• 25184 Citations
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1969 …2018

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Article
2018

High turnover of extracellular matrix reflected by specific protein fragments measured in serum is associated with poor outcomes in two metastatic breast cancer cohorts

Lipton, A., Leitzel, K., Ali, S. M., Polimera, H. V., Nagabhairu, V., Marks, E., Richardson, A. E., Krecko, L., Ali, A., Koestler, W., Esteva, F. J., Leeming, D. J., Karsdal, M. A. & Willumsen, N., Dec 1 2018, In : International Journal of Cancer. 143, 11, p. 3027-3034 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

The C-Terminal Intact Forms of Periostin (iPTN) Are Surrogate Markers for Osteolytic Lesions in Experimental Breast Cancer Bone Metastasis

Gineyts, E., Bonnet, N., Bertholon, C., Millet, M., Pagnon-Minot, A., Borel, O., Geraci, S., Bonnelye, E., Croset, M., Suhail, A., Truica, C., Lamparella, N., Leitzel, K., Hartmann, D., Chapurlat, R., Lipton, A., Garnero, P., Ferrari, S., Clézardin, P. & Rousseau, J. C., Nov 1 2018, In : Calcified Tissue International. 103, 5, p. 567-580 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Continued treatment effect of zoledronic acid dosing every 12 vs 4 weeks in women with breast cancer metastatic to bone: The OPTIMIZE-2 randomized clinical trial

Hortobagyi, G. N., Van Poznak, C., Harker, W. G., Gradishar, W. J., Chew, H., Dakhil, S. R., Haley, B. B., Sauter, N., Mohanlal, R., Zheng, M. & Lipton, A., Jul 2017, In : JAMA Oncology. 3, 7, p. 906-912 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Impact of serum HER2, TIMP-1, and CAIX on outcome for HER2+ metastatic breast cancer patients: CCTG MA.31 (lapatinib vs. trastuzumab)

Ho, D., Huang, J., Chapman, J. A. W., Leitzel, K., Ali, S. M., Shepherd, L., Parulekar, W. R., Ellis, C. E., Crescnzo, R. J., Zhu, L., Virk, S., Nomikos, D., Aparicio, S., Gelmon, K. A., Carney, W. P. & Lipton, A., Aug 1 2017, In : Breast Cancer Research and Treatment. 164, 3, p. 571-580 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Osteoporosis therapy and outcomes for postmenopausal patients with hormone receptor–positive breast cancer: NCIC CTG MA.27

Lipton, A., Chapman, J. A. W., Leitzel, K., Garg, A., Pritchard, K. I., Ingle, J. N., Budd, G. T., Ellis, M. J., Sledge, G. W., Rabaglio, M., Han, L., Elliott, C. R., Shepherd, L. E., Goss, P. E. & Ali, S. M., Jul 1 2017, In : Cancer. 123, 13, p. 2444-2451 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan

Kamalakar, A., Washam, C. L., Akel, N. S., Allen, B. J., Williams, D. K., Swain, F. L., Leitzel, K., Lipton, A., Gaddy, D. & Suva, L. J., Jul 1 2017, In : Journal of Bone and Mineral Research. 32, 7, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Changes in bone turnover marker levels and clinical outcomes in patients with advanced cancer and bone metastases treated with bone antiresorptive agents

Lipton, A., Smith, M. R., Fizazi, K., Stopeck, A. T., Henry, D., Brown, J. E., Shore, N. D., Saad, F., Spencer, A., Zhu, L. & Warner, D. J., Dec 1 2016, In : Clinical Cancer Research. 22, 23, p. 5713-5721 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of denosumab versus zoledronic acid in preventing skeletal-related events in patients with bone metastases by baseline characteristics

Lipton, A., Fizazi, K., Stopeck, A. T., Henry, D. H., Smith, M. R., Shore, N., Martin, M., Vadhan-Raj, S., Brown, J. E., Richardson, G. E., Saad, F., Yardley, D. A., Zhou, K., Balakumaran, A. & Braun, A., Jan 1 2016, In : European Journal of Cancer. 53, p. 75-83 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

N-telopeptide of type I collagen long-term dynamics in breast cancer patients with bone metastases: Clinical outcomes and influence of extraskeletal metastases

Ferreira, A. R., Alho, I., Shan, N., Matias, M., Faria, M., Casimiro, S., Leitzel, K., Ali, S., Lipton, A. & Costa, L., Dec 2016, In : Oncologist. 21, 12, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Hypocalcaemia in patients with metastatic bone disease treated with denosumab

Body, J. J., Bone, H. G., De Boer, R. H., Stopeck, A., Van Poznak, C., Damião, R., Fizazi, K., Henry, D. H., Ibrahim, T., Lipton, A., Saad, F., Shore, N., Takano, T., Shaywitz, A. J., Wang, H., Bracco, O. L., Braun, A. & Kostenuik, P. J., Aug 8 2015, In : European Journal of Cancer. 51, 13, p. 1812-1821 10 p., 9488.

