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2020

Metatranscriptomic analysis of the mouse gut microbiome response to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzofuran

Nichols, R. G., Zhang, J., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Jan 2020, In : Metabolites. 10, 1, 1.

Research output: Contribution to journalArticle

Open Access

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Das, N. K., Schwartz, A. J., Barthel, G., Inohara, N., Liu, Q., Sankar, A., Hill, D. R., Ma, X., Lamberg, O., Schnizlein, M. K., Arqués, J. L., Spence, J. R., Nunez, G., Patterson, A. D., Sun, D., Young, V. B. & Shah, Y. M., Jan 7 2020, In : Cell Metabolism. 31, 1, p. 115-130.e6

Research output: Contribution to journalArticle

2 Scopus citations

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

Zhang, L., Rimal, B., Nichols, R. G., Tian, Y., Smith, P. B., Hatzakis, E., Chang, S. C., Butenhoff, J. L., Peters, J. M. & Patterson, A. D., Feb 15 2020, In : Toxicology. 431, 152365.

Research output: Contribution to journalArticle

The microbiome modulating activity of bile acids

Tian, Y., Gui, W., Koo, I., Smith, P. B., Allman, E. L., Nichols, R. G., Rimal, B., Cai, J., Liu, Q. & Patterson, A. D., Jan 1 2020, (Accepted/In press) In : Gut microbes.

Research output: Contribution to journalArticle

2019

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation

Tian, Y., Cai, J., Gui, W., Nichols, R. G., Koo, I., Zhang, J., Anitha, M. & Patterson, A. D., Feb 2019, In : Drug Metabolism and Disposition. 47, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry

Zheng, X., Smith, F. B., Aly, N. A., Cai, J., Smith, R. D., Patterson, A. D. & Baker, E. S., Jul 19 2019, In : Analytical and Bioanalytical Chemistry. 411, 19, p. 4673-4682 10 p.

Research output: Contribution to journalArticle

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Hao, S., Xiang, J., Wu, D. C., Fraser, J. W., Ruan, B., Cai, J., Patterson, A. D., Lai, Z. C. & Paulson, R. F., Jul 23 2019, In : Blood Advances. 3, 14, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
1 Scopus citations

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

Chen, F., Coslo, D. M., Chen, T., Zhang, L., Tian, Y., Smith, P. B., Patterson, A. D. & Omiecinski, C. J., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 239-251 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Singh, V., Yeoh, B. S., Walker, R. E., Xiao, X., Saha, P., Golonka, R. M., Cai, J., Bretin, A. C. A., Cheng, X., Liu, Q., Flythe, M. D., Chassaing, B., Shearer, G. C., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., Oct 1 2019, In : Gut. 68, 10, p. 1801-1812 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

Chagwedera, D. N., Ang, Q. Y., Bisanz, J. E., Leong, Y. A., Ganeshan, K., Cai, J., Patterson, A. D., Turnbaugh, P. J. & Chawla, A., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 364-373.e7

Research output: Contribution to journalArticle

5 Scopus citations

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells

Snyder, L. M., McDaniel, K. L., Tian, Y., Wei, C. H., Kennett, M. J., Patterson, A. D., Catharine Ross, A. & Cantorna, M. T., Jan 1 2019, In : Frontiers in immunology. 10, JAN

Research output: Contribution to journalArticle

2 Scopus citations
Open Access

The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2

Bao, L., Festa, F., Freet, C. S., Lee, J. P., Hirschler-Laszkiewicz, I. M., Chen, S. J., Keefer, K. A., Wang, H. G., Patterson, A. D., Cheung, J. Y. & Miller, B. A., Dec 1 2019, In : Scientific reports. 9, 1, 14132.

