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Research Output

2001

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency

Hollander, M. C., Kovalsky, O., Salvador, J. M., Kim, K. E., Patterson, A. D., Haines, D. C. & Fornace, A. J., Mar 15 2001, In : Cancer Research. 61, 6, p. 2487-2491 5 p.

Research output: Contribution to journalArticle

97 Scopus citations
2002

A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes

Amundson, S. A., Patterson, A., Do, K. T. & Fornace, A. J., Jan 1 2002, In : Cancer Biology and Therapy. 1, 2, p. 145-149 5 p.

Research output: Contribution to journalArticle

78 Scopus citations
2003

Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin.

Zhu, P. P., Patterson, A., Lavoie, B., Stadler, J., Shoeb, M., Patel, R. & Blackstone, C., Dec 5 2003, In : The Journal of biological chemistry. 278, 49, p. 49063-49071 9 p.

Research output: Contribution to journalArticle

112 Scopus citations
2004

Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1

Zhu, P. P., Patterson, A. D., Stadler, J., Seeburg, D. P., Sheng, M. & Blackstone, C., Aug 20 2004, In : Journal of Biological Chemistry. 279, 34, p. 35967-35974 8 p.

Research output: Contribution to journalArticle

131 Scopus citations
2005

Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis

Hollander, M. C., Philburn, R. T., Patterson, A. D., Velasco-Miguel, S., Friedberg, E. C., Linnoila, R. I. & Fornace, A. J., Sep 13 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 37, p. 13200-13205 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Gadd45a acts as a modifier locus for lymphoblastic lymphoma

Hollander, M. C., Patterson, A. D., Salvador, J. M., Anver, M. R., Hunger, S. P. & Fornace, A. J., May 2005, In : Leukemia. 19, 5, p. 847-850 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects

Hollander, M. C., Philburn, R. T., Patterson, A. D., Wyatt, M. A. & Fornace, A. J., Jan 1 2005, In : Cell Cycle. 4, 5, p. 704-709 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

Gadd34 requirement for normal hemoglobin synthesis

Patterson, A. D., Hollander, M. C., Miller, G. F. & Fornace, A. J., Mar 1 2006, In : Molecular and cellular biology. 26, 5, p. 1644-1653 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Neural tube development requires the cooperation of p53- and Gadd45a-associated pathways

Patterson, A. D., Hildesheim, J., Fornace, A. J. & Hollander, M. C., Feb 1 2006, In : Birth Defects Research Part A - Clinical and Molecular Teratology. 76, 2, p. 129-132 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2007

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication

Yoo, M. H., Xu, X. M., Carlson, B. A., Patterson, A. D., Gladyshev, V. N. & Hatfield, D. L., Oct 31 2007, In : PloS one. 2, 10, e1112.

Research output: Contribution to journalArticle

90 Scopus citations

The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe

Thakurta, A. G., Selvanathan, S. P., Patterson, A. D., Gopal, G. & Dhar, R., Jun 15 2007, In : Journal of Biological Chemistry. 282, 24, p. 17507-17516 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2008

Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice

Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavík, J., Fornace, A. J., Gonzalez, F. J. & Idle, J. R., Jul 1 2008, In : Radiation research. 170, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

118 Scopus citations

UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation

Patterson, A. D., Li, H., Eichler, G. S., Krausz, K. W., Weinstein, J. N., Fornace, A. J., Gonzalez, F. J. & Idle, J. R., Feb 1 2008, In : Analytical chemistry. 80, 3, p. 665-674 10 p.

Research output: Contribution to journalArticle

121 Scopus citations
2009

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics

Liu, A., Patterson, A. D., Yang, Z., Zhang, X., Liu, W., Qiu, F., Sun, H., Krausz, K. W., Idle, J. R., Gonzalez, F. J. & Dai, R., Jun 1 2009, In : Drug Metabolism and Disposition. 37, 6, p. 1157-1163 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Human urinary metabolomic profile of PPARRα induced fatty acid β-oxidation

Patterson, A. D., Slanař, O., Krausz, K. W., Li, F., Höfer, C. C., Perlík, F., Gonzalez, F. J. & Idle, J. R., Oct 19 2009, In : Journal of Proteome Research. 8, 9, p. 4293-4300 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Radiation metabolomics. 2. dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavk, J., Fornace, A. J., Gonzalez, F. J. & Idle, J. R., Jul 1 2009, In : Radiation research. 172, 1, p. 42-57 16 p.

Research output: Contribution to journalArticle

90 Scopus citations

Radiation Metabolomics. 3. Biomarker Discovery in the Urine of Gamma-Irradiated Rats Using a Simplified Metabolomics Protocol of Gas Chromatography-Mass Spectrometry Combined with Random Forests Machine Learning Algorithm

Lanz, C., Patterson, A. D., Slavk, J., Krausz, K. W., Ledermann, M., Gonzalez, F. J. & Idle, J. R., Aug 1 2009, In : Radiation research. 172, 2, p. 198-212 15 p.

Research output: Contribution to journalArticle

73 Scopus citations
2010

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J. & Idle, J. R., Oct 1 2010, In : Biochemical Pharmacology. 80, 7, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in alzheimer's disease

Yoo, M. H., Gu, X., Xu, X. M., Kim, J. Y., Carlson, B. A., Patterson, A. D., Cai, H., Gladyshev, V. N. & Hatfield, D. L., Apr 1 2010, In : Antioxidants and Redox Signaling. 12, 7, p. 819-827 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Detection of radiation-exposure biomarkers by differential mobility prefiltered mass spectrometry (DMS-MS)

Coy, S. L., Krylov, E. V., Schneider, B. B., Covey, T. R., Brenner, D. J., Tyburski, J. B., Patterson, A. D., Krausz, K. W., Fornace, A. J. & Nazarov, E. G., Apr 15 2010, In : International Journal of Mass Spectrometry. 291, 3, p. 108-117 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the ppara -null mouse

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Li, H., Idle, J. R., Fornace, A. J. & Gonzalez, F. J., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4176-4188 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Metabolomics identifies novel Hnf1α-dependent physiological pathways in vivo

Bonzo, J. A., Patterson, A. D., Krausz, K. W. & Gonzalez, F. J., Dec 1 2010, In : Molecular Endocrinology. 24, 12, p. 2343-2355 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Patterson, A. D., Lanz, C., Gonzalez, F. J. & Idle, J. R., May 1 2010, In : Mass Spectrometry Reviews. 29, 3, p. 503-521 19 p.

Research output: Contribution to journalArticle

38 Scopus citations

Xenobiotic metabolism: A view through the metabolometer

Patterson, A. D., Gonzalez, F. J. & Idle, J. R., May 17 2010, In : Chemical research in toxicology. 23, 5, p. 851-860 10 p.

Research output: Contribution to journalReview article

36 Scopus citations
2011

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

Patterson, A. D., Maurhofer, O., Beyoǧlu, D., Lanz, C., Krausz, K. W., Pabst, T., Gonzalez, F. J., Dufour, J. F. & Idle, J. R., Nov 1 2011, In : Cancer Research. 71, 21, p. 6590-6600 11 p.

Research output: Contribution to journalArticle

159 Scopus citations

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J. & Idle, J. R., Apr 15 2011, In : Biochemical Pharmacology. 81, 8, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice

Hollander, M. C., Zhou, X., Maier, C. R., Patterson, A. D., Ding, X. & Dennis, P. A., Aug 11 2011, In : Carcinogenesis. 32, 8, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice

Matsubara, T., Tanaka, N., Patterson, A. D., Cho, J. Y., Krausz, K. W. & Gonzalez, F. J., Apr 1 2011, In : Hepatology. 53, 4, p. 1282-1293 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus

Patterson, A. D., Bonzo, J. A., Li, F., Krausz, K. W., Eichler, G. S., Aslam, S., Tigno, X., Weinstein, J. N., Hansen, B. C., Idle, J. R. & Gonzalez, F. J., Jun 3 2011, In : Journal of Biological Chemistry. 286, 22, p. 19511-19522 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

PPAR action in insulin resistance unraveled by metabolomics: Potential clinical implications

Patterson, A. D. & Peters, J. M., Aug 23 2011, In : Genome Medicine. 3, 8, 54.

Research output: Contribution to journalComment/debate

2 Scopus citations

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats

Johnson, C. H., Patterson, A. D., Krausz, K. W., Lanz, C., Kang, D. W., Luecke, H., Gonzalez, F. J. & Idle, J. R., Apr 1 2011, In : Radiation research. 175, 4, p. 473-484 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Idle, J. R., Fornace, A. J. & Gonzalez, F. J., Sep 2 2011, In : Journal of Proteome Research. 10, 9, p. 4120-4133 14 p.

Research output: Contribution to journalArticle

53 Scopus citations
2012

Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice

Zhang, Y., Li, F., Patterson, A. D., Wang, Y., Krausz, K. W., Neale, G., Thomas, S., Nachagari, D., Vogel, P., Vore, M., Gonzalez, F. J. & Schuetz, J. D., Jul 13 2012, In : Journal of Biological Chemistry. 287, 29, p. 24784-24794 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Tanos, R., Patel, R. D., Murray, I. A., Smith, P. B., Patterson, A. D. & Perdew, G. H., Jun 1 2012, In : Hepatology. 55, 6, p. 1994-2004 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Tanaka, N., Matsubara, T., Krausz, K. W., Patterson, A. D. & Gonzalez, F. J., Jul 1 2012, In : Hepatology. 56, 1, p. 118-129 12 p.

Research output: Contribution to journalArticle

128 Scopus citations

Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis

Matsubara, T., Tanaka, N., Krausz, K. W., Manna, S. K., Kang, D. W., Anderson, E. R., Luecke, H., Patterson, A. D., Shah, Y. M. & Gonzalez, F. J., Nov 7 2012, In : Cell Metabolism. 16, 5, p. 634-644 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Metabolomics reveals an essential role for peroxisome proliferator- activated receptor α in bile acid homeostasis

Li, F., Patterson, A. D., Krausz, K. W., Tanaka, N. & Gonzalez, F. J., Aug 1 2012, In : Journal of Lipid Research. 53, 8, p. 1625-1635 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Metabolomics reveals the metabolic map of procainamide in humans and mice

Li, F., Patterson, A. D., Krausz, K. W., Dick, B., Frey, F. J., Gonzalez, F. J. & Idle, J. R., May 15 2012, In : Biochemical Pharmacology. 83, 10, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

Menezes, L. F., Zhou, F., Patterson, A. D., Piontek, K. B., Krausz, K. W., Gonzalez, F. J. & Germino, G. G., Nov 1 2012, In : PLoS genetics. 8, 11, e1003053.

Research output: Contribution to journalArticle

43 Scopus citations

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics

Johnson, C. H., Slanař, O., Krausz, K. W., Kang, D. W., Patterson, A. D., Kim, J. H., Luecke, H., Gonzalez, F. J. & Idle, J. R., Oct 1 2012, In : American Journal of Clinical Nutrition. 96, 4, p. 818-830 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

Patterson, A. D., Shah, Y. M., Matsubara, T., Krausz, K. W. & Gonzalez, F. J., Jul 1 2012, In : Hepatology. 56, 1, p. 281-290 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics

Johnson, C. H., Patterson, A. D., Krausz, K. W., Kalinich, J. F., Tyburski, J. B., Kang, D. W., Luecke, H., Gonzalez, F. J., Blakely, W. F. & Idle, J. R., Oct 1 2012, In : Radiation Research. 178, 4, p. 328-340 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Tanos, R., Murray, I. A., Smith, P. B., Patterson, A. & Perdew, G. H., Oct 1 2012, In : Toxicological Sciences. 129, 2, p. 372-379 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Xenobiotic metabolomics: Major impact on the metabolome

Johnson, C. H., Patterson, A. D., Idle, J. R. & Gonzalez, F. J., Jan 20 2012, In : Annual Review of Pharmacology and Toxicology. 52, p. 37-56 20 p.

Research output: Contribution to journalArticle

121 Scopus citations
2013

cbiochemistry and physiology of the β class carbonic anhydrase (Cpb) from clostridium perfringens strain 13

Siva Sai Kumar, R., Hendrick, W., Correll, J. B., Patterson, A. D., Melville, S. B. & Ferry, J. G., May 1 2013, In : Journal of bacteriology. 195, 10, p. 2262-2269 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

Patterson, A. D., Carlson, B. A., Li, F., Bonzo, J. A., Yoo, M. H., Krausz, K. W., Conrad, M., Chen, C., Gonzalez, F. J. & Hatfield, D. L., Jul 15 2013, In : Chemical research in toxicology. 26, 7, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

Li, H. H., Doiron, K., Patterson, A. D., Gonzalez, F. J. & Fornace, A. J., Oct 23 2013, In : Journal of Translational Medicine. 11, 1, 266.

Research output: Contribution to journalArticle

16 Scopus citations

Metabolomics: An essential tool to understand the function of peroxisome proliferator-activated receptor alpha

Montanez, J. E., Peters, J. M., Correll, J. B., Gonzalez, F. J. & Patterson, A. D., Feb 1 2013, In : Toxicologic Pathology. 41, 2, p. 410-418 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Metabolomics reveals that tumor xenografts induce liver dysfunction

Li, F., Patterson, A. D., Krausz, K. W., Jiang, C., Bi, H., Sowers, A. L., Cook, J. A., Mitchell, J. B. & Gonzalez, F. J., Aug 1 2013, In : Molecular and Cellular Proteomics. 12, 8, p. 2126-2135 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
20 Scopus citations