• 34570 Citations
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1965 …2018

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Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy - Organ System Program, National Cancer Institute

Deen, D. F., Chiarodo, A., Grimm, E. A., Fike, J. R., Israel, M. A., Kun, L. E., Levin, V. A., Marton, L. J., Packer, R. J., Pegg, A., Rosenblum, M. L., Suit, H. D., Walker, M. D., Wikstrand, C. J., Wilson, C. B., Wong, A. J. & Yung, W. K. A., Oct 1 1993, In : Journal of neuro-oncology. 16, 3, p. 243-272 30 p.

Research output: Contribution to journalArticle

41 Scopus citations

Carrier-mediated uptake of methylglyoxal bis(guanylhydrazone) by rat lungs perfused in situ

Rannels, D. E., Addison, J. L. & Pegg, A. E., Jan 1 1985, In : American Journal of Physiology - Endocrinology and Metabolism. 11, 3, p. E292-E298

Research output: Contribution to journalArticle

7 Scopus citations

Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion

Stefanelli, C., Tantini, B., Fattori, M., Stanic', I., Pignatti, C., Clo, C., Guarnieri, C., Caldarera, C. M., Mackintosh, C. A., Pegg, A. & Flamigni, F., Sep 11 2002, In : FEBS Letters. 527, 1-3, p. 223-228 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Cell specific differences in o-methylguanine-dna methyltransferase activity and removal of o-methylguanine in rat pulmonary cells

Belinsky, S. A., Dolan, M. E., White, C. M., Maronpot, R. R., Pegg, A. E. & Anderson, M. W., Nov 1 1988, In : Carcinogenesis. 9, 11, p. 2053-2058 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Cell-specific differences of O 6-alkylguanine DNA repair activity during continuous exposure to carcinogen

Swenberg, J. A., Bedell, M. A., Billings, K. C., Umbenhauer, D. R. & Pegg, A. E., Dec 1 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 18 I, p. 5499-5502 4 p.

Research output: Contribution to journalArticle

98 Scopus citations
91 Scopus citations
11 Scopus citations

Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase

Xiao, L., Celano, P., Mank, A. R., Pegg, A. E. & Casero, R. A., Aug 30 1991, In : Biochemical and Biophysical Research Communications. 179, 1, p. 407-415 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase

Liu, L., Hachey, D. L., Valadez, G., Williams, K. M., Guengerich, F. P., Loktionova, N. A., Kanugula, S. & Pegg, A. E., Feb 6 2004, In : Journal of Biological Chemistry. 279, 6, p. 4250-4259 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Characterization of the P140K, PVP(138-140)MLK, and G156A O6- methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy

Davis, B. M., Roth, J. C., Liu, L., Xu-Welliver, M., Pegg, A. & Gerson, S. L., Nov 20 1999, In : Human Gene Therapy. 10, 17, p. 2769-2778 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Characterization of transgenic mice with overexpression of spermidine synthase

Shi, C., Welsh, P. A., Sass-Kuhn, S., Wang, X., McCloskey, D. E., Pegg, A. E. & Feith, D. J., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 495-505 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of transgenic mice with widespread overexpression of spermine synthase

Ikeguchi, Y., Wang, X., McCloskey, D. E., Coleman, C. S., Nelson, P., Hu, G., Shantz, L. M. & Pegg, A. E., Aug 1 2004, In : Biochemical Journal. 381, 3, p. 701-707 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas

McGarrity, T., Peiffer, L. P., Bartholomew, M. J. & Pegg, A., Jan 1 1990, In : Cancer. 66, 7, p. 1539-1543 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1N12-bis(ethyl)spermine

Porter, C. W., Pegg, A. E., Ganis, B., Madhabala, R. & Bergeron, R. J., Jan 1 1990, In : Biochemical Journal. 268, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species.

