• 25226 Citations
  • 77 h-Index
1969 …2019

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Article
2010

Prognostic factors for skeletal complications from metastatic bone disease in breast cancer

Brown, J. E., Cook, R. J., Lipton, A., Costa, L. & Coleman, R. E., Oct 1 2010, In : Breast Cancer Research and Treatment. 123, 3, p. 767-779 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Prognostic variables for survival and skeletal complications in patients with multiple myeloma osteolytic bone disease

Terpos, E., Berenson, J., Cook, R. J., Lipton, A. & Coleman, R. E., May 2010, In : Leukemia. 24, 5, p. 1043-1049 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients

Sperinde, J., Jin, X., Banerjee, J., Penuel, E., Saha, A., Diedrich, G., Huang, W., Leitzel, K., Weidler, J., Ali, S. M., Fuchs, E. M., Singer, C. F., Köstler, W. J., Bates, M., Parry, G., Winslow, J. & Lipton, A., Aug 15 2010, In : Clinical Cancer Research. 16, 16, p. 4226-4235 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Quantitative HER2 protein levels predict outcome in fluorescence in situ hybridization tastatic breast cancer treated with trastuzumab

Lipton, A., Köstler, W. J., Leitzel, K., Ali, S. M., Sperinde, J., Weidler, J., Paquet, A., Sherwood, T., Huang, W. & Bates, M., Nov 15 2010, In : Cancer. 116, 22, p. 5168-5178 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: Results of a phase Ib dose-escalation, open-label study

Molife, L. R., Fong, P. C., Paccagnella, L., Reid, A. H. M., Shaw, H. M., Vidal, L., Arkenau, H. T., Karavasilis, V., Yap, T. A., Olmos, D., Spicer, J., Postel-Vinay, S., Yin, D., Lipton, A., Demers, L., Leitzel, K., Gualberto, A. & De Bono, J. S., Jul 27 2010, In : British Journal of Cancer. 103, 3, p. 332-339 8 p.

Research output: Contribution to journalArticle

73 Scopus citations
2009

Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidity

Major, P. P., Cook, R. J., Lipton, A., Smith, M. R., Terpos, E. & Coleman, R. E., Aug 6 2009, In : BMC Cancer. 9, 1 p., 1471.

Research output: Contribution to journalArticle

34 Scopus citations

New opportunities for the management of cancer-related bone complications.

Lipton, A., Brown, G. A., Mundy, G. R., Roodman, G. D. & Smith, M. R., May 2009, In : Clinical advances in hematology & oncology : H&O. 7, 5 Suppl 11, p. 1-30; quiz 31

Research output: Contribution to journalArticle

Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates

Fizazi, K., Lipton, A., Mariette, X., Body, J. J., Rahim, Y., Gralow, J. R., Gao, G., Wu, L., Sohn, W. & Jun, S., Apr 1 2009, In : Journal of Clinical Oncology. 27, 10, p. 1564-1571 8 p.

Research output: Contribution to journalArticle

421 Scopus citations

Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin

Karp, D. D., Pollak, M. N., Cohen, R. B., Eisenberg, P. D., Haluska, P., Yin, D., Lipton, A., Demers, L., Leitzel, K., Hixon, M. L., Terstappen, L. W., Garland, L., Paz-Ares, L. G., Cardenal, F., Langer, C. J. & Gualberto, A., Nov 2009, In : Journal of Thoracic Oncology. 4, 11, p. 1397-1403 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
2008
57 Scopus citations

Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy

Lipton, A., Steger, G. G., Figueroa, J., Alvarado, C., Solal-Celigny, P., Body, J. J., De Boer, R., Berardi, R., Gascon, P., Tonkin, K. S., Coleman, R. E., Paterson, A. H. G., Gao, G. M., Kinsey, A. C., Peterson, M. C. & Jun, S., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6690-6696 7 p.

Research output: Contribution to journalArticle

127 Scopus citations

Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid

Lipton, A., Cook, R., Saad, F., Major, P., Garnero, P., Terpos, E., Brown, J. E. & Coleman, R. E., Jul 1 2008, In : Cancer. 113, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

227 Scopus citations

Practical guidance for the management of aromatase inhibitor-associated bone loss

Hadji, P., Body, J. J., Aapro, M. S., Brufsky, A., Coleman, R. E., Guise, T., Lipton, A. & Tubiana-Hulin, M., Jan 1 2008, In : Annals of Oncology. 19, 8, p. 1407-1416 10 p.

