• 34497 Citations
  • 88 h-Index
1965 …2018

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2000

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

Friedman, H. S., Pluda, J., Quinn, J. A., Ewesuedo, R. B., Long, L., Friedman, A. H., Cokgor, I., Calvin, O. M., Haglund, M. M., Ashley, D. M., Rich, J. N., Sampson, J., Pegg, A. E., Moschel, R. C., McLendon, R. E., Provenzale, J. M., Stewart, E. S., Tourt-Uhlig, S., Garcia-Turner, A. M., Herndon, J. E. & 2 others, Bigner, D. D. & Dolan, M. E., Oct 15 2000, In : Journal of Clinical Oncology. 18, 20, p. 3522-3528 7 p.

Research output: Contribution to journalArticle

123 Scopus citations
27 Scopus citations

Potentiation of BCNU antitumor efficacy by 9-substituted O6- benzylguanines. Effect of metabolism

Kokkinakis, D. M., Moschel, R. C., Pegg, A. E. & Schold, S. C., Jan 1 2000, In : Cancer Chemotherapy and Pharmacology. 45, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase

Williams, D. A., Maze, R., Kurpad, C., Pegg, A. & Erickson, L. C., May 2000, In : Bone Marrow Transplantation. 25, p. S105-S109

Research output: Contribution to journalArticle

9 Scopus citations

Repair of O6-alkylguanine by alkyltransferases

Pegg, A., Jan 1 2000, In : Mutation Research - Reviews in Mutation Research. 462, 2-3, p. 83-100 18 p.

Research output: Contribution to journalArticle

476 Scopus citations

Resistance-modifying agents. 8. Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-alkenyl-, O6-cycloalkenyl-, and O6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O6-(1-cyclopentenylmethyl) guanine

Griffin, R. J., Arris, C. E., Bleasdale, C., Boyle, F. T., Calvert, A. H., Curtin, N. J., Dalby, C., Kanugula, S., Lembicz, N. K., Newell, D. R., Pegg, A. E. & Golding, B. T., Nov 2 2000, In : Journal of Medicinal Chemistry. 43, 22, p. 4071-4083 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft

Patel, V. J., Elion, G. B., Houghton, P. J., Keir, S., Pegg, A. E., Johnson, S. P., Dolan, M. E., Bigner, D. D. & Friedman, H. S., Jan 1 2000, In : Clinical Cancer Research. 6, 10, p. 4154-4157 4 p.

Research output: Contribution to journalArticle

56 Scopus citations
31 Scopus citations
1999

Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6- benzylguanine

Xu-Welliver, M., Leitão, J., Kanugula, S. & Pegg, A., Apr 1 1999, In : Cancer Research. 59, 7, p. 1514-1519 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Characterization of the P140K, PVP(138-140)MLK, and G156A O6- methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy

Davis, B. M., Roth, J. C., Liu, L., Xu-Welliver, M., Pegg, A. & Gerson, S. L., Nov 20 1999, In : Human Gene Therapy. 10, 17, p. 2769-2778 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)-1-nitrosourea

Kokkinakis, D. M., Moschel, R. C., Pegg, A. E. & Schold, S. C., Nov 1 1999, In : Clinical Cancer Research. 5, 11, p. 3676-3681 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
30 Scopus citations

Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine

Gerson, S. L., Schupp, J., Liu, L., Pegg, A. & Srinivasen, S., Mar 1 1999, In : Clinical Cancer Research. 5, 3, p. 521-524 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate

Xiong, H. & Pegg, A., Dec 3 1999, In : Journal of Biological Chemistry. 274, 49, p. 35059-35066 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Modulation of cyclophosphamide activity by o6-alkylguanine-dna alkyltransferase

Friedman, H. S., Pegg, A. E., Johnson, S. P., Loktionova, N. A., Dolan, M. E., Modrich, P., Moschel, R. C., Struck, R., Brent, T. P., Ludeman, S., Bullock, N., Kilborn, C., Keir, S., Dong, Q., Bigner, D. D. & Colvin, O. M., Feb 1 1999, In : Cancer Chemotherapy and Pharmacology. 43, 1, p. 80-85 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation

Bauer, P. M., Fukuto, J. M., Buga, G. M., Pegg, A. E. & Ignarro, L. J., Aug 27 1999, In : Biochemical and Biophysical Research Communications. 262, 2, p. 355-358 4 p.

