• 34633 Citations
  • 88 h-Index
1965 …2018

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2013

Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Chowdhury, G., Cho, S. H., Pegg, A. & Guengerich, F. P., Dec 2 2013, In : Angewandte Chemie - International Edition. 52, 49, p. 12879-12882 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

Koomoa, D. L. T., Geerts, D., Lange, I., Koster, J., Pegg, A. E., Feith, D. J. & Bachmann, A. S., Apr 1 2013, In : International journal of oncology. 42, 4, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells

Tretyakova, N. Y., Michaelson-Richie, E. D., Gherezghiher, T. B., Kurtz, J., Ming, X., Wickramaratne, S., Campion, M., Kanugula, S., Pegg, A. E. & Campbell, C., May 7 2013, In : Biochemistry. 52, 18, p. 3171-3181 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Enhancing Human Spermine Synthase Activity by Engineered Mutations

Zhang, Z., Zheng, Y., Petukh, M., Pegg, A., Ikeguchi, Y. & Alexov, E., Feb 1 2013, In : PLoS computational biology. 9, 2, e1002924.

Research output: Contribution to journalArticle

16 Scopus citations

Kinetics of O6-pyridyloxobutyl-2′-deoxyguanosine repair by human O6-alkylguanine DNA alkyltransferase

Kotandeniya, D., Murphy, D., Yan, S., Park, S., Seneviratne, U., Koopmeiners, J. S., Pegg, A., Kanugula, S., Kassie, F. & Tretyakova, N., Jun 11 2013, In : Biochemistry. 52, 23, p. 4075-4088 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of aldehydes in the toxic and mutagenic effects of nitrosamines

Peterson, L. A., Urban, A. M., Vu, C. C., Cummings, M. E., Brown, L. C., Warmka, J. K., Li, L., Wattenberg, E. V., Patel, Y., Stram, D. O. & Pegg, A. E., Nov 4 2013, In : Chemical research in toxicology. 26, 10, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice

Feith, D. J., Pegg, A. E. & Fong, L. Y. Y., Mar 1 2013, In : Carcinogenesis. 34, 3, p. 570-576 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Characterization of transgenic mice with overexpression of spermidine synthase

Shi, C., Welsh, P. A., Sass-Kuhn, S., Wang, X., McCloskey, D. E., Pegg, A. E. & Feith, D. J., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 495-505 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography

Yamazaki, K., Ikeguchi, Y., Niwa, T., Hayashi, K., Iwaki, T., Ishii, I., Niitsu, M., Pegg, A. E. & Shirahata, A., 2012, In : Analytical Sciences. 28, 6, p. 621-624 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy

Giordano, E., Hillary, R. A., Vary, T. C., Pegg, A. E., Sumner, A. D., Caldarera, C. M., Zhang, X. Q., Song, J., Wang, J., Cheung, J. Y. & Shantz, L. M., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 507-518 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

Ishii, I., Ikeguchi, Y., Mano, H., Wada, M., Pegg, A. E. & Shirahata, A., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 619-626 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine

Šečkute, J., McCloskey, D. E., Thomas, H. J., Secrist, J. A., Pegg, A. E. & Ealick, S. E., Nov 1 2011, In : Protein Science. 20, 11, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Brain infarction correlates more closely with acrolein than with reactive oxygen species

Saiki, R., Park, H., Ishii, I., Yoshida, M., Nishimura, K., Toida, T., Tatsukawa, H., Kojima, S., Ikeguchi, Y., Pegg, A. E., Kashiwagi, K. & Igarashi, K., Jan 28 2011, In : Biochemical and Biophysical Research Communications. 404, 4, p. 1044-1049 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

Lee, S. B., Park, J. H., Folk, J. E., Deck, J. A., Pegg, A. E., Sokabe, M., Fraser, C. S. & Park, M. H., Jan 1 2011, In : Biochemical Journal. 433, 1, p. 205-213 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation

Green, R., Hanfrey, C. C., Elliott, K. A., Mccloskey, D. E., Wang, X., Kanugula, S., Pegg, A. E. & Michael, A. J., Aug 1 2011, In : Molecular Microbiology. 81, 4, p. 1109-1124 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mass spectrometry based approach to study the kinetics of O 6-alkylguanine DNA alkyltransferase-mediated repair of O 6-pyridyloxobutyl-2′-deoxyguanosine adducts in DNA

Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S. & Tretyakova, N., Nov 21 2011, In : Chemical research in toxicology. 24, 11, p. 1966-1975 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O 4BF) and metabolite in a non-human primate model

Chuk, M. K., Cole, D. E., McCully, C., Loktionova, N. A., Pegg, A. E., Parker, R. J., Pauly, G., Widemann, B. C., Balis, F. M. & Fox, E., Jun 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 6, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine

Pegg, A. E., Wang, X., Schwartz, C. E. & Mccloskey, D. E., Jan 1 2011, In : Biochemical Journal. 433, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).