Pegg, A. E. & Jacobs, G., Aug 1 1983, In : The Biochemical journal. 213, 2, p. 495-502 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney

Seely, J. E., Persson, L., Sertich, G. J. & Pegg, A., Jan 1 1985, In : Biochemical Journal. 226, 2, p. 577-586 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli

Dolan, M. E., Scicchitano, D., Singer, B. & Pegg, A., Aug 30 1984, In : Biochemical and Biophysical Research Communications. 123, 1, p. 324-330 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Comparison of S-Adenosylmethionine Decarboxylases from Rat Liver and Muscle

Pösö, H. & Pegg, A. E., Jun 1982, In : Biochemistry. 21, 13, p. 3116-3122 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

Dolan, M. E., Pegg, A., Dumenco, L. L., Moschel, R. C. & Gerson, S. L., Dec 1 1991, In : Carcinogenesis. 12, 12, p. 2305-2309 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Comparison of the Rates off Repair off O6-Alkylguanines in DNA by Rat Liver and Bacterial O6-Alkylguanine-DNA Alkyltransferase

Pegg, A. E., Scicchitano, D. & Dolan, M. E., Sep 1 1984, In : Cancer Research. 44, 9, p. 3806-3811 6 p.

Research output: Contribution to journalArticle

109 Scopus citations

Complexes of Thermotoga maritima S-adenosylmethionine decarboxylase provide insights into substrate specificity

Bale, S., Baba, K., McCloskey, D. E., Pegg, A. E. & Ealick, S. E., Feb 17 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Concentrations of putrescine and polyamines and their enzymic synthesis during androgen-induced prostatic growth.

Pegg, A., Lockwood, D. H. & Williams-Ashman, H. G., Jan 1 1970, In : The Biochemical journal. 117, 1, p. 17-31 15 p.

Research output: Contribution to journalArticle

225 Scopus citations

Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine

Xu-Welliver, M., Kanugula, S., Loktionova, N. A., Crone, T. M. & Pegg, A., Apr 15 2000, In : Biochemical Journal. 347, 2, p. 527-534 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Control of ornithine decarboxylase activity in α-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues

Pegg, A., Madhubala, R., Kameji, T. & Bergeron, R. J., Jan 1 1988, In : Journal of Biological Chemistry. 263, 22, p. 11008-11014 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Conversion of exogenous spermidine into putrescine after administration to rats

Matsui, I., Pösö, H. & Pegg, A. E., Nov 24 1982, In : BBA - General Subjects. 719, 2, p. 199-207 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Correlation between o-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-n'-nitro-N-nitrosoguanidine

Domoradzki, J., Pegg, A. E., Dolan, M. E., Maher, V. M. & Mccormick, J. J., Dec 1 1984, In : Carcinogenesis. 5, 12, p. 1641-1647 7 p.

Research output: Contribution to journalArticle

138 Scopus citations

Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A. E. & Tretyakova, N., Apr 1 2008, In : Chemical research in toxicology. 21, 4, p. 787-795 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane

Loeber, R., Rajesh, M., Fang, Q., Pegg, A. & Tretyakova, N., May 1 2006, In : Chemical Research in Toxicology. 19, 5, p. 645-654 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Crystal structure of human spermine synthase: Implications of substrate binding and catalytic mechanism

Wu, H., Min, J., Zeng, H., McCloskey, D. E., Ikeguchi, Y., Loppnau, P., Michael, A. J., Pegg, A. E. & Plotnikov, A. N., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 16135-16146 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Crystal structure of the human O6-alkylguanine-DNA alkyltransferase

Wibley, J. E. A., Pegg, A. & Moody, P. C. E., Jan 15 2000, In : Nucleic acids research. 28, 2, p. 393-401 9 p.

Research output: Contribution to journalArticle

100 Scopus citations

Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides

Guza, R., Ma, L., Fang, Q., Pegg, A. E. & Tretyakova, N., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22601-22610 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
75 Scopus citations

Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide

Hillary, R. A. & Pegg, A. E., Apr 11 2003, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1647, 1-2, p. 161-166 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Decarboxylated S-adenosylmethionine in mammalian cells.

