Projects per year
Personal profile
Research interests
Dr. Amy Arnold’s laboratory works on understanding how the brain controls blood pressure and energy balance. Her studies focus on how angiotensin-(1-7), a beneficial hormone of the renin angiotensin system, interacts with the brain to improve blood pressure and insulin sensitivity in integrated cardiometabolic diseases such as obesity and hypertension. These studies use a variety of approaches in mice including whole animal in vivo cardiovascular monitoring (e.g. direct arterial blood pressure and radiotelemetry), pharmacologic and spectral analysis of autonomic function and measurement of insulin action (e.g. hyperinsulinemic-euglycemic clamps, glucose and insulin tolerance testing) and energy balance (e.g. body composition and indirect calorimetry). She also has translational studies examining the effects of intravenous angiotensin-(1-7) infusion on blood pressure and flow, insulin sensitivity and energy balance in patients with obesity, hypertension and peripheral arterial disease. Specific projects ongoing in the laboratory include studying the ability of angiotensin-(1-7) to treat and prevent the development of diet-induced insulin resistance, the specific molecular mechanisms involved in these effects with a focus on adipose tissue and brain and potential gender differences.
In addition, her laboratory is interested in understanding mechanisms and optimal treatment strategies for patients with cardiovascular autonomic disorders including primary autonomic failure, Parkinson’s disease and postural tachycardia syndrome. Dr. Arnold has published several articles on therapeutic strategies to manage blood pressure and heart rate in these conditions. She has several ongoing studies including examining the profile and treatment of cognitive dysfunction in these conditions, with a focus on postural tachycardia syndrome.
Education/Academic qualification
Clinical Investigation, MS, Vanderbilt University
… → May 2014
Physiology and Pharmacology, PhD, Wake Forest University
… → Dec 2009
Biochemistry, BS, Pacific University
… → May 2004
External positions
Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics
Jan 1 2018 → …Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics
2018 → …Meeting Committee Member, American Autonomic Society
Jan 1 2017 → …Editorial Board Member, American Journal of Hypertension
Jan 1 2017 → …Meeting Committee Member, American Autonomic Society
2017 → …Editorial Board Member, American Journal of Hypertension
2017 → …Trainee Advocacy Committee Member, American Heart Association
Jan 1 2016 → …Editorial Board Member, Physiological Genomics
Jan 1 2016 → …Trainee Advocacy Committee Member, American Heart Association
2016 → …Editorial Board Member, Physiological Genomics
2016 → …Fingerprint
- 9 Similar Profiles
Network
Projects
- 1 Finished
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Autonomic: Angiotensin-(1-7) Interactions in Hypertension
National Heart, Lung, and Blood Institute
11/15/14 → 5/31/20
Project: Research project
Research Output
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Access schedules mediate the impact of high fat diet on ethanol intake and insulin and glucose function in mice
Coker, C. R., Aguilar, E. A., Snyder, A. E., Bingaman, S. S., Graziane, N. M., Browning, K. N., Arnold, A. C. & Silberman, Y., Aug 2020, In: Alcohol. 86, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
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Angiotensin-(1–7) attenuates protein O-GlcNAcylation in the retina by Epac/Rap1-dependent inhibition of O-GlcNAc transferase
Dierschke, S. K., Toro, A. L., Barber, A. J., Arnold, A. C. & Dennis, M. D., Feb 2020, In: Investigative Ophthalmology and Visual Science. 61, 2, 24.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Angiotensin-(1-7) improves integrated cardiometabolic function in aged mice
Miller, A. J., Bingaman, S. S., Mehay, D., Medina, D. & Arnold, A. C., Jul 2 2020, In: International journal of molecular sciences. 21, 14, p. 1-13 13 p., 5131.Research output: Contribution to journal › Article › peer-review
Open Access -
Attention and executive function are impaired during active standing in postural tachycardia syndrome
Miller, A. J., Sheehan, T., Bourne, K. M., Feeley, M. & Arnold, A. C., Sep 2020, In: Autonomic Neuroscience: Basic and Clinical. 227, 102692.Research output: Contribution to journal › Article › peer-review
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Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome
Miller, A. J., Stiles, L. E., Sheehan, T., Bascom, R., Levy, H. P., Francomano, C. A. & Arnold, A. C., Mar 2020, In: Autonomic Neuroscience: Basic and Clinical. 224, 102637.Research output: Contribution to journal › Article › peer-review
1 Scopus citations