• 34570 Citations
  • 88 h-Index
1965 …2018

Research output per year

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Personal profile

Research interests

Dr. Anthony Pegg's research interests include polyamine metabolism and DNA repair research on the cellular physiology of polyamines.

Polyamines are small basic molecules essential for cell growth and differentiation. Their concentration is very tightly regulated within the cell and is altered by endocrine and other factors having trophic effects. The research is aimed at understanding metabolic pathways responsible for polyamine biosynthesis, degradation, and interconversion; factors responsible for regulating polyamine levels; polyamine roles in growth and differentiation; and design and application of specific inhibitors of polyamine production. Such inhibitors have already been shown to have potential therapeutic value and to be useful as research tools in studying polyamine function.

A second area of research concerns DNA repair enzymes' role in protecting against carcinogenesis by N-nitroso-compounds and other alkylating agents. An alkyltransferase, which removes alkyl groups from DNA, has been isolated and it has been shown that the level of this protein is both species and cell specific. There is a good correlation between the alkyltransferase content and resistance to carcinogenesis and mutagenesis by alkylating agents. Current research is aimed at studying the specificity of this system, factors controlling its activity, and investigating whether it is missing or reduced in certain hereditary conditions. Also, the possibility that transient inactivation of this DNA repair function can be used for cancer chemotherapy to augment the action of therapeutic alkylating agents is being investigated. A potent inhibitor, O6-benzylguanine, has been developed in Dr. Pegg's laboratory and in Phase 1 trials has been shown to be effective in depleting tumor cell alkyltransferase activity in patients with cancer. It is currently undergoing Phase 2 trials to determine its efficacy in improving chemotherapy.

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Projects

  • INHIBITION OF DNA REPAIR TO ENHANCE CHEMOTHERAPY

    Pegg, A., Gerson, S., Friedman, H. S., Schold, S. & Dolan, M. E.

    National Institutes of Health

    8/17/929/29/01

    Project: Research project

  • AMINOPROPYLTRANSFERASES

    Pegg, A.

    National Institutes of Health

    4/1/797/31/10

    Project: Research project

  • PERSISTENCE OF ALKYLATED DNA IN CARCINOGENESIS

    Pegg, A. & Kanugula, S.

    National Institutes of Health

    12/1/781/31/13

    Project: Research project

  • Research Output

    Introduction to the thematic minireview series: Sixty plus years of polyamine research

    Pegg, A. E., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18681-18692 12 p.

    Research output: Contribution to journalReview article

  • 4 Scopus citations

    Mammalian dna repair enzymes

    Pegg, A. E. & Bennett, R. A., Jan 1 2018, Enzymes of Nucleic Acid Synthesis and Modification: Volume 1: DNA Enzymes. CRC Press, p. 179-205 27 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Polyamine metabolism and cancer: treatments, challenges and opportunities

    Casero, R. A., Murray Stewart, T. & Pegg, A. E., Nov 1 2018, In : Nature Reviews Cancer. 18, 11, p. 681-695 15 p.

    Research output: Contribution to journalReview article

  • 57 Scopus citations

    Unique Characteristics of the Parasite Polyamine Pathway

    Pegg, A. E., Nov 6 2018, In : Structure. 26, 11, p. 1427-1429 3 p.

    Research output: Contribution to journalShort survey

  • Functions of polyamines in mammals

    Pegg, A. E., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14904-14912 9 p.

    Research output: Contribution to journalReview article

  • 132 Scopus citations