Research Output 1955 2020

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2019
2 Citations (Scopus)

MicroRNA Expression Profiles in Upper Tract Urothelial Carcinoma Differentiate Tumor Grade, Stage, and Survival: Implications for Clinical Decision-Making

Browne, B. M., Stensland, K. D., Patel, C. K., Sullivan, T., Burks, E. J., Canes, D., Raman, J., Warrick, J. & Reiger-Christ, K. M., Jan 1 2019, In : Urology. 123, p. 93-100 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Carcinoma
Survival
Neoplasms
Recurrence
Video-Assisted Thoracic Surgery
Robotics
Thoracotomy
Propensity Score
Logistic Models

MiR-204 regulates type 1 IP 3 R to control vascular smooth muscle cell contractility and blood pressure

Gabani, M., Liu, J., Ait-Aissa, K., Koval, O., Kim, Y. R., Castañeda, D., Vikram, A., Jacobs, J. S., Grumbach, I., Trebak, M., Irani, K. & Kassan, M., Jun 1 2019, In : Cell Calcium. 80, p. 18-24 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Pressure
Angiotensin II
Mesenteric Arteries
2 Citations (Scopus)

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes

Cheung, J. Y., Gordon, J., Wang, J. F., Song, J., Zhang, X. Q., Prado, F. J., Santhanam, S., Rajan, S., Tomar, D., Tahrir, F. G., Gupta, M. K., Knezevic, T., Merabova, N., Kontos, C. D., McClung, J. M., Klotman, P. E., Madesh, M., Khalili, K. & Feldman, A. M., Apr 1 2019, In : Journal of Cellular Physiology. 234, 4, p. 4432-4444 13 p.

Research output: Contribution to journalArticle

Viruses
Cardiac Myocytes
Muscle Cells
Transgenic Mice
HIV-1
Papillary Carcinoma
Recurrence
Neoplasms
Proportional Hazards Models
Neoplasm Grading
2 Citations (Scopus)

MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors

Payne, R., Mrowczynski, O. D., Slagle-Webb, B., Bourcier, A., Mau, C., Aregawi, D., Madhankumar, A. B., Lee, S. Y., Harbaugh, K., Connor, J. & Rizk, E. B., Feb 2019, In : Journal of neurosurgery. 130, 2, p. 465-475 11 p.

Research output: Contribution to journalArticle

Neurilemmoma
Ifosfamide
Aurora Kinase A
Doxorubicin
Therapeutics

Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling

Maheshwari, P., Du, H., Sheen, J., Assmann, S. M. & Albert, R., Jan 1 2019, In : PLoS computational biology. 15, 10, e1007429.

Research output: Contribution to journalArticle

Open Access
Guard Cell
Cell signaling
Enzyme inhibition
Abscisic Acid
Phosphoprotein Phosphatases
1 Citation (Scopus)
Appalachian Region
Mississippi
Spatial Analysis
Health Policy
Rivers

Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

Black, S. J., Ozdemir, A. Y., Kashkina, E., Kent, T., Rusanov, T., Ristic, D., Shin, Y., Suma, A., Hoang, T., Chandramouly, G., Siddique, L. A., Borisonnik, N., Sullivan-Reed, K., Mallon, J. S., Skorski, T., Carnevale, V., Murakami, K. S., Wyman, C. & Pomerantz, R. T., Dec 1 2019, In : Nature communications. 10, 1, 4423.

Research output: Contribution to journalArticle

Open Access
Joining
DNA
deoxyribonucleic acid
Chromosome Pairing
Double-Stranded DNA Breaks
2 Citations (Scopus)

Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Pool, C., Walter, V., Bann, D., Goldenberg, D., Broach, J., Hennessy, M., Cottrill, E., Washburn, E., Williams, N., Crist, H., Imamura, Y. & Warrick, J., Mar 11 2019, In : Virchows Archiv. 474, 3, p. 341-351 11 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Factor IX
Neoplasms
Adenoma
RNA Sequence Analysis
3 Citations (Scopus)

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

Bonfanti, S., Lionetti, M. C., Fumagalli, M. R., Chirasani, V. R., Tiana, G., Dokholyan, N. V., Zapperi, S. & La Porta, C. A. M., Dec 1 2019, In : Scientific reports. 9, 1, 7615.

