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Personal profile

Research interests

Dr. Amy Arnold’s laboratory works on understanding how the brain controls blood pressure and energy balance. Her studies focus on how angiotensin-(1-7), a beneficial hormone of the renin angiotensin system, interacts with the brain to improve blood pressure and insulin sensitivity in integrated cardiometabolic diseases such as obesity and hypertension. These studies use a variety of approaches in mice including whole animal in vivo cardiovascular monitoring (e.g. direct arterial blood pressure and radiotelemetry), pharmacologic and spectral analysis of autonomic function and measurement of insulin action (e.g. hyperinsulinemic-euglycemic clamps, glucose and insulin tolerance testing) and energy balance (e.g. body composition and indirect calorimetry). She also has translational studies examining the effects of intravenous angiotensin-(1-7) infusion on blood pressure and flow, insulin sensitivity and energy balance in patients with obesity, hypertension and peripheral arterial disease. Specific projects ongoing in the laboratory include studying the ability of angiotensin-(1-7) to treat and prevent the development of diet-induced insulin resistance, the specific molecular mechanisms involved in these effects with a focus on adipose tissue and brain and potential gender differences.

In addition, her laboratory is interested in understanding mechanisms and optimal treatment strategies for patients with cardiovascular autonomic disorders including primary autonomic failure, Parkinson’s disease and postural tachycardia syndrome. Dr. Arnold has published several articles on therapeutic strategies to manage blood pressure and heart rate in these conditions. She has several ongoing studies including examining the profile and treatment of cognitive dysfunction in these conditions, with a focus on postural tachycardia syndrome.

Education/Academic qualification

Clinical Investigation, MS, Vanderbilt University

… → May 2014

Physiology and Pharmacology, PhD, Wake Forest University

… → Dec 2009

Biochemistry, BS, Pacific University

… → May 2004

External positions

Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics

Jan 1 2018 → …

Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics

2018 → …

Meeting Committee Member, American Autonomic Society

Jan 1 2017 → …

Editorial Board Member, American Journal of Hypertension

Jan 1 2017 → …

Meeting Committee Member, American Autonomic Society

2017 → …

Editorial Board Member, American Journal of Hypertension

2017 → …

Trainee Advocacy Committee Member, American Heart Association

Jan 1 2016 → …

Editorial Board Member, Physiological Genomics

Jan 1 2016 → …

Trainee Advocacy Committee Member, American Heart Association

2016 → …

Editorial Board Member, Physiological Genomics

2016 → …

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  • 4 Similar Profiles
Postural Orthostatic Tachycardia Syndrome Medicine & Life Sciences
Blood Pressure Medicine & Life Sciences
Baroreflex Medicine & Life Sciences
Angiotensins Medicine & Life Sciences
Solitary Nucleus Medicine & Life Sciences
Angiotensin II Medicine & Life Sciences
Insulin Resistance Medicine & Life Sciences
Hypertension Medicine & Life Sciences

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Projects 2014 2019

Hypertension
Mentors
Sympathetic Nervous System
Insulin Resistance
Renin-Angiotensin System

Research Output 2008 2019

  • 573 Citations
  • 14 h-Index
  • 33 Article
  • 8 Review article
  • 2 Comment/debate
  • 1 Chapter
High Fat Diet
GABA-A Receptors
Stomach
Neurons
Brain Stem

Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice

White, M. C., Miller, A. J., Loloi, J., Bingaman, S. S., Shen, B., Wang, M., Silberman, Y., Lindsey, S. H. & Arnold, A., Jul 17 2019, In : Biology of Sex Differences. 10, 1, 36.

Research output: Contribution to journalArticle

Open Access
Obese Mice
Sex Characteristics
tolerance
High Fat Diet
Insulin Resistance

Sex differences in the metabolic effects of the renin-angiotensin system

White, M. C., Fleeman, R. & Arnold, A., Jul 1 2019, In : Biology of Sex Differences. 10, 1, 31.

Research output: Contribution to journalArticle

Open Access
Renin-Angiotensin System
Sex Characteristics
Obesity
chronic illness
Animal Models
2 Citations (Scopus)

The renin–angiotensin system in cardiovascular autonomic control: recent developments and clinical implications

Miller, A. J. & Arnold, A., Apr 1 2019, In : Clinical Autonomic Research. 29, 2, p. 231-243 13 p.

Research output: Contribution to journalReview article

Cardiovascular System
Renin
Blood Pressure
Baroreflex
Angiotensin Receptor Antagonists
2 Citations (Scopus)

Angiotensin-(1–7) contributes to insulin-sensitizing effects of angiotensin-converting enzyme inhibition in obese mice

Loloi, J., Miller, A. J., Bingaman, S. S., Silberman, Y. & Arnold, A., Dec 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 6, p. E1204-E1211

Research output: Contribution to journalArticle

7-Ala-angiotensin (1-7)
Obese Mice
Captopril
Angiotensins
Peptidyl-Dipeptidase A

Prizes