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Research Output

2016

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota

Cai, J., Zhang, L., Jones, R. A., Correll, J. B., Hatzakis, E., Smith, P. B., Gonzalez, F. J. & Patterson, A. D., Feb 5 2016, In : Journal of Proteome Research. 15, 2, p. 563-571 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
24 Scopus citations

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism

Zhang, L., Xie, C., Nichols, R. G., Chan, S. H. J., Jiang, C., Hao, R., Smith, P. B., Cai, J., Simons, M. N., Hatzakis, E., Maranas, C. D., Gonzalez, F. J. & Patterson, A. D., Sep 1 2016, In : mSystems. 1, 5, e00070.

Research output: Contribution to journalArticle

40 Scopus citations

Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction

Phillips, B. E., Geletzke, A. K., Smith, P. B., Podany, A. B., Chacon, A., Kelleher, S. L., Patterson, A. D. & Soybel, D. I., Mar 1 2016, In : Molecular Nutrition and Food Research. 60, 3, p. 672-681 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer

Cook, J. A., Chandramouli, G. V. R., Anver, M. R., Sowers, A. L., Thetford, A., Krausz, K. W., Gonzalez, F. J., Mitchell, J. B. & Patterson, A. D., Mar 15 2016, In : Cancer Research. 76, 6, p. 1569-1577 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis

Dutta, M., Anitha, M., Smith, P. B., Chiaro, C. R., Maan, M., Chaudhury, K. & Patterson, A. D., Aug 5 2016, In : Journal of Proteome Research. 15, 8, p. 2626-2633 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research

Zhang, L., Hatzakis, E. & Patterson, A. D., Oct 1 2016, In : Current Pharmacology Reports. 2, 5, p. 231-240 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Omics Approaches to Probe Microbiota and Drug Metabolism Interactions

Nichols, R. G., Hume, N. E., Smith, P. B., Peters, J. M. & Patterson, A. D., Dec 19 2016, In : Chemical Research in Toxicology. 29, 12, p. 1987-1997 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice

Zhang, L., Krishnan, P., Ehresman, D. J., Smith, P. B., Dutta, M., Bagley, B. D., Chang, S. C., Butenhoff, J. L., Patterson, A. D. & Peters, J. M., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 186-197 12 p., kfw120.

Research output: Contribution to journalArticle

7 Scopus citations

Reversing methanogenesis to capture methane for liquid biofuel precursors

Soo, V. W. C., McAnulty, M. J., Tripathi, A., Zhu, F., Zhang, L., Hatzakis, E., Smith, P. B., Agrawal, S., Nazem-Bokaee, H., Gopalakrishnan, S., Salis, H. M., Ferry, J. G., Maranas, C. D., Patterson, A. D. & Wood, T. K., Jan 14 2016, In : Microbial Cell Factories. 15, 1, 11.

Research output: Contribution to journalArticle

54 Scopus citations

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Yu, S., Allen, J. N., Dey, A., Zhang, L., Balandaram, G., Kennett, M. J., Xia, M., Xiong, N., Peters, J. M., Patterson, A. D. & Giblin, P. H., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 256-265 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

94 Scopus citations

Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity

Gonzalez, F. J., Jiang, C., Bisson, W. H. & Patterson, A. D., Jun 1 2015, In : Journal of Hepatology. 62, 6, p. 1234-1236 3 p., 5593.

Research output: Contribution to journalEditorial

17 Scopus citations

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z. Z., Takahashi, S., Tanaka, N., Desai, D., Amin, S. G., Albert, I., Patterson, A. D. & Gonzalez, F. J., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 386-402 17 p.

Research output: Contribution to journalArticle

233 Scopus citations

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S. G., Bisson, W. H., Liu, Y., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Dec 15 2015, In : Nature communications. 6, 10166.

Research output: Contribution to journalArticle

165 Scopus citations

Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data

Zhan, X., Patterson, A. D. & Ghosh, D., Dec 12 2015, In : BMC bioinformatics. 16, 1, 77.

Research output: Contribution to journalArticle

18 Scopus citations

Lack of soluble fiber drives diet-induced adiposity in mice

Chassaing, B., Miles-Brown, J., Pellizzon, M., Ulman, E., Ricci, M., Zhang, L., Patterson, A. D., Vijay-Kumar, M. & Gewirtz, A. T., Sep 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 7, p. G528-G541

Research output: Contribution to journalArticle

63 Scopus citations

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Zhang, L., Hatzakis, E., Nichols, R. G., Hao, R., Correll, J., Smith, P. B., Chiaro, C. R., Perdew, G. H. & Patterson, A. D., Jul 7 2015, In : Environmental Science and Technology. 49, 13, p. 8067-8077 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Singh, V., Chassaing, B., Zhang, L., San Yeoh, B., Xiao, X., Kumar, M., Baker, M. T., Cai, J., Walker, R., Borkowski, K., Harvatine, K. J., Singh, N., Shearer, G. C., Ntambi, J. M., Joe, B., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., Jan 1 2015, In : Cell Metabolism. 22, 6, p. 983-996 14 p.

Research output: Contribution to journalArticle

65 Scopus citations

Modulation of colon cancer by nutmeg

Li, F., Yang, X. W., Krausz, K. W., Nichols, R. G., Xu, W., Patterson, A. D. & Gonzalez, F. J., Apr 3 2015, In : Journal of Proteome Research. 14, 4, p. 1937-1946 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

Zhang, L., Nichols, R. G., Correll, J., Murray, I. A., Tanaka, N., Smith, P. B., Hubbard, T. D., Sebastian, A., Albert, I., Hatzakis, E., Gonzalez, F. J., Perdew, G. H. & Patterson, A. D., Jul 6 2015, In : Environmental health perspectives. 123, 7, p. 679-688 10 p.

Research output: Contribution to journalArticle

120 Scopus citations

Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis

Zhao, H., Chiaro, C. R., Zhang, L., Smith, P. B., Chan, C. Y., Pedley, A. M., Pugh, R. J., French, J. B., Patterson, A. D. & Benkovic, S. J., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, p. 6705-6713 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet

Tanaka, N., Takahashi, S., Zhang, Y., Krausz, K. W., Smith, P. B., Patterson, A. D. & Gonzalez, F. J., Jul 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 7, p. 1242-1252 11 p.

Research output: Contribution to journalArticle

53 Scopus citations
2014

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Murray, I. A., Patterson, A. D. & Perdew, G. H., Nov 24 2014, In : Nature Reviews Cancer. 14, 12, p. 801-814 14 p.

Research output: Contribution to journalReview article

288 Scopus citations

Crucial role of macrophage selenoproteins in experimental colitis

Kaushal, N., Kudva, A. K., Patterson, A. D., Chiaro, C., Kennett, M. J., Desai, D., Amin, S., Carlson, B. A., Cantorna, M. T. & Prabhu, K. S., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3683-3692 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Metabolomics

Belton, B. R., Correll, J. B. & Patterson, A. D., Jan 1 2014, Applications of High-Resolution Mass Spectrometry in Drug Discovery and Development. Future Medicine Ltd., p. 106-118 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology

Patterson, A. D. & Turnbaugh, P. J., Nov 4 2014, In : Cell Metabolism. 20, 5, p. 761-768 8 p.

Research output: Contribution to journalReview article

27 Scopus citations

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer

Mathé, E. A., Patterson, A. D., Haznadar, M., Manna, S. K., Krausz, K. W., Bowman, E. D., Shields, P. G., Idle, J. R., Smith, P. B., Anami, K., Kazandjian, D. G., Hatzakis, E., Gonzalez, F. J. & Harris, C. C., Jun 15 2014, In : Cancer Research. 74, 12, p. 3259-3270 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Species-specific ant brain manipulation by a specialized fungal parasite

De Bekker, C., Quevillon, L. E., Smith, P. B., Fleming, K. R., Ghosh, D., Patterson, A. D. & Hughes, D. P., Aug 29 2014, In : BMC Evolutionary Biology. 14, 1, 166.

Research output: Contribution to journalArticle

50 Scopus citations
2013

cbiochemistry and physiology of the β class carbonic anhydrase (Cpb) from clostridium perfringens strain 13

Siva Sai Kumar, R., Hendrick, W., Correll, J. B., Patterson, A. D., Melville, S. B. & Ferry, J. G., May 1 2013, In : Journal of bacteriology. 195, 10, p. 2262-2269 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

Patterson, A. D., Carlson, B. A., Li, F., Bonzo, J. A., Yoo, M. H., Krausz, K. W., Conrad, M., Chen, C., Gonzalez, F. J. & Hatfield, D. L., Jul 15 2013, In : Chemical research in toxicology. 26, 7, p. 1088-1096 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

Li, H. H., Doiron, K., Patterson, A. D., Gonzalez, F. J. & Fornace, A. J., Oct 23 2013, In : Journal of Translational Medicine. 11, 1, 266.

