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1965 …2018
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Research Output 1965 2018

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Article
2003
63 Citations (Scopus)

Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis

Fong, L. Y. Y., Feith, D. J. & Pegg, A. E., Jul 15 2003, In : Cancer Research. 63, 14, p. 3945-3954 10 p.

Research output: Contribution to journalArticle

nitrosobenzylmethylamine
Transgenic Mice
Zinc
Carcinogenesis
Cell Proliferation
50 Citations (Scopus)

Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide

Hillary, R. A. & Pegg, A. E., Apr 11 2003, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1647, 1-2, p. 161-166 6 p.

Research output: Contribution to journalArticle

Carboxy-Lyases
Biosynthesis
Polyamines
Adenosylmethionine Decarboxylase
Nitric Oxide
418 Citations (Scopus)

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

Zimmermann, N., King, N. E., Laporte, J., Yang, M., Mishra, A., Pope, S. M., Muntel, E. E., Witte, D. P., Pegg, A. A., Foster, P. S., Hamid, Q. & Rothenberg, M. E., Jun 1 2003, In : Journal of Clinical Investigation. 111, 12, p. 1863-1874 12 p.

Research output: Contribution to journalArticle

Arginase
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Dissection
Asthma
62 Citations (Scopus)

DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase: Effects of protein and DNA alkylation on complex stability

Rasimas, J. J., Pegg, A. E. & Fried, M. G., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 7973-7980 8 p.

Research output: Contribution to journalArticle

Alkylation
DNA
Alkylating Agents
Proteins
Oligonucleotides
15 Citations (Scopus)

Effect of spermine synthase on the sensitivity of cells to anti-tumour agents

Ikeguchi, Y., Mackintosh, C. A., McCloskey, D. E. & Pegg, A. E., Aug 1 2003, In : Biochemical Journal. 373, 3, p. 885-892 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermine
Tumors
Neoplasms
Spermidine
29 Citations (Scopus)

Effects of zinc occupancy on human O6-alkylguanine - DNA alkyltransferase

Rasimas, J. J., Kanugula, S., Dalessio, P., Ropson, I., Fried, M. G. & Pegg, A., Feb 4 2003, In : Biochemistry. 42, 4, p. 980-990 11 p.

Research output: Contribution to journalArticle

Zinc
Repair
Metals
Oligodeoxyribonucleotides
Substrates
35 Citations (Scopus)

Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant

Tolbert, W. D., Zhang, Y., Cottet, S. E., Bennett, E. M., Ekstrom, J. L., Pegg, A. E. & Ealick, S. E., Mar 4 2003, In : Biochemistry. 42, 8, p. 2386-2395 10 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Enzyme Precursors
Protein Precursors
aspartate 4-decarboxylase
Anions
55 Citations (Scopus)

O6-alkylguanine-DNA alkyltransferase: Low pKa and high reactivity of cysteine 145

Guengerich, F. P., Fang, Q., Liu, L., Hachey, D. L. & Pegg, A. E., Sep 23 2003, In : Biochemistry. 42, 37, p. 10965-10970 6 p.

Research output: Contribution to journalArticle

Papain
Cysteine
Dinitrochlorobenzene
Biochemistry
Cross Reactions
14 Citations (Scopus)

O6-Alkylguanine-DNA Alkyltransferases Repair O 6-Methylguanine in DNA with Michaelis-Menten-like Kinetics

Meyer, A. S., McCain, M. D., Fang, Q., Pegg, A. & Spratt, T., Nov 1 2003, In : Chemical research in toxicology. 16, 11, p. 1405-1409 5 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
Kinetics
DNA
Oligodeoxyribonucleotides
22 Citations (Scopus)
Acetyltransferases
Spermidine
Spermine
Polyamines
Mutant Proteins
26 Citations (Scopus)

Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-methylguanine-DNA methyltransferase with O6-benzylguanine or O 6-benzyl-2′-deoxyguanosine

Kokkinakis, D. M., Ahmed, M. M., Chendil, D., Moschel, R. C. & Pegg, A., Oct 1 2003, In : Clinical Cancer Research. 9, 10 I, p. 3801-3807 7 p.

Research output: Contribution to journalArticle

temozolomide
Carmustine
Methyltransferases
Heterografts
Guanine
67 Citations (Scopus)

Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth

Pegg, A. E., Feith, D. J., Fong, L. Y. Y., Coleman, C. S., O'Brien, T. G. & Shantz, L. M., Apr 1 2003, In : Biochemical Society transactions. 31, 2, p. 356-360 5 p.

Research output: Contribution to journalArticle

Polyamines
Transgenic Mice
Ornithine Decarboxylase
Growth
Carcinogenesis
85 Citations (Scopus)

X-linked spermine synthase gene (SMS) defect: The first polyamine deficiency syndrome

Cason, A. L., Ikeguchi, Y., Skinner, C., Wood, T. C., Holden, K. R., Lubs, H. A., Martinez, F., Simensen, R. J., Stevenson, R. R., Pegg, A. & Schwartz, C. E., Dec 1 2003, In : European Journal of Human Genetics. 11, 12, p. 937-944 8 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Spermidine
Polyamines
Genes
Cerebellar Diseases
2002
54 Citations (Scopus)

Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion

Stefanelli, C., Tantini, B., Fattori, M., Stanic', I., Pignatti, C., Clo, C., Guarnieri, C., Caldarera, C. M., Mackintosh, C. A., Pegg, A. & Flamigni, F., Sep 11 2002, In : FEBS Letters. 527, 1-3, p. 223-228 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Polyamines
Etoposide
Fibroblasts
113 Citations (Scopus)

Degradation of the alkylated form of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase

Xu-Welliver, M. & Pegg, A., Jun 8 2002, In : Carcinogenesis. 23, 5, p. 823-830 8 p.

Research output: Contribution to journalArticle

Hydrogen Bonding
DNA Repair
CHO Cells
Oligodeoxyribonucleotides
Asparagine
99 Citations (Scopus)

Inactivation and degradation of O6-alkylguanine-DNA alkyltransferase after reaction with nitric oxide

Liu, L., Xu-Welliver, M., Kanugula, S. & Pegg, A., Jun 1 2002, In : Cancer Research. 62, 11, p. 3037-3043 7 p.

Research output: Contribution to journalArticle

Nitric Oxide
DNA Repair
Alkylating Agents
Alkylation
Nitroso Compounds
14 Citations (Scopus)

Interaction of mammalian O6-alkylguanine-DNA alkyltransferases with O6-benzylguanine

Loktionova, N. A. & Pegg, A. E., Apr 15 2002, In : Biochemical Pharmacology. 63, 8, p. 1431-1442 12 p.

Research output: Contribution to journalArticle

Rats
Amino Acids
Alkylating Agents
Mutation
Asparagine
24 Citations (Scopus)

Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation

Bennett, E. M., Ekstrom, J. L., Pegg, A. & Ealick, S. E., Dec 10 2002, In : Biochemistry. 41, 49, p. 14509-14517 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Putrescine
Solanum tuberosum
Enzymes
Monomers
78 Citations (Scopus)

O6-benzylguanine-mediated enhancement of chemotherapy

Friedman, H. S., Keir, S., Pegg, A., Houghton, P. J., Colvin, O. M., Moschel, R. C., Bigner, D. D. & Dolan, M. E., Sep 1 2002, In : Molecular cancer therapeutics. 1, 11, p. 943-948 6 p.

Research output: Contribution to journalArticle

irinotecan
temozolomide
Carmustine
Drug Therapy
Cyclophosphamide
11 Citations (Scopus)

Overespression of a dominant-negative ornithine decarboxylase in mouse skin: Effect on enzyme activity and papilloma formation

Shantz, L., Guo, Y., Sawicki, J. A., Pegg, A. & O'Brien, T. G., May 22 2002, In : Carcinogenesis. 23, 4, p. 657-664 8 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Papilloma
Skin
Enzymes
Transgenic Mice
45 Citations (Scopus)

Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase

Liu, L., Pegg, A. E., Williams, K. M. & Peter Guengerich, F., Oct 4 2002, In : Journal of Biological Chemistry. 277, 40, p. 37920-37928 9 p.

Research output: Contribution to journalArticle

Ethylene Dibromide
Toxicity
DNA
Glutathione
Repair
161 Citations (Scopus)

Phase II trial of carmustine plus O6-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

Quinn, J. A., Pluda, J., Dolan, M. E., Delaney, S., Kaplan, R., Rich, J. N., Friedman, A. H., Reardon, D. A., Sampson, J. H., Colvin, O. M., Haglund, M. M., Pegg, A. E., Moschel, R. C., McLendon, R. E., Provenzale, J. M., Gururangan, S., Tourt-Uhlig, S., Herndon, J. E., Bigner, D. D. & Friedman, H. S., May 1 2002, In : Journal of Clinical Oncology. 20, 9, p. 2277-2283 7 p.

Research output: Contribution to journalArticle

Carmustine
Glioma
O(6)-benzylguanine
Cytoprotection
Astrocytoma
21 Citations (Scopus)

Repair of oligodeoxyribonucleotides by O6-alkylguanine-DNA alkyltransferase

Luu, K. X., Kanugula, S., Pegg, A., Pauly, G. T. & Moschel, R. C., Jul 9 2002, In : Biochemistry. 41, 27, p. 8689-8697 9 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Repair
Substrates
Nucleotides
Chemotherapy
43 Citations (Scopus)

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

Coleman, C. S., Pegg, A. E., Megosh, L. C., Guo, Y., Sawicki, J. A. & O'Brien, T. G., Jan 1 2002, In : Carcinogenesis. 23, 2, p. 359-364 6 p.

Research output: Contribution to journalArticle

Spermine
Carcinogenesis
Skin
Carcinogens
Transgenic Mice
118 Citations (Scopus)

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

Korolev, S., Ikeguchi, Y., Skarina, T., Beasley, S., Arrowsmith, C., Edwards, A., Joachimiak, A., Pegg, A. & Savchenko, A., Jan 1 2002, In : Nature Structural Biology. 9, 1, p. 27-31 5 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Crystal structure
Polyamines
Thermotoga maritima
Oligomerization
2001
40 Citations (Scopus)

Effect of polyamine depletion on caspase activation: A study with spermine synthase-deficient cells

Stefanelli, C., Pignatti, C., Tantini, B., Fattori, M., Stanic, I., Mackintosh, C. A., Flamigni, F., Guarnieri, C., Caldarera, C. M. & Pegg, A., Apr 1 2001, In : Biochemical Journal. 355, 1, p. 199-206 8 p.

Research output: Contribution to journalArticle

Spermine Synthase
Polyamines
Spermine
Caspases
Chemical activation
42 Citations (Scopus)

ERCC1: A comparative genomic perspective

Kanugula, S. & Pegg, A., Nov 28 2001, In : Environmental and Molecular Mutagenesis. 38, 2-3, p. 209-215 7 p.

Research output: Contribution to journalArticle

repair
Exons
genomics
DNA Repair
DNA
12 Citations (Scopus)

Inactivation of human O6-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O6-benzylguanine

Pegg, A. E., Goodtzova, K., Loktionova, N. A., Kanugula, S., Pauly, G. T. & Moschel, R. C., Mar 14 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 3, p. 958-965 8 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Carmustine
HT29 Cells
Alkylating Agents
Drug Synergism
96 Citations (Scopus)

Nitric Oxide Inhibits Ornithine Decarboxylase via S-Nitrosylation of Cysteine 360 in the Active Site of the Enzyme

Bauer, P. M., Buga, G. M., Fukuto, J. M., Pegg, A. E. & Ignarro, L. J., Sep 14 2001, In : Journal of Biological Chemistry. 276, 37, p. 34458-34464 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Cysteine
Catalytic Domain
Nitric Oxide
Enzymes
20 Citations (Scopus)

Novel DNA repair alkyltransferase from Caenorhabditis elegans

Kanugula, S., Pegg, A., Thompson, L. & Von Borstel, J., Nov 28 2001, In : Environmental and Molecular Mutagenesis. 38, 2-3, p. 235-243 9 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Caenorhabditis elegans
DNA Repair
repair
Repair
48 Citations (Scopus)
Acetyltransferases
Spermidine
Spermine
Ubiquitination
Polyamines
49 Citations (Scopus)

Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant

Ekstrom, J. L., Tolbert, W. D., Xiong, H., Pegg, A. E. & Ealick, S. E., Aug 14 2001, In : Biochemistry. 40, 32, p. 9495-9504 10 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Putrescine
Esters
Enzyme Precursors
Processing
66 Citations (Scopus)
Keratin-6
Ornithine Decarboxylase
Keratin-5
Carcinogens
Transgenic Mice
35 Citations (Scopus)

Targeted overexpression of ornithine decarboxylase enhances β-adrenergic agonist-induced cardiac hypertrophy

Shantz, L., Feith, D. J. & Pegg, A., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Adrenergic Agonists
Ornithine Decarboxylase
Cardiomegaly
Hypertrophy
Isoproterenol
52 Citations (Scopus)

The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase

Tolbert, W. D., Ekstrom, J. L., Mathews, I. I., Secrist, J. A., Kapoor, P., Pegg, A. E. & Ealick, S. E., Aug 14 2001, In : Biochemistry. 40, 32, p. 9484-9494 11 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Substrate Specificity
Substrates
4-amidinoindan-1-one 2'-amidinohydrazone
Putrescine
70 Citations (Scopus)

Thresholds of O6-alkylguanine-DNA alkyltransferase which significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide

Kokkinakis, D. M., Bocangel, D. B., Schold, S. C., Moschel, R. C. & Pegg, A. E., Feb 2001, In : Clinical Cancer Research. 7, 2, p. 421-428 8 p.

Research output: Contribution to journalArticle

temozolomide
Carmustine
Heterografts
Neuroglia
Oligodendroglioma
82 Citations (Scopus)

Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O6-methylguanine

Pourquier, P., Waltman, J. L., Urasaki, Y., Loktionova, N. A., Pegg, A. E., Nitiss, J. L. & Pommier, Y., Jan 1 2001, In : Cancer Research. 61, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Methylnitronitrosoguanidine
Type I DNA Topoisomerase
DNA
CHO Cells
Alkylating Agents
27 Citations (Scopus)
Eflornithine
Zinc
Carcinogenesis
Cell Proliferation
Apoptosis
2000
150 Citations (Scopus)

Active and alkylated human AGT structures: A novel zinc site, inhibitor and extrahelical base binding

Daniels, D. S., Mol, C. D., Arvai, A. S., Kanugula, S., Pegg, A. & Tainer, J. A., Apr 3 2000, In : EMBO Journal. 19, 7, p. 1719-1730 12 p.

Research output: Contribution to journalArticle

Zinc
Alkylation
Helix-Turn-Helix Motifs
Cysteine
DNA
32 Citations (Scopus)

Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues

McCloskey, D. E. & Pegg, A. E., Sep 15 2000, In : Journal of Biological Chemistry. 275, 37, p. 28708-28714 7 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Polyamines
Enzyme Induction
14 Citations (Scopus)

Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine

Xu-Welliver, M., Kanugula, S., Loktionova, N. A., Crone, T. M. & Pegg, A., Apr 15 2000, In : Biochemical Journal. 347, 2, p. 527-534 8 p.

Research output: Contribution to journalArticle

Alkylating Agents
DNA Repair
Lysine
DNA
Repair
98 Citations (Scopus)

Crystal structure of the human O6-alkylguanine-DNA alkyltransferase

Wibley, J. E. A., Pegg, A. & Moody, P. C. E., Jan 15 2000, In : Nucleic acids research. 28, 2, p. 393-401 9 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Alkylating Agents
Prokaryotic Cells
Drug Design
Escherichia coli Proteins
107 Citations (Scopus)

Direct reversal of DNA damage mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells

Ragg, S., Xu-Welliver, M., Bailey, J., D'Souza, M., Cooper, R., Chandra, S., Seshadri, R., Pegg, A. & Williams, D. A., Sep 15 2000, In : Cancer Research. 60, 18, p. 5187-5195 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Mutant Proteins
Hematopoietic Stem Cells
DNA Damage
Carmustine
7 Citations (Scopus)

DNA repair pathways and cancer prevention

Pegg, A., Dec 1 2000, In : Advances in experimental medicine and biology. 472, p. 253-267 15 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
DNA
Neoplasms
Environmental Carcinogens
43 Citations (Scopus)

Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity in chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases

Cai, Y., Wu, M. H., Xu-Welliver, M., Pegg, A., Ludeman, S. M. & Dolan, M. E., Oct 1 2000, In : Cancer Research. 60, 19, p. 5464-5469 6 p.

Research output: Contribution to journalArticle

Alkylating Agents
Cricetulus
Ovary
temozolomide
Carmustine
42 Citations (Scopus)
Spermine Synthase
Spermine
Biosynthesis
Polyamines
Fibroblasts
19 Citations (Scopus)

In vitro study of proteolytic degradation of rat histidine decarboxylase

Olmo, M. T., Urdiales, J. L., Pegg, A. E., Medina Torres, M. A. & Sánchez-Jiménez, F., Mar 22 2000, In : European Journal of Biochemistry. 267, 5, p. 1527-1531 5 p.

Research output: Contribution to journalArticle

Histidine Decarboxylase
Rats
Degradation
Ornithine Decarboxylase
Proteins
40 Citations (Scopus)

Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis

Lopatin, A. N., Shantz, L. M., Mackintosh, C. A., Nichols, C. G. & Pegg, A. E., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 11, p. 2007-2024 18 p.

Research output: Contribution to journalArticle

Spermine
Potassium Channels
Polyamines
Putrescine
Transgenic Mice
13 Citations (Scopus)

O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts - Implications for clinical trials

Keir, S. T., Dolan, M. E., Pegg, A., Lawless, A., Moschel, R. C., Bigner, D. D. & Friedman, H. S., Jan 1 2000, In : Cancer Chemotherapy and Pharmacology. 45, 6, p. 437-440 4 p.

Research output: Contribution to journalArticle

Carmustine
Central Nervous System Neoplasms
Neurology
Heterografts
Tumors
21 Citations (Scopus)
Ornithine Decarboxylase
Polyamines
Cardiomegaly
Isoproterenol
Transgenic Mice