Research output: Contribution to journalArticle

Open Access
Huntington Disease
Molecular Conformation
Fluorescence Resonance Energy Transfer
Prions
Optical Imaging

Monoclonal Antibodies Against Human Papillomavirus E6 and E7 Oncoproteins Inhibit Tumor Growth in Experimental Cervical Cancer

Jiang, Z., Albanese, J., Kesterson, J., Warrick, J., Karabakhtsian, R., Dadachova, E. & Phaeton, R., Oct 1 2019, In : Translational Oncology. 12, 10, p. 1289-1295 7 p.

Research output: Contribution to journalArticle

Open Access
Oncogene Proteins
Uterine Cervical Neoplasms
Monoclonal Antibodies
Growth
Neoplasms
1 Citation (Scopus)

Multicenter Evaluation of Clinical Efficacy and Safety of Per-oral Endoscopic Myotomy in Children

Choné, A., Familiari, P., von Rahden, B., Desai, P., Inoue, H., Shimamura, Y., Eleftheriadis, N., Yamashita, K., Khashab, M. A., Shiwaku, H., Seewald, S., Draganov, P. V., Alvarez, L. B. M., Chaussade, S., Tantau, M., Abraham, M., Marks, J., Arevalo, G., Albéniz, E., Mion, F. & 9 others, Roman, S., Rivory, J., Dubois, R., Lachaux, A., Benech, N., Subtil, F., Ponchon, T., Barret, M. & Pioche, M., Nov 1 2019, In : Journal of pediatric gastroenterology and nutrition. 69, 5, p. 523-527 5 p.

Research output: Contribution to journalArticle

Esophageal Achalasia
Safety
Inborn Genetic Diseases
Gastroesophageal Reflux
Subcutaneous Emphysema
Open Access
decitabine
Acute Myeloid Leukemia
Therapeutics
T-Lymphocytes
DNA Methylation
2 Citations (Scopus)

Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics

Kline, B. P., Schieffer, K. M., Choi, C. S., Connelly, T., Chen, J., Harris, L., Deiling, S., Yochum, G. S. & Koltun, W. A., Nov 1 2019, In : Digestive Diseases and Sciences. 64, 11, p. 3143-3151 9 p.

Research output: Contribution to journalArticle

Diverticulitis
Recurrence
RNA

Multi-model implementation of evidence-based care in the treatment of opioid use disorder in Pennsylvania

Kawasaki, S., Francis, E., Mills, S., Buchberger, G., Hogentogler, R. & Kraschnewski, J., Nov 1 2019, In : Journal of Substance Abuse Treatment. 106, p. 58-64 7 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Buprenorphine
Therapeutics
Health
Drug Overdose
3 Citations (Scopus)

Multi-omic data interpretation to repurpose subtype specific drug candidates for breast cancer

Turanli, B., Karagoz, K., Bidkhori, G., Sinha, R., Gatza, M. L., Uhlen, M., Mardinoglu, A. & Arga, K. Y., Jan 1 2019, In : Frontiers in Genetics. 10, MAY, 420.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Breast Neoplasms
Pharmaceutical Preparations
Drug Repositioning
Aurora Kinase A

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
hematopoiesis
Hematopoiesis
Hematopoietic Stem Cells
Epigenomics
mutations

Mutations in EZH2 are associated with poor prognosis for patients with myeloid neoplasms

Zhang, Q., Han, Q., Zi, J., Ma, J., Song, H., Tian, Y., McGrath, M., Song, C. & Ge, Z., Sep 2019, In : Genes and Diseases. 6, 3, p. 276-281 6 p.

Research output: Contribution to journalArticle

Open Access
Polycomb Repressive Complex 2
Histones
Lysine
Hazards
Mutation
15 Citations (Scopus)

NAD + metabolism governs the proinflammatory senescence-associated secretome

Nacarelli, T., Lau, L., Fukumoto, T., Zundell, J., Fatkhutdinov, N., Wu, S., Aird, K. M., Iwasaki, O., Kossenkov, A. V., Schultz, D., Noma, K. I., Baur, J. A., Schug, Z., Tang, H. Y., Speicher, D. W., David, G. & Zhang, R., Mar 1 2019, In : Nature Cell Biology. 21, 3, p. 397-407 11 p.