Schwartz, C. E., Wang, X., Stevenson, R. E. & Pegg, A., May 25 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 437-445 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.

Wang, X. & Pegg, A., May 24 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 159-170 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2010

Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells

Kalapila, A. G. & Pegg, A. E., Feb 3 2010, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 684, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Complexes of Thermotoga maritima S-adenosylmethionine decarboxylase provide insights into substrate specificity

Bale, S., Baba, K., McCloskey, D. E., Pegg, A. E. & Ealick, S. E., Feb 17 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases

Fang, Q., Kanugula, S., Tubbs, J. L., Tainer, J. A. & Pegg, A. E., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 8185-8195 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein

Aramini, J. M., Tubbs, J. L., Kanugula, S., Rossi, P., Ertekin, A., Maglaqui, M., Hamilton, K., Ciccosanti, C. T., Jiang, M., Xiao, R., Soong, T. T., Rost, B., Acton, T. B., Everett, J. K., Pegg, A. E., Tainer, J. A. & Montelione, G. T., Apr 30 2010, In : Journal of Biological Chemistry. 285, 18, p. 13736-13741 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Synthesis and characterization of an O6-2′-deoxyguanosine- alkyl-O6-2′-deoxyguanosine interstrand cross-link in a 5′-GNC motif and repair by human O6-alkylguanine-DNA alkyltransferase

McManus, F. P., Fang, Q., Booth, J. D. M., Noronha, A. M., Pegg, A. E. & Wilds, C. J., Oct 7 2010, In : Organic and Biomolecular Chemistry. 8, 19, p. 4414-4426 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

Geerts, D., Koster, J., Albert, D., Koomoa, D. L. T., Feith, D. J., Pegg, A. E., Volckmann, R., Caron, H., Versteeg, R. & Bachmann, A. S., May 1 2010, In : International Journal of Cancer. 126, 9, p. 2012-2024 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2009

A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome

Becerra-Solano, L. E., Butler, J., Castañeda-Cisneros, G., McCloskey, D. E., Wang, X., Pegg, A., Schwartz, C. E., Sánchez-Corona, J. & García-Ortiz, J. E., Mar 1 2009, In : American Journal of Medical Genetics, Part A. 149, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides

Guza, R., Ma, L., Fang, Q., Pegg, A. E. & Tretyakova, N., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22601-22610 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins

Kalapila, A. G., Loktionova, N. A. & Pegg, A. E., Sep 22 2009, In : Environmental and Molecular Mutagenesis. 50, 6, p. 502-514 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P. & 2 others, Pegg, A. & Tainer, J. A., Jun 11 2009, In : Nature. 459, 7248, p. 808-813 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

Koomoa, D. L. T., Borsics, T., Feith, D. J., Coleman, C. C., Wallick, C. J., Gamper, I., Pegg, A. E. & Bachmann, A. S., Jul 1 2009, In : Molecular cancer therapeutics. 8, 7, p. 2067-2075 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mouse models to investigate the function of spermine

Pegg, A. E. & Wang, X., May 1 2009, In : Communicative and Integrative Biology. 2, 3, p. 271-274 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C 8 substitution in structural analogues of S-adenosylmethionine

McCloskey, D. E., Bale, S., Secrist, J. A., Tiwari, A., Moss, T. H., Valiyaveettil, J., Brooks, W. H., Guida, W. C., Pegg, A. E. & Ealick, S. E., Mar 12 2009, In : Journal of Medicinal Chemistry. 52, 5, p. 1388-1407 20 p.

Research output: Contribution to journalArticle

21 Scopus citations

S-Adenosylmethionine decarboxylase

Pegg, A. E., Dec 1 2009, In : Essays in biochemistry. 46, 1, p. 25-45 21 p.

Research output: Contribution to journalArticle

70 Scopus citations

Spermine synthase deficiency leads to deafness and a profound sensitivity to α-difluoromethylornithine

Wang, X., Levic, S., Gratton, M. A., Doyle, K. J., Yamoah, E. N. & Pegg, A. E., Jan 9 2009, In : Journal of Biological Chemistry. 284, 2, p. 930-937 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines

Li, L., Perdigao, J., Pegg, A. E., Lao, Y., Hecht, S. S., Lindgren, B. R., Reardon, J. T., Sancar, A., Wattenberg, E. V. & Peterson, L. A., Aug 17 2009, In : Chemical research in toxicology. 22, 8, p. 1464-1472 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Topologies of Complexes Containing O6-Alkylguanine-DNA Alkyltransferase and DNA

Adams, C. A., Melikishvili, M., Rodgers, D. W., Rasimas, J. J., Pegg, A. E. & Fried, M. G., Jun 5 2009, In : Journal of Molecular Biology. 389, 2, p. 248-263 16 p.

Research output: Contribution to journalArticle

22 Scopus citations
2008

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide

Kalapila, A. G., Loktionova, N. A. & Pegg, A. E., Sep 1 2008, In : Chemical research in toxicology. 21, 9, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A. E. & Tretyakova, N., Apr 1 2008, In : Chemical research in toxicology. 21, 4, p. 787-795 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Crystal structure of human spermine synthase: Implications of substrate binding and catalytic mechanism

Wu, H., Min, J., Zeng, H., McCloskey, D. E., Ikeguchi, Y., Loppnau, P., Michael, A. J., Pegg, A. E. & Plotnikov, A. N., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 16135-16146 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications

Philip, S., Swaminathan, S., Kuznetsov, S. G., Kanugula, S., Biswas, K., Chang, S., Loktionova, N. A., Haines, D. C., Kaldis, P., Pegg, A. E. & Sharan, S. K., Dec 1 2008, In : Cancer Research. 68, 23, p. 9973-9981 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

Fang, Q., Loktionova, N. A., Moschel, R. C., Javanmard, S., Pauly, G. T. & Pegg, A., Feb 1 2008, In : Biochemical Pharmacology. 75, 3, p. 618-626 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Expression of arginase II in prostate cancer

Mumenthaler, S. M., Yu, H., Tze, S., Cederbaum, S. D., Pegg, A. E., Seligson, D. B. & Grody, W. W., Feb 1 2008, In : International journal of oncology. 32, 2, p. 357-365 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs

Melikishvili, M., Rasimas, J. J., Pegg, A. & Fried, M. G., Dec 30 2008, In : Biochemistry. 47, 52, p. 13754-13763 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome

de Alencastro, G., McCloskey, D. E., Kliemann, S. E., Maranduba, C. M. C., Pegg, A., Wang, X., Bertola, D. R., Schwartz, C. E., Passos-Bueno, M. R. & Sertié, A. L., Jan 1 2008, In : Journal of medical genetics. 45, 8, p. 539-543 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase

Fang, Q., Noronha, A. M., Murphy, S. P., Wilds, C. J., Tubbs, J. L., Tainer, J. A., Chowdhury, G., Guengerich, F. P. & Pegg, A. E., Oct 14 2008, In : Biochemistry. 47, 41, p. 10892-10903 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase

Bale, S., Lopez, M. M., Makhatadze, G. I., Fang, Q., Pegg, A. E. & Ealick, S. E., Dec 16 2008, In : Biochemistry. 47, 50, p. 13404-13417 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii

Soriano, E. V., McCloskey, D. E., Kinsland, C., Pegg, A. E. & Ealick, S. E., Mar 19 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 4, p. 377-382 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6- benzylguanine

Pauly, G. T., Loktionova, N. A., Fang, Q., Vankayala, S. L., Guida, W. C. & Pegg, A., Nov 27 2008, In : Journal of Medicinal Chemistry. 51, 22, p. 7144-7153 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

The α9β1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel

DeHart, G. W., Jin, T., McCloskey, D. E., Pegg, A. E. & Sheppard, D., May 20 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 20, p. 7188-7193 6 p.

Research output: Contribution to journalArticle

65 Scopus citations