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Research Output 2001 2020

2011
22 Citations (Scopus)

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J. & Idle, J. R., Apr 15 2011, In : Biochemical Pharmacology. 81, 8, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

Thiotepa
Electrospray ionization
Metabolomics
Liquid chromatography
Metabolism
14 Citations (Scopus)

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice

Hollander, M. C., Zhou, X., Maier, C. R., Patterson, A. D., Ding, X. & Dennis, P. A., Aug 11 2011, In : Carcinogenesis. 32, 8, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

Carcinogenesis
Lung
Neoplasms
Chromosomes, Human, Pair 7
DNA Adducts
45 Citations (Scopus)

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice

Matsubara, T., Tanaka, N., Patterson, A. D., Cho, J. Y., Krausz, K. W. & Gonzalez, F. J., Apr 1 2011, In : Hepatology. 53, 4, p. 1282-1293 12 p.

Research output: Contribution to journalArticle

Lithocholic Acid
Sphingolipids
Cholestasis
Phospholipids
Homeostasis
49 Citations (Scopus)

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus

Patterson, A. D., Bonzo, J. A., Li, F., Krausz, K. W., Eichler, G. S., Aslam, S., Tigno, X., Weinstein, J. N., Hansen, B. C., Idle, J. R. & Gonzalez, F. J., Jun 3 2011, In : Journal of Biological Chemistry. 286, 22, p. 19511-19522 12 p.

Research output: Contribution to journalArticle

Metabolomics
Medical problems
Type 2 Diabetes Mellitus
Primates
Kidney
2 Citations (Scopus)

PPAR action in insulin resistance unraveled by metabolomics: Potential clinical implications

Patterson, A. D. & Peters, J. M., Aug 23 2011, In : Genome Medicine. 3, 8, 54.

Research output: Contribution to journalComment/debate

Peroxisome Proliferator-Activated Receptors
Metabolomics
Insulin Resistance
Adipocytes
Metabolome
71 Citations (Scopus)

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats

Johnson, C. H., Patterson, A. D., Krausz, K. W., Lanz, C., Kang, D. W., Luecke, H., Gonzalez, F. J. & Idle, J. R., Apr 1 2011, In : Radiation research. 175, 4, p. 473-484 12 p.

Research output: Contribution to journalArticle

Metabolomics
biomarkers
rats
Biomarkers
Radiation
52 Citations (Scopus)

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Idle, J. R., Fornace, A. J. & Gonzalez, F. J., Sep 2 2011, In : Journal of Proteome Research. 10, 9, p. 4120-4133 14 p.

Research output: Contribution to journalArticle

Metabolomics
Biomarkers
Liver
Liver Diseases
Alcohols
2010
42 Citations (Scopus)

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J. & Idle, J. R., Oct 1 2010, In : Biochemical Pharmacology. 80, 7, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

Electrospray ionization
Ifosfamide
Metabolomics
Liquid chromatography
Metabolism
63 Citations (Scopus)

Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in alzheimer's disease

Yoo, M. H., Gu, X., Xu, X. M., Kim, J. Y., Carlson, B. A., Patterson, A. D., Cai, H., Gladyshev, V. N. & Hatfield, D. L., Apr 1 2010, In : Antioxidants and Redox Signaling. 12, 7, p. 819-827 9 p.

Research output: Contribution to journalArticle

phospholipid-hydroperoxide glutathione peroxidase
Lipid Peroxides
Alzheimer Disease
Neurodegenerative diseases
Byproducts
42 Citations (Scopus)

Detection of radiation-exposure biomarkers by differential mobility prefiltered mass spectrometry (DMS-MS)

Coy, S. L., Krylov, E. V., Schneider, B. B., Covey, T. R., Brenner, D. J., Tyburski, J. B., Patterson, A. D., Krausz, K. W., Fornace, A. J. & Nazarov, E. G., Apr 15 2010, In : International Journal of Mass Spectrometry. 291, 3, p. 108-117 10 p.

Research output: Contribution to journalArticle

biomarkers
radiation dosage
Biomarkers
Spectrometry
Mass spectrometry
46 Citations (Scopus)

Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the ppara -null mouse

Manna, S. K., Patterson, A. D., Yang, Q., Krausz, K. W., Li, H., Idle, J. R., Fornace, A. J. & Gonzalez, F. J., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4176-4188 13 p.

Research output: Contribution to journalArticle

Metabolomics
Biomarkers
Liver
Liver Diseases
Alcohols
14 Citations (Scopus)

Metabolomics identifies novel Hnf1α-dependent physiological pathways in vivo

Bonzo, J. A., Patterson, A. D., Krausz, K. W. & Gonzalez, F. J., Dec 1 2010, In : Molecular Endocrinology. 24, 12, p. 2343-2355 13 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
Metabolomics
Type 2 Diabetes Mellitus
Laron Syndrome
Urine
38 Citations (Scopus)

The role of mass spectrometry-based metabolomics in medical countermeasures against radiation

Patterson, A. D., Lanz, C., Gonzalez, F. J. & Idle, J. R., May 1 2010, In : Mass Spectrometry Reviews. 29, 3, p. 503-521 19 p.

Research output: Contribution to journalArticle

Metabolomics
countermeasures
Mass spectrometry
Mass Spectrometry
mass spectroscopy
36 Citations (Scopus)

Xenobiotic metabolism: A view through the metabolometer

Patterson, A. D., Gonzalez, F. J. & Idle, J. R., May 17 2010, In : Chemical research in toxicology. 23, 5, p. 851-860 10 p.

Research output: Contribution to journalReview article

Xenobiotics
Metabolism
aminoflavone
Arecoline
Areca
2009
23 Citations (Scopus)

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics

Liu, A., Patterson, A. D., Yang, Z., Zhang, X., Liu, W., Qiu, F., Sun, H., Krausz, K. W., Idle, J. R., Gonzalez, F. J. & Dai, R., Jun 1 2009, In : Drug Metabolism and Disposition. 37, 6, p. 1157-1163 7 p.

Research output: Contribution to journalArticle

Fenofibrate
Metabolomics
Macaca fascicularis
Liquid Chromatography
Mass Spectrometry
43 Citations (Scopus)

Human urinary metabolomic profile of PPARRα induced fatty acid β-oxidation

Patterson, A. D., Slanař, O., Krausz, K. W., Li, F., Höfer, C. C., Perlík, F., Gonzalez, F. J. & Idle, J. R., Oct 19 2009, In : Journal of Proteome Research. 8, 9, p. 4293-4300 8 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Metabolomics
Fatty Acids
Biomarkers
Oxidation
89 Citations (Scopus)

Radiation metabolomics. 2. dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavk, J., Fornace, A. J., Gonzalez, F. J. & Idle, J. R., Jul 1 2009, In : Radiation research. 172, 1, p. 42-57 16 p.

Research output: Contribution to journalArticle

Pyrimidines
excretion
Purines
purines
Metabolomics
73 Citations (Scopus)

Radiation Metabolomics. 3. Biomarker Discovery in the Urine of Gamma-Irradiated Rats Using a Simplified Metabolomics Protocol of Gas Chromatography-Mass Spectrometry Combined with Random Forests Machine Learning Algorithm

Lanz, C., Patterson, A. D., Slavk, J., Krausz, K. W., Ledermann, M., Gonzalez, F. J. & Idle, J. R., Aug 1 2009, In : Radiation research. 172, 2, p. 198-212 15 p.

Research output: Contribution to journalArticle

machine learning
Metabolomics
urine
biomarkers
gas chromatography
2008
118 Citations (Scopus)

Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice

Tyburski, J. B., Patterson, A. D., Krausz, K. W., Slavík, J., Fornace, A. J., Gonzalez, F. J. & Idle, J. R., Jul 1 2008, In : Radiation research. 170, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Metabolomics
urine
biomarkers
Gamma Rays
radiation dosage
119 Citations (Scopus)

UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation

Patterson, A. D., Li, H., Eichler, G. S., Krausz, K. W., Weinstein, J. N., Fornace, A. J., Gonzalez, F. J. & Idle, J. R., Feb 1 2008, In : Analytical chemistry. 80, 3, p. 665-674 10 p.

Research output: Contribution to journalArticle

Ionizing radiation
Gene expression
Metabolites
Dosimetry
Mass spectrometry
2007
88 Citations (Scopus)

Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication

Yoo, M. H., Xu, X. M., Carlson, B. A., Patterson, A. D., Gladyshev, V. N. & Hatfield, D. L., Oct 31 2007, In : PloS one. 2, 10, e1112.

