• United States

Organization profile

Organization profile

Research Interests

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cells Chemical Compounds
Rats Chemical Compounds
Epoxy Compounds Medicine & Life Sciences
Melanoma Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences

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Profiles

Photo of Matthew Coates

Matthew Coates, MD, PhD

  • Department of Medicine - Margot E. Walrath Career Development Professorship in Gastroenterology, Peter and Marshia Carlino Early Career Professorship in Inflammatory Bowel Disease, Assistant Professor
  • Department of Pharmacology - Assistant Professor

Person: Academic

20042018
Photo of Nikolay Dokholyan

Nikolay Dokholyan, PhD, MS

Person: Academic

19942021
Photo of John Ellis
19802018
Photo of Nicholas Graziane
20092018

Research Output 1964 2019

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents

2017 Meeting of the National Directors of Graduate Studies in Pharmacology and Physiology

Victor, T. R., Thompson, K. K., Barnett, J. V. & Karpa, K. D., Jun 1 2018, In : Advances in physiology education. 42, 2, p. 396-403 8 p.

Research output: Contribution to journalArticle

Practice Guidelines
Pharmacology
Graduate Education
Curriculum
1 Citations

5′-methylschweinfurthin G reduces chondrosarcoma tumor growth

Stevens, J. W., Meyerholz, D. K., Neighbors, J. & Morcuende, J. A., Apr 1 2018, In : Journal of Orthopaedic Research. 36, 4, p. 1283-1293 11 p.

Research output: Contribution to journalArticle

Chondrosarcoma
Growth
Hyaline Cartilage
Neoplasms
Inhibitory Concentration 50

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia

Ge, Z., Han, Q., Gu, Y., Ge, Q., Ma, J., Sloane, J., Gao, G., Payne, K. J., Szekely, L., Song, C. & Dovat, S., Nov 1 2018, In : Oncogenesis. 7, 11, 84.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fingers
Cell Proliferation
Protein Domains
Casein Kinase II

Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1

Mao, W., Salzberg, A. C., Uchigashima, M., Hasegawa, Y., Hock, H., Watanabe, M., Akbarian, S., Kawasawa, Y. I. & Futai, K., Jun 12 2018, In : Cell Reports. 23, 11, p. 3209-3222 14 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Brain Neoplasms
Synaptic Transmission
Chromatin
Hippocampus
1 Citations
Habenula
Street Drugs
Reward
Aptitude
Learning

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2018, (Accepted/In press) In : Immunology.

Research output: Contribution to journalArticle

2 Citations

Alterations in nociception and morphine antinociception in mice fed a high-fat diet

Nealon, C. M., Patel, C., Worley, B. L., Henderson-Redmond, A. N., Morgan, D. & Czyzyk, T. A., Apr 1 2018, In : Brain Research Bulletin. 138, p. 64-72 9 p.

Research output: Contribution to journalArticle

Nociception
High Fat Diet
Morphine
Tail
Induced Hypothermia
1 Citations
Phosphatidylinositol 3-Kinases
Interleukin-4
Dendritic Cells
Malaria
Interleukin-12

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

Takahashi, Y., He, H., Tang, Z., Hattori, T., Liu, Y., Young, M. M., Serfass, J. M., Chen, L., Gebru, M., Chen, C., Wills, C. A., Atkinson, J. M., Chen, H., Abraham, T. & Wang, H. G., Dec 1 2018, In : Nature Communications. 9, 1, 2855.

Research output: Contribution to journalArticle

Endosomal Sorting Complexes Required for Transport
regulators
Autophagy
classifying
closures

Projects 1975 2023

Nucleus Accumbens-Associated Protein-1 in Melanoma Immunotherapy

Yang, J. & Song, J.

National Institutes of Health

7/3/186/30/23

Project: Research projectResearch Project

Nucleus Accumbens
Immunotherapy
Melanoma
Adoptive Transfer
Proteins
Castration
Deoxyglucose
Prostatic Neoplasms
Hexokinase
Toxicology
Molecular Probes
Dopamine D1 Receptors
Ligands
Single-Photon Emission-Computed Tomography
Catechols
Neurogenesis
Olfactory Bulb
Olfactory Receptor Neurons
Automatic Data Processing
Neurons

Cationic Bolaamphiphiles (CAB) and Phosphorothioate Gapmers as Antisense Therapy for C. difficile

Sharma, A. & Stewart, D. B.

National Institutes of Health

6/5/175/31/19

Project: Research projectExploratory/Developmental Grants

Infection
Anti-Bacterial Agents
Therapeutics
Bacteria
bolaamphiphile

Engineering allostery for in vivo protein control

Dokholyan, N.

National Institutes of Health

5/1/173/31/21

Project: Research projectResearch Project

Allosteric Regulation
Protein Interaction Maps
Guanine
Proteins
Guanosine Triphosphate
Screening
Ligands
Pharmaceutical Preparations
Proteins
Chemical compounds

Mechanisms of vinculin activation and force transmission

Dokholyan, N. & Campbell, S.

National Institutes of Health

4/1/163/31/20

Project: Research projectResearch Project

Vinculin
Actins
Null Lymphocytes
Adherens Junctions
Focal Adhesions
Selenium
Prostate
Carcinogenesis
Methionine
Prostatic Neoplasms

TOWARDS MORE REALISTIC DESIGN OF PROTEINS

Dokholyan, N.

National Institutes of Health

9/1/99 → …

Project: Research projectPostdoctoral Individual National Research Service Award

Proteins
Molecular dynamics
Machine design
Conformations
Amino acids

Activities 2017 2017

  • 3 Oral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation

Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)

Keith Cheng (Speaker)
Nov 4 2017

Activity: Talk typesOral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation