Organization profile

Organization profile

The Department of Pharmacology at Penn State College of Medicine is dedicated to teaching and research in the biomedical sciences. Its missions are to provide high-quality training of the next generation of scientists and physicians and to develop new diagnostic tests, medicines and delivery systems.

At its home in Hershey, Pennsylvania, the Department of Pharmacology occupies 20,000 square feet of state-of-the-art laboratory space in the Hershey Center for Applied Research, Penn State Cancer Institute and Penn State Institute for Personalized Medicine.

The faculty comprises more than 25 primary faculty members with an additional 20 joint faculty from clinical and basic science departments. Research ranges from cell and molecular studies of cancer, to biochemical/pharmacological investigation of nervous system function, to whole-animal studies of drug development.

As educational leaders in their fields, departmental faculty are involved in medical, graduate and allied health instruction and training.

We are assistant deans, course directors, textbook authors and PhD program directors. We are research scientists, endowed professors and entrepreneurs. We are Penn State.

Fingerprint Dive into the research topics where Department of Pharmacology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.

Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cells Chemical Compounds
Apoptosis Medicine & Life Sciences
Rats Chemical Compounds
DNA Medicine & Life Sciences
Genes Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Profiles

Photo of Alfredo Bellon

Alfredo Bellon, MD, PhD

Person: Academic

20032019
Photo of Anthony Bonavia
20062019
Photo of Matthew Coates

Matthew Coates, MD, PhD

Person: Academic

20042019
Photo of Nikolay Dokholyan
19942021
Photo of John Ellis
19802019

Research Output 1964 2019

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson-Kennedy, P. S., Deneke, E., Vrana, K., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V., Ang, K., Wang, Y., Xiao, X., De Carlo, F., Van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling
mouth
deactivation
Mouth
calcium

A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

Chirasani, V. R., Xu, L., Addis, H. G., Pasek, D. A., Dokholyan, N., Meissner, G. & Yamaguchi, N., Aug 1 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C358-C365

Research output: Contribution to journalArticle

Central Core Myopathy
Ryanodine Receptor Calcium Release Channel
Skeletal Muscle
Binding Sites
Mutation
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H-G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
P-Glycoprotein
Drug Resistance
Acute Myeloid Leukemia
Up-Regulation

Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics

Dinavahi, S. S., Bazewicz, C. G., Gowda, R. & Robertson, G., Oct 1 2019, In : Trends in Pharmacological Sciences. 40, 10, p. 774-789 16 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Neoplasms
Therapeutics
Chemotherapy
Health Services Needs and Demand
4 Citations (Scopus)

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance
11 Citations (Scopus)

Allostery in Its Many Disguises: From Theory to Applications

Wodak, S. J., Paci, E., Dokholyan, N., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., Hamm, P., Stote, R. H., Eberhardt, J., Chebaro, Y., Dejaegere, A., Cecchini, M., Changeux, J. P., Bolhuis, P. G., Vreede, J., Faccioli, P. & 19 others, Orioli, S., Ravasio, R., Yan, L., Brito, C., Wyart, M., Gkeka, P., Rivalta, I., Palermo, G., McCammon, J. A., Panecka-Hofman, J., Wade, R. C., Di Pizio, A., Niv, M. Y., Nussinov, R., Tsai, C. J., Jang, H., Padhorny, D., Kozakov, D. & McLeish, T., Apr 2 2019, In : Structure. 27, 4, p. 566-578 13 p.

Research output: Contribution to journalReview article

Allosteric Regulation
Biological Phenomena
Education
Drug Design
Signal Transduction
Open Access
Wnt Proteins
Alternative Splicing
Proteins
Yeasts
mu Opioid Receptor
Open Access
Colorectal Surgery
Angiotensins
Acute Kidney Injury
Cohort Studies
Retrospective Studies

A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition

Elcheva, I., Sneed, M., Frazee, S., Liu, Z., Zhu, J., Wood, T., Hendrickson, S., Oehler, C., Garcia, B. & Spiegelman, V., Dec 1 2019, In : Toxicology in Vitro. 61, 104622.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cytotoxicity
Toxicity
GATA2 Transcription Factor
Screening

Projects 1975 2024

Ovarian Neoplasms
Survival
Neoplasm Metastasis
Ascites
Neoplasms
gemcitabine
Pancreatic Neoplasms
Adenocarcinoma
Therapeutics
Heterografts
Castration
Deoxyglucose
Prostatic Neoplasms
Hexokinase
Toxicology
Molecular Probes
Dopamine D1 Receptors
Ligands
Single-Photon Emission-Computed Tomography
Catechols
Neurogenesis
Olfactory Bulb
Olfactory Receptor Neurons
Automatic Data Processing
Neurons
Allosteric Regulation
Protein Interaction Maps
Guanine
Proteins
Guanosine Triphosphate
Screening
Ligands
Pharmaceutical Preparations
Proteins
Chemical compounds
medical student
training program
student
physician
career
Vinculin
Actins
Null Lymphocytes
Adherens Junctions
Focal Adhesions
Proteins
Molecular dynamics
Machine design
Conformations
Amino acids

Activities 2017 2017

  • 3 Oral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation