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Research Output 2001 2019

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Article
2019
4 Citations (Scopus)

Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation

Tian, Y., Cai, J., Gui, W., Nichols, R. G., Koo, I., Zhang, J., Anitha, M. & Patterson, A. D., Feb 1 2019, In : Drug Metabolism and Disposition. 47, 2, p. 86-93 8 p.

Research output: Contribution to journalArticle

Berberine
Bacteria
choloylglycine hydrolase
Metabolomics
Bile Acids and Salts

Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry

Zheng, X., Smith, F. B., Aly, N. A., Cai, J., Smith, R. D., Patterson, A. D. & Baker, E. S., Jul 19 2019, In : Analytical and Bioanalytical Chemistry. 411, 19, p. 4673-4682 10 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Spectrometry
Spectrum Analysis
Ions
Isomers
1 Citation (Scopus)

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche

Hao, S., Xiang, J., Wu, D. C., Fraser, J. W., Ruan, B., Cai, J., Patterson, A. D., Lai, Z. C. & Paulson, R. F., Jul 23 2019, In : Blood Advances. 3, 14, p. 2205-2217 13 p.

Research output: Contribution to journalArticle

Open Access
Growth Differentiation Factor 15
Erythropoiesis
Erythroid Cells
Monocytes
Homeostasis
Agaricus
Aryl Hydrocarbon Receptors
Agaricus bisporus
Agaricales
Hydrocarbons
1 Citation (Scopus)

Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism

Chen, F., Coslo, D. M., Chen, T., Zhang, L., Tian, Y., Smith, P. B., Patterson, A. D. & Omiecinski, C. J., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 239-251 13 p.

Research output: Contribution to journalArticle

Metabolomics
Energy Metabolism
Fatty Acids
Chemical activation
Glucose
6 Citations (Scopus)

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Singh, V., Yeoh, B. S., Walker, R. E., Xiao, X., Saha, P., Golonka, R. M., Cai, J., Bretin, A. C. A., Cheng, X., Liu, Q., Flythe, M. D., Chassaing, B., Shearer, G. C., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., Oct 1 2019, In : Gut. 68, 10, p. 1801-1812 12 p.

Research output: Contribution to journalArticle

Microbiota
Dietary Fiber
Colitis
Fermentation
Butyrates
3 Citations (Scopus)

Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline

Hubbard, T. D., Liu, Q., Murray, I. A., Dong, F., Miller, C., Smith, P. B., Gowda, K., Lin, J. M., Amin, S., Patterson, A. D. & Perdew, G. H., Apr 5 2019, In : Journal of Proteome Research. 18, 4, p. 1715-1724 10 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Microbiota
Metabolism
Hydroxyquinolines
Chemical activation
3 Citations (Scopus)

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

Chagwedera, D. N., Ang, Q. Y., Bisanz, J. E., Leong, Y. A., Ganeshan, K., Cai, J., Patterson, A. D., Turnbaugh, P. J. & Chawla, A., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 364-373.e7

Research output: Contribution to journalArticle

Microbiota
Eating
Appetite Regulation
Food
Body Weight
2 Citations (Scopus)

Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells

Snyder, L. M., McDaniel, K. L., Tian, Y., Wei, C. H., Kennett, M. J., Patterson, A. D., Catharine Ross, A. & Cantorna, M. T., Jan 1 2019, In : Frontiers in immunology. 10, JAN

Research output: Contribution to journalArticle

Citrobacter rodentium
Tretinoin
Vitamin A
T-Lymphocytes
Interleukin-17
Open Access
parasites
Ants
metabolites
Metabolites
muscles

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon

Cantorna, M. T-A., Lin, Y. D., Arora, J., Bora, S., Tian, Y., Nichols, R. G. & Patterson, A. D., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Microbiota
Regulatory T-Lymphocytes
Vitamin D
Colon
Colitis
2018
4 Citations (Scopus)

Attenuation of microbiotal dysbiosis and hypertension in a CRISPR/Cas9 gene ablation rat model of GPER1

Waghulde, H., Cheng, X., Galla, S., Mell, B., Cai, J., Pruett-Miller, S. M., Vazquez, G., Patterson, A., Kumar, M. V. & Joe, B., Jan 1 2018, In : Hypertension. 72, 5, p. 1125-1132 8 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Dysbiosis
Microbiota
Blood Pressure
Hypertension
44 Citations (Scopus)

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W. B., Hao, S., Flythe, M. D., Gonzalez, D. J., Cani, P. D., Conejo-Garcia, J. R., Xiong, N., Kennett, M. J., Joe, B., Patterson, A. D., Gewirtz, A. T. & Vijay-Kumar, M., Oct 18 2018, In : Cell. 175, 3, p. 679-694.e22

Research output: Contribution to journalArticle

Liver Neoplasms
Liver
Fermentation
Inulin
Hepatocellular Carcinoma
54 Citations (Scopus)

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Sun, L., Xie, C., Wang, G., Wu, Y., Wu, Q., Wang, X., Liu, J., Deng, Y., Xia, J., Chen, B., Zhang, S., Yun, C., Lian, G., Zhang, X., Zhang, H., Bisson, W. H., Shi, J., Gao, X., Ge, P., Liu, C. & 8 others, Krausz, K. W., Nichols, R. G., Cai, J., Rimal, B., Patterson, A. D., Wang, X., Gonzalez, F. J. & Jiang, C., Dec 1 2018, In : Nature Medicine. 24, 12, p. 1919-1929 11 p.

Research output: Contribution to journalArticle

Metformin
Bacteroides fragilis
Glucose Intolerance
Hyperglycemia
Glucose
45 Citations (Scopus)

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

Pathak, P., Xie, C., Nichols, R. G., Ferrell, J. M., Boehme, S., Krausz, K. W., Patterson, A. D., Gonzalez, F. J. & Chiang, J. Y. L., Oct 1 2018, In : Hepatology. 68, 4, p. 1574-1588 15 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
GTP-Binding Proteins
Intestines
Glucagon-Like Peptide 1
Taurolithocholic Acid
15 Citations (Scopus)

Lipid metabolism and lipophagy in cancer

Maan, M., Peters, J. M., Dutta, M. & Patterson, A. D., Oct 7 2018, In : Biochemical and Biophysical Research Communications. 504, 3, p. 582-589 8 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Tumors
Neoplasms
Lipids
Cells
2 Citations (Scopus)

Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice

Belton, K. R., Tian, Y., Zhang, L., Anitha, M., Smith, P. B., Perdew, G. H. & Patterson, A. D., Apr 6 2018, In : Journal of Proteome Research. 17, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Metabolomics
Human Mammary Glands
beta-Naphthoflavone
Liver

Multiplatform physiologic and metabolic phenotyping reveals microbial toxicity

Cai, J., Nichols, R. G., Koo, I., Kalikow, Z. A., Zhang, L., Tian, Y., Zhang, J., Smith, P. B. & Patterson, A. D., Nov 1 2018, In : mSystems. 3, 6, e00123.

Research output: Contribution to journalArticle

Flow cytometry
Physiology
Toxicity
intestinal microorganisms
Mass spectrometry
3 Citations (Scopus)

Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease

Dey, A., Allen, J. N., Fraser, J. W., Snyder, L. M., Tian, Y., Zhang, L., Paulson, R. F., Patterson, A., Cantorna, M. T. & Hankey-Giblin, P. A., Mar 19 2018, In : Frontiers in immunology. 9, MAR, 513.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Central Nervous System
Inflammation
Health
Nerve Tissue
3 Citations (Scopus)

Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice

Tian, Y., Nichols, R. G., Roy, P., Gui, W., Smith, P. B., Zhang, J., Lin, Y., Weaver, V., Cai, J., Patterson, A. D. & Cantorna, M. T-A., Jun 1 2018, In : Journal of Functional Foods. 45, p. 223-232 10 p.

Research output: Contribution to journalArticle

Agaricus
Prebiotics
Agaricus bisporus
Gluconeogenesis
gluconeogenesis
3 Citations (Scopus)
Calcitriol Receptors
Microbiota
Metabolism
Vitamin D
Anti-Bacterial Agents

Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model

Allen, J., Zhang, J., Quickel, M. D., Kennett, M. J., Patterson, A. D. & Giblin, P. H., Sep 7 2018, In : Journal of Proteome Research. 17, 9, p. 3268-3280 13 p.

Research output: Contribution to journalArticle

Nutrition
Liver
Fibrosis
Collagen
Diet

Structural and Functional Analysis of the Gut Microbiome for Toxicologists

Nichols, R. G., Cai, J., Murray, I. A., Koo, I., Smith, P. B., Perdew, G. H. & Patterson, A. D., Nov 1 2018, In : Current Protocols in Toxicology. 78, 1, e54.

Research output: Contribution to journalArticle

Functional analysis
Structural analysis
Metabolomics
Poisons
Metabolites
1 Citation (Scopus)
lactation stage
Micelles
micelles
skim milk
Caseins
16 Citations (Scopus)

The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23

Bora, S. A., Kennett, M. J., Smith, P. B., Patterson, A. D. & Cantorna, M. T., Mar 2 2018, In : Frontiers in immunology. 9, MAR, 408.

Research output: Contribution to journalArticle

Dihydroxycholecalciferols
Vitamin D
Microbiota
Citrobacter rodentium
Homeostasis
12 Citations (Scopus)
Vitamin A Deficiency
Vitamin A
Metabolism
Homeostasis
Liver
2017
27 Citations (Scopus)

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Xie, C., Yagai, T., Luo, Y., Liang, X., Chen, T., Wang, Q., Sun, D., Zhao, J., Ramakrishnan, S. K., Sun, L., Jiang, C., Xue, X., Tian, Y., Krausz, K. W., Patterson, A. D., Shah, Y. M., Wu, Y., Jiang, C. & Gonzalez, F. J., Nov 1 2017, In : Nature Medicine. 23, 11, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

Intestines
Obesity
Chemical activation
Liver
Ceramides
39 Citations (Scopus)

An intestinal farnesoid x receptor-ceramide signaling axis modulates hepatic gluconeogenesis in mice

Xie, C., Jiang, C., Shi, J., Gao, X., Sun, D., Sun, L., Wang, T., Takahashi, S., Anitha, M., Krausz, K. W., Patterson, A. D. & Gonzalez, F. J., Mar 1 2017, In : Diabetes. 66, 3, p. 613-626 14 p.

Research output: Contribution to journalArticle

Gluconeogenesis
Ceramides
Liver
Pyruvate Carboxylase
Acetyl-CoA Carboxylase
18 Citations (Scopus)

Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner

Hubbard, T. D., Murray, I. A., Nichols, R. G., Cassel, K., Podolsky, M., Kuzu, G., Tian, Y., Smith, P. B., Kennett, M. J., Patterson, A. D. & Perdew, G. H., Oct 1 2017, In : Journal of Functional Foods. 37, p. 685-698 14 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Brassica
colitis
broccoli
Colitis
3 Citations (Scopus)

Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA

DiMarzio, M., Rusconi, B., Yennawar, N. H., Eppinger, M., Patterson, A. D. & Dudley, E. G., Sep 2017, In : PloS one. 12, 9, e0183564.

Research output: Contribution to journalArticle

choloylglycine hydrolase
Lactobacillus johnsonii
beta acids
antagonists
receptors
54 Citations (Scopus)

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., Krausz, K. W., Xiang, R., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Oct 3 2017, In : Cell Metabolism. 26, 4, p. 672-685.e4

Research output: Contribution to journalArticle

Fasting
Obesity
Microbiota
White Adipose Tissue
Metabolic Diseases
19 Citations (Scopus)

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease

Gonzalez, F. J., Jiang, C., Xie, C. & Patterson, A. D., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 178-184 7 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Ceramides
Intestines
Bile Acids and Salts
Ileum
2 Citations (Scopus)
Lipogenesis
Emulsions
Running
Carbohydrates
Diet
6 Citations (Scopus)

Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice

Xiao, X., Yeoh, B. S., Saha, P., Tian, Y., Singh, V., Patterson, A. D. & Vijay-Kumar, M., Mar 1 2017, In : Journal of Nutritional Biochemistry. 41, p. 25-33 9 p.

Research output: Contribution to journalArticle

Siderophores
Nutrition
Modulation
Diet
Inflammation
11 Citations (Scopus)

Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation

Cai, J., Zhang, J., Tian, Y., Zhang, L., Hatzakis, E., Krausz, K. W., Smith, P. B., Gonzalez, F. J. & Patterson, A. D., Aug 1 2017, In : Analytical Chemistry. 89, 15, p. 7900-7906 7 p.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Gas chromatography
Nuclear magnetic resonance spectroscopy
Mass spectrometry
Butyric Acid
2016
10 Citations (Scopus)

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota

Cai, J., Zhang, L., Jones, R. A., Correll, J. B., Hatzakis, E., Smith, P. B., Gonzalez, F. J. & Patterson, A. D., Feb 5 2016, In : Journal of Proteome Research. 15, 2, p. 563-571 9 p.

Research output: Contribution to journalArticle

Antioxidants
Metabolomics
Pharmaceutical Preparations
Liver
Weight Gain
23 Citations (Scopus)
Aryl Hydrocarbon Receptors
Verrucomicrobia
Metagenomics
Metabolomics
Microbiota
39 Citations (Scopus)

Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism

Zhang, L., Xie, C., Nichols, R. G., Chan, S. H. J., Jiang, C., Hao, R., Smith, P. B., Cai, J., Simons, M. N., Hatzakis, E., Maranas, C. D., Gonzalez, F. J. & Patterson, A. D., Sep 1 2016, In : mSystems. 1, 5, e00070.

Research output: Contribution to journalArticle

Lipid Metabolism
intestinal microorganisms
lipid metabolism
Glycine
Receptor
5 Citations (Scopus)

Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction

Phillips, B. E., Geletzke, A. K., Smith, P. B., Podany, A. B., Chacon, A., Kelleher, S., Patterson, A. D. & Soybel, D., Mar 1 2016, In : Molecular Nutrition and Food Research. 60, 3, p. 672-681 10 p.

Research output: Contribution to journalArticle

Zinc
inflammation
animal models
zinc
Inflammation
12 Citations (Scopus)

Mass spectrometry-based metabolomics identifies longitudinal urinary metabolite profiles predictive of radiation-induced cancer

Cook, J. A., Chandramouli, G. V. R., Anver, M. R., Sowers, A. L., Thetford, A., Krausz, K. W., Gonzalez, F. J., Mitchell, J. B. & Patterson, A. D., Mar 15 2016, In : Cancer Research. 76, 6, p. 1569-1577 9 p.

Research output: Contribution to journalArticle

Radiation-Induced Neoplasms
Metabolomics
Mass Spectrometry
Radiation
Neoplasms
15 Citations (Scopus)

Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis

Dutta, M., Anitha, M., Smith, P. B., Chiaro, C. R., Maan, M., Chaudhury, K. & Patterson, A. D., Aug 5 2016, In : Journal of Proteome Research. 15, 8, p. 2626-2633 8 p.

Research output: Contribution to journalArticle

Metabolomics
Endometriosis
Phosphatidylcholines
Lipid Metabolism
Phosphatidylethanolamine N-Methyltransferase
5 Citations (Scopus)

Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice

Zhang, L., Krishnan, P., Ehresman, D. J., Smith, P. B., Dutta, M., Bagley, B. D., Chang, S. C., Butenhoff, J. L., Patterson, A. D. & Peters, J. M., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 186-197 12 p., kfw120.

Research output: Contribution to journalArticle

Oxidative stress
Choline
Oxidative Stress
Ions
Liver
52 Citations (Scopus)

Reversing methanogenesis to capture methane for liquid biofuel precursors

Soo, V. W. C., McAnulty, M. J., Tripathi, A., Zhu, F., Zhang, L., Hatzakis, E., Smith, P. B., Agrawal, S., Nazem-Bokaee, H., Gopalakrishnan, S., Salis, H. M., Ferry, J. G., Maranas, C. D., Patterson, A. D. & Wood, T. K., Jan 14 2016, In : Microbial Cell Factories. 15, 1, 11.

Research output: Contribution to journalArticle

Biofuels
Methane
Liquids
Coenzymes
Acetates
8 Citations (Scopus)

The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis

Yu, S., Allen, J. N., Dey, A., Zhang, L., Balandaram, G., Kennett, M. J., Xia, M., Xiong, N., Peters, J. M., Patterson, A. D. & Giblin, P. H., Jul 1 2016, In : Journal of Immunology. 197, 1, p. 256-265 10 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Atherosclerosis
Obesity
Macrophages
Diet
2015
86 Citations (Scopus)

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S., Patterson, A. D. & Perdew, G. H., Aug 3 2015, In : Scientific reports. 5, 12689.

Research output: Contribution to journalArticle

Indoles
Microbiota
Hydrocarbons
Ligands
Gastrointestinal Tract
216 Citations (Scopus)

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z. Z., Takahashi, S., Tanaka, N., Desai, D., Amin, S. G., Albert, I., Patterson, A. D. & Gonzalez, F. J., Jan 2 2015, In : Journal of Clinical Investigation. 125, 1, p. 386-402 17 p.

Research output: Contribution to journalArticle

Ceramides
Liver
Anti-Bacterial Agents
Bile Acids and Salts
Triglycerides
150 Citations (Scopus)

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S. G., Bisson, W. H., Liu, Y., Gavrilova, O., Patterson, A. D. & Gonzalez, F. J., Dec 15 2015, In : Nature communications. 6, 10166.

Research output: Contribution to journalArticle

obesity
intestines
Glycine
glycine
Intestines
16 Citations (Scopus)

Kernel approaches for differential expression analysis of mass spectrometry-based metabolomics data

Zhan, X., Patterson, A. D. & Ghosh, D., Dec 12 2015, In : BMC bioinformatics. 16, 1, 77.

Research output: Contribution to journalArticle

Metabolomics
Differential Expression
Mass Spectrometry
Mass spectrometry
kernel
57 Citations (Scopus)

Lack of soluble fiber drives diet-induced adiposity in mice

Chassaing, B., Miles-Brown, J., Pellizzon, M., Ulman, E., Ricci, M., Zhang, L., Patterson, A. D., Vijay-Kumar, M. & Gewirtz, A. T., Sep 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 7, p. G528-G541

Research output: Contribution to journalArticle

Adiposity
High Fat Diet
Diet
Inulin
Volatile Fatty Acids
41 Citations (Scopus)

Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice

Zhang, L., Hatzakis, E., Nichols, R. G., Hao, R., Correll, J., Smith, P. B., Chiaro, C. R., Perdew, G. H. & Patterson, A. D., Jul 7 2015, In : Environmental Science and Technology. 49, 13, p. 8067-8077 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Dioxins
Chemical activation
hydrocarbon
Metabolites