Research output: Contribution to journalArticle

54 Scopus citations
2014

Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans

Kamalakar, A., Bendre, M. S., Washam, C. L., Fowler, T. W., Carver, A., Dilley, J. D., Bracey, J. W., Akel, N. S., Margulies, A. G., Skinner, R. A., Swain, F. L., Hogue, W. R., Montgomery, C. O., Lahiji, P., Maher, J. J., Leitzel, K. E., Ali, S. M., Lipton, A., Nicholas, R. W., Gaddy, D. & 1 others, Suva, L. J., Apr 1 2014, In : Bone. 61, p. 176-185 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Elevation in multiple serum inflammatory biomarkers predicts survival of pancreatic cancer patients with inoperable disease

Alkhateeb, A., Zubritsky, L., Kinsman, B., Leitzel, K., Campbell-Baird, C., Ali, S. M., Connor, J. & Lipton, A., Jun 2014, In : Journal of Gastrointestinal Cancer. 45, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Would screening for lung cancer benefit 75- to 84-year-old residents of the United States?

Varlotto, J. M., DeCamp, M. M., Flickinger, J. C., Lake, J., Recht, A., Belani, C. P., Reed, M. F., Toth, J. W., Mackley, H. B., Sciamanna, C. N., Lipton, A., Ali, S. M., Mahraj, R. P. M., Gilbert, C. R. & Yao, N., Jan 1 2014, In : Frontiers in Oncology. 4 MAR, Article 37.

Research output: Contribution to journalArticle

8 Scopus citations
2013

HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer

Lipton, A., Goodman, L., Leitzel, K., Cook, J., Sperinde, J., Haddad, M., Köstler, W. J., Huang, W., Weidler, J. M., Ali, S., Newton, A., Fuchs, E. M., Paquet, A., Singer, C. F., Horvat, R., Jin, X., Banerjee, J., Mukherjee, A., Tan, Y., Shi, Y. & 9 others, Chenna, A., Larson, J., Lie, Y., Sherwood, T., Petropoulos, C. J., Williams, S., Winslow, J., Parry, G. & Bates, M., Aug 1 2013, In : Breast Cancer Research and Treatment. 141, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis

Washam, C. L., Byrum, S. D., Leitzel, K., Ali, S. M., Tackett, A. J., Gaddy, D., Sundermann, S. E., Lipton, A. & Suva, L. J., May 1 2013, In : Cancer Epidemiology Biomarkers and Prevention. 22, 5, p. 972-983 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Pain outcomes in patients with advanced breast cancer and bone metastases: Results from a randomized, double-blind study of denosumab and zoledronic acid

Cleeland, C. S., Body, J. J., Stopeck, A., Von Moos, R., Fallowfield, L., Mathias, S. D., Patrick, D. L., Clemons, M., Tonkin, K., Masuda, N., Lipton, A., De Boer, R., Salvagni, S., Oliveira, C. T., Qian, Y., Jiang, Q., Dansey, R., Braun, A. & Chung, K., Feb 15 2013, In : Cancer. 119, 4, p. 832-838 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Possible survival benefits from zoledronic acid treatment in patients with bone metastases from solid tumours and poor prognostic features - An exploratory analysis of placebo-controlled trials

Coleman, R. E., Lipton, A., Costa, L., Cook, R. J., Lee, K. A., Saad, F., Brown, J. E., Terpos, E., Major, P. P., Kohno, N., Smith, M. & Body, J. J., Jun 2013, In : Journal of Bone Oncology. 2, 2, p. 70-76 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro

Casimiro, S., Mohammad, K. S., Pires, R., Tato-Costa, J., Alho, I., Teixeira, R., Carvalho, A., Ribeiro, S., Lipton, A., Guise, T. A. & Costa, L., May 16 2013, In : PloS one. 8, 5, e63153.

Research output: Contribution to journalArticle

46 Scopus citations

RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells

Casimiro, S., Alho, I., Bettencourt, M., Pires, R., Lipton, A. & Costa, L., 2013, In : Journal of Bone Oncology. 2, 3, p. 116-122 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Skeletal-related events and clinical outcomes in patients with bone metastases and normal levels of osteolysis: Exploratory analyses

Lipton, A., Cook, R., Brown, J., Body, J. J., Smith, M. & Coleman, R., Apr 1 2013, In : Clinical Oncology. 25, 4, p. 217-226 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Treatment of bone metastases before the onset of pain

Costa, L., Lipton, A., Hadji, P., Chen, Y. M. & Kosmidis, P., Jun 1 2013, In : International Journal of Clinical Oncology. 18, 3, p. 531-538 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Elevation in Inflammatory Serum Biomarkers Predicts Response to Trastuzumab-Containing Therapy

Alkhateeb, A. A., Leitzel, K., Ali, S. M., Campbell-Baird, C., Evans, M., Fuchs, E. M., Köstler, W. J., Lipton, A. & Connor, J., Dec 29 2012, In : PloS one. 7, 12, e51379.

Research output: Contribution to journalArticle

21 Scopus citations

Prognostic role of serum parathyroid hormone levels in advanced prostate cancer patients undergoing zoledronic acid administration

Berruti, A., Cook, R., Saad, F., Buttigliero, C., Lipton, A., Tampellini, M., Lee, K. A., Coleman, R. E. & Smith, M. R., Jun 4 2012, In : Oncologist. 17, 5, p. 645-652 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: A retrospective analysis in bisphosphonate-treated patients

Brown, J. E., Cook, R. J., Lipton, A. & Coleman, R. E., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6348-6355 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: A combined analysis of 3 pivotal, randomised, phase 3 trials

Lipton, A., Fizazi, K., Stopeck, A. T., Henry, D. H., Brown, J. E., Yardley, D. A., Richardson, G. E., Siena, S., Maroto, P., Clemens, M., Bilynskyy, B., Charu, V., Beuzeboc, P., Rader, M., Viniegra, M., Saad, F., Ke, C., Braun, A. & Jun, S., Nov 1 2012, In : European Journal of Cancer. 48, 16, p. 3082-3092 11 p.

Research output: Contribution to journalArticle

319 Scopus citations
2011

Denosumab in breast cancer

Lipton, A., Feb 1 2011, In : Current oncology reports. 13, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Elevated bone turnover predicts for bone metastasis in postmenopausal breast cancer: Results of NCIC CTG MA.14

Lipton, A., Chapman, J. A. W., Demers, L., Shepherd, L. E., Han, L., Wilson, C. F., Pritchard, K. I., Leitzel, K. E., Ali, S. M. & Pollak, M., Sep 20 2011, In : Journal of Clinical Oncology. 29, 27, p. 3605-3610 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Elevated plasma tissue inhibitor of metalloproteinase-1 levels predict decreased survival in castration-resistant prostate cancer patients

Oh, W. K., Vargas, R., Jacobus, S., Leitzel, K., Regan, M. M., Hamer, P., Pierce, K., Brown-Shimer, S., Carney, W., Ali, S. M., Kantoff, P. W. & Lipton, A., Feb 1 2011, In : Cancer. 117, 3, p. 517-525 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human epidermal growth factor receptor 2 (HER2) extracellular domain levels are associated with progression-free survival in patients with HER2-positive metastatic breast cancer receiving lapatinib monotherapy

Lipton, A., Leitzel, K., Ali, S. M., Carney, W., Platek, G., Steplewski, K., Westlund, R., Gagnon, R., Martin, A. M. & Maltzman, J., Nov 1 2011, In : Cancer. 117, 21, p. 5013-5020 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of a subpopulation of metastatic breast cancer patients with very high HER2 expression levels and possible resistance to trastuzumab

Bates, M., Sperinde, J., Köstler, W. J., Ali, S. M., Leitzel, K., Fuchs, E. M., Paquet, A., Lie, Y., Sherwood, T., Horvat, R., Singer, C. F., Winslow, J., Weidler, J. M., Huang, W. & Lipton, A., Sep 1 2011, In : Annals of Oncology. 22, 9, p. 2014-2020 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes

Ha, N. H., Nair, V. S., Reddy, D. N. S., Mudvari, P., Ohshiro, K., Ghanta, K. S., Pakala, S. B., Li, D. Q., Costa, L., Lipton, A., Badwe, R. A., Fuqua, S., Wallon, M., Prendergast, G. C. & Kumar, R., Dec 1 2011, In : Cancer Research. 71, 23, p. 7259-7269 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

New strategies to prevent and manage bone complications in cancer

Lipton, A., Jan 1 2011, In : Clinical Advances in Hematology and Oncology. 9, 1, p. 42-44 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phase II study of sunitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer

Gervais, R., Hainsworth, J. D., Blais, N., Besse, B., Laskin, J., Hamm, J. T., Lipton, A., Albain, K. S., Masters, G. A., Natale, R. B., Selaru, P., Kim, S. T., Chao, R. C. & Page, R. D., Dec 1 2011, In : Lung Cancer. 74, 3, p. 474-480 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers

Ghosh, R., Narasanna, A., Wang, S. E., Liu, S., Chakrabarty, A., Balko, J. M., González-Angulo, A. M., Mills, G. B., Penuel, E., Winslow, J., Sperinde, J., Dua, R., Pidaparthi, S., Mukherjee, A., Leitzel, K., Kostler, W. J., Lipton, A., Bates, M. & Arteaga, C. L., Mar 1 2011, In : Cancer Research. 71, 5, p. 1871-1882 12 p.