Research output: Contribution to journalArticle

NAD
Phenotype
Nicotinamide Phosphoribosyltransferase
High Mobility Group Proteins
Neoplasms
1 Citation (Scopus)

Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases

Iyer, R., Kuriakose, A. E., Yaman, S., Su, L. C., Shan, D., Yang, J., Liao, J., Tang, L., Banerjee, S., Xu, H. & Nguyen, K. T., Jan 10 2019, In : International Journal of Pharmaceutics. 554, p. 212-223 12 p.

Research output: Contribution to journalArticle

Balloon Angioplasty
Nanoparticles
Cardiovascular Diseases
Hydrogel
Pharmaceutical Preparations
4 Citations (Scopus)

Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing

Gao, J., Li, H., Torab, P., Mach, K. E., Craft, D. W., Thomas, N. J., Puleo, C. M., Liao, J. C., Wang, T. H. & Wong, P. K., Apr 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 246-253 8 p.

Research output: Contribution to journalArticle

Nanotubes
Electroporation
Pathogens
Microwaves
Testing
2 Citations (Scopus)

National trends and disparities of minimally invasive surgery for localized renal cancer, 2010 to 2015

Xia, L., Talwar, R., Taylor, B. L., Shin, M. H., Berger, I. B., Sperling, C. D., Chelluri, R. R., Zambrano, I. A., Raman, J. D. & Guzzo, T. J., Mar 2019, In : Urologic Oncology: Seminars and Original Investigations. 37, 3, p. 182.e17-182.e27

Research output: Contribution to journalArticle

Minimally Invasive Surgical Procedures
Kidney Neoplasms
Nephrectomy
Robotics
Odds Ratio

Neck circumference is associated with hyperuricemia: a cross-sectional study

Shen, X., Wu, S., Xu, R., Wu, Y., Li, J., Cui, L., Shu, R. & Gao, X., Sep 1 2019, In : Clinical Rheumatology. 38, 9, p. 2373-2381 9 p.

Research output: Contribution to journalArticle

Hyperuricemia
Neck
Cross-Sectional Studies
Uric Acid
Serum
1 Citation (Scopus)

Nicotine absorption during electronic cigarette use among regular users

Yingst, J. M., Foulds, J., Veldheer, S., Hrabovsky, S., Trushin, N., Eissenberg, T. T., Williams, J., Richie, J. P., Nichols, T. T., Wilson, S. J. & Hobkirk, A. L., Jan 1 2019, In : PloS one. 14, 7, e0220300.

Research output: Contribution to journalArticle

Open Access
cigarettes
nicotine
Nicotine
Tobacco Products
electronics

Nicotine Absorption Profile Among Regular Users of a Pod-Based Electronic Nicotine Delivery System

Yingst, J. M., Hrabovsky, S., Hobkirk, A., Trushin, N., Richie, J. P. & Foulds, J., Nov 1 2019, In : JAMA network open. 2, 11, p. e1915494

Research output: Contribution to journalArticle

Open Access
Tobacco Use Disorder
Atherosclerosis
Smoking
Lung
Tobacco Products

Nitrous Oxide Impairs Axon Regeneration after Nervous System Injury in Male Rats

Stewart, K. J., Iskandar, B. J., Meier, B. M., Rizk, E. B., Hariharan, N., Koueik, J., Andrei, A. C. & Hogan, K. J., Nov 1 2019, In : Anesthesiology. 131, 5, p. 1063-1076 14 p.

Research output: Contribution to journalArticle

Nervous System Trauma
Nitrous Oxide
Axons
Regeneration
Needlestick Injuries

Noise-cancelling repeat finder: Uncovering tandem repeats in error-prone long-read sequencing data

Harris, R. S., Cechova, M., Makova, K. D. & Birol, I., Nov 1 2019, In : Bioinformatics. 35, 22, p. 4809-4811 3 p.

Research output: Contribution to journalArticle

Open Access
Tandem Repeat Sequences
Sequencing
Noise
Heat-Shock Response
Nanopore
4 Citations (Scopus)

Nonawake vs awake placement of spinal cord stimulators: A prospective, multicenter study comparing safety and efficacy

Falowski, S. M., Sharan, A., McInerney, J., Jacobs, D., Venkatesan, L. & Agnesi, F., Jan 1 2019, In : Clinical neurosurgery. 84, 1, p. 198-205 8 p.

Research output: Contribution to journalArticle

Paresthesia
Multicenter Studies
Spinal Cord
Prospective Studies
Spinal Cord Stimulation
1 Citation (Scopus)

Novel Use of Chatbot Technology to Educate Patients Before Breast Biopsy

Chetlen, A., Artrip, R., Drury, B., Arbaiza, A. & Moore, M., Sep 1 2019, In : Journal of the American College of Radiology. 16, 9, p. 1305-1308 4 p.

Research output: Contribution to journalArticle

Breast
Technology
Biopsy

np2QTL: networking phenotypic plasticity quantitative trait loci across heterogeneous environments

Ye, M., Jiang, L., Chen, C., Zhu, X., Wang, M. & Wu, R., Jan 1 2019, In : Plant Journal. 99, 4, p. 796-806 11 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
phenotypic plasticity
quantitative trait loci
plant adaptation
Plastics

np2QTL: networking phenotypic plasticity quantitative trait loci across heterogeneous environments

Ye, M., Jiang, L., Chen, C., Zhu, X., Wang, M. & Wu, R., Apr 22 2019, In : the Plant Journal.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays

Bass, M. V., Nikitina, T., Norouzi, D., Zhurkin, V. B. & Grigoryev, S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 11, p. 4233-4246 14 p.

Research output: Contribution to journalArticle

Open Access
Nucleosomes
Topology
DNA
Chromatin
Association reactions
2 Citations (Scopus)

Nucleotide Excision Repair and Impact of Site-Specific 5′,8-Cyclopurine and Bulky DNA Lesions on the Physical Properties of Nucleosomes

Shafirovich, V., Kolbanovskiy, M., Kropachev, K., Liu, Z., Cai, Y., Terzidis, M. A., Masi, A., Chatgilialoglu, C., Amin, S., Dadali, A., Broyde, S. & Geacintov, N. E., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

Nucleosomes
DNA Repair
Repair
Nucleotides
Physical properties
3 Citations (Scopus)

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

Chagwedera, D. N., Ang, Q. Y., Bisanz, J. E., Leong, Y. A., Ganeshan, K., Cai, J., Patterson, A. D., Turnbaugh, P. J. & Chawla, A., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 364-373.e7

Research output: Contribution to journalArticle

Microbiota
Eating
Appetite Regulation
Food
Body Weight

Occupationally Related Nickel Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 1998-2016

Warshaw, E. M., Schlarbaum, J. P., Dekoven, J. G., Silverberg, J. I., Zug, K. A., Marks, J. G., Belsito, D. V., Mathias, T., Reeder, M. J., Atwater, A. R., Maibach, H. I., Sasseville, D., Zirwas, M. J., Fransway, A. F., Pratt, M. D., Deleo, V. A., Fowler, J. F. & Taylor, J. S., Sep 1 2019, In : Dermatitis. 30, 5, p. 306-313 8 p.

Research output: Contribution to journalArticle

Contact Dermatitis
Nickel
Hypersensitivity
Occupations
Industry

Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Khetan, P., Boffetta, P., Luce, D., Stucker, I., Curado, M. P., Menezes, A., Wunsch-Filho, V., Ahrens, W., Lagiou, P., Serraino, D., Richiardi, L., Kjaerheim, K., Conway, D., Thomson, P., Muscat, J., Mates, D., Ramroth, H., Menvielle, G., Vaughan, T. L., Brenner, H. & 4 others, Lee, Y. C. A., La Vecchia, C., Hashibe, M. & Hashim, D., May 1 2019, In : Journal of occupational and environmental medicine. 61, 5, p. 397-404 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Occupations
Epidemiology
Odds Ratio
Confidence Intervals

Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women

Sun, Y. W., Xu, H., Benitez, G., Chen, K. M., Stanley, A., Stanley, B., Zhu, J., Thompson, H., Manni, A. & El-Bayoumy, K., Sep 6 2019, In : Journal of Proteome Research. 18, 9, p. 3461-3469 9 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Vitamin D-Binding Protein
Protein Isoforms
Proteins
Hemopexin

Opioid Analgesics Do Not Improve Abdominal Pain or Quality of Life in Crohn’s Disease

Coates, M. D., Seth, N., Clarke, K., Abdul-Baki, H., Mahoney, N., Walter, V., Regueiro, M. D., Ramos-Rivers, C., Koutroubakis, I. E., Bielefeldt, K. & Binion, D. G., Jan 1 2019, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Crohn Disease
Abdominal Pain
Opioid Analgesics
Quality of Life
Pain
Health Expenditures
Opioid Analgesics
State Government
Federal Government
Costs and Cost Analysis
5 Citations (Scopus)

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures

Caesar, L. K., Kellogg, J., Kvalheim, O. M. & Cech, N. B., Mar 22 2019, In : Journal of Natural Products. 82, 3, p. 469-484 16 p.

