• United States

Organization profile

Organization profile

Research Interests

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Neoplasms Medicine & Life Sciences
Proteins Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Cells Chemical Compounds
Rats Chemical Compounds
Melanoma Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Epoxy Compounds Medicine & Life Sciences

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Profiles

Photo of Matthew Coates

Matthew Coates, MD, PhD

  • Department of Medicine - Margot E. Walrath Career Development Professorship in Gastroenterology, Peter and Marshia Carlino Early Career Professorship in Inflammatory Bowel Disease, Assistant Professor
  • Department of Pharmacology - Assistant Professor

Person: Academic

20042019
Photo of Nikolay Dokholyan
19942021
Photo of John Ellis
19802018
Photo of Nicholas Graziane
20092018

Research Output 1964 2019

Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer

Bazewicz, C. G., Dinavahi, S. S., Schell, T. & Robertson, G., Jan 1 2019, In : Immunology. 156, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Immunity
Neoplasms
Immune Tolerance

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

oxaliplatin
Bioactivity
Stem cells
Fluorouracil
Antineoplastic Agents

Brain cholesterol metabolism and Parkinson’s disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Jan 1 2019, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Parkinson Disease
Cholesterol
Brain
Odds Ratio
Logistic Models

Computational translation of genomic responses from experimental model systems to humans

Brubaker, D. K., Proctor, E. A., Haigis, K. M. & Lauffenburger, D. A., Jan 1 2019, In : PLoS computational biology. 15, 1, p. e1006286

Research output: Contribution to journalArticle

translation (genetics)
Genomics
Mouse
genomics
Theoretical Models

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jan 1 2019, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Sulfur
Isothiocyanates
Neoplasms
Organoselenium Compounds
Glucosinolates

Emissions of Free Radicals, Carbonyls, and Nicotine from the NIDA Standardized Research Electronic Cigarette and Comparison to Similar Commercial Devices

Bitzer, Z. T., Goel, R., Reilly, S. M., Bhangu, G., Trushin, N., Foulds, J., Muscat, J. & Richie, J., Jan 22 2019, In : Chemical Research in Toxicology. 32, 1, p. 130-138 9 p.

Research output: Contribution to journalReview article

National Institute on Drug Abuse (U.S.)
Aerosols
Nicotine
Tobacco Products
Free Radicals

Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions

Podany, A., Rauchut, J., Wu, T., Imamura, Y., Wright, J., Lamendella, R., Soybel, D. & Kelleher, S. L., Feb 1 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800947.

Research output: Contribution to journalArticle

Zinc
neonates
Oxidative Stress
oxidative stress
zinc

Identification of a Novel Quinoxaline-Isoselenourea Targeting the STAT3 Pathway as a Potential Melanoma Therapeutic

Alcolea, V., Karelia, D. N., Pandey, M. K., Plano, D., Singh, P., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., Jan 26 2019, In : International journal of molecular sciences. 20, 3

Research output: Contribution to journalArticle

quinoxalines
STAT3 Transcription Factor
Quinoxalines
Transcription
Transducers
1 Citations

Increased Risk of Influenza and Influenza-Related Complications Among 140,480 Patients With Inflammatory Bowel Disease

Tinsley, A., Navabi, S., Williams, E., Liu, G., Kong, L., Coates, M. & Clarke, K., Jan 10 2019, In : Inflammatory bowel diseases. 25, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Human Influenza
Incidence
Hospitalization
Confidence Intervals

Individual preferences in motor coordination seen across the two hands: relations to movement stability and optimality

de Freitas, P. B., Freitas, S. M. S. F., Lewis, M., Huang, X. & Latash, M., Jan 31 2019, In : Experimental Brain Research. 237, 1

Research output: Contribution to journalArticle

Hand
Fingers
Sensory Feedback
Social Adjustment
Task Performance and Analysis

Projects 1975 2022

Castration
Deoxyglucose
Prostatic Neoplasms
Hexokinase
Toxicology
Molecular Probes
Dopamine D1 Receptors
Ligands
Single-Photon Emission-Computed Tomography
Catechols
Neurogenesis
Olfactory Bulb
Olfactory Receptor Neurons
Automatic Data Processing
Neurons

Cationic Bolaamphiphiles (CAB) and Phosphorothioate Gapmers as Antisense Therapy for C. difficile

Sharma, A. & Stewart, D. B.

National Institutes of Health

6/5/175/31/19

Project: Research projectExploratory/Developmental Grants

Infection
Anti-Bacterial Agents
Therapeutics
Bacteria
bolaamphiphile

Engineering allostery for in vivo protein control

Dokholyan, N.

National Institutes of Health

5/1/173/31/21

Project: Research projectResearch Project

Allosteric Regulation
Protein Interaction Maps
Guanine
Proteins
Guanosine Triphosphate
Screening
Ligands
Pharmaceutical Preparations
Proteins
Chemical compounds

Medical Student Training Program

Levenson, R.

National Institutes of Health

7/1/166/30/21

Project: Research projectInstitutional National Research Service Award

medical student
training program
student
physician
career

Mechanisms of vinculin activation and force transmission

Dokholyan, N. & Campbell, S.

National Institutes of Health

4/1/163/31/20

Project: Research projectResearch Project

Vinculin
Actins
Null Lymphocytes
Adherens Junctions
Focal Adhesions
Selenium
Prostate
Carcinogenesis
Methionine
Prostatic Neoplasms

TOWARDS MORE REALISTIC DESIGN OF PROTEINS

Dokholyan, N.

National Institutes of Health

9/1/99 → …

Project: Research projectPostdoctoral Individual National Research Service Award

Proteins
Molecular dynamics
Machine design
Conformations
Amino acids

Activities 2017 2017

  • 3 Oral presentation

Motivations and Potential for a 3D Image Informatics for Histopathology (Panel Discussion)

Keith Cheng (Speaker)
Nov 4 2017

Activity: Talk typesOral presentation

From Morphology to Math: Using whole zebrafish to create the engineering and computational infrastructure for Microanatomic Phenomics

Keith Cheng (Speaker), Y Ding (Speaker), SR Katz (Speaker), AY Lin (Speaker), D van Rossum (Speaker), D Vanselow (Speaker)
Sep 27 2017

Activity: Talk typesOral presentation

Morphometric phenomics and Cross-Atlas Registration of Virtual 3D soft tissue microCT images of Zebrafish

Keith Cheng (Speaker), Y Ding (Speaker), AY Lin (Speaker), M Yakovlev (Speaker), D Vanselow (Speaker), X Xin (Speaker), S Katz (Speaker), D Vanselow (Speaker), PJ La Riviere (Speaker)
Jul 5 2017

Activity: Talk typesOral presentation