Screening
Ligands
Pharmaceutical Preparations
Proteins
Chemical compounds
medical student
training program
student
physician
career
Vinculin
Actins
Null Lymphocytes
Adherens Junctions
Focal Adhesions

Targeted Sphingolipid Metabolism for Treatment of AML

Claxton, D., Wang, H., Wang, H., Amin, S., Liao, J. (., Fox, T., Loughran, T. P., Loughran, T. P., Kester, M., Kester, M. & Cabot, M. C.

National Institutes of Health

9/10/138/31/19

Project: Research project

Acute Myeloid Leukemia
Acid Ceramidase
Sphingolipids
Ceramides
Tamoxifen

Activities 2017 2017

  • 3 Oral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation