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1965 …2018
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Research Output 1965 2018

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Article
2013
10 Citations (Scopus)

Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Chowdhury, G., Cho, S. H., Pegg, A. & Guengerich, F. P., Dec 2 2013, In : Angewandte Chemie - International Edition. 52, 49, p. 12879-12882 4 p.

Research output: Contribution to journalArticle

Ethylene Dibromide
DNA
O(6)-Methylguanine-DNA Methyltransferase
Mutagenesis
Chemical modification
27 Citations (Scopus)

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

Koomoa, D. L. T., Geerts, D., Lange, I., Koster, J., Pegg, A. E., Feith, D. J. & Bachmann, A. S., Apr 1 2013, In : International journal of oncology. 42, 4, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

Eflornithine
Neuroblastoma
Ornithine Decarboxylase
G1 Phase Cell Cycle Checkpoints
Phosphorylation
20 Citations (Scopus)

DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells

Tretyakova, N. Y., Michaelson-Richie, E. D., Gherezghiher, T. B., Kurtz, J., Ming, X., Wickramaratne, S., Campion, M., Kanugula, S., Pegg, A. & Campbell, C., May 7 2013, In : Biochemistry. 52, 18, p. 3171-3181 11 p.

Research output: Contribution to journalArticle

Mutagenesis
Cell death
Cell Death
Cells
DNA
16 Citations (Scopus)

Enhancing Human Spermine Synthase Activity by Engineered Mutations

Zhang, Z., Zheng, Y., Petukh, M., Pegg, A., Ikeguchi, Y. & Alexov, E., Feb 1 2013, In : PLoS computational biology. 9, 2, e1002924.

Research output: Contribution to journalArticle

Spermine Synthase
mutation
Mutation
amino acid
Amino Acids
5 Citations (Scopus)

Kinetics of O 6 -pyridyloxobutyl-2′-deoxyguanosine repair by human O 6 -alkylguanine DNA alkyltransferase

Kotandeniya, D., Murphy, D., Yan, S., Park, S., Seneviratne, U., Koopmeiners, J. S., Pegg, A., Kanugula, S., Kassie, F. & Tretyakova, N., Jun 11 2013, In : Biochemistry. 52, 23, p. 4075-4088 14 p.

Research output: Contribution to journalArticle

O(6)-Methylguanine-DNA Methyltransferase
Deoxyguanosine
Repair
Nitrosamines
Kinetics
5 Citations (Scopus)

Role of aldehydes in the toxic and mutagenic effects of nitrosamines

Peterson, L. A., Urban, A. M., Vu, C. C., Cummings, M. E., Brown, L. C., Warmka, J. K., Li, L., Wattenberg, E. V., Patel, Y., Stram, D. O. & Pegg, A. E., Nov 4 2013, In : Chemical research in toxicology. 26, 10, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

Nitrosamines
Nitrosomethylurethane
Poisons
Aldehydes
Butanones
7 Citations (Scopus)

Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice

Feith, D. J., Pegg, A. E. & Fong, L. Y. Y., Mar 1 2013, In : Carcinogenesis. 34, 3, p. 570-576 7 p.

Research output: Contribution to journalArticle

Carcinogenesis
Zinc
Keratin-5
Neoplasms
nitrosobenzylmethylamine
2012
7 Citations (Scopus)

Characterization of transgenic mice with overexpression of spermidine synthase

Shi, C., Welsh, P. A., Sass-Kuhn, S., Wang, X., McCloskey, D. E., Pegg, A. E. & Feith, D. J., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 495-505 11 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Transgenic Mice
Spermidine
Polyamines
Spermine
1 Citation (Scopus)

Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography

Yamazaki, K., Ikeguchi, Y., Niwa, T., Hayashi, K., Iwaki, T., Ishii, I., Niitsu, M., Pegg, A. E. & Shirahata, A., 2012, In : Analytical Sciences. 28, 6, p. 621-624 4 p.

Research output: Contribution to journalArticle

Spermidine Synthase
High performance liquid chromatography
Spermine Synthase
Spermidine
Spermine
7 Citations (Scopus)

Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy

Giordano, E., Hillary, R. A., Vary, T. C., Pegg, A. E., Sumner, A. D., Caldarera, C. M., Zhang, X. Q., Song, J., Wang, J., Cheung, J. Y. & Shantz, L. M., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 507-518 12 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Ventricular Function
Cardiomegaly
Isoproterenol
Polyamines
20 Citations (Scopus)

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

Ishii, I., Ikeguchi, Y., Mano, H., Wada, M., Pegg, A. E. & Shirahata, A., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 619-626 8 p.

Research output: Contribution to journalArticle

3T3-L1 Cells
Adipogenesis
Polyamines
Metabolism
Spermidine
2011
4 Citations (Scopus)

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine

Šečkute, J., McCloskey, D. E., Thomas, H. J., Secrist, J. A., Pegg, A. E. & Ealick, S. E., Nov 1 2011, In : Protein Science. 20, 11, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Putrescine
Polyamines
Spermine Synthase
Enzymes
44 Citations (Scopus)

Brain infarction correlates more closely with acrolein than with reactive oxygen species

Saiki, R., Park, H., Ishii, I., Yoshida, M., Nishimura, K., Toida, T., Tatsukawa, H., Kojima, S., Ikeguchi, Y., Pegg, A. E., Kashiwagi, K. & Igarashi, K., Jan 28 2011, In : Biochemical and Biophysical Research Communications. 404, 4, p. 1044-1049 6 p.

Research output: Contribution to journalArticle

Brain Infarction
Acrolein
Reactive Oxygen Species
Brain
Spermine
20 Citations (Scopus)

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

Lee, S. B., Park, J. H., Folk, J. E., Deck, J. A., Pegg, A. E., Sokabe, M., Fraser, C. S. & Park, M. H., Jan 1 2011, In : Biochemical Journal. 433, 1, p. 205-213 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Acetylation
Acetyltransferases
Spermidine
Spermine
16 Citations (Scopus)

Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation

Green, R., Hanfrey, C. C., Elliott, K. A., Mccloskey, D. E., Wang, X., Kanugula, S., Pegg, A. E. & Michael, A. J., Aug 1 2011, In : Molecular Microbiology. 81, 4, p. 1109-1124 16 p.

Research output: Contribution to journalArticle

Proteobacteria
Diamines
Gene Fusion
Polyamines
Spermidine Synthase
8 Citations (Scopus)

Mass spectrometry based approach to study the kinetics of O 6-alkylguanine DNA alkyltransferase-mediated repair of O 6-pyridyloxobutyl-2′-deoxyguanosine adducts in DNA

Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S. & Tretyakova, N., Nov 21 2011, In : Chemical research in toxicology. 24, 11, p. 1966-1975 10 p.

Research output: Contribution to journalArticle

O(6)-Methylguanine-DNA Methyltransferase
Deoxyguanosine
DNA Adducts
Mass spectrometry
Mass Spectrometry
1 Citation (Scopus)

Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O 4BF) and metabolite in a non-human primate model

Chuk, M. K., Cole, D. E., McCully, C., Loktionova, N. A., Pegg, A. E., Parker, R. J., Pauly, G., Widemann, B. C., Balis, F. M. & Fox, E., Jun 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 6, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Metabolites
Primates
Cerebrospinal fluid
Plasmas
11 Citations (Scopus)

Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine

Pegg, A. E., Wang, X., Schwartz, C. E. & Mccloskey, D. E., Jan 1 2011, In : Biochemical Journal. 433, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

Spermine Synthase
S-Adenosylmethionine
Mammals
Polyamines
Nucleosides
19 Citations (Scopus)

Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).

Schwartz, C. E., Wang, X., Stevenson, R. E. & Pegg, A., May 25 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 437-445 9 p.

Research output: Contribution to journalArticle

Spermine Synthase
Polyamines
Spermidine Synthase
Intellectual Disability
Spermidine
1 Citation (Scopus)

Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.

Wang, X. & Pegg, A., May 24 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 159-170 12 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermine
Transgenic Mice
Putrescine
Spermidine
2010
7 Citations (Scopus)

Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells

Kalapila, A. G. & Pegg, A., Feb 3 2010, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 684, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Ethylene Dibromide
Mutation
CHO Cells
Hypoxanthine Phosphoribosyltransferase
4 Citations (Scopus)

Complexes of Thermotoga maritima S-adenosylmethionine decarboxylase provide insights into substrate specificity

Bale, S., Baba, K., McCloskey, D. E., Pegg, A. E. & Ealick, S. E., Feb 17 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Thermotoga maritima
Substrate Specificity
Polyamines
Catalytic Domain
21 Citations (Scopus)

Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases

Fang, Q., Kanugula, S., Tubbs, J. L., Tainer, J. A. & Pegg, A. E., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 8185-8195 11 p.

Research output: Contribution to journalArticle

Repair
DNA Repair
Nucleotides
Escherichia coli
Mutation
15 Citations (Scopus)

Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein

Aramini, J. M., Tubbs, J. L., Kanugula, S., Rossi, P., Ertekin, A., Maglaqui, M., Hamilton, K., Ciccosanti, C. T., Jiang, M., Xiao, R., Soong, T. T., Rost, B., Acton, T. B., Everett, J. K., Pegg, A. E., Tainer, J. A. & Montelione, G. T., Apr 30 2010, In : Journal of Biological Chemistry. 285, 18, p. 13736-13741 6 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
DNA Repair
Repair
DNA
Proteins
25 Citations (Scopus)

Synthesis and characterization of an O6-2′-deoxyguanosine- alkyl-O6-2′-deoxyguanosine interstrand cross-link in a 5′-GNC motif and repair by human O6-alkylguanine-DNA alkyltransferase

McManus, F. P., Fang, Q., Booth, J. D. M., Noronha, A. M., Pegg, A. E. & Wilds, C. J., Oct 7 2010, In : Organic and Biomolecular Chemistry. 8, 19, p. 4414-4426 13 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Repair
deoxyribonucleic acid
DNA
synthesis
38 Citations (Scopus)

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

Geerts, D., Koster, J., Albert, D., Koomoa, D. L. T., Feith, D. J., Pegg, A. E., Volckmann, R., Caron, H., Versteeg, R. & Bachmann, A. S., May 1 2010, In : International Journal of Cancer. 126, 9, p. 2012-2024 13 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Polyamines
Neuroblastoma
Genes
Messenger RNA
2009
30 Citations (Scopus)

A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome

Becerra-Solano, L. E., Butler, J., Castañeda-Cisneros, G., McCloskey, D. E., Wang, X., Pegg, A., Schwartz, C. E., Sánchez-Corona, J. & García-Ortiz, J. E., Mar 1 2009, In : American Journal of Medical Genetics, Part A. 149, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Missense Mutation
X-Linked Mental Retardation
Genes
Facial Asymmetry
12 Citations (Scopus)

Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides

Guza, R., Ma, L., Fang, Q., Pegg, A. E. & Tretyakova, N., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22601-22610 10 p.

Research output: Contribution to journalArticle

Methylation
Cytosine
Repair
DNA
Codon
8 Citations (Scopus)

Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins

Kalapila, A. G., Loktionova, N. A. & Pegg, A. E., Sep 22 2009, In : Environmental and Molecular Mutagenesis. 50, 6, p. 502-514 13 p.

Research output: Contribution to journalArticle

DNA
Cysteine
Epichlorohydrin
Mechlorethamine
DNA Adducts
78 Citations (Scopus)

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P. & 2 others, Pegg, A. & Tainer, J. A., Jun 11 2009, In : Nature. 459, 7248, p. 808-813 6 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Alkyl and Aryl Transferases
Schizosaccharomyces
DNA
17 Citations (Scopus)

Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

Koomoa, D. L. T., Borsics, T., Feith, D. J., Coleman, C. C., Wallick, C. J., Gamper, I., Pegg, A. E. & Bachmann, A. S., Jul 1 2009, In : Molecular cancer therapeutics. 8, 7, p. 2067-2075 9 p.

Research output: Contribution to journalArticle

4-amidinoindan-1-one 2'-amidinohydrazone
Proto-Oncogene Proteins c-mdm2
Adenosylmethionine Decarboxylase
Proto-Oncogene Proteins c-akt
Polyamines
11 Citations (Scopus)

Mouse models to investigate the function of spermine

Pegg, A. E. & Wang, X., May 1 2009, In : Communicative and Integrative Biology. 2, 3, p. 271-274 4 p.

Research output: Contribution to journalArticle

Spermine
spermine
Spermine Synthase
animal models
mice
20 Citations (Scopus)

New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C 8 substitution in structural analogues of S-adenosylmethionine

McCloskey, D. E., Bale, S., Secrist, J. A., Tiwari, A., Moss, T. H., Valiyaveettil, J., Brooks, W. H., Guida, W. C., Pegg, A. E. & Ealick, S. E., Mar 12 2009, In : Journal of Medicinal Chemistry. 52, 5, p. 1388-1407 20 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
S-Adenosylmethionine
Adenine
Catalytic Domain
Enzymes
68 Citations (Scopus)

S-Adenosylmethionine decarboxylase

Pegg, A. E., Dec 1 2009, In : Essays in biochemistry. 46, 1, p. 25-45 21 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Decarboxylation
Polyamines
Pyruvic Acid
Spermidine Synthase
25 Citations (Scopus)

Spermine synthase deficiency leads to deafness and a profound sensitivity to α-difluoromethylornithine

Wang, X., Levic, S., Gratton, M. A., Doyle, K. J., Yamoah, E. N. & Pegg, A. E., Jan 9 2009, In : Journal of Biological Chemistry. 284, 2, p. 930-937 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Eflornithine
Deafness
Polyamines
Audition
22 Citations (Scopus)

The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines

Li, L., Perdigao, J., Pegg, A. E., Lao, Y., Hecht, S. S., Lindgren, B. R., Reardon, J. T., Sancar, A., Wattenberg, E. V. & Peterson, L. A., Aug 17 2009, In : Chemical research in toxicology. 22, 8, p. 1464-1472 9 p.

Research output: Contribution to journalArticle

Nitrosamines
Tobacco
Cytotoxicity
DNA Repair
Repair
22 Citations (Scopus)

Topologies of Complexes Containing O6-Alkylguanine-DNA Alkyltransferase and DNA

Adams, C. A., Melikishvili, M., Rodgers, D. W., Rasimas, J. J., Pegg, A. & Fried, M. G., Jun 5 2009, In : Journal of Molecular Biology. 389, 2, p. 248-263 16 p.

Research output: Contribution to journalArticle

DNA
Proteins
Alkylating Agents
B-Form DNA
Circular DNA
2008
17 Citations (Scopus)

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide

Kalapila, A. G., Loktionova, N. A. & Pegg, A. E., Sep 1 2008, In : Chemical research in toxicology. 21, 9, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Toxicity
DNA
Ethylene Dibromide
Mutation
48 Citations (Scopus)

Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A. E. & Tretyakova, N., Apr 1 2008, In : Chemical research in toxicology. 21, 4, p. 787-795 9 p.

Research output: Contribution to journalArticle

Mechlorethamine
DNA Repair
Repair
DNA
Guanine
67 Citations (Scopus)

Crystal structure of human spermine synthase: Implications of substrate binding and catalytic mechanism

Wu, H., Min, J., Zeng, H., McCloskey, D. E., Ikeguchi, Y., Loppnau, P., Michael, A. J., Pegg, A. E. & Plotnikov, A. N., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 16135-16146 12 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermidine Synthase
Crystal structure
Spermine
Dimerization
13 Citations (Scopus)

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications

Philip, S., Swaminathan, S., Kuznetsov, S. G., Kanugula, S., Biswas, K., Chang, S., Loktionova, N. A., Haines, D. C., Kaldis, P., Pegg, A. E. & Sharan, S. K., Dec 1 2008, In : Cancer Research. 68, 23, p. 9973-9981 9 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
DNA Repair
Neoplasms
Germ-Line Mutation
Alkylating Agents
13 Citations (Scopus)

Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

Fang, Q., Loktionova, N. A., Moschel, R. C., Javanmard, S., Pauly, G. T. & Pegg, A., Feb 1 2008, In : Biochemical Pharmacology. 75, 3, p. 618-626 9 p.

Research output: Contribution to journalArticle

Folic Acid
Clinical Trials
Esters
Deoxyguanosine
Alkylating Agents
27 Citations (Scopus)

Expression of arginase II in prostate cancer

Mumenthaler, S. M., Yu, H., Tze, S., Cederbaum, S. D., Pegg, A., Seligson, D. B. & Grody, W. W., Feb 1 2008, In : International journal of oncology. 32, 2, p. 357-365 9 p.

Research output: Contribution to journalArticle

Arginase
Prostatic Neoplasms
Androgens
Cell Line
Polyamines
22 Citations (Scopus)

Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs

Melikishvili, M., Rasimas, J. J., Pegg, A. & Fried, M. G., Dec 30 2008, In : Biochemistry. 47, 52, p. 13754-13763 10 p.

Research output: Contribution to journalArticle

DNA
Proteins
DNA Adducts
Binding Sites
Chromatin Assembly and Disassembly
37 Citations (Scopus)

New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome

de Alencastro, G., McCloskey, D. E., Kliemann, S. E., Maranduba, C. M. C., Pegg, A., Wang, X., Bertola, D. R., Schwartz, C. E., Passos-Bueno, M. R. & Sertié, A. L., Jan 1 2008, In : Journal of medical genetics. 45, 8, p. 539-543 5 p.

Research output: Contribution to journalArticle

Spermine Synthase
X-Linked Mental Retardation
Mutation
Proteins
Genetic Databases
34 Citations (Scopus)

Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase

Fang, Q., Noronha, A. M., Murphy, S. P., Wilds, C. J., Tubbs, J. L., Tainer, J. A., Chowdhury, G., Guengerich, F. P. & Pegg, A. E., Oct 14 2008, In : Biochemistry. 47, 41, p. 10892-10903 12 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Guanine
Catalytic Domain
Repair
Heptanes
24 Citations (Scopus)

Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase

Bale, S., Lopez, M. M., Makhatadze, G. I., Fang, Q., Pegg, A. E. & Ealick, S. E., Dec 16 2008, In : Biochemistry. 47, 50, p. 13404-13417 14 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Putrescine
Chemical activation
Catalytic Domain
Static Electricity
4 Citations (Scopus)

Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii

Soriano, E. V., McCloskey, D. E., Kinsland, C., Pegg, A. E. & Ealick, S. E., Mar 19 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 4, p. 377-382 6 p.

Research output: Contribution to journalArticle

Methanocaldococcus
Mutant Proteins
decarboxylation
Decarboxylation
proteins
18 Citations (Scopus)

Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6- benzylguanine

Pauly, G. T., Loktionova, N. A., Fang, Q., Vankayala, S. L., Guida, W. C. & Pegg, A., Nov 27 2008, In : Journal of Medicinal Chemistry. 51, 22, p. 7144-7153 10 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
O(6)-Methylguanine-DNA Methyltransferase
Alkylating Agents
Hydrogen
Linear Models
61 Citations (Scopus)

The α9β1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel

DeHart, G. W., Jin, T., McCloskey, D. E., Pegg, A. E. & Sheppard, D., May 20 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 20, p. 7188-7193 6 p.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Spermine
Polyamines
Integrins
Cell Movement