• 500 University Drive

    17033 Hershey

    United States

Research Output 1975 2019

2018
31 Citations (Scopus)

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

George, J., Walter, V., Peifer, M., Alexandrov, L. B., Seidel, D., Leenders, F., Maas, L., Müller, C., Dahmen, I., Delhomme, T. M., Ardin, M., Leblay, N., Byrnes, G., Sun, R., De Reynies, A., McLeer-Florin, A., Bosco, G., Malchers, F., Menon, R., Altmüller, J. & 42 others, Becker, C., Nürnberg, P., Achter, V., Lang, U., Schneider, P. M., Bogus, M., Soloway, M. G., Wilkerson, M. D., Cun, Y., McKay, J. D., Moro-Sibilot, D., Brambilla, C. G., Lantuejoul, S., Lemaitre, N., Soltermann, A., Weder, W., Tischler, V., Brustugun, O. T., Lund-Iversen, M., Helland, Å., Solberg, S., Ansén, S., Wright, G., Solomon, B., Roz, L., Pastorino, U., Petersen, I., Clement, J. H., Sänger, J., Wolf, J., Vingron, M., Zander, T., Perner, S., Travis, W. D., Haas, S. A., Olivier, M., Foll, M., Büttner, R., Hayes, D. N., Brambilla, E., Fernandez-Cuesta, L. & Thomas, R. K., Dec 1 2018, In : Nature communications. 9, 1, 1048.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Large Cell Carcinoma
Neuroendocrine Tumors
lungs
Tumors
11 Citations (Scopus)

Isolation and Identification of the Follicular Microbiome: Implications for Acne Research

Hall, J. B., Cong, Z., Imamura, Y., Kidd, B. A., Dudley, J. T., Thiboutot, D. & Nelson, A., Sep 1 2018, In : Journal of Investigative Dermatology. 138, 9, p. 2033-2040 8 p.

Research output: Contribution to journalArticle

Microbiota
Acne Vulgaris
Skin
Propionibacterium acnes
Sampling
1 Citation (Scopus)

MVisAGe identifies concordant and discordant genomic alterations of driver genes in squamous tumors

Walter, V., Du, Y., Danilova, L., Hayward, M. C. & Hayes, D. N., Jun 15 2018, In : Cancer Research. 78, 12, p. 3375-3385 11 p.

Research output: Contribution to journalArticle

Oncogenes
Gene Expression
DNA Copy Number Variations
Genes
Neoplasms
4 Citations (Scopus)
Long Noncoding RNA
Untranslated RNA
MicroRNAs
Liver Diseases
Hepatocellular Carcinoma
2 Citations (Scopus)

Paired Box 5 (PAX5) Expression in Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal and Pancreatobiliary Tract: Diagnostic and Potentially Therapeutic Implications

Ainechi, S., Mann, S. A., Lin, J., Patil, D., Sheehan, C. E., Yang, Z., Zuo, C. & Lee, H., Sep 1 2018, In : Applied Immunohistochemistry and Molecular Morphology. 26, 8, p. 545-551 7 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Gastrointestinal Tract
Small Cell Carcinoma
Therapeutics
Neuroendocrine Tumors
6 Citations (Scopus)

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

Schleicher, E. M., Galvan, A. M., Imamura-Kawasawa, Y., Moldovan, G. L. & Nicolae, C. M., Jan 1 2018, In : Nucleic acids research. 46, 17, p. 8908-8916 9 p.

Research output: Contribution to journalArticle

Carcinogenesis
Cell Proliferation
HeLa Cells
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling

Matthew, E. M., Yang, Z., Peri, S., Andrake, M., Dunbrack, R., Ross, E. & El-Deiry, W. S., Mar 1 2018, In : Neoplasia (United States). 20, 3, p. 244-255 12 p.

Research output: Contribution to journalArticle

Adenoma
Colorectal Neoplasms
S 6
Adenocarcinoma
Neoplasms
5 Citations (Scopus)

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

Jiang, Y., Chen, S., McGuire, D., Chen, F., Liu, M., Iacono, W. G., Hewitt, J. K., Hokanson, J. E., Krauter, K., Laakso, M., Li, K. W., Lutz, S. M., McGue, M., Pandit, A., Zajac, G. J. M., Boehnke, M., Abecasis, G. R., Vrieze, S. I., Zhan, X., Jiang, B. & 1 others, Liu, D. J., Jul 2018, In : PLoS genetics. 14, 7, e1007452.

Research output: Contribution to journalArticle

tobacco use
meta-analysis
Tobacco Use
tobacco
Meta-Analysis
4 Citations (Scopus)

Rare loss of function variants in candidate genes and risk of colorectal cancer

NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group & 15 others, Steering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In : Human genetics. 137, 10, p. 795-806 12 p.

Research output: Contribution to journalArticle

Polyps
Colorectal Neoplasms
Genes
Penetrance
Genetic Testing
1 Citation (Scopus)

Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids

Benko, A. L., McAloose, C. A., Becker, P. M., Wright, D., Sunyer, T., Kawasawa, Y. I., Olsen, N. J. & Kovacs, W. J., Apr 2018, In : Clinical and Experimental Immunology. 192, 1, p. 68-81 14 p.

Research output: Contribution to journalArticle

Adrenocorticotropic Hormone
Glucocorticoids
B-Lymphocytes
Gene Expression
Messenger RNA
16 Citations (Scopus)

Spatiotemporal transcriptomic divergence across human and macaque brain development

Zhu, Y., Sousa, A. M. M., Gao, T., Skarica, M., Li, M., Santpere, G., Esteller-Cucala, P., Juan, D., Ferrández-Peral, L., Gulden, F. O., Yang, M., Miller, D. J., Marques-Bonet, T., Imamura, Y., Zhao, H. & Sestan, N., Dec 14 2018, In : Science. 362, 6420, 1267.

Research output: Contribution to journalArticle

Macaca
Brain
Human Development
Prefrontal Cortex
Macaca mulatta
32 Citations (Scopus)

The 3D Genome Browser: A web-based browser for visualizing 3D genome organization and long-range chromatin interactions

Wang, Y., Song, F., Zhang, B., Zhang, L., Xu, J., Kuang, D., Li, D., Choudhary, M. N. K., Li, Y., Hu, M., Hardison, R., Wang, T. & Yue, F., Oct 4 2018, In : Genome biology. 19, 1, 151.

Research output: Contribution to journalArticle

Web Browser
Chromatin
chromatin
genome
Genome
1 Citation (Scopus)

The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development

Tebbenkamp, A. T. N., Varela, L., Choi, J., Paredes, M. I., Giani, A. M., Song, J. E., Sestan-Pesa, M., Franjic, D., Sousa, A. M. M., Liu, Z. W., Li, M., Bichsel, C., Koch, M., Szigeti-Buck, K., Liu, F., Li, Z., Kawasawa, Y. I., Paspalas, C. D., Mineur, Y. S., Prontera, P. & 5 others, Merla, G., Picciotto, M. R., Arnsten, A. F. T., Horvath, T. L. & Sestan, N., Nov 1 2018, In : Cell. 175, 4, p. 1088-1104.e23

Research output: Contribution to journalArticle

Mitochondrial Proton-Translocating ATPases
Williams Syndrome
Mitochondria
Machinery
Brain
4 Citations (Scopus)

The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes

Meng, Q., Wang, K., Brunetti, T., Xia, Y., Jiao, C., Dai, R., Fitzgerald, D., Thomas, A., Jay, L., Eckart, H., Grennan, K., Imamura, Y., Li, M., Sestan, N., White, K. P., Chen, C. & Liu, C., Dec 19 2018, In : Science Translational Medicine. 10, 472, eaat6912.

Research output: Contribution to journalArticle

Long Noncoding RNA
Schizophrenia
Genes
RNA Sequence Analysis
Induced Pluripotent Stem Cells

The expression of TTF1, CDX2 and ISL1 in 74 poorly differentiated neuroendocrine carcinomas

Lee, H., Fu, Z., Koo, B. H., Sheehan, C. E., Young, G. Q., Lin, J., Patil, D. T. & Yang, Z., Dec 1 2018, In : Annals of Diagnostic Pathology. 37, p. 30-34 5 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Small Cell Carcinoma
Staining and Labeling
Lung
Students
22 Citations (Scopus)

The Integrated Genomic Landscape of Thymic Epithelial Tumors

The Cancer Genome Atlas Network, Feb 12 2018, In : Cancer Cell. 33, 2, p. 244-258.e10

Research output: Contribution to journalArticle

Thymoma
Myasthenia Gravis
Autoantigens
Aneuploidy
Mutation

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming

Bellon, A., Wegener, A., Lescallette, A. R., Valente, M., Yang, S. K., Gardette, R., Matricon, J., Mouaffak, F., Watts, P., Vimeux, L., Yun, J. K., Kawasawa, Y. I., Clawson, G. A., Blandin, E., Chaumette, B., Jay, T. M., Krebs, M. O., Feuillet, V. & Hosmalin, A., Sep 19 2018, In : Frontiers in Molecular Neuroscience. 11, 323.

Research output: Contribution to journalArticle

Monocytes
Neurons
Neuronal Plasticity
Electrophysiology
Dopamine Receptors
1 Citation (Scopus)

Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study

Posadas, K., Ankola, A., Yang, Z. & Yee, N. S., Jun 1 2018, In : Biomedicines. 6, 2, 46.

Research output: Contribution to journalArticle

Tumors
Hepatocellular Carcinoma
oxaliplatin
Chemotherapy
Catenins
15 Citations (Scopus)

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

The New York Genome Center ALS Consortium, Jul 13 2018, In : eLife. 7, e37754.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Heterogeneous-Nuclear Ribonucleoprotein Group F-H
Brain
RNA-Binding Proteins
Genes
1 Citation (Scopus)

WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells

Wang, Q., Geng, Z., Gong, Y., Warren, K., Zheng, H., Imamura, Y. & Gao, Z., Dec 1 2018, In : Stem Cell Research. 33, p. 206-214 9 p.

Research output: Contribution to journalArticle

Open Access
Autistic Disorder
Transcriptional Activation
Polycomb Repressive Complex 1
Genes
Mouse Embryonic Stem Cells
2019

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L. & 102 others, Regmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K. C., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In : Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journalArticle

An R package for model fitting, model selection and the simulation for longitudinal data with dropout missingness

Xu, C., Li, Z., Xue, Y., Zhang, L. & Wang, M., Oct 21 2019, In : Communications in Statistics: Simulation and Computation. 48, 9, p. 2812-2829 18 p.

Research output: Contribution to journalArticle

Drop out
Model Fitting
Longitudinal Data
Model Selection
Weighted Estimating Equations
1 Citation (Scopus)
Open Access
dopamine beta-monooxygenase
Dopamine beta-Hydroxylase
inflammatory bowel disease
Polymorphism
Inflammatory Bowel Diseases
5 Citations (Scopus)

Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents

He, F., Berg, A., Imamura, Y., Bixler, E., Fernandez-Mendoza, J., Whitsel, E. A. & Liao, D., Dec 1 2019, In : Scientific reports. 9, 1, 2079.

Research output: Contribution to journalArticle

DNA Methylation
Body Mass Index
Obesity
Genes
Pediatric Obesity
35 Citations (Scopus)

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

23andMe Research Team, HUNT All-In Psychiatry, Liu, M., Jiang, Y., Wedow, R., Li, Y., Brazel, D. M., Chen, F., Datta, G., Davila-Velderrain, J., McGuire, D., Tian, C., Zhan, X., Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P. & 32 others, Furlotte, N. A., Hinds, D. A., Hromatka, B. S., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Northover, C. A. M., Sathirapongsasuti, J. F., Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Pitts, S. J., Mitchell, A., Skogholt, A. H., Winsvold, B. S., Sivertsen, B., Stordal, E., Morken, G., Kallestad, H., Heuch, I., Zwart, J. A., Fjukstad, K. K., Pedersen, L. M., Gabrielsen, M. E., Johnsen, M. B. & Liu, D., Feb 1 2019, In : Nature Genetics. 51, 2, p. 237-244 8 p.

Research output: Contribution to journalLetter

Tobacco Use
Alcohols
Tobacco Use Cessation
Genetic Association Studies
Synaptic Transmission
1 Citation (Scopus)
Acute Myeloid Leukemia
Respiratory Insufficiency
Non-Hodgkin's Lymphoma
Autopsy
Pathology
1 Citation (Scopus)

Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems

Buckwalter, J. M., Chan, W., Shuman, L., Wildermuth, T., Ellis-Mohl, J., Walter, V., Warrick, J. I., Wu, X. R., Kaag, M., Raman, J. D. & Degraff, D. J., May 2 2019, In : International journal of molecular sciences. 20, 10, 2599.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
bladder
Polymerase chain reaction
Urinary Bladder Neoplasms
cancer
1 Citation (Scopus)

Circulating microRNAs in plasma among men with low-grade and high-grade prostate cancer at prostate biopsy

McDonald, A. C., Vira, M., Walter, V., Shen, J., Raman, J. D., Sanda, M. G., Patil, D. & Taioli, E., Jun 15 2019, In : Prostate. 79, 9, p. 961-968 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Prostatic Neoplasms
Biopsy
Neoplasm Grading
Prostate-Specific Antigen

Differential impact of co-expressed SP-A1/SP-A2 protein on AM miRNome; Sex differences

Thorenoor, N., Imamura, Y., Gandhi, C., Zhang, X. & Floros, J., Jan 1 2019, In : Frontiers in immunology. 10, AUG, 1960.

Research output: Contribution to journalArticle

Open Access
Alveolar Macrophages
varespladib methyl
Sex Characteristics
Pulmonary Surfactant-Associated Protein A
Oxidative Stress
4 Citations (Scopus)

Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

Liu, Z., Yee, P. P., Wei, Y., Liu, Z., Imamura, Y. & Li, W., Mar 1 2019, In : Journal of Cell Science. 132, 5, jcs225714.

Research output: Contribution to journalArticle

Open Access
Glioma
Carcinogenesis
Neoplasms
Glioblastoma
Growth
1 Citation (Scopus)

Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms

Teissier, A., Le Magueresse, C., Olusakin, J., Andrade da Costa, B. L. S., De Stasi, A. M., Bacci, A., Imamura Kawasawa, Y., Vaidya, V. A. & Gaspar, P., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Oligodendroglia
Psychological Stress
Prefrontal Cortex
Neurons
Immediate-Early Genes
Open Access
Students
evaluation
student
Nonparametric Statistics
Medical Students

Empirical-likelihood-based criteria for model selection on marginal analysis of longitudinal data with dropout missingness

Chen, C., Shen, B., Zhang, L., Xue, Y. & Wang, M., Sep 1 2019, In : Biometrics. 75, 3, p. 950-965 16 p.

Research output: Contribution to journalArticle

dropouts
Information Criterion
Empirical Likelihood
Drop out
Longitudinal Data
1 Citation (Scopus)

Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions

Podany, A., Rauchut, J., Wu, T., Imamura, Y., Wright, J., Lamendella, R., Soybel, D. & Kelleher, S. L., Feb 1 2019, In : Molecular Nutrition and Food Research. 63, 3, 1800947.

Research output: Contribution to journalArticle

Zinc
neonates
Oxidative Stress
oxidative stress
zinc
6 Citations (Scopus)

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

CHD Exome+ Consortium, Consortium for Genetics of Smoking Behaviour, Brazel, D. M., Jiang, Y., Hughey, J. M., Turcot, V., Zhan, X., Gong, J., Batini, C., Weissenkampen, J. D., Liu, M. Z., Surendran, P., Young, R., Barnes, D. R., Nielsen, S. F., Rasheed, A., Samuel, M., Zhao, W., Kontto, J., Perola, M. & 32 others, Caslake, M., de Craen, A. J. M., Trompet, S., Uria-Nickelsen, M., Malarstig, A., Reily, D. F., Hoek, M., Vogt, T., Jukema, J. W., Sattar, N., Ford, I., Packard, C. J., Alam, D. S., Majumder, A. A. S., Di Angelantonio, E., Chowdhury, R., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., EPIC-CVD Consortium, C., Frossard, P., Nordestgaard, B. G., Saleheen, D., Danesh, J., Butterworth, A. S. & Liu, D., Jun 1 2019, In : Biological Psychiatry. 85, 11, p. 946-955 10 p.

Research output: Contribution to journalArticle

Exome
Meta-Analysis
Smoking
Alcohols
Phenotype
2 Citations (Scopus)

Gene Expression Subtype Predicts Nodal Metastasis and Survival in Human Papillomavirus–Negative Head and Neck Cancer

Zevallos, J. P., Mazul, A. L., Walter, V. & Hayes, D. N., Jan 1 2019, In : Laryngoscope. 129, 1, p. 154-161 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Squamous Cell Carcinoma
Neoplasm Metastasis
Gene Expression
Survival

Genetic variants implicate dual oxidase-2 in familial and sporadic nonmedullary thyroid cancer

Bann, D. V., Jin, Q., Sheldon, K. E., Houser, K. R., Nguyen, L., Warrick, J. I., Baker, M. J., Broach, J. R., Gerhard, G. S. & Goldenberg, D., Nov 1 2019, In : Cancer Research. 79, 21, p. 5490-5499 10 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Penetrance
Oxidoreductases
Exome
Hydrogen Peroxide
2 Citations (Scopus)

GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment

Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A., Warrick, J. I., Timmins, P. F., Kesterson, J. P., Phaëton, R., Lee, N. Y., Walter, V., Endres, L., Mythreye, K., Aird, K. M. & Hempel, N., Jul 2019, In : Redox Biology. 25, 101051.

Research output: Contribution to journalArticle

Glutathione Peroxidase
Ovarian Neoplasms
Oxidation-Reduction
Ascites
Adenocarcinoma

HBV induces different responses of the hepatocytes and oval cells during HBV-related hepatic cirrhosis

Zhang, L., Chen, Y., Zhang, L. J., Wang, M., Chang, D. L., Wan, W. W., Zhang, B. X., Zhang, W. G. & Chen, X. P., Feb 28 2019, In : Cancer Letters. 443, p. 47-55 9 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Liver Cirrhosis
Hepatocytes
Transgenic Mice
Fibrosis

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

Osei-Amponsa, V., Buckwalter, J. M., Shuman, L., Zheng, Z., Yamashita, H., Walter, V., Wildermuth, T., Ellis-Mohl, J., Liu, C., Warrick, J. I., Shantz, L. M., Feehan, R. P., Al-Ahmadie, H., Mendelsohn, C., Raman, J. D., Kaestner, K. H., Wu, X. R. & DeGraff, D. J., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Urinary Bladder Neoplasms
Urothelium
Inborn Genetic Diseases
DNA

Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke

Janicki, P., Eyileten, C., Ruiz-Velasco, V., Pordzik, J., Czlonkowska, A., Kurkowska-Jastrzebska, I., Sugino, S., Imamura, Y., Mirowska-Guzel, D. & Postula, M., Apr 1 2019, In : Molecular medicine reports. 19, 4, p. 3263-3272 10 p.

Research output: Contribution to journalArticle

Platelets
Genes
Stroke
Quality control
Blood Platelets
21 Citations (Scopus)

Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]

Warrick, J., Sjödahl, G., Kaag, M. G., Raman, J., Merrill, S., Shuman, L., Chen, G., Walter, V. & Degraff, D., Jan 1 2019, In : European Urology. 75, 1, p. 18-22 5 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Neoplasms
Histology
Selection Bias
Carcinoma
4 Citations (Scopus)

Measuring the reproducibility and quality of Hi-C data

Yardımcı, G. G., Ozadam, H., Sauria, M. E. G., Ursu, O., Yan, K. K., Yang, T., Chakraborty, A., Kaul, A., Lajoie, B. R., Song, F., Zhan, Y., Ay, F., Gerstein, M., Kundaje, A., Li, Q., Taylor, J., Yue, F., Dekker, J. & Noble, W. S., Mar 19 2019, In : Genome biology. 20, 1, 57.

Research output: Contribution to journalArticle

reproducibility
Noise
Benchmarking
DNA Replication
Practice Guidelines
2 Citations (Scopus)

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium, Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S. & 31 others, Boehnke, M., Bots, M. L., Brazel, D. M., Chambers, J. C., Chang-Claude, J., Chen, C., Corley, J., Chou, Y. L., David, S. P., de Boer, R. A., de Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A. & Liu, D., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
Genetic Loci
Meta-Analysis
Smoking
Nucleotides
Exome
1 Citation (Scopus)

Methods for the Analysis and Interpretation for Rare Variants Associated with Complex Traits

Weissenkampen, J. D., Jiang, Y., Eckert, S., Jiang, B., Li, B. & Liu, D., Apr 1 2019, In : Current protocols in human genetics. 101, 1, e83.

Research output: Contribution to journalArticle

Exome
Precision Medicine
DNA Sequence Analysis
Sequence Analysis
Meta-Analysis
Papillary Carcinoma
Recurrence
Neoplasms
Proportional Hazards Models
Neoplasm Grading
1 Citation (Scopus)

Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Pool, C., Walter, V., Bann, D., Goldenberg, D., Broach, J., Hennessy, M., Cottrill, E., Washburn, E., Williams, N., Crist, H., Imamura, Y. & Warrick, J., Mar 11 2019, In : Virchows Archiv. 474, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Factor IX
Neoplasms
Adenoma
RNA Sequence Analysis

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1 dependent mitochondrial dysfunction in the retina

Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Kawasawa, Y. I., Salzberg, A. C., Kimball, S. R., Jefferson, L. S. & Dennis, M. D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5508-5520 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Retina
Messenger RNA
Ribosomes
Eukaryotic Initiation Factors
5 Citations (Scopus)

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium, Mar 1 2019, In : Nature Genetics. 51, 3, p. 452-469 18 p.

Research output: Contribution to journalArticle

Body Fat Distribution
Homeostasis
Lipids
Fats
Genes

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators & Understanding Society Scientific Group, Jan 1 2019, (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalComment/debate

Open Access
Energy Intake
Energy Metabolism
Body Mass Index
Obesity
Proteins