Research output: Contribution to journalArticle

16 Scopus citations

Metabolomics: An essential tool to understand the function of peroxisome proliferator-activated receptor alpha

Montanez, J. E., Peters, J. M., Correll, J. B., Gonzalez, F. J. & Patterson, A. D., Feb 1 2013, In : Toxicologic Pathology. 41, 2, p. 410-418 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Metabolomics reveals that tumor xenografts induce liver dysfunction

Li, F., Patterson, A. D., Krausz, K. W., Jiang, C., Bi, H., Sowers, A. L., Cook, J. A., Mitchell, J. B. & Gonzalez, F. J., Aug 1 2013, In : Molecular and Cellular Proteomics. 12, 8, p. 2126-2135 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
20 Scopus citations

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D. & Gonzalez, F. J., Sep 24 2013, In : Nature communications. 4, 2384.

Research output: Contribution to journalArticle

274 Scopus citations

Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: A study expanding tempol pharmacology

Li, F., Pang, X., Krausz, K. W., Jiang, C., Chen, C., Cook, J. A., Krishna, M. C., Mitchell, J. B., Gonzalez, F. J. & Patterson, A. D., Mar 11 2013, In : Journal of Proteome Research. 12, 3, p. 1369-1376 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

White Button mushrooms increase microbialdiversity and accelerate the resolution of Citrobacter rodentium infection in mice

Varshney, J., Ooi, J. H., Jayarao, B. M., Albert, I., Fisher, J., Smith, R. L., Patterson, A. D. & Cantorna, M. T., Apr 1 2013, In : Journal of Nutrition. 143, 4, p. 526-532 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice

Zhang, Y., Li, F., Patterson, A. D., Wang, Y., Krausz, K. W., Neale, G., Thomas, S., Nachagari, D., Vogel, P., Vore, M., Gonzalez, F. J. & Schuetz, J. D., Jul 13 2012, In : Journal of Biological Chemistry. 287, 29, p. 24784-24794 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner

Tanos, R., Patel, R. D., Murray, I. A., Smith, P. B., Patterson, A. D. & Perdew, G. H., Jun 1 2012, In : Hepatology. 55, 6, p. 1994-2004 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Tanaka, N., Matsubara, T., Krausz, K. W., Patterson, A. D. & Gonzalez, F. J., Jul 1 2012, In : Hepatology. 56, 1, p. 118-129 12 p.

Research output: Contribution to journalArticle

128 Scopus citations

Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis

Matsubara, T., Tanaka, N., Krausz, K. W., Manna, S. K., Kang, D. W., Anderson, E. R., Luecke, H., Patterson, A. D., Shah, Y. M. & Gonzalez, F. J., Nov 7 2012, In : Cell Metabolism. 16, 5, p. 634-644 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Metabolomics reveals an essential role for peroxisome proliferator- activated receptor α in bile acid homeostasis

Li, F., Patterson, A. D., Krausz, K. W., Tanaka, N. & Gonzalez, F. J., Aug 1 2012, In : Journal of Lipid Research. 53, 8, p. 1625-1635 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Metabolomics reveals the metabolic map of procainamide in humans and mice

Li, F., Patterson, A. D., Krausz, K. W., Dick, B., Frey, F. J., Gonzalez, F. J. & Idle, J. R., May 15 2012, In : Biochemical Pharmacology. 83, 10, p. 1435-1444 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

Menezes, L. F., Zhou, F., Patterson, A. D., Piontek, K. B., Krausz, K. W., Gonzalez, F. J. & Germino, G. G., Nov 1 2012, In : PLoS genetics. 8, 11, e1003053.

Research output: Contribution to journalArticle

43 Scopus citations

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics

Johnson, C. H., Slanař, O., Krausz, K. W., Kang, D. W., Patterson, A. D., Kim, J. H., Luecke, H., Gonzalez, F. J. & Idle, J. R., Oct 1 2012, In : American Journal of Clinical Nutrition. 96, 4, p. 818-830 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

Patterson, A. D., Shah, Y. M., Matsubara, T., Krausz, K. W. & Gonzalez, F. J., Jul 1 2012, In : Hepatology. 56, 1, p. 281-290 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics

Johnson, C. H., Patterson, A. D., Krausz, K. W., Kalinich, J. F., Tyburski, J. B., Kang, D. W., Luecke, H., Gonzalez, F. J., Blakely, W. F. & Idle, J. R., Oct 1 2012, In : Radiation Research. 178, 4, p. 328-340 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver

Tanos, R., Murray, I. A., Smith, P. B., Patterson, A. & Perdew, G. H., Oct 1 2012, In : Toxicological Sciences. 129, 2, p. 372-379 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Xenobiotic metabolomics: Major impact on the metabolome

Johnson, C. H., Patterson, A. D., Idle, J. R. & Gonzalez, F. J., Jan 20 2012, In : Annual Review of Pharmacology and Toxicology. 52, p. 37-56 20 p.

Research output: Contribution to journalArticle

121 Scopus citations