Research output: Contribution to journalArticle

Open Access

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon

Cantorna, M. T., Lin, Y. D., Arora, J., Bora, S., Tian, Y., Nichols, R. G. & Patterson, A. D., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1

Waghulde, H., Cheng, X., Galla, S., Mell, B., Cai, J., Pruett-Miller, S. M., Vazquez, G., Patterson, A., Kumar, M. V. & Joe, B., Jan 1 2018, In : Hypertension. 72, 5, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W. B., Hao, S., Flythe, M. D., Gonzalez, D. J., Cani, P. D., Conejo-Garcia, J. R., Xiong, N., Kennett, M. J., Joe, B., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., Oct 18 2018, In : Cell. 175, 3, p. 679-694.e22

Research output: Contribution to journalArticle

59 Scopus citations

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Sun, L., Xie, C., Wang, G., Wu, Y., Wu, Q., Wang, X., Liu, J., Deng, Y., Xia, J., Chen, B., Zhang, S., Yun, C., Lian, G., Zhang, X., Zhang, H., Bisson, W. H., Shi, J., Gao, X., Ge, P., Liu, C. & 8 others, Krausz, K. W., Nichols, R. G., Cai, J., Rimal, B., Patterson, A. D., Wang, X., Gonzalez, F. J. & Jiang, C., Dec 1 2018, In : Nature Medicine. 24, 12, p. 1919-1929 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Pathak, P., Xie, C., Nichols, R. G., Ferrell, J. M., Boehme, S., Krausz, K. W., Patterson, A. D., Gonzalez, F. J. & Chiang, J. Y. L., Oct 2018, In : Hepatology. 68, 4, p. 1574-1588 15 p.

Research output: Contribution to journalArticle

58 Scopus citations

Lipid metabolism and lipophagy in cancer

Maan, M., Peters, J. M., Dutta, M. & Patterson, A. D., Oct 7 2018, In : Biochemical and Biophysical Research Communications. 504, 3, p. 582-589 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice

Belton, K. R., Tian, Y., Zhang, L., Anitha, M., Smith, P. B., Perdew, G. H. & Patterson, A. D., Apr 6 2018, In : Journal of Proteome Research. 17, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity

Cai, J., Nichols, R. G., Koo, I., Kalikow, Z. A., Zhang, L., Tian, Y., Zhang, J., Smith, P. B. & Patterson, A. D., Nov 1 2018, In : mSystems. 3, 6, e00123.

Research output: Contribution to journalArticle

3 Scopus citations

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Dey, A., Allen, J. N., Fraser, J. W., Snyder, L. M., Tian, Y., Zhang, L., Paulson, R. F., Patterson, A., Cantorna, M. T. & Hankey-Giblin, P. A., Mar 19 2018, In : Frontiers in immunology. 9, MAR, 513.

Research output: Contribution to journalArticle

4 Scopus citations

Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice

Tian, Y., Nichols, R. G., Roy, P., Gui, W., Smith, P. B., Zhang, J., Lin, Y., Weaver, V., Cai, J., Patterson, A. D. & Cantorna, M. T., Jun 2018, In : Journal of Functional Foods. 45, p. 223-232 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
4 Scopus citations

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model

Allen, J., Zhang, J., Quickel, M. D., Kennett, M., Patterson, A. D. & Hankey-Giblin, P. A., Sep 7 2018, In : Journal of Proteome Research. 17, 9, p. 3268-3280 13 p.

Research output: Contribution to journalArticle

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Nichols, R. G., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Nov 2018, In : Current Protocols in Toxicology. 78, 1, e54.

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23

Bora, S. A., Kennett, M. J., Smith, P. B., Patterson, A. D. & Cantorna, M. T., Mar 2 2018, In : Frontiers in immunology. 9, MAR, 408.

Research output: Contribution to journalArticle

21 Scopus citations
15 Scopus citations
2017

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Xie, C., Yagai, T., Luo, Y., Liang, X., Chen, T., Wang, Q., Sun, D., Zhao, J., Ramakrishnan, S. K., Sun, L., Jiang, C., Xue, X., Tian, Y., Krausz, K. W., Patterson, A. D., Shah, Y. M., Wu, Y., Jiang, C. & Gonzalez, F. J., Nov 1 2017, In : Nature Medicine. 23, 11, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice

Xie, C., Jiang, C., Shi, J., Gao, X., Sun, D., Sun, L., Wang, T., Takahashi, S., Anitha, M., Krausz, K. W., Patterson, A. D. & Gonzalez, F. J., Mar 1 2017, In : Diabetes. 66, 3, p. 613-626 14 p.

