• 34273 Citations
  • 87 h-Index
1965 …2018
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Personal profile

Research interests

Dr. Anthony Pegg's research interests include polyamine metabolism and DNA repair research on the cellular physiology of polyamines.

Polyamines are small basic molecules essential for cell growth and differentiation. Their concentration is very tightly regulated within the cell and is altered by endocrine and other factors having trophic effects. The research is aimed at understanding metabolic pathways responsible for polyamine biosynthesis, degradation, and interconversion; factors responsible for regulating polyamine levels; polyamine roles in growth and differentiation; and design and application of specific inhibitors of polyamine production. Such inhibitors have already been shown to have potential therapeutic value and to be useful as research tools in studying polyamine function.

A second area of research concerns DNA repair enzymes' role in protecting against carcinogenesis by N-nitroso-compounds and other alkylating agents. An alkyltransferase, which removes alkyl groups from DNA, has been isolated and it has been shown that the level of this protein is both species and cell specific. There is a good correlation between the alkyltransferase content and resistance to carcinogenesis and mutagenesis by alkylating agents. Current research is aimed at studying the specificity of this system, factors controlling its activity, and investigating whether it is missing or reduced in certain hereditary conditions. Also, the possibility that transient inactivation of this DNA repair function can be used for cancer chemotherapy to augment the action of therapeutic alkylating agents is being investigated. A potent inhibitor, O6-benzylguanine, has been developed in Dr. Pegg's laboratory and in Phase 1 trials has been shown to be effective in depleting tumor cell alkyltransferase activity in patients with cancer. It is currently undergoing Phase 2 trials to determine its efficacy in improving chemotherapy.

Fingerprint Dive into the research topics where Anthony Pegg is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Polyamines Medicine & Life Sciences
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Adenosylmethionine Decarboxylase Medicine & Life Sciences
Ornithine Decarboxylase Medicine & Life Sciences
Spermidine Chemical Compounds
Putrescine Medicine & Life Sciences
DNA Medicine & Life Sciences
Eflornithine Medicine & Life Sciences

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Projects 1975 2017

Alkyl and Aryl Transferases
Drug Therapy
Alkylating Agents
Neoplasms
Carmustine

INHIBITION OF DNA REPAIR TO ENHANCE CHEMOTHERAPY

Pegg, A., Gerson, S., Friedman, H. S., Schold, S. & Dolan, M. E.

National Institutes of Health

8/17/929/29/01

Project: Research project

DNA Repair
Alkyl and Aryl Transferases
Carmustine
Drug Therapy
Neoplasms

AMINOPROPYLTRANSFERASES

Pegg, A.

National Institutes of Health

4/1/797/31/10

Project: Research project

Spermidine Synthase
Spermine
Polyamines
Spermine Synthase
Acetyltransferases

PERSISTENCE OF ALKYLATED DNA IN CARCINOGENESIS

Pegg, A. & Kanugula, S.

National Institutes of Health

12/1/781/31/13

Project: Research project

Carcinogenesis
DNA
Alkylation
Dimethylnitrosamine
Alkyl and Aryl Transferases

Research Output 1965 2018

4 Citations (Scopus)

Introduction to the thematic minireview series: Sixty plus years of polyamine research

Pegg, A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18681-18692 12 p.

Research output: Contribution to journalReview article

Polyamines
Research
Biochemical Phenomena
Protozoa
Biochemistry
1 Citation (Scopus)

Mammalian dna repair enzymes

Pegg, A. E. & Bennett, R. A., Jan 1 2018, Enzymes of Nucleic Acid Synthesis and Modification: Volume 1: DNA Enzymes. CRC Press, p. 179-205 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
Repair
DNA
Enzymes
Chromatin
38 Citations (Scopus)

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A., Nov 1 2018, In : Nature Reviews Cancer. 18, 11, p. 681-695 15 p.

Research output: Contribution to journalReview article

Polyamines
Neoplasms
Therapeutics
Carcinogenesis
Clinical Trials

Unique Characteristics of the Parasite Polyamine Pathway

Pegg, A. E., Nov 6 2018, In : Structure. 26, 11, p. 1427-1429 3 p.

Research output: Contribution to journalShort survey

Eukaryotic Initiation Factors
Gene Duplication
Spermidine
Drug Design
Polyamines
109 Citations (Scopus)

Functions of polyamines in mammals

Pegg, A. E., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14904-14912 9 p.

Research output: Contribution to journalReview article

Mammals
Spermidine
Polyamines
Spermine
Spermine Synthase