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Research Output

Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice

Zhang, Y., Li, F., Patterson, A. D., Wang, Y., Krausz, K. W., Neale, G., Thomas, S., Nachagari, D., Vogel, P., Vore, M., Gonzalez, F. J. & Schuetz, J. D., Jul 13 2012, In : Journal of Biological Chemistry. 287, 29, p. 24784-24794 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

Patterson, A. D., Maurhofer, O., Beyoǧlu, D., Lanz, C., Krausz, K. W., Pabst, T., Gonzalez, F. J., Dufour, J. F. & Idle, J. R., Nov 1 2011, In : Cancer Research. 71, 21, p. 6590-6600 11 p.

Research output: Contribution to journalArticle

159 Scopus citations

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J. & Idle, J. R., Apr 15 2011, In : Biochemical Pharmacology. 81, 8, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Xie, C., Yagai, T., Luo, Y., Liang, X., Chen, T., Wang, Q., Sun, D., Zhao, J., Ramakrishnan, S. K., Sun, L., Jiang, C., Xue, X., Tian, Y., Krausz, K. W., Patterson, A. D., Shah, Y. M., Wu, Y., Jiang, C. & Gonzalez, F. J., Nov 1 2017, In : Nature Medicine. 23, 11, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice

Hollander, M. C., Zhou, X., Maier, C. R., Patterson, A. D., Ding, X. & Dennis, P. A., Aug 11 2011, In : Carcinogenesis. 32, 8, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

94 Scopus citations

An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice

Xie, C., Jiang, C., Shi, J., Gao, X., Sun, D., Sun, L., Wang, T., Takahashi, S., Anitha, M., Krausz, K. W., Patterson, A. D. & Gonzalez, F. J., Mar 1 2017, In : Diabetes. 66, 3, p. 613-626 14 p.

Research output: Contribution to journalArticle

47 Scopus citations

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

Gonzalez, F. J., Jiang, C. & Patterson, A. D., Nov 1 2016, In : Gastroenterology. 151, 5, p. 845-859 15 p.

Research output: Contribution to journalReview article

69 Scopus citations

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota

Cai, J., Zhang, L., Jones, R. A., Correll, J. B., Hatzakis, E., Smith, P. B., Gonzalez, F. J. & Patterson, A. D., Feb 5 2016, In : Journal of Proteome Research. 15, 2, p. 563-571 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes

Amundson, S. A., Patterson, A., Do, K. T. & Fornace, A. J., Jan 1 2002, In : Cancer Biology and Therapy. 1, 2, p. 145-149 5 p.

Research output: Contribution to journalArticle

78 Scopus citations

A review of analytical platforms for accurate bile acid measurement

Dutta, M., Cai, J., Gui, W. & Patterson, A. D., Jul 19 2019, In : Analytical and Bioanalytical Chemistry. 411, 19, p. 4541-4549 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Murray, I. A., Patterson, A. D. & Perdew, G. H., Nov 24 2014, In : Nature Reviews Cancer. 14, 12, p. 801-814 14 p.

Research output: Contribution to journalReview article

288 Scopus citations

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Tanos, R., Patel, R. D., Murray, I. A., Smith, P. B., Patterson, A. D. & Perdew, G. H., Jun 1 2012, In : Hepatology. 55, 6, p. 1994-2004 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1

Waghulde, H., Cheng, X., Galla, S., Mell, B., Cai, J., Pruett-Miller, S. M., Vazquez, G., Patterson, A., Kumar, M. V. & Joe, B., Jan 1 2018, In : Hypertension. 72, 5, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation

Tian, Y., Cai, J., Gui, W., Nichols, R. G., Koo, I., Zhang, J., Anitha, M. & Patterson, A. D., Feb 2019, In : Drug Metabolism and Disposition. 47, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

cbiochemistry and physiology of the β class carbonic anhydrase (Cpb) from clostridium perfringens strain 13

Siva Sai Kumar, R., Hendrick, W., Correll, J. B., Patterson, A. D., Melville, S. B. & Ferry, J. G., May 1 2013, In : Journal of bacteriology. 195, 10, p. 2262-2269 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin.

Zhu, P. P., Patterson, A., Lavoie, B., Stadler, J., Shoeb, M., Patel, R. & Blackstone, C., Dec 5 2003, In : The Journal of biological chemistry. 278, 49, p. 49063-49071 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J. & Idle, J. R., Oct 1 2010, In : Biochemical Pharmacology. 80, 7, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Crucial role of macrophage selenoproteins in experimental colitis

Kaushal, N., Kudva, A. K., Patterson, A. D., Chiaro, C., Kennett, M. J., Desai, D., Amin, S., Carlson, B. A., Cantorna, M. T. & Prabhu, K. S., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3683-3692 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis

Hollander, M. C., Philburn, R. T., Patterson, A. D., Velasco-Miguel, S., Friedberg, E. C., Linnoila, R. I. & Fornace, A. J., Sep 13 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 37, p. 13200-13205 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in alzheimer's disease

Yoo, M. H., Gu, X., Xu, X. M., Kim, J. Y., Carlson, B. A., Patterson, A. D., Cai, H., Gladyshev, V. N. & Hatfield, D. L., Apr 1 2010, In : Antioxidants and Redox Signaling. 12, 7, p. 819-827 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Detection of radiation-exposure biomarkers by differential mobility prefiltered mass spectrometry (DMS-MS)

Coy, S. L., Krylov, E. V., Schneider, B. B., Covey, T. R., Brenner, D. J., Tyburski, J. B., Patterson, A. D., Krausz, K. W., Fornace, A. J. & Nazarov, E. G., Apr 15 2010, In : International Journal of Mass Spectrometry. 291, 3, p. 108-117 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P., Kennett, M. J., Patterson, A. D. & Perdew, G. H., Oct 2017, In : Journal of Functional Foods. 37, p. 685-698 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency

Hollander, M. C., Kovalsky, O., Salvador, J. M., Kim, K. E., Patterson, A. D., Haines, D. C. & Fornace, A. J., Mar 15 2001, In : Cancer Research. 61, 6, p. 2487-2491 5 p.

Research output: Contribution to journalArticle

97 Scopus citations

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Tanaka, N., Matsubara, T., Krausz, K. W., Patterson, A. D. & Gonzalez, F. J., Jul 1 2012, In : Hepatology. 56, 1, p. 118-129 12 p.

Research output: Contribution to journalArticle

128 Scopus citations

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

Patterson, A. D., Carlson, B. A., Li, F., Bonzo, J. A., Yoo, M. H., Krausz, K. W., Conrad, M., Chen, C., Gonzalez, F. J. & Hatfield, D. L., Jul 15 2013, In : Chemical research in toxicology. 26, 7, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W. B., Hao, S., Flythe, M. D., Gonzalez, D. J., Cani, P. D., Conejo-Garcia, J. R., Xiong, N., Kennett, M. J., Joe, B., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., Oct 18 2018, In : Cell. 175, 3, p. 679-694.e22

Research output: Contribution to journalArticle

59 Scopus citations
12 Scopus citations

Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry

Zheng, X., Smith, F. B., Aly, N. A., Cai, J., Smith, R. D., Patterson, A. D. & Baker, E. S., Jul 19 2019, In : Analytical and Bioanalytical Chemistry. 411, 19, p. 4673-4682 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism

Zhang, L., Xie, C., Nichols, R. G., Chan, S. H. J., Jiang, C., Hao, R., Smith, P. B., Cai, J., Simons, M. N., Hatzakis, E., Maranas, C. D., Gonzalez, F. J. & Patterson, A. D., Sep 1 2016, In : mSystems. 1, 5, e00070.

Research output: Contribution to journalArticle

40 Scopus citations

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics

Liu, A., Patterson, A. D., Yang, Z., Zhang, X., Liu, W., Qiu, F., Sun, H., Krausz, K. W., Idle, J. R., Gonzalez, F. J. & Dai, R., Jun 1 2009, In : Drug Metabolism and Disposition. 37, 6, p. 1157-1163 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Gadd34 requirement for normal hemoglobin synthesis

Patterson, A. D., Hollander, M. C., Miller, G. F. & Fornace, A. J., Mar 1 2006, In : Molecular and cellular biology. 26, 5, p. 1644-1653 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Gadd45a acts as a modifier locus for lymphoblastic lymphoma

Hollander, M. C., Patterson, A. D., Salvador, J. M., Anver, M. R., Hunger, S. P. & Fornace, A. J., May 2005, In : Leukemia. 19, 5, p. 847-850 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Hao, S., Xiang, J., Wu, D. C., Fraser, J. W., Ruan, B., Cai, J., Patterson, A. D., Lai, Z. C. & Paulson, R. F., Jul 23 2019, In : Blood Advances. 3, 14, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
1 Scopus citations

Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects

Hollander, M. C., Philburn, R. T., Patterson, A. D., Wyatt, M. A. & Fornace, A. J., Jan 1 2005, In : Cell Cycle. 4, 5, p. 704-709 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Sun, L., Xie, C., Wang, G., Wu, Y., Wu, Q., Wang, X., Liu, J., Deng, Y., Xia, J., Chen, B., Zhang, S., Yun, C., Lian, G., Zhang, X., Zhang, H., Bisson, W. H., Shi, J., Gao, X., Ge, P., Liu, C. & 8 others, Krausz, K. W., Nichols, R. G., Cai, J., Rimal, B., Patterson, A. D., Wang, X., Gonzalez, F. J. & Jiang, C., Dec 1 2018, In : Nature Medicine. 24, 12, p. 1919-1929 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Qi, X., Yun, C., Sun, L., Xia, J., Wu, Q., Wang, Y., Wang, L., Zhang, Y., Liang, X., Wang, L., Gonzalez, F. J., Patterson, A. D., Liu, H., Mu, L., Zhou, Z., Zhao, Y., Li, R., Liu, P., Zhong, C., Pang, Y. & 2 others, Jiang, C. & Qiao, J., Aug 1 2019, In : Nature Medicine. 25, 8, p. 1225-1233 9 p.

Research output: Contribution to journalLetter

8 Scopus citations

Human urinary metabolomic profile of PPARRα induced fatty acid β-oxidation

Patterson, A. D., Slanař, O., Krausz, K. W., Li, F., Höfer, C. C., Perlík, F., Gonzalez, F. J. & Idle, J. R., Oct 19 2009, In : Journal of Proteome Research. 8, 9, p. 4293-4300 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

DiMarzio, M., Rusconi, B., Yennawar, N. H., Eppinger, M., Patterson, A. D. & Dudley, E. G., Sep 2017, In : PloS one. 12, 9, e0183564.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the ppara -null mouse

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Li, H., Idle, J. R., Fornace, A. J. & Gonzalez, F. J., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4176-4188 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

Li, H. H., Doiron, K., Patterson, A. D., Gonzalez, F. J. & Fornace, A. J., Oct 23 2013, In : Journal of Translational Medicine. 11, 1, 266.

Research output: Contribution to journalArticle

16 Scopus citations

Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction

Phillips, B. E., Geletzke, A. K., Smith, P. B., Podany, A. B., Chacon, A., Kelleher, S. L., Patterson, A. D. & Soybel, D. I., Mar 1 2016, In : Molecular Nutrition and Food Research. 60, 3, p. 672-681 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity

Gonzalez, F. J., Jiang, C., Bisson, W. H. & Patterson, A. D., Jun 1 2015, In : Journal of Hepatology. 62, 6, p. 1234-1236 3 p., 5593.

Research output: Contribution to journalEditorial

17 Scopus citations

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., Krausz, K. W., Xiang, R., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Oct 3 2017, In : Cell Metabolism. 26, 4, p. 672-685.e4

Research output: Contribution to journalArticle

73 Scopus citations

Interplay Between the Host, the Human Microbiome, and Drug Metabolism

Nichols, R. G., Peters, J. M. & Patterson, A. D., Jun 11 2019, In : Human genomics. 13, 1, 1 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease

Gonzalez, F. J., Jiang, C., Xie, C. & Patterson, A. D., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 178-184 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z. Z., Takahashi, S., Tanaka, N., Desai, D., Amin, S. G., Albert, I., Patterson, A. D. & Gonzalez, F. J., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 386-402 17 p.

Research output: Contribution to journalArticle

233 Scopus citations

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Pathak, P., Xie, C., Nichols, R. G., Ferrell, J. M., Boehme, S., Krausz, K. W., Patterson, A. D., Gonzalez, F. J. & Chiang, J. Y. L., Oct 2018, In : Hepatology. 68, 4, p. 1574-1588 15 p.

Research output: Contribution to journalArticle

58 Scopus citations