Research output: Contribution to journalArticle

Thioredoxin Reductase 1
DNA replication
DNA Replication
Cells
neoplasms
8 Citations (Scopus)

The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe

Thakurta, A. G., Selvanathan, S. P., Patterson, A. D., Gopal, G. & Dhar, R., Jun 15 2007, In : Journal of Biological Chemistry. 282, 24, p. 17507-17516 10 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Nuclear Pore
Porins
Schizosaccharomyces
Nuclear Proteins
2006
28 Citations (Scopus)

Gadd34 requirement for normal hemoglobin synthesis

Patterson, A. D., Hollander, M. C., Miller, G. F. & Fornace, A. J., Mar 1 2006, In : Molecular and cellular biology. 26, 5, p. 1644-1653 10 p.

Research output: Contribution to journalArticle

DNA Damage
Hemoglobins
Protein Phosphatase 1
Growth
Reticulocytes
10 Citations (Scopus)

Neural tube development requires the cooperation of p53- and Gadd45a-associated pathways

Patterson, A. D., Hildesheim, J., Fornace, A. J. & Hollander, M. C., Feb 1 2006, In : Birth Defects Research Part A - Clinical and Molecular Teratology. 76, 2, p. 129-132 4 p.

Research output: Contribution to journalArticle

Neural Tube
Neural Tube Defects
Embryonic Structures
Xeroderma Pigmentosum
Cyclin-Dependent Kinase Inhibitor p21
2005
96 Citations (Scopus)

Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis

Hollander, M. C., Philburn, R. T., Patterson, A. D., Velasco-Miguel, S., Friedberg, E. C., Linnoila, R. I. & Fornace, A. J., Sep 13 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 37, p. 13200-13205 6 p.

Research output: Contribution to journalArticle

Carcinogenesis
Lung
Neoplasms
Lung Neoplasms
Loss of Heterozygosity
2 Citations (Scopus)

Gadd45a acts as a modifier locus for lymphoblastic lymphoma

Hollander, M. C., Patterson, A. D., Salvador, J. M., Anver, M. R., Hunger, S. P. & Fornace, A. J., May 2005, In : Leukemia. 19, 5, p. 847-850 4 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms
T-Cell Lymphoma
Inbred AKR Mouse
Phenotype
16 Citations (Scopus)

Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects

Hollander, M. C., Philburn, R. T., Patterson, A. D., Wyatt, M. A. & Fornace, A. J., Jan 1 2005, In : Cell Cycle. 4, 5, p. 704-709 6 p.

Research output: Contribution to journalArticle

S Phase Cell Cycle Checkpoints
Centrosome
Genomic Instability
Gene Amplification
DNA Replication
2004
129 Citations (Scopus)

Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1

Zhu, P. P., Patterson, A. D., Stadler, J., Seeburg, D. P., Sheng, M. & Blackstone, C., Aug 20 2004, In : Journal of Biological Chemistry. 279, 34, p. 35967-35974 8 p.

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
Guanosine Triphosphate
Mitochondrial Dynamics
Mitochondrial Membranes
2003
110 Citations (Scopus)

Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin.

Zhu, P. P., Patterson, A. D., Lavoie, B., Stadler, J., Shoeb, M., Patel, R. & Blackstone, C., Jan 1 2003, In : The Journal of biological chemistry. 278, 49, p. 49063-49071 9 p.

Research output: Contribution to journalArticle

Hereditary Spastic Paraplegia
Oligomerization
GTP Phosphohydrolases
Association reactions
Membranes
2002
78 Citations (Scopus)

A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes

Amundson, S. A., Patterson, A., Do, K. T. & Fornace, A. J., Jan 1 2002, In : Cancer Biology and Therapy. 1, 2, p. 145-149 5 p.

Research output: Contribution to journalArticle

DNA Repair
Genes
Alkylating Agents
p53 Genes
Cell Cycle Checkpoints
2001
96 Citations (Scopus)

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency

Hollander, M. C., Kovalsky, O., Salvador, J. M., Kim, K. E., Patterson, A. D., Haines, D. C. & Fornace, A. J., Mar 15 2001, In : Cancer Research. 61, 6, p. 2487-2491 5 p.

Research output: Contribution to journalArticle

Mutation Rate
DNA Repair
Carcinogenesis
Neoplasms
Liver