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Research Output 2008 2019

  • 583 Citations
  • 15 h-Index
  • 33 Article
  • 8 Review article
  • 2 Comment/debate
  • 1 Chapter
2019
High Fat Diet
GABA-A Receptors
Stomach
Neurons
Brain Stem

Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice

White, M. C., Miller, A. J., Loloi, J., Bingaman, S. S., Shen, B., Wang, M., Silberman, Y., Lindsey, S. H. & Arnold, A., Jul 17 2019, In : Biology of Sex Differences. 10, 1, 36.

Research output: Contribution to journalArticle

Open Access
Obese Mice
Sex Characteristics
tolerance
High Fat Diet
Insulin Resistance

Sex differences in the metabolic effects of the renin-angiotensin system

White, M. C., Fleeman, R. & Arnold, A., Jul 1 2019, In : Biology of Sex Differences. 10, 1, 31.

Research output: Contribution to journalArticle

Open Access
Renin-Angiotensin System
Sex Characteristics
Obesity
chronic illness
Animal Models
3 Citations (Scopus)

The renin–angiotensin system in cardiovascular autonomic control: recent developments and clinical implications

Miller, A. J. & Arnold, A., Apr 1 2019, In : Clinical Autonomic Research. 29, 2, p. 231-243 13 p.

Research output: Contribution to journalReview article

Cardiovascular System
Renin
Blood Pressure
Baroreflex
Angiotensin Receptor Antagonists
2018
3 Citations (Scopus)

Angiotensin-(1–7) contributes to insulin-sensitizing effects of angiotensin-converting enzyme inhibition in obese mice

Loloi, J., Miller, A. J., Bingaman, S. S., Silberman, Y. & Arnold, A., Dec 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 6, p. E1204-E1211

Research output: Contribution to journalArticle

7-Ala-angiotensin (1-7)
Obese Mice
Captopril
Angiotensins
Peptidyl-Dipeptidase A
4 Citations (Scopus)

Cognitive and psychological issues in postural tachycardia syndrome

Raj, V., Opie, M. & Arnold, A., Dec 1 2018, In : Autonomic Neuroscience: Basic and Clinical. 215, p. 46-55 10 p.

Research output: Contribution to journalReview article

Postural Orthostatic Tachycardia Syndrome
Psychology
Orthostatic Intolerance
Social Adjustment
Neuropsychological Tests
15 Citations (Scopus)

Postural tachycardia syndrome – Diagnosis, physiology, and prognosis

Arnold, A., Ng, J. & Raj, S. R., Dec 1 2018, In : Autonomic Neuroscience: Basic and Clinical. 215, p. 3-11 9 p.

Research output: Contribution to journalReview article

Postural Orthostatic Tachycardia Syndrome
Syncope
Tachycardia
Tilt-Table Test
Orthostatic Intolerance
2017
3 Citations (Scopus)

Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management

Arnold, A., Ng, J., Lei, L. & Raj, S. R., Dec 1 2017, In : Canadian Journal of Cardiology. 33, 12, p. 1524-1534 11 p.

Research output: Contribution to journalReview article

Syncope
Cardiology
Hemodynamics
Physical Examination
Postural Orthostatic Tachycardia Syndrome
4 Citations (Scopus)

Hyperinsulinemia and insulin resistance in dopamine b-hydroxylase deficiency

Arnold, A., Garland, E. M., Celedonio, J. E., Raj, S. R., Abumrad, N. N., Biaggioni, I., Robertson, D., Luther, J. M. & Shibao, C. A., Jan 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Mixed Function Oxygenases
Insulin Resistance
Dopamine
Droxidopa
3 Citations (Scopus)

Hypertension in obese black women is not caused by increased sympathetic vascular tone

Marinos, A., Gamboa, A., Celedonio, J. E., Preheim, B. A., Okamoto, L. E., Ramirez, C. E., Arnold, A., Diedrich, A., Biaggioni, I. & Shibao, C. A., Nov 1 2017, In : Journal of the American Heart Association. 6, 11, e006971.

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Trimethaphan
Arterial Pressure
Body Mass Index
8 Citations (Scopus)

Orthostatic Hypotension: A Practical Approach to Investigation and Management

Arnold, A. & Raj, S. R., Dec 1 2017, In : Canadian Journal of Cardiology. 33, 12, p. 1725-1728 4 p.

Research output: Contribution to journalArticle

Orthostatic Hypotension
Blood Pressure
Posture
Droxidopa
Midodrine
2016
6 Citations (Scopus)

A common CD36 variant influences endothelial function and response to treatment with phosphodiesterase 5 inhibition

Shibao, C. A., Celedonio, J. E., Ramirez, C. E., Love-Gregory, L., Arnold, A., Choi, L., Okamoto, L. E., Gamboa, A., Biaggioni, I., Abumrad, N. N. & Abumrad, N. A., Jul 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 7, p. 2751-2758 8 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Dilatation
Insulin Resistance
African Americans
Insulin
10 Citations (Scopus)

Chronic angiotensin-(1-7) improves insulin sensitivity in high-fat fed mice independent of blood pressure

Williams, I. M., Otero, Y. F., Bracy, D. P., Wasserman, D. H., Biaggioni, I. & Arnold, A., May 1 2016, In : Hypertension. 67, 5, p. 983-991 9 p.

Research output: Contribution to journalArticle

Insulin Resistance
Fats
Blood Pressure
Glucose
Insulin
13 Citations (Scopus)

Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure

Arnold, A., Okamoto, L. E., Gamboa, A., Black, B. K., Raj, S. R., Elijovich, F., Robertson, D., Shibao, C. A. & Biaggioni, I., Feb 1 2016, In : Hypertension. 67, 2, p. 424-429 6 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Hypertension
Blood Pressure
Placebos
Aldosterone
1 Citation (Scopus)

To sensitize or not to sensitize: Leptin is the question

Arnold, A., May 1 2016, In : Hypertension. 67, 5, p. 843-844 2 p.

Research output: Contribution to journalComment/debate

2015
13 Citations (Scopus)

Cognitive dysfunction in postural tachycardia syndrome

Arnold, A., Haman, K., Garland, E. M., Raj, V., Dupont, W. D., Biaggioni, I., Robertson, D. & Raj, S. R., Jan 1 2015, In : Clinical Science. 128, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Healthy Volunteers
Cognitive Dysfunction
Neuropsychological Tests
Executive Function
6 Citations (Scopus)

Defective Wnt signaling: A potential contributor to cardiometabolic disease?

Arnold, A. & Robertson, D., Oct 1 2015, In : Diabetes. 64, 10, p. 3342-3344 3 p.

Research output: Contribution to journalComment/debate

Wnt Proteins
Glycogen Synthase Kinase 3
Insulin Receptor Substrate Proteins
Solitary Nucleus
Insulin
2 Citations (Scopus)

Inspiratory Resistance Improves Postural Tachycardia: A Randomized Study

Gamboa, A., Paranjape, S. Y., Black, B. K., Arnold, A., Figueroa, R., Okamoto, L. E., Nwazue, V. C., Diedrich, A., Plummer, W. D., Dupont, W. D., Robertson, D. & Raj, S. R., Jun 4 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 3, p. 651-658 8 p.

Research output: Contribution to journalArticle

Tachycardia
Electric Impedance
Equipment and Supplies
Postural Orthostatic Tachycardia Syndrome
Heart Rate
1 Citation (Scopus)

Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure

Celedonio, J. E., Arnold, A., Dupont, W. D., Ramirez, C. E., Diedrich, A., Okamoto, L. E., Raj, S. R., Robertson, D., Peltier, A. C., Biaggioni, I. & Shibao, C. A., Oct 1 2015, In : Clinical Autonomic Research. 25, 5, p. 309-315 7 p.

Research output: Contribution to journalArticle

Insulin Resistance
Multiple System Atrophy
Glucose Intolerance
Linear Models
Diabetes Mellitus
8 Citations (Scopus)

Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: Lessons from postural tachycardia syndrome and obesity

Okamoto, L. E., Raj, S. R., Gamboa, A., Shibao, C. A., Arnold, A., Garland, E. M., Black, B. K., Farley, G., Diedrich, A. & Biaggioni, I., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 309, 12, p. H2098-H2107

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Interleukin-6
Obesity
Adiposity
Inflammation
2014
14 Citations (Scopus)

Acute volume loading and exercise capacity in postural tachycardia syndrome

Figueroa, R. A., Arnold, A., Nwazue, V. C., Okamoto, L. E., Paranjape, S. Y., Black, B. K., Diedrich, A., Robertson, D., Biaggioni, I., Raj, S. R. & Gamboa, A., Jan 1 2014, In : Journal of Applied Physiology. 117, 6, p. 663-668 6 p.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Placebos
Exercise
Heart Rate
Hypovolemia
17 Citations (Scopus)

Autonomic blockade improves insulin sensitivity in obese subjects

Gamboa, A., Okamoto, L. E., Arnold, A., Figueroa, R. A., Diedrich, A., Raj, S. R., Paranjape, S. Y., Farley, G., Abumrad, N. & Biaggioni, I., Jan 1 2014, In : Hypertension. 64, 4, p. 867-874 8 p.

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Glucose
Obesity
Trimethaphan
8 Citations (Scopus)

Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure

Arnold, A., Ramirez, C. E., Choi, L., Okamoto, L. E., Gamboa, A., Diedrich, A., Raj, S. R., Robertson, D., Biaggioni, I. & Shibao, C., Jan 1 2014, In : Frontiers in Physiology. 5 JUN, Article 270.

Research output: Contribution to journalArticle

Blood Pressure
Midodrine
Treatment Failure
Pharmaceutical Preparations
Coronary Artery Disease
41 Citations (Scopus)

Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure

Ramirez, C. E., Okamoto, L. E., Arnold, A., Gamboa, A., Diedrich, A., Choi, L., Raj, S. R., Robertson, D., Biaggioni, I. & Shibao, C. A., Jan 1 2014, In : Hypertension. 64, 6, p. 1235-1240 6 p.

Research output: Contribution to journalArticle

Midodrine
Orthostatic Hypotension
Blood Pressure
Therapeutics
Placebos
6 Citations (Scopus)
Solitary Nucleus
Baroreflex
Leptin
Bradycardia
Leptin Receptors
11 Citations (Scopus)

Hemodynamic profiles and tolerability of modafinil in the treatment of postural tachycardia syndrome a randomized, placebo-controlled trial

Kpaeyeh, J., Mar, P. L., Raj, V., Black, B. K., Arnold, A., Biaggioni, I., Shibao, C. A., Paranjape, S. Y., Dupont, W. D., Robertson, D. & Raj, S. R., Jan 1 2014, In : Journal of Clinical Psychopharmacology. 34, 6, p. 738-741 4 p.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Randomized Controlled Trials
Hemodynamics
Placebos
Blood Pressure
20 Citations (Scopus)

Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension

Okamoto, L. E., Gamboa, A., Shibao, C. A., Arnold, A., Choi, L., Black, B. K., Raj, S. R., Robertson, D. & Biaggioni, I., Jan 1 2014, In : Hypertension. 64, 6, p. 1241-1247 7 p.

Research output: Contribution to journalArticle

Nebivolol
Metoprolol
Nitric Oxide
Blood Pressure
Hypertension
5 Citations (Scopus)

Understanding the placebo effect in clinical trials for postural tachycardia syndrome

Nwazue, V. C., Arnold, A., Raj, V., Black, B. K., Biaggioni, I., Paranjape, S. Y., Orozco, C., Dupont, W. D., Robertson, D. & Raj, S. R., Jan 1 2014, In : Clinical and Experimental Pharmacology and Physiology. 41, 5, p. 325-330 6 p.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Placebo Effect
Clinical Trials
Heart Rate
Placebos
2013
42 Citations (Scopus)

Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure

Arnold, A., Okamoto, L. E., Gamboa, A., Shibao, C., Raj, S. R., Robertson, D. & Biaggioni, I., Mar 1 2013, In : Hypertension. 61, 3, p. 701-706 6 p.

Research output: Contribution to journalArticle

Renin
Angiotensin II
Hypertension
Losartan
Blood Pressure
24 Citations (Scopus)

Brain renin-angiotensin system in the nexus of hypertension and aging

Arnold, A., Gallagher, P. E. & Diz, D. I., Jan 1 2013, In : Hypertension Research. 36, 1, p. 5-13 9 p.

Research output: Contribution to journalReview article

Renin-Angiotensin System
Hypertension
Baroreflex
Brain
Blood Pressure
37 Citations (Scopus)

Current concepts in orthostatic hypotension management

Arnold, A. & Shibao, C., Aug 1 2013, In : Current Hypertension Reports. 15, 4, p. 304-312 9 p.

Research output: Contribution to journalArticle

Orthostatic Hypotension
Blood Pressure
Midodrine
Fludrocortisone
Syncope
21 Citations (Scopus)

Low-dose propranolol and exercise capacity in postural tachycardia syndrome a randomized study

Arnold, A., Okamoto, L. E., Diedrich, A., Paranjape, S. Y., Raj, S. R., Biaggioni, I. & Gamboa, A., May 21 2013, In : Neurology. 80, 21, p. 1927-1933 7 p.

Research output: Contribution to journalArticle

Postural Orthostatic Tachycardia Syndrome
Propranolol
Exercise
Placebos
Heart Rate
12 Citations (Scopus)

The brain renin-angiotensin system and mitochondrial function: Influence on blood pressure and baroreflex in transgenic rat strains

Nautiyal, M., Arnold, A., Chappell, M. C. & Diz, D. I., Mar 11 2013, In : International Journal of Hypertension. 2013, 136028.

Research output: Contribution to journalReview article

Transgenic Rats
Baroreflex
Renin-Angiotensin System
Angiotensin II
Blood Pressure
2012
17 Citations (Scopus)

Management approaches to hypertension in autonomic failure

Arnold, A. & Biaggioni, I., Sep 1 2012, In : Current Opinion in Nephrology and Hypertension. 21, 5, p. 481-485 5 p.

Research output: Contribution to journalReview article

Orthostatic Hypotension
Hypertension
Blood Pressure
Baroreflex
Supine Position
4 Citations (Scopus)

Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function

Arnold, A., Nautiyal, M. & Diz, D. I., May 2012, In : Journal of Cardiovascular Pharmacology. 59, 5, p. 472-478 7 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Baroreflex
Phosphoprotein Phosphatases
Arterial Pressure
Heart Rate

Renin-Angiotensin

Arnold, A. & Diz, D. I., Dec 1 2012, Primer on the Autonomic Nervous System. Elsevier Inc., p. 113-116 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Angiotensins
Chymosin
Renin
Angiotensin II
Cardiovascular Physiological Phenomena
14 Citations (Scopus)

The brain renin-Angiotensin system and cardiovascular responses to stress: Insights from transgenic rats with low brain angiotensinogen

Arnold, A., Sakima, A., Kasper, S. O., Vinsant, S., Garcia-Espinosa, M. A. & Diz, D. I., Dec 15 2012, In : Journal of Applied Physiology. 113, 12, p. 1929-1936 8 p.

Research output: Contribution to journalArticle

Transgenic Rats
Angiotensinogen
Renin-Angiotensin System
Angiotensins
Peptides
2011
14 Citations (Scopus)

Angiotensin-converting enzyme inhibition, but not at 1 receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats

Isa, K., Arnold, A., Westwood, B. M., Chappell, M. C. & Diz, D. I., Dec 1 2011, In : Hypertension Research. 34, 12, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Baroreflex
Peptidyl-Dipeptidase A
Bradykinin
Angiotensin II
26 Citations (Scopus)

Angiotensin peptides and central autonomic regulation

Diz, D. I., Arnold, A., Nautiyal, M., Isa, K., Shaltout, H. A. & Tallant, E. A., Jan 1 2011, In : Current Opinion in Pharmacology. 11, 2, p. 131-137 7 p.

Research output: Contribution to journalReview article

Angiotensins
Angiotensin II
Peptides
MAP Kinase Kinase 3
Hypertension
7 Citations (Scopus)

Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis

Arnold, A., Shaltout, H. A., Gilliam-Davis, S., Kock, N. D. & Diz, D. I., Jun 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 6

Research output: Contribution to journalArticle

Baroreflex
Hydronephrosis
Sprague Dawley Rats
Angiotensin II
Renin-Angiotensin System
2010
35 Citations (Scopus)

Angiotensin-(1-12) requires angiotensin converting enzyme and AT 1 receptors for cardiovascular actions within the solitary tract nucleus

Arnold, A., Isa, K., Shaltout, H. A., Nautiyal, M., Ferrario, C. M., Chappell, M. C. & Diz, D. I., Sep 1 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 299, 3

Research output: Contribution to journalArticle

Solitary Nucleus
Angiotensins
Peptidyl-Dipeptidase A
Baroreflex
Angiotensin II
2009
28 Citations (Scopus)

Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats

Isa, K., García-Espinosa, M. A., Arnold, A., Pirro, N. T., Tommasi, E. N., Ganten, D., Chappell, M. C., Ferrario, C. M. & Diz, D. I., Jul 1 2009, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297, 1

Research output: Contribution to journalArticle

Angiotensins
Blood Pressure
Brain
Immunoglobulin G
Osmolar Concentration
51 Citations (Scopus)

Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus

Arnold, A., Shaltout, H. A., Gallagher, P. E. & Diz, D. I., Nov 1 2009, In : Hypertension. 54, 5, p. 1001-1008 8 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Baroreflex
Leptin
Leptin Receptors
Microinjections
2008
26 Citations (Scopus)

Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen

Arnold, A., Sakima, A., Ganten, D., Ferrario, C. M. & Diz, D. I., May 1 2008, In : Hypertension. 51, 5, p. 1326-1331 6 p.

Research output: Contribution to journalArticle

Transgenic Rats
Angiotensinogen
Angiotensins
Baroreflex
Neuroglia