• United States

Organization profile

Organization profile

Research Interests

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cells Chemical Compounds
Melanoma Medicine & Life Sciences
Epoxy Compounds Medicine & Life Sciences
Rats Chemical Compounds
Parkinson Disease Medicine & Life Sciences

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Profiles

Photo of Matthew Coates

Matthew Coates, MD, PhD

  • Department of Medicine - Margot E. Walrath Career Development Professorship in Gastroenterology, Peter and Marshia Carlino Early Career Professorship in Inflammatory Bowel Disease, Assistant Professor
  • Department of Pharmacology - Assistant Professor

Person: Academic

20042018
No photo of Nikolay Dokholyan

Nikolay Dokholyan, PhD, MS

Person: Academic

19942021
Photo of John Ellis
19802018
Photo of Nicholas Graziane
20092018

Research Output 1964 2018

2017 Meeting of the National Directors of Graduate Studies in Pharmacology and Physiology

Victor, T. R., Thompson, K. K., Barnett, J. V. & Karpa, K. D., Jun 1 2018, In : Advances in physiology education. 42, 2, p. 396-403 8 p.

Research output: Contribution to journalArticle

5′-methylschweinfurthin G reduces chondrosarcoma tumor growth

Stevens, J. W., Meyerholz, D. K., Neighbors, J. D. & Morcuende, J. A., Apr 1 2018, In : Journal of Orthopaedic Research. 36, 4, p. 1283-1293 11 p.

Research output: Contribution to journalArticle

Chondrosarcoma
Animal Models
Growth
Hyaline Cartilage
Neoplasms

Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1

Mao, W., Salzberg, A. C., Uchigashima, M., Hasegawa, Y., Hock, H., Watanabe, M., Akbarian, S., Kawasawa, Y. I. & Futai, K., Jun 12 2018, In : Cell Reports. 23, 11, p. 3209-3222 14 p.

Research output: Contribution to journalArticle

Efflorescence
Brain Neoplasms
Chromatin
Histone Code
Fault tolerance
1 Citations
Habenula
Street Drugs
Reward
Aptitude
Learning
1 Citations

Alterations in nociception and morphine antinociception in mice fed a high-fat diet

Nealon, C. M., Patel, C., Worley, B. L., Henderson-Redmond, A. N., Morgan, D. J. & Czyzyk, T. A., Apr 1 2018, In : Brain Research Bulletin. 138, p. 64-72 9 p.

Research output: Contribution to journalArticle

Nociception
High Fat Diet
Morphine
Tail
Induced Hypothermia
Phosphatidylinositol 3-Kinases
Interleukin-4
Dendritic Cells
Malaria
Proteins

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H. G., Dec 1 2018, In : Nature Communications. 9, 1, 2855

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
regulators
Autophagy
classifying
closures

Anxiety, depression, and inflammation after restorative proctocolectomy

Gorrepati, V. S., Yadav, S., Stuart, A., Koltun, W., Messaris, E., Williams, E. D. & Coates, M. D., Jun 29 2018, (Accepted/In press) In : International Journal of Colorectal Disease. p. 1-6 6 p.

Research output: Contribution to journalArticle

Restorative Proctocolectomy
Colonic Pouches
Anxiety
Pouchitis
Depression

Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3

Selvam, S. P., Roth, B. M., Nganga, R., Kim, J., Cooley, M. A., Helke, K., Smith, C. D. & Ogretmen, B., Jan 1 2018, In : Journal of Biological Chemistry. 293, 25, p. 9784-9800 17 p.

Research output: Contribution to journalArticle

Telomere
Caspase 3
Apoptosis
Telomerase
Lung Neoplasms

B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

Domeier, P. P., Chodisetti, S. B., Schell, S. L., Kawasawa, Y. I., Fasnacht, M. J., Soni, C. & Rahman, Z. S. M., Jul 10 2018, In : Cell Reports. 24, 2, p. 406-418 13 p.

Research output: Contribution to journalArticle

Sewage lagoons
Interferon Type I
Delta wing aircraft
B-Lymphocytes
Germinal Center

Projects 1975 2023

Nucleus Accumbens-Associated Protein-1 in Melanoma Immunotherapy

Yang, J. & Song, J.

National Institutes of Health

7/3/186/30/23

Project: Research projectResearch Project

Nucleus Accumbens
Immunotherapy
Melanoma
Adoptive Transfer
Proteins
Castration
Deoxyglucose
Prostatic Neoplasms
Hexokinase
Toxicology
Molecular Probes
Dopamine D1 Receptors
Ligands
Single-Photon Emission-Computed Tomography
Catechols
Neurogenesis
Olfactory Bulb
Olfactory Receptor Neurons
Automatic Data Processing
Neurons

Cationic Bolaamphiphiles (CAB) and Phosphorothioate Gapmers as Antisense Therapy for C. difficile

Sharma, A. & Stewart, D. B.

National Institutes of Health

6/5/175/31/19

Project: Research projectExploratory/Developmental Grants

Infection
Anti-Bacterial Agents
Therapeutics
Bacteria
bolaamphiphile

Engineering allostery for in vivo protein control

Dokholyan, N.

National Institutes of Health

5/1/173/31/21

Project: Research projectResearch Project

Allosteric Regulation
Protein Interaction Maps
Guanine
Proteins
Guanosine Triphosphate
Screening
Ligands
Pharmaceutical Preparations
Proteins
Chemical compounds

Mechanisms of vinculin activation and force transmission

Dokholyan, N. & Campbell, S.

National Institutes of Health

4/1/163/31/20

Project: Research projectResearch Project

Vinculin
Actins
Null Lymphocytes
Adherens Junctions
Focal Adhesions
Selenium
Prostate
Carcinogenesis
Methionine
Prostatic Neoplasms

TOWARDS MORE REALISTIC DESIGN OF PROTEINS

Dokholyan, N.

National Institutes of Health

9/1/99 → …

Project: Research projectPostdoctoral Individual National Research Service Award

Proteins
Molecular dynamics
Machine design
Conformations
Amino acids

Activities 2017 2017

  • 3 Oral presentation

Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)

Cheng, K. (Speaker)
Nov 4 2017

Activity: Talk or presentationOral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Cheng, K. (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk or presentationOral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Cheng, K. (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk or presentationOral presentation