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1965 …2018
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Research Output 1965 2018

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Article
120 Citations (Scopus)

[23] Ornithine Decarboxylase (Mouse Kidney)

Seely, J. E. & Pegg, A., Jan 1 1983, In : Methods in Enzymology. 94, C, p. 158-161 4 p.

Research output: Contribution to journalArticle

Inbred Strains Mice
Ornithine Decarboxylase
Affinity Chromatography
Gel Chromatography
Kidney
44 Citations (Scopus)

2-Amino-O4-benzylpteridine derivatives: Potent inactivators of O6-alkylguanine-DNA alkyltransferase

Nelson, M. E., Loktionova, N. A., Pegg, A. E. & Moschel, R. C., Jul 1 2004, In : Journal of Medicinal Chemistry. 47, 15, p. 3887-3891 5 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Carmustine
Carboxylic Acids
Folic Acid
Acids
94 Citations (Scopus)

8-Substituted O6-Benzylguanine, Substituted 6(4)-(Benzyloxy)pyrimidine, and Related Derivatives as Inactivators of Human O6-Alkylguanine-DNA Alkyltransfer ase

Chae, M. Y., Swenn, K., Kanugula, S., Dolan, M. E., Pegg, A. & Moschel, R. C., Jan 1 1995, In : Journal of Medicinal Chemistry. 38, 2, p. 359-365 7 p.

Research output: Contribution to journalArticle

Pyrimidines
DNA
Purines
Colon
Alkyl and Aryl Transferases
28 Citations (Scopus)
Deoxyribonuclease (Pyrimidine Dimer)
Deoxyribonuclease I
DNA Repair
Escherichia coli
Recombinant Proteins
10 Citations (Scopus)
RNA Polymerase I
Phosphorylation
Ornithine Decarboxylase
Nuclear Proteins
Phosphotransferases
20 Citations (Scopus)

Acetylation of Decarboxylated S-Adenosylmethionine by Mammalian Cells

Pegg, A., Wechter, R. S., Clark, R. S., Wiest, L. & Erwin, B. G., Jan 1 1986, In : Biochemistry. 25, 2, p. 379-384 6 p.

Research output: Contribution to journalArticle

Acetylation
Cells
Histones
Eflornithine
Spermidine
36 Citations (Scopus)

Activation of bis-electrophiles to mutagenic conjugates by human O 6-alkylgvanine-DNA alkyltransferase

Valadez, J. G., Liu, L., Loktionova, N. A., Pegg, A. & Guengerich, F. P., Jul 1 2004, In : Chemical research in toxicology. 17, 7, p. 972-982 11 p.

Research output: Contribution to journalArticle

Ethylene Dibromide
Chemical activation
Mutation
Salmonella
DNA
30 Citations (Scopus)

Activation of Human O6-Alkylguanine-DNA Alkyltransferase by DNA

Goodtzova, K., Crone, T. M. & Pegg, A. E., Jul 1 1994, In : Biochemistry. 33, 28, p. 8385-8390 6 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Chemical activation
Guanine
DNA
Oligodeoxyribonucleotides
150 Citations (Scopus)

Active and alkylated human AGT structures: A novel zinc site, inhibitor and extrahelical base binding

Daniels, D. S., Mol, C. D., Arvai, A. S., Kanugula, S., Pegg, A. & Tainer, J. A., Apr 3 2000, In : EMBO Journal. 19, 7, p. 1719-1730 12 p.

Research output: Contribution to journalArticle

Zinc
Alkylation
Helix-Turn-Helix Motifs
Cysteine
DNA
23 Citations (Scopus)

Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase

Rasimas, J. J., Dalessio, P., Ropson, I., Pegg, A. & Fried, M. G., Jan 1 2004, In : Protein Science. 13, 1, p. 301-305 5 p.

Research output: Contribution to journalArticle

Alkylation
Catalytic Domain
Ubiquitination
DNA
Proteins
147 Citations (Scopus)

Activity of Temozolomide in the Treatment of Central Nervous System Tumor Xenografts

Friedman, H. S., Dolan, M. E., Pegg, A. E., Marcelli, S., Keir, S., Catino, J. J., Bigner, D. D. & Schold, S. C., Jul 1 1995, In : Cancer Research. 55, 13, p. 2853-2857 5 p.

