Division of Hematology and Oncology

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2020

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

Flower, T. G., Takahashi, Y., Hudait, A., Rose, K., Tjahjono, N., Pak, A. J., Yokom, A. L., Liang, X., Wang, H. G., Bouamr, F., Voth, G. A. & Hurley, J. H., Jun 1 2020, In : Nature Structural and Molecular Biology. 27, 6, p. 570-580 11 p.

Research output: Contribution to journalArticle

Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis

Li, Y., Liao, Z., Luo, H., Benyoucef, A., Kang, Y., Lai, Q., Dovat, S., Miller, B., Chepelev, I., Li, Y., Zhao, K., Brand, M. & Huang, S., Apr 6 2020, In : Nucleic acids research. 48, 6, p. 3119-3133 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors

Santana, V. M., Sahr, N., Tatevossian, R. G., Jia, S., Campagne, O., Sykes, A., Stewart, C. F., Furman, W. L. & McGregor, L. M., Apr 15 2020, In : Cancer. 126, 8, p. 1749-1757 9 p.

Research output: Contribution to journalArticle

A subset analysis of a phase II trial evaluating the use of DFMO as maintenance therapy for high-risk neuroblastoma

Lewis, E. C., Kraveka, J. M., Ferguson, W., Eslin, D., Brown, V. I., Bergendahl, G., Roberts, W., Wada, R. K., Oesterheld, J., Mitchell, D., Foley, J., Zage, P., Rawwas, J., Rich, M., Lorenzi, E., Broglio, K., Berry, D. & Saulnier Sholler, G. L., Jan 1 2020, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Open Access

Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant

Dandoy, C. E., Kim, S., Chen, M., Ahn, K. W., Ardura, M. I., Brown, V., Chhabra, S., Diaz, M. A., Dvorak, C., Farhadfar, N., Flagg, A., Ganguly, S., Hale, G. A., Hashmi, S. K., Hematti, P., Martino, R., Nishihori, T., Nusrat, R., Olsson, R. F., Rotz, S. J. & 5 others, Sung, A. D., Perales, M. A., Lindemans, C. A., Komanduri, K. V. & Riches, M. L., Jan 3 2020, In : JAMA network open. 3, 1, p. e1918668

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

LATS kinase–mediated CTCF phosphorylation and selective loss of genomic binding

Luo, H., Yu, Q., Liu, Y., Tang, M., Liang, M., Zhang, D., Xiao, T. S., Wu, L., Tan, M., Ruan, Y., Bungert, J. & Lu, J., Jan 1 2020, In : Science Advances. 6, 8, eaaw4651.

Research output: Contribution to journalArticle

Open Access

Long-Term Efficacy of Single-Agent Vemurafenib for Pleomorphic Xanthoastrocytoma

Finch, E. A., Elton, S. W., Huang, B. Y., Trembath, D. G. & Blatt, J., Mar 1 2020, In : Journal of pediatric hematology/oncology. 42, 2, p. 152-155 4 p.

Research output: Contribution to journalArticle

Open Access

Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia

Payne, J. L., Song, C., Ding, Y., Dhanyamraju, P. K., Bamme, Y., Schramm, J. W., Desai, D., Sharma, A., Gowda, C. & Dovat, S., Mar 1 2020, In : International journal of molecular sciences. 21, 5, 1718.

Research output: Contribution to journalArticle

Open Access

RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1

Elcheva, I. A., Wood, T., Chiarolanzio, K., Chim, B., Wong, M., Singh, V., Gowda, C. P., Lu, Q., Hafner, M., Dovat, S., Liu, Z., Muljo, S. A. & Spiegelman, V. S., May 1 2020, In : Leukemia. 34, 5, p. 1354-1363 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature

Mrowczynski, O. D., Lane, J. R., Specht, C. S., Greiner, R. J., Iantosca, M. R. & Rizk, E. B., Jan 1 2020, (Accepted/In press) In : Child's Nervous System.