Research output: Contribution to journalArticle

183 Scopus citations

RANKL inhibition in the treatment of bone metastases

Lipton, A. & Jun, S., Sep 1 2008, In : Current Opinion in Supportive and Palliative Care. 2, 3, p. 197-203 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer

Ali, S. M., Carney, W. P., Esteva, F. J., Fornier, M., Harris, L., Köstler, W. J., Lotz, J. P., Luftner, D., Pichon, M. F., Lipton, A. & Leitzel, K., Sep 15 2008, In : Cancer. 113, 6, p. 1294-1301 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer

Lipton, A., Leitzel, K., Chaudri-Ross, H. A., Evans, D. B., Ali, S. M., Demers, L., Hamer, P., Brown-Shimer, S., Pierce, K., Gaur, V. & Carney, W., Sep 15 2008, In : Journal of Clinical Oncology. 26, 16, p. 2653-2658 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor

Witters, L., Scherle, P., Friedman, S., Fridman, J., Caulder, E., Newton, R. & Lipton, A., Sep 1 2008, In : Cancer Research. 68, 17, p. 7083-7089 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity

Hirsh, V., Major, P. P., Lipton, A., Cook, R. J., Langer, C. J., Smith, M. R., Brown, J. E. & Coleman, R. E., Mar 2008, In : Journal of Thoracic Oncology. 3, 3, p. 228-236 9 p.

Research output: Contribution to journalArticle

123 Scopus citations
2007

A novel cross-disciplinary multi-institute approach to translational cancer research: Lessons learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)

Patel, A. A., Gilbertson, J. R., Showe, L. C., London, J. W., Ross, E., Ochs, M. F., Carver, J., Lazarus, A., Parwani, A. V., Dhir, R., Beck, J. R., Liebman, M., Garcia, F. U., Prichard, J., Wilkerson, M., Herberman, R. B., Becich, M. J., Whelan, N., Mathews, L., Winters, S. & 76 others, Urda, S., Gianella, H., Bisceglia, M., Gupta, R., Singh, H., Li, S., Nie, Y., Chu, V., Mohanty, S., Mann, D., Mignogna, L., Monzon-Bordonaba, F., Katsur, A., Kirkwood, J., Brufsky, A., Colecchia, T., Green, C., Glick, J., Tigges, J., Fenstermacher, D., Rebbeck, T. R., DeMichele, A., Weber, B., Guerry, D. P., Poppert, E., Haney, K., Brusstar, S., Malick, J., Capriotti, A., Balshem, A., Uzzo, R. G., Goldstein, L. J., Lessin, S. R., Harsche, P., London, W. T., Davidson, R. L., DeBaca, M., Orrico, A. R., Hannes, A., Palazzo, J. P., Dicker, A., Mastrangelo, M., Chou, K., Loughran, T., Whayland, P., Swetland, P., Lazarus, P., Harriet, I., Beard, D., Snyder, A. J., Rybka, W. B., Lorence, D., Lipton, A., Harvey, H. A., Robertson, G., Claxton, D., Rauscher, R., Carlisle, J., Kaufman, R. E., Ewert, D., O'Brien, E., Melnicoff, M., Blank, K., Hailu, T., Petushi, S., Steele, G. D., Buckley, S., Hunter, N., Yantus, K., Hu, H., Sheridan, C., Rigby, H., Jacobs, F. N., Bronder, P., Palmer, D. & Glick, J. H., Dec 1 2007, In : Cancer Informatics. 3, p. 255-274 20 p.

Research output: Contribution to journalArticle

14 Scopus citations

Clinical Benefits and Considerations of Bisphosphonate Treatment in Metastatic Bone Disease

Saad, F. & Lipton, A., Dec 2007, In : Seminars in oncology. 34, SUPPL. 4, p. S17-S23

Research output: Contribution to journalArticle

38 Scopus citations
27 Scopus citations

Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer

Lipton, A., Ali, S. M., Leitzel, K., Demers, L., Evans, D. B., Hamer, P., Brown-Shimer, S., Pierce, K. & Carney, W., May 15 2007, In : Cancer. 109, 10, p. 1933-1939 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pathologic fractures correlate with reduced survival in patients with malignant bone disease

Saad, F., Lipton, A., Cook, R., Chen, Y. M., Smith, M. & Coleman, R., Oct 15 2007, In : Cancer. 110, 8, p. 1860-1867 8 p.

Research output: Contribution to journalArticle

393 Scopus citations

Phase I study of the farnesyltransferase inhibitor lonafarnib with weekly paclitaxel in patients with solid tumors

Ready, N. E., Lipton, A., Zhu, Y., Statkevich, P., Frank, E., Curtis, D. & Bukowski, R. M., Jan 15 2007, In : Clinical Cancer Research. 13, 2 I, p. 576-583 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Predictors of Skeletal Complications in Men with Hormone-Refractory Metastatic Prostate Cancer

Smith, M. R., Cook, R. J., Coleman, R., Brown, J., Lipton, A., Major, P., Hei, Y. J. & Saad, F., Aug 2007, In : Urology. 70, 2, p. 315-319 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases

Lipton, A., Steger, G. G., Figueroa, J., Alvarado, C., Solal-Celigny, P., Body, J. J., De Boer, R., Berardi, R., Gascon, P., Tonkin, K. S., Coleman, R., Paterson, A. H. G., Peterson, M. C., Fan, M., Kinsey, A. & Jun, S., Oct 1 2007, In : Journal of Clinical Oncology. 25, 28, p. 4431-4437 7 p.

Research output: Contribution to journalArticle

292 Scopus citations

Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor

Witters, L. M., Witkoski, A., Planas-Silva, M. D., Berger, M., Viallet, J. & Lipton, A., Feb 1 2007, In : Oncology reports. 17, 2, p. 465-469 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity

Lipton, A., Cook, R. J., Major, P., Smith, M. R. & Coleman, R. E., Sep 1 2007, In : Oncologist. 12, 9, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

87 Scopus citations
2006

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T. A., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6209s-6212s

Research output: Contribution to journalArticle

11 Scopus citations

A study of the biological receptor activator of nuclear factor-κ ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer

Body, J. J., Facon, T., Coleman, R. E., Lipton, A., Geurs, F., Fan, M., Holloway, D., Peterson, M. C. & Bekker, P. J., Feb 15 2006, In : Clinical Cancer Research. 12, 4, p. 1221-1228 8 p.

Research output: Contribution to journalArticle

403 Scopus citations

Biochemical bone markers in breast cancer

Lipton, A., May 9 2006, In : Cancer Treatment Reviews. 32, SUPPL. 1, p. 20-22 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancer

Cook, R. J., Coleman, R., Brown, J., Lipton, A., Major, P., Hei, Y. J., Saad, F. & Smith, M. R., Jun 1 2006, In : Clinical Cancer Research. 12, 11 I, p. 3361-3367 7 p.

Research output: Contribution to journalArticle

124 Scopus citations

Serum epidermal growth factor receptor/HER-2 predicts poor survival in patients with metastatic breast cancer

Souder, C., Leitzel, K., Ali, S. M., Demers, L., Evans, D. B., Chaudri-Ross, H. A., Hackl, W., Hamer, P., Carney, W. & Lipton, A., Nov 15 2006, In : Cancer. 107, 10, p. 2337-2345 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2005

Bone turnover markers as predictors of skeketal complications in prostate cancer, lung cancer, and other solid tumors

Brown, J. E., Cook, R. J., Major, P., Lipton, A., Saad, F., Smith, M., Lee, K. A., Zheng, M., Hel, Y. J. & Coleman, R. E., Jan 5 2005, In : Journal of the National Cancer Institute. 97, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

422 Scopus citations

Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid

Coleman, R. E., Major, P., Lipton, A., Brown, J. E., Lee, K. A., Smith, M., Saad, F., Zheng, M., Hei, Y. J., Seaman, J. & Cook, R., Dec 1 2005, In : Journal of Clinical Oncology. 23, 22, p. 4925-4935 11 p.

Research output: Contribution to journalArticle

407 Scopus citations

Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy

Lipton, A., Leitzel, K., Ali, S. M., Demers, L., Harvey, H. A., Chaudri-Ross, H. A., Evans, D., Lang, R., Hackl, W., Hamer, P. & Carney, W., Jul 15 2005, In : Cancer. 104, 2, p. 257-263 7 p.

Research output: Contribution to journalArticle

86 Scopus citations
2004

Baseline serum NTx levels are prognostic in metastatic breast cancer patients with bone-only metastasis

Ali, S. M., Demers, L. M., Leitzel, K., Harvey, H. A., Clemens, D., Mallinak, N., Engle, L., Chinchilli, V., Costa, L., Brady, C., Seaman, J. & Lipton, A., Mar 1 2004, In : Annals of Oncology. 15, 3, p. 455-459 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Bevacizumab for patients with metastatic renal cancer: An update

Yang, J. C., Gordon, M., Atkins, M., Motzer, R., Lipton, A., Flanigan, R., Figlin, R., Kaelin, W., George, D. & Linehan, W. M., Sep 15 2004, In : Clinical Cancer Research. 10, 18 II, p. 6367s-6370s

Research output: Contribution to journalArticle

107 Scopus citations

Combining flavopiridol with various signal transduction inhibitors

Witters, L. M., Myers, A. & Lipton, A., Mar 1 2004, In : Oncology reports. 11, 3, p. 693-698 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gemcitabine/Irinotecan/celecoxib in pancreatic cancer.

Lipton, A., Harvey, H., Witters, L., Kerr, S., Legore, K. & Campbell, C., Jan 1 2004, In : Oncology (Williston Park, N.Y.). 18, 14 Suppl 14, p. 43-45 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Innovations and challenges in renal cancer: Consensus statement from the first international conference

Atkins, M. B., Avigan, D. E., Bukowski, R. M., Childs, R. W., Dutcher, J. P., Eisen, T. G., Figlin, R. A., Finke, J. H., Flanigan, R. C., George, D. J., Goldberg, S. N., Gordon, M. S., Iliopoulos, O., Kaelin, W. G., Linehan, W. M., Lipton, A., Motzer, R. J., Novick, A. C., Stadler, W. M., Teh, B. T. & 2 others, Yang, J. C. & King, L., Sep 15 2004, In : Clinical Cancer Research. 10, 18 II, p. 6277s-6281s

Research output: Contribution to journalArticle

34 Scopus citations

Novel antiangiogenic therapies for renal cell cancer

Gordon, M. S., Atkins, M., Lipton, A., Stadler, W., Flanigan, R., George, D., Yang, J., Figlin, R. & Kaelin, W., Sep 15 2004, In : Clinical Cancer Research. 10, 18 II, p. 6377s-6381s

Research output: Contribution to journalArticle

24 Scopus citations

Skeletal complications in patients with bone metastases from renal cell carcinoma and therapeutic benefits of zoledronic acid

Lipton, A., Colombo-Berra, A., Bukowski, R. M., Rosen, L., Zheng, M., Urbanowitz, G., Figlin, R., Yang, J., Gordon, M., Stadler, W., Eisen, T. & George, D., Sep 15 2004, In : Clinical Cancer Research. 10, 18 II, p. 6397s-6403s

Research output: Contribution to journalArticle

70 Scopus citations

Toward new horizons: The future of bisphosphonate therapy

Lipton, A., Oct 25 2004, In : Oncologist. 9, SUPPL. 4, p. 38-47 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma

Atkins, M. B., Regan, M., McDermott, D., Yang, J., Bukowski, R., Linehan, W. M. & Lipton, A., Sep 15 2004, In : Clinical Cancer Research. 10, 18 II, p. 6342s-6346s

Research output: Contribution to journalArticle

118 Scopus citations
2003

American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer

Hillner, B. E., Ingle, J. N., Chlebowski, R. T., Gralow, J., Yee, G. C., Janjan, N. A., Cauley, J. A., Blumenstein, B. A., Albain, K. S., Lipton, A. & Brown, S., Nov 1 2003, In : Journal of Clinical Oncology. 21, 21, p. 4042-4057 16 p.

Research output: Contribution to journalArticle

837 Scopus citations

A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

Body, J. J., Greipp, P., Coleman, R. E., Facon, T., Geurs, F., Fermand, J. P., Harousseau, J. L., Lipton, A., Mariette, X., Williams, C. D., Nakanishi, A., Holloway, D., Martin, S. W., Dunstan, C. R. & Bekker, P. J., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 887-892 6 p.

Research output: Contribution to journalArticle

332 Scopus citations

Biochemical Markers and Skeletal Metastases

Demers, L. M., Costa, L. & Lipton, A., Oct 2003, In : Clinical orthopaedics and related research. 415 SUPPL., p. S138-S147

Research output: Contribution to journalArticle

34 Scopus citations

Bisphosphonates and metastatic breast carcinoma

Lipton, A., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 848-853 6 p.

Research output: Contribution to journalArticle

53 Scopus citations