Research output: Contribution to journalArticle

temozolomide
Central Nervous System Neoplasms
Heterografts
Glioma
Medulloblastoma

Administration of Ethylnitrosourea to Neonate Hamsters Increases Growth and Frequency of SV40-Induced Fibrosarcomas

Choudhury, S., Pegg, A. E., Kreider, J. W., Mayo, D. R. & Howett, M. K., Oct 1989, In : Proceedings of the Society for Experimental Biology and Medicine. 192, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Ethylnitrosourea
Simian virus 40
Fibrosarcoma
Viruses
Cricetinae
38 Citations (Scopus)

Alkylating intermediates in nitrosamine metabolism

Magee, P. N., Nicoll, J. W., Pegg, A. & Swann, P. F., Dec 1 1975, In : Biochemical Society transactions. 3, 1, p. 62-65 4 p.

Research output: Contribution to journalArticle

Ethylnitrosourea
Dimethylnitrosamine
Nitrosamines
Alkylating Agents
Guanine
9 Citations (Scopus)
Archaeoglobus fulgidus
Alkylation
Molecular mass
Repair
Purification
16 Citations (Scopus)

Alkylation of dna and carcinogenicity of w-nitroso compounds

Montesano, R., Pegg, A. E. & Margison, G. P., Jan 1 1980, In : Journal of Toxicology and Environmental Health. 6, 5-6, p. 81-88 8 p.

Research output: Contribution to journalArticle

Nitroso Compounds
Alkylation
DNA
Nitrosamines
Alkylating Agents
143 Citations (Scopus)

Alkylation of DNA in rat tissues following administration of streptozotocin

Bennett, R. A. & Pegg, A. E., Jul 1 1981, In : Cancer Research. 41, 7, p. 2786-2790 5 p.

Research output: Contribution to journalArticle

Alkylation
Streptozocin
DNA Methylation
Kidney
DNA
45 Citations (Scopus)

Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes

Umbenhauer, D. R. & Pegg, A. E., Sep 1 1981, In : Cancer Research. 41, p. 3471-3474 4 p.

Research output: Contribution to journalArticle

Dimethylnitrosamine
Alkylation
Hepatocytes
DNA
DNA Methylation
4 Citations (Scopus)

Alkylation of messenger RNA by dimethylnitrosamine

Pegg, A. & Jackson, A., Jan 1 1976, In : Chemico-Biological Interactions. 12, 3-4, p. 279-284 6 p.

Research output: Contribution to journalArticle

Dimethylnitrosamine
Alkylation
Methyl Methanesulfonate
Nuclear RNA
Ribosomal RNA
57 Citations (Scopus)

Alkylation of Nucleic Acids and Metabolism of Small Doses of Dimethylnitrosamine in the Rat

Pegg, A. E. & Perry, W., Aug 1 1981, In : Cancer Research. 41, 8, p. 3128-3132 5 p.

Research output: Contribution to journalArticle

Dimethylnitrosamine
Alkylation
Nucleic Acids
Kidney
DNA
101 Citations (Scopus)
Dimethylnitrosamine
Alkylation
Liver
DNA
Guanine
22 Citations (Scopus)

Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea

Pegg, A. E., Jun 1973, In : Chemico-Biological Interactions. 6, 6, p. 393-406 14 p.

Research output: Contribution to journalArticle

Ethylnitrosourea
Methylnitrosourea
Alkylation
Transfer RNA
Nucleic Acids
17 Citations (Scopus)

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide

Kalapila, A. G., Loktionova, N. A. & Pegg, A. E., Sep 1 2008, In : Chemical research in toxicology. 21, 9, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Toxicity
DNA
Ethylene Dibromide
Mutation
7 Citations (Scopus)

Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells

Kalapila, A. G. & Pegg, A., Feb 3 2010, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 684, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Ethylene Dibromide
Mutation
CHO Cells
Hypoxanthine Phosphoribosyltransferase
53 Citations (Scopus)
DNA Repair
Alanine
Arginine
Repair
DNA
26 Citations (Scopus)

Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6- benzylguanine

Xu-Welliver, M., Leitão, J., Kanugula, S. & Pegg, A., Apr 1 1999, In : Cancer Research. 59, 7, p. 1514-1519 6 p.

Research output: Contribution to journalArticle

Histidine
Tyrosine
DNA Repair
Lysine
Nitrosoguanidines
32 Citations (Scopus)

Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues

McCloskey, D. E. & Pegg, A. E., Sep 15 2000, In : Journal of Biological Chemistry. 275, 37, p. 28708-28714 7 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Polyamines
Enzyme Induction
46 Citations (Scopus)

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase

Crone, T. M., Goodtzova, K. & Pegg, A., May 15 1996, In : Mutation Research - DNA Repair. 363, 1, p. 15-25 11 p.

Research output: Contribution to journalArticle

Human Activities
Methylnitronitrosoguanidine
Amino Acids
Mutation
Complex Mixtures
54 Citations (Scopus)
Adenosylmethionine Decarboxylase
Enzyme Precursors
Putrescine
Catalyst activity
Amino Acids
30 Citations (Scopus)

A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome

Becerra-Solano, L. E., Butler, J., Castañeda-Cisneros, G., McCloskey, D. E., Wang, X., Pegg, A., Schwartz, C. E., Sánchez-Corona, J. & García-Ortiz, J. E., Mar 1 2009, In : American Journal of Medical Genetics, Part A. 149, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Missense Mutation
X-Linked Mental Retardation
Genes
Facial Asymmetry
22 Citations (Scopus)

An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress

Poulin, R., Wechter, R. S. & Pegg, A. E., Jul 23 1991, In : Journal of Biological Chemistry. 266, 10, p. 6142-6151 10 p.

Research output: Contribution to journalArticle

Leukemia L1210
Putrescine
Growth
Ornithine Decarboxylase
Osmotic Pressure
23 Citations (Scopus)

A new model for how O6-methylguanine-DNA methyltransferase binds DNA

Vora, R. A., Pegg, A. E. & Ealick, S. E., Jul 1 1998, In : Proteins: Structure, Function and Genetics. 32, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle

Guanine
Methyltransferases
DNA
Catalytic Domain
Nucleotide Motifs
63 Citations (Scopus)

Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis

Fong, L. Y. Y., Feith, D. J. & Pegg, A. E., Jul 15 2003, In : Cancer Research. 63, 14, p. 3945-3954 10 p.

Research output: Contribution to journalArticle

nitrosobenzylmethylamine
Transgenic Mice
Zinc
Carcinogenesis
Cell Proliferation
33 Citations (Scopus)

A reappraisal of the effects of adenosine 3':5'-cyclic monophosphate on the function and morphology of the rat prostate gland.

Mangan, F. R., Pegg, A. E. & Mainwaring, I. P., May 1973, In : The Biochemical journal. 134, 1, p. 129-142 14 p.

Research output: Contribution to journalArticle

Cyproterone
Ultraviolet Spectrophotometry
S-Adenosylmethionine
Ornithine
Carboxy-Lyases
86 Citations (Scopus)

A Single Amino Acid Change in Human O6-Alkylguanine-DNA Alkyltransferase Decreasing Sensitivity to Inactivation by O6-Benzylguanine

Crone, U. M. & Pegg, A., Jan 1 1993, In : Cancer Research. 53, 20, p. 4750-4753 4 p.

Research output: Contribution to journalArticle

Amino Acids
Guanine
Escherichia coli Proteins
Proline
Alkylating Agents
12 Citations (Scopus)

Assay of Aminopropyltransferases

Pegg, A., Jan 1 1983, In : Methods in Enzymology. 94, C, p. 260-265 6 p.

Research output: Contribution to journalArticle

Spermidine Synthase
S-Adenosylmethionine
DEAE-Cellulose Chromatography
Decarboxylation
Transferases
22 Citations (Scopus)

Assay of mammalian ornithine decarboxylase activity using [14C]ornithine.

Coleman, C. & Pegg, A., Jan 1 1998, In : Methods in molecular biology (Clifton, N.J.). 79, p. 41-44 4 p.

Research output: Contribution to journalArticle

Carbon Radioisotopes
Scintillation Counting
Ornithine
Ornithine Decarboxylase
Mammals
10 Citations (Scopus)

Assay of mammalian S-adenosylmethionine decarboxylase activity.

Shantz, L. & Pegg, A., Jan 1 1998, In : Methods in molecular biology (Clifton, N.J.). 79, p. 45-49 5 p.

Research output: Contribution to journalArticle

Carbon Radioisotopes
Adenosylmethionine Decarboxylase
Scintillation Counting
S-Adenosylmethionine
Mammals
14 Citations (Scopus)

Assay of spermidine and spermine synthases.

Wiest, L. & Pegg, A. E., 1998, In : Methods in molecular biology (Clifton, N.J.). 79, p. 51-57 7 p.

Research output: Contribution to journalArticle

Sulfur Radioisotopes
Spermine Synthase
Spermidine Synthase
Isotope Labeling
S-Adenosylmethionine
43 Citations (Scopus)

Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of α-[5-14C]difluoromethylornithine

Pegg, A. E., Seely, J. & Zagon, I. S., Jan 1 1982, In : Science. 217, 4554, p. 68-70 3 p.

Research output: Contribution to journalArticle

Eflornithine
Ornithine Decarboxylase
Kidney
Androgens
Enzymes
12 Citations (Scopus)

Autoradiographic Localization of Ornithine Decarboxylase

Zagon, I., Seely, J. E. & Pegg, A., Jan 1 1983, In : Methods in Enzymology. 94, C, p. 169-176 8 p.

Research output: Contribution to journalArticle

Eflornithine
Ornithine
Ornithine Decarboxylase
Autoradiography
Kidney
23 Citations (Scopus)

Autoradiographic localization of ornithine decarboxylase in mouse kidney by use of radiolabeled α-difluoromethylornithine

Zagon, I. S., McLaughlin1, P. J., Seely, J. E., Hoeksema, G. W. & Pegg, A. E., Feb 1 1984, In : Cell And Tissue Research. 235, 2, p. 371-377 7 p.

Research output: Contribution to journalArticle

Eflornithine
Ornithine Decarboxylase
Kidney
Enzymes
Cytoplasm
14 Citations (Scopus)

Base composition of normal and megaloblastic bone marrow DNA

Hoffbrand, A. V. & Pegg, A. E., Feb 9 1972, In : Nature New Biology. 235, 58, p. 187-188 2 p.

Research output: Contribution to journalArticle

Macrocytic Anemia
Folic Acid Deficiency
Vitamin B 12 Deficiency
Cytidine
Thymine
4 Citations (Scopus)

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine

Šečkute, J., McCloskey, D. E., Thomas, H. J., Secrist, J. A., Pegg, A. E. & Ealick, S. E., Nov 1 2011, In : Protein Science. 20, 11, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Putrescine
Polyamines
Spermine Synthase
Enzymes
59 Citations (Scopus)

Binding of radioactive α-difluoromethylorithine to rat liver ornithine decarboxylase

Lynn Pritchard, M., Seely, J. E., Pösö, H., Jefferson, L. J. & Pegg, A., Jun 30 1981, In : Biochemical and Biophysical Research Communications. 100, 4, p. 1597-1603 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Liver
Rats
Eflornithine
Enzymes
1 Citation (Scopus)
28 Citations (Scopus)

Bioditribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL

Dolan, M. E., Pegg, A., Moschel, R. C., Vishnuvajjala, B. R., Flora, K. P., Grever, M. R. & Friedman, H. S., Mar 1 1994, In : Cancer Chemotherapy and Pharmacology. 35, 2, p. 121-126 6 p.

Research output: Contribution to journalArticle

Heterografts
Brain Neoplasms
Tumors
Brain
Carmustine
24 Citations (Scopus)

BIOSYNTHESIS OF PUTRESCINE AND POLYAMINES IN MAMMALIAN TISSUES

Pegg, A., Jan 1 1970, In : Annals of the New York Academy of Sciences. 171, 3, p. 977-987 11 p.

Research output: Contribution to journalArticle

Putrescine
Polyamines
273 Citations (Scopus)

Biosynthesis of putrescine in the prostate gland of the rat.

Pegg, A. E. & Williams-Ashman, H. G., Jul 1968, In : The Biochemical journal. 108, 4, p. 533-539 7 p.

Research output: Contribution to journalArticle

Carbon Isotopes
Chemical Stimulation
Pyridoxal Phosphate
Ornithine
Carboxy-Lyases
44 Citations (Scopus)

Brain infarction correlates more closely with acrolein than with reactive oxygen species

Saiki, R., Park, H., Ishii, I., Yoshida, M., Nishimura, K., Toida, T., Tatsukawa, H., Kojima, S., Ikeguchi, Y., Pegg, A. E., Kashiwagi, K. & Igarashi, K., Jan 28 2011, In : Biochemical and Biophysical Research Communications. 404, 4, p. 1044-1049 6 p.

Research output: Contribution to journalArticle

Brain Infarction
Acrolein
Reactive Oxygen Species
Brain
Spermine
32 Citations (Scopus)

Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations

Bacolod, M. D., Johnson, S. P., Pegg, A. E., Dolan, M. E., Moschel, R. C., Bullock, N. S., Fang, Q., Colvin, O. M., Modrich, P., Bigner, D. D. & Friedman, H. S., Sep 1 2004, In : Molecular cancer therapeutics. 3, 9, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

Carmustine
Tumor Cell Line
Brain Neoplasms
Drug Therapy
Mutation