Research output: Contribution to journalArticle

1 Scopus citations

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Annageldiyev, C., Gowda, K., Patel, T., Bhattacharya, P., Tan, S. F., Iyer, S., Desai, D., Dovat, S., Feith, D. J., Loughran, T. P., Amin, S., Claxton, D. & Sharma, A., Mar 1 2020, In : Haematologica. 105, 3, p. 687-696 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy

Chen, S. J., Bao, L., Keefer, K., Shanmughapriya, S., Chen, L., Lee, J., Wang, J. F., Zhang, X. Q., Hirschler-Laszkiewicz, I., Merali, S., Merali, C., Imamura, Y., Dovat, S., Madesh, M., Cheung, J. Y., Wang, H. G. & Miller, B. A., Apr 1 2020, In : Cell Death and Disease. 11, 4, 247.

Research output: Contribution to journalArticle

Open Access
2019

17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner

Fuentes, N., Nicoleau, M., Cabello, N., Montes, D., Zomorodi, N., Chroneos, Z. C. & Silveyra, P., Jan 1 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 5, p. L702-L716

Research output: Contribution to journalArticle

2 Scopus citations

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Tan, S. F., Dunton, W., Liu, X., Fox, T. E., Morad, S. A. F., Desai, D., Doi, K., Conaway, M. R., Amin, S., Claxton, D. F., Wang, H. G., Kester, M., Cabot, M. C., Feith, D. J. & Loughran, T. P., Jan 1 2019, In : Journal of Lipid Research. 60, 6, p. 1078-1086 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

A nonsense mutation in COL4A4 gene causing isolated hematuria in either heterozygous or homozygous state

Yang, C., Song, Y., Chen, Z., Yuan, X., Chen, X., Ding, G., Guan, Y., McGrath, M., Song, C., Tong, Y. & Wang, H., Jan 1 2019, In : Frontiers in Genetics. 10, JUL, 628.

Research output: Contribution to journalArticle

Open Access

A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition

Elcheva, I., Sneed, M., Frazee, S., Liu, Z., Zhu, J., Wood, T., Hendrickson, S., Oehler, C., Garcia, B. & Spiegelman, V. S., Dec 2019, In : Toxicology in Vitro. 61, 104622.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis

Yang, D., Zhang, Q., Ma, Y., Che, Z., Zhang, W., Wu, M., Wu, L., Liu, F., Chu, Y., Xu, W., McGrath, M., Song, C. & Liu, J., Sep 2019, In : EBioMedicine. 47, p. 114-127 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation

Ustun, C., Young, J. A. H., Papanicolaou, G. A., Kim, S., Ahn, K. W., Chen, M., Abdel-Azim, H., Aljurf, M., Beitinjaneh, A., Brown, V., Cerny, J., Chhabra, S., Kharfan-Dabaja, M. A., Dahi, P. B., Daly, A., Dandoy, C. E., Dvorak, C. C., Freytes, C. O., Hashmi, S., Lazarus, H. & 13 others, Ljungman, P., Nishihori, T., Page, K., Pingali, S. R. K., Saad, A., Savani, B. N., Weisdorf, D., Williams, K., Wirk, B., Auletta, J. J., Lindemans, C. A., Komanduri, K. & Riches, M., Aug 1 2019, In : Bone Marrow Transplantation. 54, 8, p. 1254-1265 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis

Touyama, K., Khan, M., Aoki, K., Matsuda, M., Hiura, F., Takakura, N., Matsubara, T., Harada, Y., Hirohashi, Y., Tamura, Y., Gao, J., Mori, K., Kokabu, S., Yasuda, H., Fujita, Y., Watanabe, K., Takahashi, Y., Maki, K. & Jimi, E., Nov 1 2019, In : Journal of cellular biochemistry. 120, 11, p. 18793-18804 12 p.