Research output: Contribution to journalArticle

131 Scopus citations

Treatment of Langerhans cell histiocytosis bone lesions with zoledronic acid: A case series

Sivendran, S., Harvey, H., Lipton, A. & Drabick, J., Jun 1 2011, In : International journal of hematology. 93, 6, p. 782-786 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Treatment persistence with monthly zoledronic acid is associated with lower risk and frequency of skeletal complications in patients with breast cancer and bone metastasis

Hatoum, H. T., Lin, S. J., Smith, M. R., Guo, A. & Lipton, A., Jun 2011, In : Clinical Breast Cancer. 11, 3, p. 177-183 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Zoledronic acid: Multiplicity of use across the cancer continuum

Lipton, A., Jul 2011, In : Expert Review of Anticancer Therapy. 11, 7, p. 1001-1014 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Zoledronic acid therapy impacts risk and frequency of skeletal complications and follow-up duration in prostate cancer patients with bone metastasis

Hatoum, H. T., Lin, S. J., Guo, A., Lipton, A. & Smith, M. R., Jan 1 2011, In : Current Medical Research and Opinion. 27, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Zoledronic acid use in cancer patients

Coleman, R., Cook, R., Hirsh, V., Major, P. & Lipton, A., Jan 1 2011, In : Cancer. 117, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
2010

Bone-marker levels in patients with prostate cancer: Potential correlations with outcomes

Saad, F. & Lipton, A., Sep 1 2010, In : Current Opinion in Supportive and Palliative Care. 4, 3, p. 127-134 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study

Stopeck, A. T., Lipton, A., Body, J. J., Steger, G. G., Tonkin, K., De Boer, R. H., Lichinitser, M., Fujiwara, Y., Yardley, D. A., Viniegra, M., Fan, M., Jiang, Q., Dansey, R., Jun, S. & Braun, A., Dec 10 2010, In : Journal of Clinical Oncology. 28, 35, p. 5132-5139 8 p.

Research output: Contribution to journalArticle

983 Scopus citations

Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure

Body, J. J., Lipton, A., Gralow, J., Steger, G. G., Gao, G., Yeh, H. & Fizazi, K., Mar 2010, In : Journal of Bone and Mineral Research. 25, 3, p. 440-446 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Elevated plasma endoglin (CD105) predicts decreased response and survival in a metastatic breast cancer trial of hormone therapy

Vo, M. N., Evans, M., Leitzel, K., Ali, S. M., Wilson, M., Demers, L., Evans, D. B. & Lipton, A., Feb 1 2010, In : Breast Cancer Research and Treatment. 119, 3, p. 767-771 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents

Terpos, E., Dimopoulos, M. A., Shrivastava, V., Leitzel, K., Christoulas, D., Migkou, M., Gavriatopoulou, M., Anargyrou, K., Hamer, P., Kastritis, E., Carney, W. & Lipton, A., Mar 1 2010, In : Leukemia Research. 34, 3, p. 399-402 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
5 Scopus citations

New approaches to treating and preventing bone metastases

Lipton, A., Sep 1 2010, In : Current Opinion in Supportive and Palliative Care. 4, 3, p. 178-181 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer

Lipton, A., Campbell-Baird, C., Witters, L., Harvey, H. & Ali, S., Apr 1 2010, In : Journal of clinical gastroenterology. 44, 4, p. 286-288 3 p.

Research output: Contribution to journalArticle

55 Scopus citations

Phase I trial of zoledronic acid + imatinib mesylate (Gleevec) in patients with bone metastases

Lipton, A., Campbell-Baird, C., Harvey, H., Kim, C., Demers, L. & Costa, L., Feb 1 2010, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 33, 1, p. 75-78 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Proceedings of the first global workshop on breast cancer: Pathways to the evaluation and clinical development of novel agents for breast cancer

Albain, K. S., Carey, L., Gradishar, W. J., Gralow, J. R., Lipton, A., Rugo, H., Tripathy, D., Peck, S., Abair, T. & Pegram, M., Dec 2010, In : Clinical Breast Cancer. 10, 6, p. 421-439 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prognostic factors for skeletal complications from metastatic bone disease in breast cancer

Brown, J. E., Cook, R. J., Lipton, A., Costa, L. & Coleman, R. E., Oct 1 2010, In : Breast Cancer Research and Treatment. 123, 3, p. 767-779 13 p.

Research output: Contribution to journalArticle

52 Scopus citations