Research output: Contribution to journalArticle

Metabolomics
Biological Products
Mass spectrometry
Mass Spectrometry
Biosynthetic Pathways

Optimal route planning for image-guided EBUS bronchoscopy

Zang, X., Gibbs, J. D., Cheirsilp, R., Byrnes, P. D., Toth, J., Bascom, R. & Higgins, W. E., Sep 2019, In : Computers in Biology and Medicine. 112, 103361.

Research output: Contribution to journalArticle

Biopsy
Bronchoscopy
Planning
Tissue
Thorax

Optimizing live-animal bioluminescence imaging prediction of tumor burden in human prostate cancer xenograft models in SCID-NSG mice

Kim, S., Zhang, Y., Tang, S., Qin, C., Karelia, D., Sharma, A., Jiang, C. & Lu, J., Jun 15 2019, In : Prostate. 79, 9, p. 949-960 12 p.

Research output: Contribution to journalArticle

SCID Mice
Tumor Burden
Luciferases
Heterografts
Prostatic Neoplasms

Oroxylum indicum (L.) extract protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell injury

Mairuae, N., Connor, J. R., Buranrat, B. & Lee, S. Y., Jan 1 2019, In : Molecular medicine reports. 20, 2, p. 1933-1942 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Neuroblastoma
Amyloid
Caspase 7
Caspase 3
7 Citations (Scopus)

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

Wei, J., Marisetty, A., Schrand, B., Gabrusiewicz, K., Hashimoto, Y., Ott, M., Grami, Z., Kong, L. Y., Ling, X., Caruso, H., Zhou, S., Wang, Y. A., Fuller, G. N., Huse, J., Gilboa, E., Kang, N., Huang, X., Verhaak, R., Li, S. & Heimberger, A. B., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI121266.

Research output: Contribution to journalArticle

Osteopontin
Glioblastoma
Macrophages
Glioma
Therapeutics
3 Citations (Scopus)

Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia

Lund, T. C., Ahn, K. W., Tecca, H. R., Hilgers, M. V., Abdel-Azim, H., Abraham, A., Diaz, M. A., Badawy, S. M., Broglie, L., Brown, V., Dvorak, C. C., Gonzalez-Vicent, M., Hashem, H., Hayashi, R. J., Jacobsohn, D. A., Kent, M. W., Li, C. K., Margossian, S. P., Martin, P. L., Mehta, P. & 9 others, Myers, K., Olsson, R., Page, K., Pulsipher, M. A., Shaw, P. J., Smith, A. R., Triplett, B. M., Verneris, M. R. & Eapen, M., Feb 2019, In : Biology of Blood and Marrow Transplantation. 25, 2, p. 301-306 6 p.

Research output: Contribution to journalArticle

Cell Transplantation
Young Adult
Leukemia
Recurrence
Transplantation

Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction

National Audit of Small Bowel Obstruction Steering Group & National Audit of Small Bowel Obstruction Collaborators, Dec 2019, In : European Journal of Surgical Oncology. 45, 12, p. 2319-2324 6 p.

Research output: Contribution to journalArticle

Neoplasms
Colonic Neoplasms
Hospital Mortality
Morbidity
Malnutrition

Outcomes of Cadaveric Allograft versus Autologous Cartilage Graft in Functional Septorhinoplasty

Saadi, R., Loloi, J., Schaefer, E. & Lighthall, J. G., Nov 1 2019, In : Otolaryngology - Head and Neck Surgery (United States). 161, 5, p. 779-786 8 p.

Research output: Contribution to journalArticle

Nasal Obstruction
Symptom Assessment
Cartilage
Allografts
Transplants

Outcomes of upper tract urothelial cancer managed non-surgically

Syed, J. S., Nguyen, K. A., Suarez-Sariemento, A., Leung, C., Casilla-Lennon, M., Raman, J. D. & Shuch, B., Apr 1 2019, In : The Canadian journal of urology. 26, 2, p. 9699-9707 9 p.

Research output: Contribution to journalArticle

Survival
Neoplasms
Comorbidity
Drug Therapy
Radiation