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1965 …2018
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Research Output 1965 2018

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Article
1997

Study of the structure of human O6-alkylguanine-DNA alkyl transferase (hAGT) protein in alkylated and DNA bound states by limited proteolysis

Kanugula, S., Goodtzova, K. V. & Pegg, A., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Proteolysis
Transferases
DNA
Proteins
Digestion
1996
46 Citations (Scopus)

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase

Crone, T. M., Goodtzova, K. & Pegg, A., May 15 1996, In : Mutation Research - DNA Repair. 363, 1, p. 15-25 11 p.

Research output: Contribution to journalArticle

Human Activities
Methylnitronitrosoguanidine
Amino Acids
Mutation
Complex Mixtures
47 Citations (Scopus)

DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: Stoichiometry and effects of DNA base composition and secondary structure on complex stability

Fried, M. G., Kanugula, S., Bromberg, J. L. & Pegg, A. E., Dec 17 1996, In : Biochemistry. 35, 48, p. 15295-15301 7 p.

Research output: Contribution to journalArticle

Base Composition
Stoichiometry
DNA
Chemical analysis
Monomers
31 Citations (Scopus)

Experimental evidence for structure-activity features in common between mammalian histidine decarboxylase and ornithine decarboxylase

Engel, N., Olmo, M. T., Coleman, C., Medina, M. A., Pegg, A. & Sánchez-Jiménez, F., Dec 1 1996, In : Biochemical Journal. 320, 2, p. 365-368 4 p.

Research output: Contribution to journalArticle

Histidine Decarboxylase
Amino Acid Motifs
Decarboxylation
Ornithine Decarboxylase
Threonine
35 Citations (Scopus)

Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation

Shantz, L., Coleman, C. & Pegg, A., Nov 15 1996, In : Cancer Research. 56, 22, p. 5136-5140 5 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Ornithine Decarboxylase
Clone Cells
Phenotype
Peptide Initiation Factors
11 Citations (Scopus)

Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-benzyl-2'-deoxyguanosine. Role of metabolism

Kokkinakis, D. M., Moschel, R. C., Vuong, T. H., Reddy, M. V., Schold, S. C. & Pegg, A., Jan 1 1996, In : In Vivo. 10, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Methyltransferases
Metabolism
Rats
Tissue
45 Citations (Scopus)
Carmustine
Point Mutation
Cricetulus
Ovary
Alanine
69 Citations (Scopus)

Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E

Shantz, L. M., Hu, R. H. & Pegg, A. E., Jul 15 1996, In : Cancer Research. 56, 14, p. 3265-3269 5 p.

Research output: Contribution to journalArticle

Peptide Initiation Factors
Transformed Cell Line
Ornithine Decarboxylase
5' Untranslated Regions
3T3 Cells
76 Citations (Scopus)

Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine

Edara, S., Kanugula, S., Goodtzova, K. & Pegg, A., Dec 15 1996, In : Cancer Research. 56, 24, p. 5571-5575 5 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Codon
Arginine
Guanine
Glycine
48 Citations (Scopus)

Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase

Coleman, C., Huang, H. & Pegg, A., Jun 15 1996, In : Biochemical Journal. 316, 3, p. 697-701 5 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Catalytic Domain
Acetyl Coenzyme A
18 Citations (Scopus)

Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase

Wu, R., Saab, N. H., Huang, H., Wiest, L., Pegg, A. E., Casero, R. A. & Woster, P. M., Jun 1996, In : Bioorganic and Medicinal Chemistry. 4, 6, p. 825-836 12 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Polyamines
diamine N-acetyltransferase
86 Citations (Scopus)
Adenosylmethionine Decarboxylase
Polyamines
Open Reading Frames
Messenger RNA
Peptides
41 Citations (Scopus)

Treatment of human brain tumor xenografts with O6-benzyl-2′-deoxyguanosine and BCNU

Schold, S. C., Kokkinakis, D. M., Rudy, J. L., Moschel, R. C. & Pegg, A. E., May 1 1996, In : Cancer Research. 56, 9, p. 2076-2081 6 p.

Research output: Contribution to journalArticle

Carmustine
Deoxyguanosine
Heterografts
Brain Neoplasms
Methyltransferases
1995
94 Citations (Scopus)

8-Substituted O6-Benzylguanine, Substituted 6(4)-(Benzyloxy)pyrimidine, and Related Derivatives as Inactivators of Human O6-Alkylguanine-DNA Alkyltransfer ase

Chae, M. Y., Swenn, K., Kanugula, S., Dolan, M. E., Pegg, A. & Moschel, R. C., Jan 1 1995, In : Journal of Medicinal Chemistry. 38, 2, p. 359-365 7 p.

Research output: Contribution to journalArticle

Pyrimidines
DNA
Purines
Colon
Alkyl and Aryl Transferases
147 Citations (Scopus)

Activity of Temozolomide in the Treatment of Central Nervous System Tumor Xenografts

Friedman, H. S., Dolan, M. E., Pegg, A. E., Marcelli, S., Keir, S., Catino, J. J., Bigner, D. D. & Schold, S. C., Jul 1 1995, In : Cancer Research. 55, 13, p. 2853-2857 5 p.

Research output: Contribution to journalArticle

temozolomide
Central Nervous System Neoplasms
Heterografts
Glioma
Medulloblastoma
53 Citations (Scopus)
DNA Repair
Alanine
Arginine
Repair
DNA
21 Citations (Scopus)

Effect of Expression of Human Spermidine/Spermine Nl -Acetyltransferase in Escherichia coli

Parry, L., Lopez-Ballester, J., Wiest, L. & Pegg, A. E., Feb 1995, In : Biochemistry. 34, 8, p. 2701-2709 9 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Escherichia coli
Polyamines
24 Citations (Scopus)
Acetylesterase
Spermine
Polyamines
Cell Proliferation
CHO Cells
45 Citations (Scopus)

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N′-bis(2-chloroethyl)-N-nitrosourea

Pegg, A., Swenn, K., Mi-Young, C., Dolan, M. E. & Moschel, R. C., Oct 12 1995, In : Biochemical Pharmacology. 50, 8, p. 1141-1148 8 p.

Research output: Contribution to journalArticle

Carmustine
Tumors
Prostate
Guanine
Colon
139 Citations (Scopus)

Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells

Poulin, R., Pelletier, G. & Pegg, A., Jan 1 1995, In : Biochemical Journal. 311, 3, p. 723-727 5 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Polyamines
Apoptosis
Putrescine
Spermidine
33 Citations (Scopus)

Mutations in the ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine

Crone, T. M., Knaugula, S. & Pegg, A., Aug 1 1995, In : Carcinogenesis. 16, 8, p. 1687-1692 6 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Guanine
Mutant Proteins
Mutation
Protein C
160 Citations (Scopus)

Ornithine decarboxylase as a target for chemoprevention

Pegg, A. E., Shantz, L. M. & Coleman, C. S., 1995, In : Journal of cellular biochemistry. 59, 22 S, p. 132-138 7 p.

Research output: Contribution to journalArticle

Eflornithine
Ornithine Decarboxylase
Chemoprevention
Polyamines
NIH 3T3 Cells
51 Citations (Scopus)

Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine

Parry, L., Balana Fouce, R. & Pegg, A., Jan 1 1995, In : Biochemical Journal. 305, 2, p. 451-458 8 p.

Research output: Contribution to journalArticle

Acetyltransferases
Spermidine
Spermine
Messenger RNA
Polyamines
53 Citations (Scopus)
Acetyltransferases
Spermidine
Spermine
Amines
Stabilization
18 Citations (Scopus)

Specific Labeling of O6-Alkylguanine-DNA Alkyltransferase by Reaction with O6-(p-Hydroxy[3H]methylbenzyl)guanine

Ciocco, G. M., Pegg, A. E., McLaughlin, P. J., Zagon, I. S., Moschel, R. C. & Chae, M. Y., Sep 15 1995, In : Cancer Research. 55, 18, p. 4085-4091 7 p.

Research output: Contribution to journalArticle

Guanine
HT29 Cells
Cysteine
Radioactivity
Proteins
8 Citations (Scopus)
Eflornithine
Leukemia L1210
Spermine
Acidification
Polyamines
474 Citations (Scopus)

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

Pegg, A. E., Dolan, M. E. & Moschel, R. C., Jan 1 1995, In : Progress in Nucleic Acid Research and Molecular Biology. 51, C, p. 167-223 57 p.

Research output: Contribution to journalArticle

DNA alkyltransferase
23 Citations (Scopus)

Synthesis and Biochemical Evaluation of Adenosylspermidine, a Nucleoside-Polyamine Adduct Inhibitor of Spermidine Synthase

Lakanen, J. R., Pegg, A. & Coward, J. K., Jul 1 1995, In : Journal of Medicinal Chemistry. 38, 14, p. 2714-2727 14 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Polyamines
Nucleosides
Carbon
Amination
12 Citations (Scopus)

The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity

Edara, S., Goodtzova, K. & Pegg, A., Jul 1 1995, In : Carcinogenesis. 16, 7, p. 1637-1642 6 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Tyrosine
DNA
Guanine
Phenylalanine
1994
30 Citations (Scopus)

Activation of Human O6-Alkylguanine-DNA Alkyltransferase by DNA

Goodtzova, K., Crone, T. M. & Pegg, A. E., Jul 1 1994, In : Biochemistry. 33, 28, p. 8385-8390 6 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Chemical activation
Guanine
DNA
Oligodeoxyribonucleotides
28 Citations (Scopus)

Bioditribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL

Dolan, M. E., Pegg, A., Moschel, R. C., Vishnuvajjala, B. R., Flora, K. P., Grever, M. R. & Friedman, H. S., Mar 1 1994, In : Cancer Chemotherapy and Pharmacology. 35, 2, p. 121-126 6 p.

Research output: Contribution to journalArticle

Heterografts
Brain Neoplasms
Tumors
Brain
Carmustine
10 Citations (Scopus)

Effects of Inhibition of O6‐Alkylguanine‐DNA Alkyltransferase in Rats on Carcinogenesis by Methylnitrosourea and Ethylnitrosourea

Lijinsky, W., Pegg, A. E., Anver, M. R. & Moschel, R. C., Mar 1994, In : Japanese Journal of Cancer Research. 85, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Ethylnitrosourea
Methylnitrosourea
Carcinogenesis
Neoplasms
19 Citations (Scopus)
Adenosylmethionine Decarboxylase
Polyamines
Cell growth
Cricetulus
Cell culture
52 Citations (Scopus)
Adenosylmethionine Decarboxylase
Putrescine
Escherichia coli
Chemical activation
Mutation
31 Citations (Scopus)

Immunohistochemical Staining of Human Spermidine/Spermine N1-Acetyltransferase Superinduced in Response to Treatment with Antitumor Polyamine Analogues

Casero, R. A., Gabrielson, E. W. & Pegg, A. E., Aug 1994, In : Cancer Research. 54, 15, p. 3955-3958 4 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Staining and Labeling
Immune Sera
Therapeutics
8 Citations (Scopus)

Metabolism and Disposition of O6-Benzyl-2′-deoxyguanosine in Sprague-Dawley Rats

Kokkinakis, D. M., Moschel, R. C., Pegg, A., Dolan, M. E. & Schold, S. C., Nov 1 1994, In : Chemical Research in Toxicology. 7, 6, p. 762-769 8 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Metabolism
Sprague Dawley Rats
Rats
Alkyl and Aryl Transferases
106 Citations (Scopus)

Mutations in Human O6-Alkylguanine-DNA Alkyltransferase Imparting Resistance to O6-Benzylguanine

Crone, T. M., Goodtzova, K., Edara, S. & Pegg, A., Jan 1 1994, In : Cancer Research. 54, 23, p. 6221-6227 7 p.

Research output: Contribution to journalArticle

Mutation
Alkylating Agents
Proline
Cysteine
DNA
51 Citations (Scopus)

Ornithine decarboxylase: Structure, function and translational regulation

Pegg, A., Shantz, L. & Coleman, C., Jan 1 1994, In : Biochemical Society Transactions. 22, 4, p. 846-852 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
208 Citations (Scopus)
Ornithine Decarboxylase
Adenosylmethionine Decarboxylase
5' Untranslated Regions
3T3 Cells
Protein Biosynthesis
74 Citations (Scopus)

Rapid exchange of subunits of mammalian ornithine decarboxylase

Coleman, C. S., Stanley, B. A., Viswanath, R. & Pegg, A. E., Feb 4 1994, In : Journal of Biological Chemistry. 269, 5, p. 3155-3158 4 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Dimers
Enzymes
Lysine
Amino Acids
29 Citations (Scopus)

Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine

Shantz, L., Viswanath, R. & Pegg, A., Jan 1 1994, In : Biochemical Journal. 302, 3, p. 765-772 8 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Spermine
5' Untranslated Regions
Messenger RNA
Open Reading Frames
79 Citations (Scopus)

Substituted O6-Benzylguanine Derivatives and Their Inactivation of Human O6-Alkylguanine-DNA Alkyltransferase

Chae, M. Y., McDougall, M. G., Dolan, M. E., Swenn, K., Pegg, A. & Moschel, R. C., Feb 1 1994, In : Journal of Medicinal Chemistry. 37, 3, p. 342-347 6 p.

Research output: Contribution to journalArticle

Benzene
DNA Repair
Proteins
O(6)-benzylguanine
DNA alkyltransferase
64 Citations (Scopus)

The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: New evidence provided by 1-methylspermidine and 1,12-dimethylspermine

Byers, T. L., Lakanen, J. R., Coward, J. K. & Pegg, A., Jan 1 1994, In : Biochemical Journal. 303, 2, p. 363-368 6 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Spermine
Spermidine
Polyamines
Cells
1993
86 Citations (Scopus)

A Single Amino Acid Change in Human O6-Alkylguanine-DNA Alkyltransferase Decreasing Sensitivity to Inactivation by O6-Benzylguanine

Crone, U. M. & Pegg, A., Jan 1 1993, In : Cancer Research. 53, 20, p. 4750-4753 4 p.

Research output: Contribution to journalArticle

Amino Acids
Guanine
Escherichia coli Proteins
Proline
Alkylating Agents
41 Citations (Scopus)

Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy - Organ System Program, National Cancer Institute

Deen, D. F., Chiarodo, A., Grimm, E. A., Fike, J. R., Israel, M. A., Kun, L. E., Levin, V. A., Marton, L. J., Packer, R. J., Pegg, A., Rosenblum, M. L., Suit, H. D., Walker, M. D., Wikstrand, C. J., Wilson, C. B., Wong, A. J. & Yung, W. K. A., Oct 1 1993, In : Journal of neuro-oncology. 16, 3, p. 243-272 30 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Brain Neoplasms
Polyamines
Research
Immunotherapy
71 Citations (Scopus)
Ornithine Decarboxylase
Eflornithine
Catalytic Domain
Mutation
Lysine
10 Citations (Scopus)

Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents

Pegg, A. E. & Coward, J. K., Aug 17 1993, In : Biochemical Pharmacology. 46, 4, p. 717-724 8 p.

Research output: Contribution to journalArticle

Spermine
Polyamines
Cell growth
Metabolism
Growth
37 Citations (Scopus)

Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer

Dolan, M. E., Pegg, A., Biser, N. D., Moschel, R. C. & English, H. F., May 1 1993, In : Cancer Chemotherapy and Pharmacology. 32, 3, p. 221-225 5 p.

Research output: Contribution to journalArticle

Carmustine
Prostatic Neoplasms
Tumors
Animals
Rats
70 Citations (Scopus)

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

Dolan, M. E., Pegg, A., Moschel, R. C. & Grindey, G. B., Jul 20 1993, In : Biochemical Pharmacology. 46, 2, p. 285-290 6 p.

Research output: Contribution to journalArticle

Carmustine
Heterografts
Tumors
Colon
Neoplasms
22 Citations (Scopus)
Leukemia L1210
Polyamines
Metabolism
Spermidine
Spermine