Research output: Contribution to journalArticle

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

3 Scopus citations

Disparities in pediatric acute myeloid leukemia (AML) clinical trial enrollment

Winestone, L. E., Getz, K. D., Rao, P., Li, Y., Hall, M., Huang, Y. S. V., Seif, A. E., Fisher, B. T. & Aplenc, R., Jul 29 2019, In : Leukemia and Lymphoma. 60, 9, p. 2190-2198 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
2 Scopus citations

Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis

Ghoshal, A., Rodrigues, L. C., Gowda, C. P., Elcheva, I. A., Liu, Z., Abraham, T. & Spiegelman, V. S., May 23 2019, In : Oncogene. 38, 21, p. 4182-4196 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia

Yan, B., Chen, Q., Shimada, K., Tang, M., Li, H., Gurumurthy, A., Khoury, J. D., Xu, B., Huang, S. & Qiu, Y., Apr 1 2019, In : Leukemia. 33, 4, p. 931-944 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M. & Huang, S., Dec 9 2019, In : Cancer Cell. 36, 6, p. 645-659.e8

Research output: Contribution to journalArticle

5 Scopus citations

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Luo, H., Sobh, A., Vulpe, C. D., Brewer, E., Dovat, S., Qiu, Y. & Huang, S., Mar 31 2019, In : Journal of visualized experiments : JoVE. 145

Research output: Contribution to journalArticle

1 Scopus citations

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ding, Y., Zhang, B., Payne, J. L., Song, C., Ge, Z., Gowda, C., Iyer, S., Dhanyamraju, P. K., Dorsam, G., Reeves, M. E., Desai, D., Huang, S., Payne, K. J., Yue, F. & Dovat, S., Nov 1 2019, In : Leukemia. 33, 11, p. 2720-2731 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1

Ustun, C., Kim, S., Chen, M., Beitinjaneh, A. M., Brown, V. I., Dahi, P. B., Daly, A., Diaz, M. A., Freytes, C. O., Ganguly, S., Hashmi, S., Hildebrandt, G. C., Lazarus, H. M., Nishihori, T., Olsson, R. F., Page, K. M., Papanicolaou, G., Saad, A., Seo, S., William, B. M. & 8 others, Wingard, J. R., Wirk, B., Yared, J. A., Perales, M. A., Auletta, J. J., Komanduri, K. V., Lindemans, C. A. & Riches, M. L., Sep 10 2019, In : Blood Advances. 3, 17, p. 2525-2536 12 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells

Zhang, L., Cheng, F., Wei, Y., Zhang, L., Guo, D., Wang, B. & Li, W., Apr 11 2019, In : Oncogene. 38, 15, p. 2788-2799 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Kinase inhibitor screening in self-assembled human protein microarrays

Festa, F. & Labaer, J., Oct 2019, In : Journal of Visualized Experiments. 2019, 152, e59886.

Research output: Contribution to journalArticle

Open Access

Loss of miR-155 upregulates WEE1 in metastatic melanoma

Disano, J. A., Huffnagle, I., Gowda, R., Spiegelman, V. S., Robertson, G. P. & Pameijer, C. R., Apr 1 2019, In : Melanoma Research. 29, 2, p. 216-219 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Modulation of the lung inflammatory response to ozone by the estrous cycle

Fuentes, N., Cabello, N., Nicoleau, M., Chroneos, Z. C. & Silveyra, P., Mar 2019, In : Physiological reports. 7, 5, e14026.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Mutations in EZH2 are associated with poor prognosis for patients with myeloid neoplasms

Zhang, Q., Han, Q., Zi, J., Ma, J., Song, H., Tian, Y., McGrath, M., Song, C. & Ge, Z., Sep 2019, In : Genes and Diseases. 6, 3, p. 276-281 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia

Lund, T. C., Ahn, K. W., Tecca, H. R., Hilgers, M. V., Abdel-Azim, H., Abraham, A., Diaz, M. A., Badawy, S. M., Broglie, L., Brown, V., Dvorak, C. C., Gonzalez-Vicent, M., Hashem, H., Hayashi, R. J., Jacobsohn, D. A., Kent, M. W., Li, C. K., Margossian, S. P., Martin, P. L., Mehta, P. & 9 others, Myers, K., Olsson, R., Page, K., Pulsipher, M. A., Shaw, P. J., Smith, A. R., Triplett, B. M., Verneris, M. R. & Eapen, M., Feb 2019, In : Biology of Blood and Marrow Transplantation. 25, 2, p. 301-306 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells

Nicolae, C. M., O’Connor, M. J., Schleicher, E. M., Song, C., Gowda, R., Robertson, G., Dovat, S. & Moldovan, G. L., Jul 4 2019, In : Oncogene. 38, 27, p. 5530-5540 11 p.

