Research Output 1964 2019


Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson-Kennedy, P. S., Deneke, E., Vrana, K., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V., Ang, K., Wang, Y., Xiao, X., De Carlo, F., Van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

Zhang, X., Pathak, T., Yoast, R., Emrich, S., Xin, P., Nwokonko, R. M., Johnson, M., Wu, S., Delierneux, C., Gueguinou, M., Hempel, N., Putney, J. W., Gill, D. & Trebak, M., Dec 1 2019, In : Nature communications. 10, 1, 1971.

Research output: Contribution to journalArticle

Open Access
Calcium Signaling

A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

Chirasani, V. R., Xu, L., Addis, H. G., Pasek, D. A., Dokholyan, N., Meissner, G. & Yamaguchi, N., Aug 1 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C358-C365

Research output: Contribution to journalArticle

Central Core Myopathy
Ryanodine Receptor Calcium Release Channel
Skeletal Muscle
Binding Sites
1 Citation (Scopus)

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

Acid Ceramidase
Drug Resistance
Acute Myeloid Leukemia
Open Access
Wnt Proteins
Alternative Splicing
mu Opioid Receptor
Open Access
Colorectal Surgery
Acute Kidney Injury
Cohort Studies
Retrospective Studies

A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition

Elcheva, I., Sneed, M., Frazee, S., Liu, Z., Zhu, J., Wood, T., Hendrickson, S., Oehler, C., Garcia, B. & Spiegelman, V., Dec 1 2019, In : Toxicology in Vitro. 61, 104622.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
GATA2 Transcription Factor
Randomized Controlled Trials

Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?

Winkels, R., Van Brakel, L., Van Baar, H., Beelman, R. B., Van Duijnhoven, F. J. B., Geijsen, A., Van Halteren, H. K., Hansson, B. M. E., Richie, J., Sun, D., Wesselink, E., Van Zutphen, M., Kampman, E. & Kok, D. E., Jan 1 2019, In : Nutrition and cancer.

Research output: Contribution to journalArticle

Open Access
Peripheral Nervous System Diseases
Colorectal Neoplasms
Drug Therapy
Sample Size
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Inflammatory Bowel Diseases

ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells

Narayan, S., Ramisetti, S., Jaiswal, A. S., Law, B. K., Singh-Pillay, A., Singh, P., Amin, S. & Sharma, A., Jan 1 2019, In : European Journal of Medicinal Chemistry. 161, p. 456-467 12 p.

Research output: Contribution to journalArticle

Stem cells
Antineoplastic Agents
5 Citations (Scopus)

Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents

He, F., Berg, A., Imamura, Y., Bixler, E., Fernandez-Mendoza, J., Whitsel, E. A. & Liao, D., Dec 1 2019, In : Scientific reports. 9, 1, 2079.

Research output: Contribution to journalArticle

DNA Methylation
Body Mass Index
Pediatric Obesity
Shape optimization
Heat flux
Thermal load

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H-G. & Dong, Z., Jul 1 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Mitochondrial Dynamics
2 Citations (Scopus)

Brain cholesterol metabolism and Parkinson's disease

Huang, X., Sterling, N. W., Du, G., Sun, D., Stetter, C., Kong, L., Zhu, Y., Neighbors, J., Lewis, M., Chen, H., Hohl, R. & Mailman, R., Mar 1 2019, In : Movement Disorders. 34, 3, p. 386-395 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Odds Ratio
Logistic Models
1 Citation (Scopus)

Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies

Sarker, M., Lee, H. T., Mei, L., Krokhotin, A., de los Reyes, S. E., Yen, L., Costantini, L. M., Griffith, J., Dokholyan, N., Alushin, G. M. & Campbell, S. L., Apr 5 2019, In : Journal of Molecular Biology. 431, 8, p. 1604-1618 15 p.

Research output: Contribution to journalArticle


Clinical and genetic validity of quantitative bipolarity

Bruce, H. A., Kochunov, P., Mitchell, B., Strauss, K. A., Ament, S. A., Rowland, L. M., Du, X., Fisseha, F., Kavita, T., Chiappelli, J., Wisner, K., Sampath, H., Chen, S., Kvarta, M. D., Seneviratne, C., Postolache, T. T., Bellon, A., McMahon, F. J., Shuldiner, A. & Elliot Hong, L., Sep 16 2019, In : Translational psychiatry. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Bipolar Disorder
Mental Disorders
Major Depressive Disorder

Computational translation of genomic responses from experimental model systems to humans

Brubaker, D. K., Proctor, E. A., Haigis, K. M. & Lauffenburger, D. A., Jan 1 2019, In : PLoS computational biology. 15, 1, e1006286.

Research output: Contribution to journalArticle

translation (genetics)
Theoretical Models

Conductance-Based Biophysical Distinction and Microfluidic Enrichment of Nanovesicles Derived from Pancreatic Tumor Cells of Varying Invasiveness

Moore, J. H., Varhue, W. B., Su, Y. H., Linton, S. S., Farmehini, V., Fox, T. E., Matters, G., Kester, M. & Swami, N. S., Aug 20 2019, In : Analytical chemistry. 91, 16, p. 10424-10431 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations

Brodie, N. I., Popov, K. I., Petrotchenko, E. V., Dokholyan, N. & Borchers, C. H., Mar 1 2019, In : PLoS computational biology. 15, 3, e1006859.

Research output: Contribution to journalArticle

Open Access
Discrete Dynamics
molecular dynamics
protein structure
Molecular Dynamics Simulation

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Nakada, E. M., Bhakta, N. R., Korwin-Mihavics, B. R., Kumar, A., Chamberlain, N., Bruno, S. R., Chapman, D. G., Hoffman, S. M., Daphtary, N., Aliyeva, M., Irvin, C. G., Dixon, A. E., Woodruff, P. G., Amin, S., Poynter, M. E., Desai, D. & Anathy, V., Jan 1 2019, In : JCI Insight. 4, 9, e98101.

Research output: Contribution to journalArticle

Open Access
Unfolded Protein Response
Bile Acids and Salts

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. & Trebak, M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Current Basal and Squamous Cell Skin Cancer Management

Massand, S. & Neves, R., Sep 1 2019, In : Plastic and reconstructive surgery. 144, 3, p. 520e-521e

Research output: Contribution to journalArticle

Squamous Cell Neoplasms
Skin Neoplasms
1 Citation (Scopus)

Development of Isoselenocyanate Compounds' Syntheses and Biological Applications

Frieben, E. E., Amin, S. & Sharma, A., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5261-5275 15 p.

Research output: Contribution to journalArticle

Organoselenium Compounds

Differential impact of co-expressed SP-A1/SP-A2 protein on AM miRNome; Sex differences

Thorenoor, N., Imamura, Y., Gandhi, C. K., Zhang, X. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, AUG, 1960.

Research output: Contribution to journalArticle

Open Access
Alveolar Macrophages
varespladib methyl
Sex Characteristics
Pulmonary Surfactant-Associated Protein A
Oxidative Stress
3 Citations (Scopus)

Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

Liu, Z., Yee, P. P., Wei, Y., Liu, Z., Imamura, Y. & Li, W., Mar 1 2019, In : Journal of Cell Science. 132, 5, jcs225714.

Research output: Contribution to journalArticle

Open Access

Downregulation of CD73 associates with T cell exhaustion in AML patients

Kong, Y., Jia, B., Zhao, C., Claxton, D., Sharma, A., Annageldiyev, C., Fotos, J., Zeng, H., Paulson, R., Prabhu, K. S. & Zheng, H., Apr 24 2019, In : Journal of Hematology and Oncology. 12, 1, 40.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia

Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms

Teissier, A., Le Magueresse, C., Olusakin, J., Andrade da Costa, B. L. S., De Stasi, A. M., Bacci, A., Imamura, Y., Vaidya, V. A. & Gaspar, P., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Psychological Stress
Prefrontal Cortex
Immediate-Early Genes

E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Nelson, A., Cong, Z., Gettle, S. L., Longenecker, A. L., Kidacki, M., Sciacca Kirby, J., Adams, D., Stairs, D. & Danby, F. W., Jul 1 2019, In : Experimental Dermatology. 28, 7, p. 867-871 5 p.

Research output: Contribution to journalArticle

Hidradenitis Suppurativa

Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats

Randall, P. A., Fortino, B., Huynh, Y. W., Thompson, B. M., Larsen, C. E., Callen, M. P., Barrett, S. T., Murray, J. E., Bevins, R. A. & Besheer, J., Apr 1 2019, In : Pharmacology Biochemistry and Behavior. 179, p. 1-8 8 p.

Research output: Contribution to journalArticle

Self Administration
Oral Leukoplakia

Engineering proteins for allosteric control by light or ligands

Dagliyan, O., Dokholyan, N. & Hahn, K. M., Jun 1 2019, In : Nature Protocols. 14, 6, p. 1863-1883 21 p.

Research output: Contribution to journalArticle

Protein Engineering
1 Citation (Scopus)
Open Access
Acute Myeloid Leukemia
Transcription Factors
Induction Chemotherapy
1 Citation (Scopus)

Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions

Podany, A., Rauchut, J., Wu, T., Imamura, Y., Wright, J., Lamendella, R., Soybel, D. & Kelleher, S. L., Feb 1 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800947.

Research output: Contribution to journalArticle

Oxidative Stress
oxidative stress
1 Citation (Scopus)

Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis

Ghoshal, A., Rodrigues, L. C., Gowda, C. P., Elcheva, I., Liu, Z., Abraham, T. & Spiegelman, V., May 23 2019, In : Oncogene. 38, 21, p. 4182-4196 15 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
RNA-Binding Proteins
Neoplasm Metastasis
Messenger RNA
1 Citation (Scopus)

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Nicholas, D. A., Proctor, E. A., Agrawal, M., Belkina, A. C., Van Nostrand, S. C., Panneerseelan-Bharath, L., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., Cacicedo, J. M., Habib, C., Sainz-Rueda, N., Persky, L., Sullivan, P. G., Corkey, B. E., Apovian, C. M., Kern, P. A., Lauffenburger, D. A. & Nikolajczyk, B. S., Sep 3 2019, In : Cell Metabolism. 30, 3, p. 447-461.e5

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Fatty Acids

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M., Kong, L., Yanosky, J., Mailman, R. & Huang, X., Apr 1 2019, In : Toxicological Sciences. 168, 2, p. 486-496 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Diffusion tensor imaging
2 Citations (Scopus)

Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia

Yan, B., Chen, Q., Shimada, K., Tang, M., Li, H., Gurumurthy, A., Khoury, J. D., Xu, B., Huang, S. & Qiu, Y., Apr 1 2019, In : Leukemia. 33, 4, p. 931-944 14 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Acute Myeloid Leukemia
1 Citation (Scopus)

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Luo, H., Sobh, A., Vulpe, C. D., Brewer, E., Dovat, S., Qiu, Y. & Huang, S., Mar 31 2019, In : Journal of visualized experiments : JoVE. 145

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Gene Expression

Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic

Alcolea, V., Karelia, D. N., Pandey, M. K., Plano, D., Singh, P., Palop, J. A., Amin, S., Sanmartín, C. & Sharma, A., Feb 1 2019, In : International journal of molecular sciences. 20, 3, 521.

Research output: Contribution to journalArticle

STAT3 Transcription Factor

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Cell Differentiation
Reversal Learning

Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke

Janicki, P., Eyileten, C., Ruiz-Velasco, V., Pordzik, J., Czlonkowska, A., Kurkowska-Jastrzebska, I., Sugino, S., Imamura, Y., Mirowska-Guzel, D. & Postula, M., Apr 1 2019, In : Molecular medicine reports. 19, 4, p. 3263-3272 10 p.

Research output: Contribution to journalArticle

Quality control
Blood Platelets
2 Citations (Scopus)
Inflammatory Bowel Diseases
Human Influenza
Confidence Intervals

Individual preferences in motor coordination seen across the two hands: relations to movement stability and optimality

de Freitas, P. B., Freitas, S. M. S. F., Lewis, M., Huang, X. & Latash, M., Jan 31 2019, In : Experimental Brain Research. 237, 1

Research output: Contribution to journalArticle

Sensory Feedback
Social Adjustment
Task Performance and Analysis
5 Citations (Scopus)

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Liu, Z., Wei, Y., Zhang, L., Yee, P. P., Johnson, M., Zhang, X., Gulley, M., Atkinson, J. M., Trebak, M., Wang, H-G. & Li, W., Jan 3 2019, In : Oncogene. 38, 1, p. 120-139 20 p.

Research output: Contribution to journalArticle

Protein Kinase C beta

Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models

Weissenrieder, J. S., Reilly, J. E., Neighbors, J. & Hohl, R., Jan 1 2019, In : Prostate. 79, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
Cytoplasmic and Nuclear Receptors
Prostatic Neoplasms

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors

Desai, D., Lauver, M., Ostman, A., Cruz, L., Ferguson, K., Jin, G., Roper, B., Brosius, D., Lukacher, A., Amin, S. & Buchkovich, N., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1795-1803 9 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Stem cells

Inter-Active Site Communication Mediated by the Dimer Interface β-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase

Sapienza, P. J., Popov, K. I., Mowrey, D. D., Falk, B. T., Dokholyan, N. & Lee, A. L., Jul 30 2019, In : Biochemistry. 58, 30, p. 3302-3313 12 p.

Research output: Contribution to journalArticle

Thymidylate Synthase
Catalytic Domain
Nuclear magnetic resonance
Magnetic Resonance Spectroscopy
1 Citation (Scopus)

Leishmanicidal activity of isoselenocyanate derivatives

Fernández-Rubio, C., Larrea, E., Guerrero, J. P., Herrero, E. S., Gamboa, I., Berrio, C., Plano, D., Amin, S., Sharma, A. & Nguewa, P. A., Feb 1 2019, In : Antimicrobial agents and chemotherapy. 63, 2, e00904-18.

Research output: Contribution to journalArticle

Leishmania major
Amphotericin B
Cell Cycle