Hibasami, H., Hoffman, J. L. & Pegg, A., Jul 25 1980, In : Journal of Biological Chemistry. 255, 14, p. 6675-6678 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

Decarboxylation of ornithine and lysine in rat tissues

Pegg, A. E. & McGill, S., Jun 6 1979, In : BBA - Enzymology. 568, 2, p. 416-427 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

Decarboxylation of α-difluoromethylornithine by ornithine decarboxylase

Pegg, A. E., McGovern, K. A. & Wiest, L., Jan 1 1987, In : Biochemical Journal. 241, 1, p. 305-307 3 p.

Research output: Contribution to journalArticle

47 Scopus citations

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications

Philip, S., Swaminathan, S., Kuznetsov, S. G., Kanugula, S., Biswas, K., Chang, S., Loktionova, N. A., Haines, D. C., Kaldis, P., Pegg, A. E. & Sharan, S. K., Dec 1 2008, In : Cancer Research. 68, 23, p. 9973-9981 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Degradation of the alkylated form of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase

Xu-Welliver, M. & Pegg, A., Jun 8 2002, In : Carcinogenesis. 23, 5, p. 823-830 8 p.

Research output: Contribution to journalArticle

114 Scopus citations
473 Scopus citations

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

Dolan, M. E., Larkin, G. L., English, H. F. & Pegg, A. E., Mar 1 1989, In : Cancer Chemotherapy and Pharmacology. 25, 2, p. 103-108 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Depletion of o-methylguanine-dna-methyltransferase in human fibroblasts increases the mutagenic response to n-methyl-n'-nitro-n-nitrosoguanidine

Domoradzki, J., Pegg, A. E., Dolan, M. E., Maher, V. M. & Mccormick, J. J., Dec 1 1985, In : Carcinogenesis. 6, 12, p. 1823-1826 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Chowdhury, G., Cho, S. H., Pegg, A. & Guengerich, F. P., Dec 2 2013, In : Angewandte Chemie - International Edition. 52, 49, p. 12879-12882 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Detection of proenzyme form of S-adenosylmethionine decarboxylase in extracts from rat prostate

Pegg, A., Wiest, L. & Pajunen, A., Jan 29 1988, In : Biochemical and Biophysical Research Communications. 150, 2, p. 788-793 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography

Yamazaki, K., Ikeguchi, Y., Niwa, T., Hayashi, K., Iwaki, T., Ishii, I., Niitsu, M., Pegg, A. E. & Shirahata, A., 2012, In : Analytical Sciences. 28, 6, p. 621-624 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Determination of Cellular Decarboxylated S-Adenosylmethionine Content

Pegg, A. E. & Bennett, R. A., Jan 1 1983, In : Methods in enzymology. 94, C, p. 69-72 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]-2′-deoxyguanosine

Thomson, N. M., Mijal, R. S., Ziegel, R., Fleischer, N. L., Pegg, A. E., Tretyakova, N. Y. & Peterson, L. A., Dec 1 2004, In : Chemical research in toxicology. 17, 12, p. 1600-1606 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

Koomoa, D. L. T., Geerts, D., Lange, I., Koster, J., Pegg, A. E., Feith, D. J. & Bachmann, A. S., Apr 1 2013, In : International journal of oncology. 42, 4, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Differences between tissues in response of S-adenosylmethionine decarboxylase to administration of polyamines

Poso, H. & Pegg, A. E., Jan 1 1981, In : Biochemical Journal. 200, 3, p. 629-637 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase

Coulter, R., Blandino, M., Tomlinson, J. M., Pauly, G. T., Krajewska, M., Moschel, R. C., Peterson, L. A., Pegg, A. E. & Spratt, T. E., Dec 1 2007, In : Chemical research in toxicology. 20, 12, p. 1966-1971 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells

Fontes, A. M., Davis, B. M., Encell, L. P., Lingas, K., Covas, D. T., Zago, M. A., Loeb, L. A., Pegg, A. E. & Gerson, S. L., Jan 1 2006, In : Molecular cancer therapeutics. 5, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

8 Scopus citations