Research output: Contribution to journalArticle

Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen

Morad, S. A. F., MacDougall, M. R., Abdelmageed, N., Kao, L. P., Feith, D. J., Tan, S. F., Kester, M., Loughran, T. P., Wang, H. G. & Cabot, M. C., Aug 15 2019, In : Experimental Cell Research. 381, 2, p. 256-264 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia

Han, Q., Ma, J., Gu, Y., Song, H., Kapadia, M., Kawasawa, Y. I., Dovat, S., Song, C. & Ge, Z., Jan 1 2019, In : Journal of Cancer. 10, 16, p. 3842-3850 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Barth, B. M., Wang, W., Toran, P. T., Fox, T. E., Annageldiyev, C., Ondrasik, R. M., Keasey, N. R., Brown, T. J., Devine, V. G., Sullivan, E. C., Cote, A. L., Papakotsi, V., Tan, S. F., Shanmugavelandy, S. S., Deering, T. G., Needle, D. B., Stern, S. T., Zhu, J., Liao, J., Viny, A. D. & 7 others, Feith, D. J., Levine, R. L., Wang, H. G., Loughran, T. P., Sharma, A., Kester, M. & Claxton, D. F., Sep 10 2019, In : Blood Advances. 3, 17, p. 2598-2603 6 p.

Research output: Contribution to journalArticle

Open Access

Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

Nalian, A., Umstead, T. M., Yang, C. H., Silveyra, P., Thomas, N. J., Floros, J., McCormack, F. X. & Chroneos, Z. C., Nov 7 2019, In : Frontiers in immunology. 10, 2613.

Research output: Contribution to journalArticle

Open Access

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

Cury, N. M., Mühlethaler, T., Laranjeira, A. B. A., Canevarolo, R. R., Zenatti, P. P., Lucena-Agell, D., Barasoain, I., Song, C., Sun, D., Dovat, S., Yunes, R. A., Prota, A. E., Steinmetz, M. O., Díaz, J. F. & Yunes, J. A., Nov 22 2019, In : iScience. 21, p. 95-109 15 p.

Research output: Contribution to journalArticle

Open Access

Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study

Naik, S., Riches, M., Hari, P., Kim, S., Chen, M., Bachier, C., Shaughnessy, P., Hill, J., Ljungman, P., Battiwalla, M., Chhabra, S., Daly, A., Storek, J., Ustun, C., Diaz, M. A., Cerny, J., Beitinjaneh, A., Yared, J., Brown, V., Page, K. & 13 others, Dahi, P. B., Ganguly, S., Seo, S., Chao, N., Freytes, C. O., Saad, A., Savani, B. N., Woo Ahn, K., Boeckh, M., Heslop, H. E., Lazarus, H. M., Auletta, J. J. & Kamble, R. T., Oct 1 2019, In : Transplant Infectious Disease. 21, 5, e13145.

Research output: Contribution to journalArticle

4 Scopus citations

The Exceptional Teacher Initiative: Finding a Silver Lining in Addressing Medical Student Mistreatment

Blackall, G. F., Wolpaw, T. & Shapiro, D., Jul 1 2019, In : Academic Medicine. 94, 7, p. 992-995 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Bao, L., Festa, F., Freet, C. S., Lee, J. P., Hirschler-Laszkiewicz, I. M., Chen, S. J., Keefer, K. A., Wang, H. G., Patterson, A. D., Cheung, J. Y. & Miller, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 14132.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins

Atkinson, J. M., Ye, Y., Gebru, M. T., Liu, Q., Zhou, S., Young, M. M., Takahashi, Y., Lin, Q., Tian, F. & Wang, H. G., Sep 20 2019, In : Journal of Biological Chemistry. 294, 38, p. 14033-14042 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations