• 680 Citations
  • 16 h-Index
20082020

Research output per year

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Personal profile

Research interests

Dr. Amy Arnold’s laboratory works on understanding how the brain controls blood pressure and energy balance. Her studies focus on how angiotensin-(1-7), a beneficial hormone of the renin angiotensin system, interacts with the brain to improve blood pressure and insulin sensitivity in integrated cardiometabolic diseases such as obesity and hypertension. These studies use a variety of approaches in mice including whole animal in vivo cardiovascular monitoring (e.g. direct arterial blood pressure and radiotelemetry), pharmacologic and spectral analysis of autonomic function and measurement of insulin action (e.g. hyperinsulinemic-euglycemic clamps, glucose and insulin tolerance testing) and energy balance (e.g. body composition and indirect calorimetry). She also has translational studies examining the effects of intravenous angiotensin-(1-7) infusion on blood pressure and flow, insulin sensitivity and energy balance in patients with obesity, hypertension and peripheral arterial disease. Specific projects ongoing in the laboratory include studying the ability of angiotensin-(1-7) to treat and prevent the development of diet-induced insulin resistance, the specific molecular mechanisms involved in these effects with a focus on adipose tissue and brain and potential gender differences.

In addition, her laboratory is interested in understanding mechanisms and optimal treatment strategies for patients with cardiovascular autonomic disorders including primary autonomic failure, Parkinson’s disease and postural tachycardia syndrome. Dr. Arnold has published several articles on therapeutic strategies to manage blood pressure and heart rate in these conditions. She has several ongoing studies including examining the profile and treatment of cognitive dysfunction in these conditions, with a focus on postural tachycardia syndrome.

Education/Academic qualification

Clinical Investigation, MS, Vanderbilt University

… → May 2014

Physiology and Pharmacology, PhD, Wake Forest University

… → Dec 2009

Biochemistry, BS, Pacific University

… → May 2004

External positions

Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics

Jan 1 2018 → …

Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics

2018 → …

Meeting Committee Member, American Autonomic Society

Jan 1 2017 → …

Editorial Board Member, American Journal of Hypertension

Jan 1 2017 → …

Meeting Committee Member, American Autonomic Society

2017 → …

Editorial Board Member, American Journal of Hypertension

2017 → …

Trainee Advocacy Committee Member, American Heart Association

Jan 1 2016 → …

Editorial Board Member, Physiological Genomics

Jan 1 2016 → …

Trainee Advocacy Committee Member, American Heart Association

2016 → …

Editorial Board Member, Physiological Genomics

2016 → …

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Projects

  • Research Output

    • 680 Citations
    • 16 h-Index
    • 34 Article
    • 9 Review article
    • 2 Comment/debate
    • 1 Chapter

    Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

    Miller, A. J., Stiles, L. E., Sheehan, T., Bascom, R., Levy, H. P., Francomano, C. A. & Arnold, A. C., Mar 2020, In : Autonomic Neuroscience: Basic and Clinical. 224, 102637.

    Research output: Contribution to journalArticle

  • Angiotensin-(1-7): Translational Avenues in Cardiovascular Control

    Medina, D. & Arnold, A. C., Nov 15 2019, In : American journal of hypertension. 32, 12, p. 1133-1142 10 p.

    Research output: Contribution to journalReview article

  • Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice

    White, M. C., Miller, A. J., Loloi, J., Bingaman, S. S., Shen, B., Wang, M., Silberman, Y., Lindsey, S. H. & Arnold, A. C., Jul 17 2019, In : Biology of Sex Differences. 10, 1, 36.

    Research output: Contribution to journalArticle

    Open Access
  • Sex differences in the metabolic effects of the renin-angiotensin system

    White, M. C., Fleeman, R. & Arnold, A. C., Jul 1 2019, In : Biology of Sex Differences. 10, 1, 31.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Prizes