Research output: Contribution to journalArticle

65 Scopus citations

O6-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes

Nutt, C. L., Loktionova, N. A., Pegg, A. E., Chambers, A. F. & Cairncross, J. G., Jan 1 1999, In : Carcinogenesis. 20, 12, p. 2361-2365 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Primary structure of rat spermidine synthase: An example of refining the cDNA-derived amino acid sequence

Wada, M., Amano, D., Hosoda, H., Shirahata, A., Samejima, K. & Pegg, A. E., Sep 1999, In : Biological and Pharmaceutical Bulletin. 22, 9, p. 889-895 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Properties and regulation of human spermidine/spermine N1- acetyltransferase stably expressed in Chinese hamster ovary cells

McCloskey, D. E., Coleman, C. & Pegg, A., Mar 5 1999, In : Journal of Biological Chemistry. 274, 10, p. 6175-6182 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine

Loktionova, N. A., Xu-Welliver, M., Crone, T. M., Kanugula, S. & Pegg, A. E., Jul 15 1999, In : Biochemical Pharmacology. 58, 2, p. 237-244 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase

Spratt, T., Wu, J. D., Levy, D. E., Kanugula, S. & Pegg, A., May 25 1999, In : Biochemistry. 38, 21, p. 6801-6806 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
19 Scopus citations

Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine

Xu-Welliver, M., Leitão, J., Kanugula, S., Meehan, W. J. & Pegg, A. E., Oct 15 1999, In : Biochemical Pharmacology. 58, 8, p. 1279-1285 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Role of cysteine-82 in the catalytic mechanism of human S- adenosylmethionine decarboxylase

Xiong, H., Stanley, B. A. & Pegg, A. E., Feb 23 1999, In : Biochemistry. 38, 8, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
27 Scopus citations

The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 Å resolution reveals a novel fold

Ekstrom, J. L., Mathews, I. I., Stanley, B., Pegg, A. & Ealick, S. E., May 1999, In : Structure. 7, 5, p. 583-595 13 p.

Research output: Contribution to journalArticle

68 Scopus citations
34 Scopus citations
1998

A new model for how O6-methylguanine-DNA methyltransferase binds DNA

Vora, R. A., Pegg, A. E. & Ealick, S. E., Jul 1 1998, In : Proteins: Structure, Function and Genetics. 32, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Assay of mammalian ornithine decarboxylase activity using [14C]ornithine.

Coleman, C. & Pegg, A., Jan 1 1998, In : Methods in molecular biology (Clifton, N.J.). 79, p. 41-44 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Assay of mammalian S-adenosylmethionine decarboxylase activity.

Shantz, L. & Pegg, A., Jan 1 1998, In : Methods in molecular biology (Clifton, N.J.). 79, p. 45-49 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Assay of spermidine and spermine synthases.

Wiest, L. & Pegg, A. E., 1998, In : Methods in molecular biology (Clifton, N.J.). 79, p. 51-57 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Investigation of the role of tyrosine-114 in the activity of human O6- alkylguanine-DNA alkyltranferase

Goodtzova, K., Kanugula, S., Edara, S. & Pegg, A., Sep 8 1998, In : Biochemistry. 37, 36, p. 12489-12495 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine

Xu-Welliver, M., Kanugula, S. & Pegg, A., May 1 1998, In : Cancer Research. 58, 9, p. 1936-1945 10 p.

