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Personal profile

Research interests

Dr. Amy Arnold’s laboratory works on understanding how the brain controls blood pressure and energy balance. Her studies focus on how angiotensin-(1-7), a beneficial hormone of the renin angiotensin system, interacts with the brain to improve blood pressure and insulin sensitivity in integrated cardiometabolic diseases such as obesity and hypertension. These studies use a variety of approaches in mice including whole animal in vivo cardiovascular monitoring (e.g. direct arterial blood pressure and radiotelemetry), pharmacologic and spectral analysis of autonomic function and measurement of insulin action (e.g. hyperinsulinemic-euglycemic clamps, glucose and insulin tolerance testing) and energy balance (e.g. body composition and indirect calorimetry). She also has translational studies examining the effects of intravenous angiotensin-(1-7) infusion on blood pressure and flow, insulin sensitivity and energy balance in patients with obesity, hypertension and peripheral arterial disease. Specific projects ongoing in the laboratory include studying the ability of angiotensin-(1-7) to treat and prevent the development of diet-induced insulin resistance, the specific molecular mechanisms involved in these effects with a focus on adipose tissue and brain and potential gender differences.

In addition, her laboratory is interested in understanding mechanisms and optimal treatment strategies for patients with cardiovascular autonomic disorders including primary autonomic failure, Parkinson’s disease and postural tachycardia syndrome. Dr. Arnold has published several articles on therapeutic strategies to manage blood pressure and heart rate in these conditions. She has several ongoing studies including examining the profile and treatment of cognitive dysfunction in these conditions, with a focus on postural tachycardia syndrome.

Education/Academic qualification

Clinical Investigation, MS, Vanderbilt University

… → May 2014

Physiology and Pharmacology, PhD, Wake Forest University

… → Dec 2009

Biochemistry, BS, Pacific University

… → May 2004

External positions

Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics

2018 → …

Meeting Committee Member, American Autonomic Society

2017 → …

Editorial Board Member, American Journal of Hypertension

2017 → …

Trainee Advocacy Committee Member, American Heart Association

2016 → …

Editorial Board Member, Physiological Genomics

2016 → …

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Projects 2014 2019

Autonomic: Angiotensin-(1-7) Interactions in Hypertension

Arnold, A.

National Institutes of Health

11/15/145/31/19

Project: Research projectCareer Transition Award, Research Transition Award

Hypertension
Mentors
Sympathetic Nervous System
Insulin Resistance
Renin-Angiotensin System

Research Output 2008 2018

  • 450 Citations
  • 14 h-Index
  • 32 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Chapter

Cognitive and psychological issues in postural tachycardia syndrome

Raj, V., Opie, M. & Arnold, A. C., Jan 1 2018, (Accepted/In press) In : Autonomic Neuroscience: Basic and Clinical.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Psychology
Orthostatic Intolerance
Social Adjustment
Neuropsychological Tests
1 Citations

Postural tachycardia syndrome – Diagnosis, physiology, and prognosis

Arnold, A. C., Ng, J. & Raj, S. R., Jan 1 2018, (Accepted/In press) In : Autonomic Neuroscience: Basic and Clinical.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Orthostatic Intolerance
Syncope
Tachycardia
Tilt-Table Test
1 Citations

Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management

Arnold, A. C., Ng, J., Lei, L. & Raj, S. R., Dec 1 2017, In : Canadian Journal of Cardiology. 33, 12, p. 1524-1534 11 p.

Research output: Contribution to journalReview article

Syncope
Cardiology
Hemodynamics
Physical Examination
Postural Orthostatic Tachycardia Syndrome
1 Citations

Hyperinsulinemia and insulin resistance in dopamine b-hydroxylase deficiency

Arnold, A. C., Garland, E. M., Celedonio, J. E., Raj, S. R., Abumrad, N. N., Biaggioni, I., Robertson, D., Luther, J. M. & Shibao, C. A., Jan 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Mixed Function Oxygenases
Insulin Resistance
Dopamine
Droxidopa

Hypertension in obese black women is not caused by increased sympathetic vascular tone

Marinos, A., Gamboa, A., Celedonio, J. E., Preheim, B. A., Okamoto, L. E., Ramirez, C. E., Arnold, A. C., Diedrich, A., Biaggioni, I. & Shibao, C. A., Nov 1 2017, In : Journal of the American Heart Association. 6, 11, e006971

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Trimethaphan
Arterial Pressure
Body Mass Index

Prizes