Research output: Contribution to journalArticle

47 Scopus citations

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P., Kennett, M. J., Patterson, A. D. & Perdew, G. H., Oct 2017, In : Journal of Functional Foods. 37, p. 685-698 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

DiMarzio, M., Rusconi, B., Yennawar, N. H., Eppinger, M., Patterson, A. D. & Dudley, E. G., Sep 2017, In : PloS one. 12, 9, e0183564.

Research output: Contribution to journalArticle

4 Scopus citations

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., Krausz, K. W., Xiang, R., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Oct 3 2017, In : Cell Metabolism. 26, 4, p. 672-685.e4

Research output: Contribution to journalArticle

73 Scopus citations

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease

Gonzalez, F. J., Jiang, C., Xie, C. & Patterson, A. D., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 178-184 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
2 Scopus citations

Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice

Xiao, X., Yeoh, B. S., Saha, P., Tian, Y., Singh, V., Patterson, A. D. & Vijay-Kumar, M., Mar 1 2017, In : Journal of Nutritional Biochemistry. 41, p. 25-33 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation

Cai, J., Zhang, J., Tian, Y., Zhang, L., Hatzakis, E., Krausz, K. W., Smith, P. B., Gonzalez, F. J. & Patterson, A. D., Aug 1 2017, In : Analytical chemistry. 89, 15, p. 7900-7906 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota

Cai, J., Zhang, L., Jones, R. A., Correll, J. B., Hatzakis, E., Smith, P. B., Gonzalez, F. J. & Patterson, A. D., Feb 5 2016, In : Journal of Proteome Research. 15, 2, p. 563-571 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
24 Scopus citations

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism

Zhang, L., Xie, C., Nichols, R. G., Chan, S. H. J., Jiang, C., Hao, R., Smith, P. B., Cai, J., Simons, M. N., Hatzakis, E., Maranas, C. D., Gonzalez, F. J. & Patterson, A. D., Sep 1 2016, In : mSystems. 1, 5, e00070.

Research output: Contribution to journalArticle

40 Scopus citations

Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction

Phillips, B. E., Geletzke, A. K., Smith, P. B., Podany, A. B., Chacon, A., Kelleher, S. L., Patterson, A. D. & Soybel, D. I., Mar 1 2016, In : Molecular Nutrition and Food Research. 60, 3, p. 672-681 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer

Cook, J. A., Chandramouli, G. V. R., Anver, M. R., Sowers, A. L., Thetford, A., Krausz, K. W., Gonzalez, F. J., Mitchell, J. B. & Patterson, A. D., Mar 15 2016, In : Cancer Research. 76, 6, p. 1569-1577 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis

Dutta, M., Anitha, M., Smith, P. B., Chiaro, C. R., Maan, M., Chaudhury, K. & Patterson, A. D., Aug 5 2016, In : Journal of Proteome Research. 15, 8, p. 2626-2633 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice

Zhang, L., Krishnan, P., Ehresman, D. J., Smith, P. B., Dutta, M., Bagley, B. D., Chang, S. C., Butenhoff, J. L., Patterson, A. D. & Peters, J. M., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 186-197 12 p., kfw120.

Research output: Contribution to journalArticle

7 Scopus citations

Reversing methanogenesis to capture methane for liquid biofuel precursors

Soo, V. W. C., McAnulty, M. J., Tripathi, A., Zhu, F., Zhang, L., Hatzakis, E., Smith, P. B., Agrawal, S., Nazem-Bokaee, H., Gopalakrishnan, S., Salis, H. M., Ferry, J. G., Maranas, C. D., Patterson, A. D. & Wood, T. K., Jan 14 2016, In : Microbial Cell Factories. 15, 1, 11.

Research output: Contribution to journalArticle

54 Scopus citations

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Yu, S., Allen, J. N., Dey, A., Zhang, L., Balandaram, G., Kennett, M. J., Xia, M., Xiong, N., Peters, J. M., Patterson, A. D. & Giblin, P. H., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 256-265 10 p.

Research output: Contribution to journalArticle

8 Scopus citations