Research output: Contribution to journalArticle

96 Scopus citations

O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases

Dolan, M. E., Roy, S. K., Garbiras, B. J., Helft, P., Paras, P., Chae, M. Y., Moschel, R. C. & Pegg, A., May 15 1998, In : Biochemical Pharmacology. 55, 10, p. 1701-1709 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ornithine decarboxylase induction in transformation by H-Ras and RhoA

Shantz, L. & Pegg, A., Jul 1 1998, In : Cancer Research. 58, 13, p. 2748-2753 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma

Friedman, H. S., Kokkinakis, D. M., Pluda, J., Friedman, A. H., Cokgor, I., Haglund, M. M., Ashley, D. M., Rich, J., Dolan, M. E., Pegg, A., Moschel, R. C., McLendon, R. E., Kerby, T., Herndon, J. E., Bigner, D. D. & Schold, S. C., Jan 1 1998, In : Journal of Clinical Oncology. 16, 11, p. 3570-3575 6 p.

Research output: Contribution to journalArticle

190 Scopus citations

Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis

Kanugula, S., Goodtzova, K. & Pegg, A., Feb 1 1998, In : Biochemical Journal. 329, 3, p. 545-550 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Reaction of O6-benzylguanine-resistant mutants of human O6- alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides

Pegg, A. E., Kanugula, S., Edara, S., Pauly, G. T., Moschel, R. C. & Goodtzova, K., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 10863-10867 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

S-adenosylmethionine decarboxylase: Structure, function and regulation by polyamines

Pegg, A. E., Xiong, H., Feith, D. J. & Shantz, L. M., Jan 1 1998, In : Biochemical Society transactions. 26, 4, p. 580-586 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Structure/function relationship studies on the T/S residues 173-177 of rat ODC

Matés, J. M., Del Valle, A. E., Urdiales, J. L., Coleman, C., Feith, D., Olmo, M. T., Pegg, A. & Sánchez-Jiménez, F., Jul 28 1998, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1386, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
30 Scopus citations
1997

Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives

Pegg, A. E., Chung, L. & Moschel, R. C., May 15 1997, In : Biochemical Pharmacology. 53, 10, p. 1559-1564 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Inhibition of spermidine synthase gene expression by transforming growth factor-β1 in hepatoma cells

Nishikawa, Y., Kar, S., Wiest, L., Pegg, A. E. & Carr, B. I., Jan 1 1997, In : Biochemical Journal. 321, 2, p. 537-543 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea

Kurpad, S. N., Dolan, M. E., McLendon, R. E., Archer, G. E., Moschel, R. C., Pegg, A. E., Bigner, D. D. & Friedman, H. S., Jan 1 1997, In : Cancer Chemotherapy and Pharmacology. 39, 4, p. 307-316 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Processing of mammalian and plant S-adenosylmethionine decarboxylase proenzymes

Xiong, H., Stanley, B., Tekwani, B. L. & Pegg, A., Nov 7 1997, In : Journal of Biological Chemistry. 272, 45, p. 28342-28348 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

Proteasomal degradation of spermidine/spermine N1-acetyltransferase requires the carboxyl-terminal glutamic acid residues

Colemant, C. S. & Pegg, A. E., May 2 1997, In : Journal of Biological Chemistry. 272, 18, p. 12164-12169 6 p.

Research output: Contribution to journalArticle

44 Scopus citations
92 Scopus citations

Rapid induction of apoptosis by deregulated uptake of polyamine analogues

Hu, R. H. & Pegg, A. E., Nov 15 1997, In : Biochemical Journal. 328, 1, p. 307-316 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases

Goodtzova, K., Kanugula, S., Edara, S., Pauly, G. T., Moschel, R. C. & Pegg, A. E., Mar 28 1997, In : Journal of Biological Chemistry. 272, 13, p. 8332-8339 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

Hazra, T. K., Roy, R., Biswas, T., Giabowski, D. T., Pegg, A. & Mitra, S., May 13 1997, In : Biochemistry. 36, 19, p. 5769-5776 8 p.

Research output: Contribution to journalArticle

53 Scopus citations